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About This Item
Empirical Formula (Hill Notation):
C19H33NO2 · HCl
CAS Number:
Molecular Weight:
343.93
UNSPSC Code:
41116107
NACRES:
NA.24
biological source
synthetic
grade
pharmaceutical primary standard
agency
EP
API family
fingolimod
form
powder
packaging
pkg of 110 mg
manufacturer/tradename
EDQM
storage condition
protect from light
solubility
water: 100-1000 g/L
application(s)
pharmaceutical
format
neat
shipped in
ambient
storage temp.
2-8°C
SMILES string
Cl.NC(CO)(CO)CCc1ccc(cc1)CCCCCCCC
InChI
1S/C19H33NO2.ClH/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22;/h9-12,21-22H,2-8,13-16,20H2,1H3;1H
InChI key
SWZTYAVBMYWFGS-UHFFFAOYSA-N
General description
Fingolimod Hydrochloride (fingolimod HCl), an S1P-receptor modulator, belongs to the class of synthetic glucocorticoid steroid drugs.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Application
This European Pharmacopoeia reference standard is intended for use only as specifically prescribed in the European Pharmacopoeia.
Biochem/physiol Actions
FTY720 is an immunomodulating drug and sphingosine 1-phosphate (S1P) receptor modulator. Phosphorylation of FTY270 by sphingosine kinase causes S1P1R internalization, which sequesters lymphocytes in lymph nodes, preventing them from taking part in an autoimmune response. Clinically, it has been approved for the treatment of multiple sclerosis (MS). It has also been shown to block and reverse paclitaxel-induced chemotherapy induced peripheral neuropathy (CIPN) through S1PR inhibition as well as inhibit the activity of histone deacetylases in the hippocampus of mouse brains, thereby modulating memory.
FTY720, an immunomodulating drug, acts as a sphingosine 1-phosphate (S1P) receptor modulator.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Other Notes
Sales restrictions may apply.
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signalword
Warning
hcodes
pcodes
Hazard Classifications
STOT RE 2
target_organs
Immune system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Solubility of dexamethasone in supercritical carbon dioxide
Chim RB, et al.
Journal of Chemical and Engineering Data, 57(12), 3756-3760 (2012)
Fingolimod Hydrochloride
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 4(1), 4989-4990 (2019)
A randomized, open-label study assessing the bioequivalence of two formulations of Fingolimod 0.5 mg in healthy subjects
Tanguay M, et al.
AAPS Open, 4(1), 3-3 (2018)