W0519
WS-12
≥98% (HPLC), TRPM8 agonist, powder
Synonym(s):
(1R,2S,5R)-2-Isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexanecarboxamide
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About This Item
Empirical Formula (Hill Notation):
C18H27NO2
CAS Number:
Molecular Weight:
289.41
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.25
MDL number:
Form:
powder
Assay:
≥98% (HPLC)
Product Name
WS-12, ≥98% (HPLC), powder
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to off-white
solubility
DMSO: >20 mg/mL
storage temp.
−20°C
SMILES string
COc1ccc(NC(=O)C2C[C@H](C)CC[C@H]2C(C)C)cc1
InChI
1S/C18H27NO2/c1-12(2)16-10-5-13(3)11-17(16)18(20)19-14-6-8-15(21-4)9-7-14/h6-9,12-13,16-17H,5,10-11H2,1-4H3,(H,19,20)/t13-,16?,17?/m1/s1
InChI key
HNSGVPAAXJJOPQ-NVPAJSRCSA-N
Biochem/physiol Actions
WS-12 is a menthol derivative, that shows a specific binding affinity towards TRPM8 (transient receptor potential cation channel subfamily M member 8) receptor. TRPM8 is associated with prostate cancer and thus, WS-12 might be useful in reducing the progression of cancer.
WS-12 is a high-affinity, selective TRPM8 (cold menthol receptor 1; CMR1) agonist.
WS-12 is a high-affinity, selective TRPM8 (cold menthol receptor 1; CMR1) agonist. TRPM8 agonists induce a cooling sensation in sensory neurons and produce profound, mechanistically novel analgesia in chronic pain states such as neuropathic pain.
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
flash_point_f
No data available
flash_point_c
No data available
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TRP Channels, 378-378 (2016)
Norihiro Suzuki et al.
Molecular nutrition & food research, e2000853-e2000853 (2020-11-15)
Peppermint is traditionally used as an antigalactagogue in breastfeeding women. However, the suppressive mechanism remains unclear. The authors investigate whether and how peppermint influences milk production at the cellular and molecular levels. A lactating mammary epithelial cell (MEC) culture model
Ying Yin et al.
Science (New York, N.Y.), 363(6430) (2019-02-09)
Transient receptor potential melastatin member 8 (TRPM8) is a calcium ion (Ca2+)-permeable cation channel that serves as the primary cold and menthol sensor in humans. Activation of TRPM8 by cooling compounds relies on allosteric actions of agonist and membrane lipid
Global Trade Item Number
| SKU | GTIN |
|---|---|
| W0519-5MG | 04061833237052 |