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11024AST

Astec^® CHIROBIOTIC^® V Chiral HPLC Column

Name: Astec<SUP>®</SUP> CHIROBIOTIC<SUP>®</SUP> V Chiral HPLC Column
Brand: SUPELCO

5 μm particle size, L × I.D. 25 cm × 4.6 mm

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eCl@ss:

32110501

NACRES:

SB.52

material

stainless steel column

Quality Level

100

Agency

suitable for USP L88

description

HPLC Column

product line

Astec^®

packaging

pkg of 1 ea

manufacturer/tradename

Astec^®

parameter

0-45 °C temperature
241 bar pressure (3500 psi)

technique(s)

HPLC: suitable
LC/MS: suitable

L × I.D.

25 cm × 4.6 mm

matrix

High-purity silica gel particle platform
fully porous particle

matrix active group

vancomycin phase

particle size

5 μm

pore size

100 Å

operating pH range

3.5-7.0

separation technique

chiral

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General description

Neutral molecules, amides, acids, esters and amines show considerable enantioselectivity on these vancomycin-based CSPs. A wide variety of secondary and tertiary amines have been separated on the CHIROBIOTIC^® V in the polar ionic mode. The CHIROBIOTIC^® V has demonstrated many of the separation characteristics of protein-based stationary phases, but with exceptional stability and much higher sample capacity. Some chiral analytes have been resolved that have not been reported separated on any other chiral stationary phase. CHIROBIOTIC^® V and V2 differ in their bonding chemistry the pore size of the support particle, giving them different selectivity and preparative capacity.

Bonded phase: Vancomycin
Operating pH range: 3.5 - 7.0
Particle diameter: 5, 10 or 16 μm
Pore size: 100 Å (CHIROBIOTIC^® V) or 200 Å (CHIROBIOTIC^® V2)

Application

Astec^® CHIROBIOTIC^® V Chiral HPLC column may be used for the separation of different types of racemic compounds (ß-blockers, ß-agonists, benzodiazipines, non-steroidal anti-inflammatory drugs, barbiturates, free and derivatized amino acids in packed column subcritical fluid chromatography (pSFC). It may also be used for the separation of citalopram enantiomers and its two N-demethylated metabolites and of alprenolol that is the internal standard, in human plasma using chiral liquid chromatography. It may also be used in the chiral liquid chromatography analysis of ketoprofen and flurbiprofen.

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Legal Information

Astec is a registered trademark of Merck KGaA, Darmstadt, Germany

CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC

Application

Product No.

Description

Pricing

related product

Product No.

Description

Pricing

11100AST

Astec^® CHIROBIOTIC^® V Chiral HPLC Guard Column, Cartridge, 5 μm particle size, L × I.D. 2 cm × 4 mm

21150AST

Supelguard^™ Guard Cartridge Holder, Stand-Alone (Swivel-type), for use with Supelguard cartridges (2 cm L. x 2 to 4.6 mm I.D.)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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1000309185

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Chiral packed column subcritical fluid chromatography on polysaccharide and macrocyclic antibiotic chiral stationary phases.

Andrei M

Journal of Chromatography A, 785 (1), 159-171 (1997)

Chiral resolution of flurbiprofen and ketoprofen enantiomers by HPLC on a glycopeptide-type column chiral stationary phase.

F Péhourcq et al.

Biomedical chromatography : BMC, 15(3), 217-222 (2001-06-08)

Vancomycin is an amphoteric, glycopeptide, macrocyclic antibiotic. When attached to 5 microspherical silica gel, vancomycin proved to be an effective chromatographic chiral stationary phase that could be used in the reversed-phase mode. In this study, a bonded vancomycin chiral stationary

Analysis of the enantiomers of citalopram and its demethylated metabolites using chiral liquid chromatography.

M Kosel et al.

Journal of chromatography. B, Biomedical sciences and applications, 719(1-2), 234-238 (1998-12-30)

A procedure using a chirobiotic V column is presented which allows separation of the enantiomers of citalopram and its two N-demethylated metabolites, and of the internal standard, alprenolol, in human plasma. Citalopram, demethylcitalopram and didemethylcitalopram, as well as the internal

Effect of chromatographic conditions on liquid chromatographic chiral separation of terbutaline and salbutamol on Chirobiotic V column.

Hisham Hashem et al.

Journal of chromatography. A, 1218(38), 6727-6731 (2011-08-23)

In this study, a method for enantioseparation of terbutaline and salbutamol was established using Chirobiotic V column as a stationary phase. Polar ionic mode applying mobile phase containing ammonium nitrate in 100% ethanol, pH 5.1 was found to give the

Chiral stability-indicating HPLC method for analysis of arotinolol in pharmaceutical formulation and human plasma

Sultan, Maha A., et al.

Arabian Journal of Chemistry, 3 (3), 147-153 (2010)

View All Related Papers

Chromatograms

HPLC Analysis of Warfarin Enantiomers on Astec^® CHIROBIOTIC^® V

application for HPLC

HPLC Analysis of Coumafuryl Enantiomers on Astec^® CHIROBIOTIC^® V

application for HPLC

HPLC Analysis of Clenbuterol Enantiomers on Astec^® CHIROBIOTIC^® V

application for HPLC

HPLC Analysis of Mephenytoin Enantiomers on Astec^® CHIROBIOTIC^® V

application for HPLCShow More

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Documents

Astec® CHIROBIOTIC® V Chiral HPLC Column

5 μm particle size, L × I.D. 25 cm × 4.6 mm

Properties

material

Quality Level

Agency

description

product line

packaging

manufacturer/tradename

parameter

technique(s)

L × I.D.

matrix

matrix active group

particle size

pore size

operating pH range

separation technique

Related Categories

Description

General description

Application

Recommended products

Legal Information

Related Products

Application

related product

Safety Information

Storage Class Code

WGK

Flash Point(F)

Flash Point(C)

Documentation

Certificates of Analysis (COA)

Already Own This Product?

Difficulty Finding Your Product Or Lot/Batch Number?

Aldrich Products

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Peer Reviewed Papers

Protocols and Articles

Chromatograms

Technical Service

Astec^® CHIROBIOTIC^® V Chiral HPLC Column