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Merck
CN

Z4751

Anti-Zyxin antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

Anti-ESP-2, Anti-HED-2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD01634364

Key Documents

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Product Name

Anti-Zyxin antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution

biological source

rabbit

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 82-84 kDa

species reactivity

mouse, human, rat

technique(s)

indirect immunofluorescence: 1:100 using Rat1 cells
western blot (chemiluminescent): 1:1,000 using whole extract of human HeLa cells
western blot (chemiluminescent): 1:2,000 using whole extract of mouse NIH3T3 cells

UniProt accession no.

Q15942

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... ZYX(7791)
mouse ... Zyx(22793)
rat ... Zyx(114636)

Application

Anti-Zyxin antibody has been used in fluorescence microscopy.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 papers)

Biochem/physiol Actions

Zyxin (ZYX ) participates in the modulation of actin assembly at focal adhesions and stress fibers. It also regulates cell adhesion and cell cycle. Overexpression of ZYX is associated with melanoma. Suppression of ZYX  prevents cell growth.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Zyxin (ZYX ), a zinc-binding phosphoprotein of ∼61kDa is located at focal adhesions and along the actin cytoskeleton. It has three LIM domains. This structural protein is located on human chromosome 7q34.

Immunogen

synthetic peptide corresponding to amino acid residues 134-150 of human zyxin with N-terminal added cysteine conjugated to KLH. The corresponding sequence differs by one amino acid in mouse.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000340637
0000340637
0000242512
0000242512
0000143671

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Functional analysis of Zyxin in cell migration and invasive potential of oral squamous cell carcinoma cells Corrigendum in/10.3892/ijo. 2016.3702
Yamamura MN, et al.
International Journal of Oncology, 42(3), 873-880 (2013)
A cell culture model for investigation of Hirano bodies
Davis RC, et al.
Acta Neuropathologica, 115(2), 205-205 (2008)
Loss of the mechanotransducer zyxin promotes a synthetic phenotype of vascular smooth muscle cells
Ghosh SK, et al.
Journal of the American Heart Association, 4(6), e001712-e001712 (2015)
Novel identification of zyxin upregulations in the motile phenotype of hepatocellular carcinoma
Sy SMH, et al.
Modern Pathology, 19(8), 1108-1108 (2006)
Aniqua Rahman et al.
Molecular biology of the cell (2016-03-11)
During metastasis, cells can use proteolytic activity to form tube-like "microtracks" within the extracellular matrix (ECM). Using these microtracks, cells can migrate unimpeded through the stroma. To investigate the molecular mechanisms of microtrack migration, we developed an in vitro 3D
View All Related Papers

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