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Sigma-Aldrich

Xylometazoline hydrochloride

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Synonym(s):
2-(4-tert-Butyl-2,6-dimethylbenzyl)-2-imidazoline hydrochloride
Empirical Formula (Hill Notation):
C16H24N2 · HCl
CAS Number:
1218-35-5
Molecular Weight:
280.84
EC Number:
214-936-4
MDL number:
MFCD00238707
PubChem Substance ID:
24278781
NACRES:
NA.77

Quality Level

200

originator

Novartis

SMILES string

CC1=CC(C(C)(C)C)=CC(C)=C1CC2=NCCN2.Cl

InChI

1S/C16H24N2.ClH/c1-11-8-13(16(3,4)5)9-12(2)14(11)10-15-17-6-7-18-15;/h8-9H,6-7,10H2,1-5H3,(H,17,18);1H

InChI key

YGWFCQYETHJKNX-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152)

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Biochem/physiol Actions

α-adrenoceptor agonist; imidazoline binding site ligand.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

新产品

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H Sakuta et al.
European journal of pharmacology, 259(3), 223-231 (1994-07-11)
The effects of imidazoline and imidazolidine derivatives on glibenclamide-sensitive K+ currents induced by the novel K+ channel opener, Y-26763 ((+)-(3S,4R)-4-(N-acetyl-N-benzyloxyamino)-6-cyano-3,4-dihydro-2,2 -dimethyl-2H-1-benzopyran-3-ol), were investigated in voltage-clamped follicle-enclosed Xenopus oocytes. Of 14 imidazoline derivatives and seven imidazolidine derivatives tested, phenotalmine, (-)-cibenzoline, (+)-cibenzoline
Jiaoping Mi et al.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 31(6), 837-841 (2011-12-17)
This study prospectively examined the intranasal distribution of nasal spray after nasal septal correction and decongestant administration. A cohort of 20 patients was assessed for the distribution of nasal spray before and after nasal septum surgery. Sprays were dyed and
Comments on: Central serous chorioretinopathy after dacryocystorhinostomy operation on the same side.
Parthasarathi Roy
Indian journal of ophthalmology, 58(2), 167-168 (2010-03-03)
Sami Bercin et al.
Acta oto-laryngologica, 129(11), 1257-1261 (2009-10-30)
This study revealed that the nasal topical drops, which could be purchased without a proper prescription, should not be used randomly and non-selectively. To investigate the effect of nasal drops and sprays on the nasal air flow and mucociliary transport
Daniela Leupold et al.
The neurologist, 17(1), 41-43 (2010-12-31)
substance abuse is an important cause of ischemic stroke in the young. This includes over-the-counter dietary supplements and cough and cold remedies, which were reported to be an independent risk factor for hemorrhagic stroke. this article describes a young male
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