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Solid Phase Extraction (SPE) and QuEChERS

SPE Cartridges

We offer a diverse range of SPE-phase chemistries and cartridges ideal for many applications including pharmaceutical, clinical, food and beverage, environmental, petrochemical, and agriculture. The phase chemistry selection allows users to screen for the retention and selectivity required to achieve sample preparation objectives.

Discovery® DSC-18 Supelco® 96 well plate assembly for high throughput pharmaceutical screening and analysis

SPE Well Plates

Our SPE plates allow users to process up to 96 samples simultaneously for increased reproducibility and throughput, while maintaining excellent recoveries and increased sensitivity. 96-well plates offer compatibility with multi-channel pipettors and automation and are available with silica sorbent and polymeric adsorbent.

Centrifuge tube containing pre-determined amount of Supel™ QuE Verde sorbent for dSPE in challenging green matrices.

QuEChERS

The “QuEChERS” (Dispersive SPE, dSPE) method has emerged as a popular sample preparation technique in the area of multi-residue pesticide analysis for food and agricultural products. The QuEChERS technique offers the advantage of higher recoveries, accurate results, and high sample throughput.

DPX^® Tips

Dispersive Pipette Extraction (DPX) tips provide an in tip solution for complete sample preparation that can be easily automated to achieve extraction in seconds. HybridSPE^® sorbent material is loosely contained within a tip, for selective retention and removal of endogenous phospholipid interferences from biological matrices for LC-MS or LC-MS/MS analysis.

Supelclean™ ENVI™-8 DSK SPE membrane for faster processing of larger sample volumes

Disks

SPE disks are porous glass fiber membranes embedded with modified silica particles that provide fast flow rates for processing large sample volumes. We offer SPE disks that accommodate rapid organic contaminant extraction, making them ideal for the EPA 500 series, including 525.1 and 508.1.

Solid Phase Extraction Accessories

To facilitate sample preparation requirements, we offer a range of accessories including SPE tube components, elution racks, drying attachments, single SPE tube processors, vacuum pump trap kits, disk holders, and vacuum manifolds.

Related Applications

Mass Spectrometry

Mass spectrometry (MS) is an analytical tool used to identify compounds, determine chemical structure, and assess isotopic abundance. In MS, samples are ionized, and the resulting ions are identified based on their mass-to-charge (m/z) ratios.

Low Pressure Liquid Chromatography

Low pressure liquid chromatography (LPLC) is a chromatographic technique that operates at low pressures to drive the mobile phase onto the column containing a stationary phase by the action of a pump.

Sample Preparation

Protocols and technical articles relating to solid phase extraction (SPE), solid phase microextraction (SPME), QuEChERS dispersive SPE, filtration, purification, and other sample preparation techniques.

Solid Phase Extraction (SPE)

Solid phase extraction (SPE) is a technique used for rapid, selective sample preparation and purification prior to chromatographic analysis (e.g. HPLC, GC, TLC). SPE is used to exchange sample matrices, concentrate analytes, and remove interferences and contaminants to improve data and protect the analytical column.

QuEChERS Sample Preparation Method

QuEChERS is a ‘Quick, Easy, Cheap, Effective, Rugged and Safe’ sample cleanup method used to prepare food and agricultural samples for pesticides analysis. QuEChERS is based on the Solid Phase Extraction (SPE) technique of sample preparation.

Gas Chromatography (GC)

Gas chromatography is a common analytic technique used to separate and analyze volatile compounds in the gas phase. GC is applied in many industries for quality control, and to identify and/or quantify compounds in a mixture.

Large Molecule HPLC

High performance liquid chromatography (HPLC) can be used to separate and identify different large biomolecules such as protein and peptides in a sample. It is based on the pumping of a sample with a solvent (mobile phase) through a column packed with sorbent material (stationary phase) at a high pressure.

Small Molecule HPLC

Small molecules are ions and compounds of molecular weight typically less than 900 daltons. These compounds can be effectively separated and analyzed by HPLC, UHPLC and LC-MS using mainly silica particles or monolithic stationary phases with a broad range of column chemistries (modifications).

Highlights

Webinar: Supel™ Swift HLB SPE Cartridges

The key benefits of using a polymeric stationary phase extraction (SPE) material over traditional silica-based materials include a wider pH range, a spherical shape to create column-to-column consistency, and more.