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V5015

VU0152100

≥98% (HPLC)

Synonym(s):

3-Amino-N-[(4-methoxyphenyl)methyl]-4,6-dimethyl-thieno[2,3-b]pyridine-2-carboxamide

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About This Item

Empirical Formula (Hill Notation):
C18H19N3O2S
CAS Number:
409351-28-6
Molecular Weight:
341.43
NACRES:
NA.77
PubChem Substance ID:
329829056
UNSPSC Code:
12352200
MDL number:
MFCD02742972
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
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Quality Level

100

assay

≥98% (HPLC)

form

powder

solubility

DMSO: >50 mg/mL

storage temp.

2-8°C

SMILES string

COc1ccc(CNC(=O)c2sc3nc(C)cc(C)c3c2N)cc1

InChI

1S/C18H19N3O2S/c1-10-8-11(2)21-18-14(10)15(19)16(24-18)17(22)20-9-12-4-6-13(23-3)7-5-12/h4-8H,9,19H2,1-3H3,(H,20,22)

InChI key

MDNWGCQSCGNTKH-UHFFFAOYSA-N

Biochem/physiol Actions

Positive allosteric modulator of muscarinic choline receptor M4.
Positive allosteric modulator of muscarinic choline receptor M4. Potentiates activation by acetylcholine, but posesses no intrinsic agonist activity alone.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301,H319

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000173651
0000173651
047M4608V
066M4610V
011M4608V

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Paulina Cieślik et al.
Behavioural brain research, 359, 671-685 (2018-09-30)
Recent preclinical studies point to muscarinic and GABAB receptors as novel therapeutic targets for the treatment of schizophrenia. This study was aimed to assess the role of muscarinic and GABAB receptor interactions in animal models of schizophrenia, using positive allosteric
Bing Xue et al.
European journal of pharmacology, 820, 45-52 (2017-12-16)
Two key transmitters in the medial prefrontal cortex (mPFC), dopamine and acetylcholine, are believed to interact with each other to modulate local glutamatergic transmission, although molecular mechanisms underlying their crosstalk are poorly understood. Here we investigated effects of pharmacological manipulations
Kristine B Jørgensen et al.
Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 202(1), 7-15 (2015-11-02)
The present study investigated the cholinergic system in the African naked mole-rat (Heterocephalus glaber) with focus on the muscarinic acetylcholine receptor subtypes M1 and M4. The protein sequences for the subtypes m 1-5 of the naked mole-rat were compared to
Michael Bubser et al.
ACS chemical neuroscience, 5(10), 920-942 (2014-08-20)
Positive allosteric modulators (PAMs) of the M4 muscarinic acetylcholine receptor (mAChR) represent a novel approach for the treatment of psychotic symptoms associated with schizophrenia and other neuropsychiatric disorders. We recently reported that the selective M4 PAM VU0152100 produced an antipsychotic
Alberto Brugnoli et al.
Neurobiology of disease, 144, 105044-105044 (2020-08-18)
Acetylcholine muscarinic receptors (mAChRs) contribute to both the facilitation and inhibition of levodopa-induced dyskinesia operated by striatal cholinergic interneurons, although the receptor subtypes involved remain elusive. Cholinergic afferents from the midbrain also innervate the substantia nigra reticulata, although the role
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Articles

Muscarinic Acetylcholine Receptors

Muscarinic acetylcholine receptors mediate acetylcholine actions in CNS and non-nervous tissues, crucial for cell signaling.

DISCOVER Bioactive Small Molecules for Neuroscience

DISCOVER Bioactive Small Molecules for Neuroscience

Global Trade Item Number

SKUGTIN
V5015-25MG04061837481079
V5015-5MG04061832078243

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