Solid phase extraction is a form of digital (step-wise) chromatography designed to extract, partition, and/or adsorb one or more components from a liquid phase (sample) onto stationary phase (sorbent or resin). Over the last twenty years, SPE has become the most powerful technique available for rapid and selective sample preparation (prep) prior to analytical chromatography. SPE extends a chromatographic system’s lifetime, improves qualitative and quantitative analysis, and by changing an analyte of interest’s original matrix environment to a simpler matrix more suitable for subsequent analysis, the demand placed on an analytical instrument is considerably lessened.
Reversed-Phase SPE methodology
Ion-Exchange SPE methodology
Normal Phase SPE methodology
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