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About This Item
Empirical Formula (Hill Notation):
C17H19NO5
CAS Number:
Molecular Weight:
317.34
UNSPSC Code:
12352100
NACRES:
NA.24
MDL number:
InChI
1S/C17H19NO5/c1-21-13-10-12(11-14(22-2)17(13)23-3)7-8-16(20)18-9-5-4-6-15(18)19/h4,6-8,10-11H,5,9H2,1-3H3/b8-7+
SMILES string
COc1cc(\C=C\C(=O)N2CCC=CC2=O)cc(OC)c1OC
InChI key
VABYUUZNAVQNPG-BQYQJAHWSA-N
grade
primary reference standard
product line
phyproof® Reference Substance
assay
≥90.0%
manufacturer/tradename
PhytoLab
application(s)
food and beverages
pharmaceutical
storage temp.
2-8°C
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General description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Biochem/physiol Actions
Piperlongumine is an inhibitor or Glutathione S-transferase pi 1; Apoptosis Inducer in cancer, not normal cells
Piperlongumine selectively kills cancer cells regardless of p53 status without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1). It increases the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells with little effect on either rapidly or slowly dividing primary normal cells. Piperlongumine showed significant antitumour effects in a variety of mouse tumour models and inhibited growth of spontaneously formed malignant breast tumours and their associated metastases.
Legal Information
phyproof is a registered trademark of PhytoLab GmbH & Co. KG
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
涉药品监管产品
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