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Showing 1-30 of 103 results for "00090590" within Papers
Sang Duck Jeon et al.
International journal of biological macromolecules, 75, 1-6 (2015-01-21)
Clostridium cellulovorans, produce multi-enzymatic complexes known as cellulosomes, which assemble via the interaction of a dockerin module in the cellulosomal subunit with one of the several cohesin modules in the scaffolding protein, to degrade the plant cell wall polymer. An
Diego A Fernández et al.
Toxicon : official journal of the International Society on Toxinology, 91, 23-34 (2014-09-03)
Cylindrospermopsin is a freshwater and widespread cyanotoxin considered hazardous for human health. Climate change and eutrophication are the main factors influencing the increasing presence of cylindrospermopsin producers that can contaminate human and animal drinking waters, leading to a rise in
Marcela S Villaverde et al.
International immunopharmacology, 22(1), 167-175 (2014-06-29)
In an aggressive B16-F10 murine melanoma model, we evaluated the effectiveness and antitumor mechanisms triggered by a surgery adjuvant treatment that combined a local suicide gene therapy (SG) with a subcutaneous genetic vaccine (Vx) composed of B16-F10 cell extracts and
Rhoda E Kuc et al.
Life sciences, 118(2), 391-396 (2014-03-04)
In pulmonary arterial hypertension (PAH), increases in endothelin-1 (ET-1) contribute to elevated pulmonary vascular resistance which ultimately causes death by right ventricular (RV) heart failure. ET antagonists are effective in treating PAH but lack efficacy in treating left ventricular (LV)
Marco Cespi et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(3), 954-961 (2014-09-10)
The purpose of this study was to develop and evaluate a delivery system comprising a thermosensitive gel for the sustained release of steroidal hormones in fish, over an extended period of time after a single intramuscular (i.m.) injection and for
Trudy H Grossman et al.
Antimicrobial agents and chemotherapy, 59(3), 1534-1541 (2014-12-24)
Previous studies indicated that inhibition of efflux pumps augments tuberculosis therapy. In this study, we used timcodar (formerly VX-853) to determine if this efflux pump inhibitor could increase the potency of antituberculosis (anti-TB) drugs against Mycobacterium tuberculosis in in vitro
Sang-Soo Kim et al.
ACS nano, 8(6), 5494-5514 (2014-05-09)
Temozolomide (TMZ)-resistance in glioblastoma multiforme (GBM) has been linked to upregulation of O(6)-methylguanine-DNA methyltransferase (MGMT). Wild-type (wt) p53 was previously shown to down-modulate MGMT. However, p53 therapy for GBM is limited by lack of efficient delivery across the blood brain
Marianela Garcia-Munoz et al.
Neuropharmacology, 89, 54-63 (2014-09-23)
N-methyl-D-aspartate receptors (NMDAR) are crucial for the function of excitatory neurotransmission and are present at the synapse and on the extrasynaptic membrane. The major nucleus of the basal ganglia, striatum, receives a large glutamatergic excitatory input carrying information about movements
Collin C Luk et al.
Scientific reports, 5, 9523-9523 (2015-04-02)
Highly coordinated and coincidental patterns of activity-dependent mechanisms ("fire together wire together") are thought to serve as inductive signals during synaptogenesis, enabling neuronal pairing between specific sub-sets of excitatory partners. However, neither the nature of activity triggers, nor the "activity
Fei Li et al.
Journal of proteome research, 14(4), 1937-1946 (2015-02-26)
Colon cancer is the most common cancer and the third leading cause of cancer mortality in humans. Using mass spectrometry-based metabolomics, the current study revealed the accumulation of four uremic toxins (cresol sulfate, cresol glucuronide, indoxyl sulfate, and phenyl sulfate)
Andre F Correa et al.
Infection and immunity, 82(12), 5154-5165 (2014-10-01)
Tuberculosis (TB) remains a major global health problem, and although multiple studies have addressed the relationship between Mycobacterium tuberculosis and the host on an immunological level, few studies have addressed the impact of host physiological responses. Proteases produced by bacteria
Elaine L Ferguson et al.
Molecular pharmaceutics, 11(12), 4437-4447 (2014-11-02)
Polymer therapeutics offer potential benefits in the treatment of multidrug resistant (MDR) infections; affording targeted delivery of biologically active agents to the site of inflammation, potential decreases in systemic toxicity, and the retention of antimicrobial activity at the target site.
Tommy Jönsson et al.
BMC biochemistry, 16, 3-3 (2015-01-21)
Leptin resistance is considered a primary risk factor for obesity. It has been hypothesized that dietary cereal grain protein could cause leptin resistance by preventing leptin from binding to its receptor. Non-degraded dietary wheat protein has been found in human
E Calleri et al.
Chembiochem : a European journal of chemical biology, 15(8), 1154-1160 (2014-05-07)
Resveratrol, a modulator of several signaling proteins, can exert off-target effects involving the peroxisome proliferator-activated receptor (PPAR) transcription factors. However, evidence for the direct interaction between this polyphenol and PPARs is lacking. Here, we addressed the hypothesis that resveratrol and
Waihay J Wong et al.
The Journal of investigative dermatology, 135(2), 454-461 (2014-07-08)
A functional epidermal skin barrier requires the formation of a cornified envelope from terminally differentiating keratinocytes. During this process, multiple genetic and environmental signals coordinately regulate protein expression and tissue differentiation. Here we describe a critical role for hypoxia-inducible factors
Hao Yu et al.
Phytotherapy research : PTR, 29(2), 228-240 (2014-10-18)
The aim of the present paper was to investigate the effects and possible mechanisms of the total saponins from Dioscorea nipponica Makino (TSDN) against type 2 diabetes mellitus. Streptozotocin (STZ) with high-fat diet induced type 2 diabetes mellitus (T2DM) rats
Juhui Ko et al.
Journal of hazardous materials, 285, 11-17 (2014-12-03)
Aflatoxin B1 (AFB1) is a well-known carcinogenic contaminant in foods. It is classified as an extremely hazardous compound because of its potential toxicity to the human nervous system. AFB1 has also been extensively used as a biochemical marker to evaluate
Yoshito Fujii et al.
PLoS neglected tropical diseases, 8(7), e3040-e3040 (2014-08-01)
A strategy to combat infectious diseases, including neglected tropical diseases (NTDs), will depend on the development of reliable epidemiological surveillance methods. To establish a simple and practical seroprevalence detection system, we developed a microsphere-based multiplex immunoassay system and evaluated utility
Alessandro Bertucci et al.
Biosensors & bioelectronics, 63, 248-254 (2014-08-12)
Microstructured optical fibers containing microchannels and Bragg grating inscribed were internally functionalized with a peptide nucleic acid (PNA) probe specific for a gene tract of the genetically modified Roundup Ready soy. These fibers were used as an optofluidic device for
Meenakshi Choudhary et al.
Applied biochemistry and biotechnology, 174(3), 1188-1200 (2014-07-16)
A label-free electrochemical bianalyte immunosensor has been designed for simultaneous detection of lung cancer biomarkers (anti-MAGE A2 and anti-MAGE A11) using carbon nanotubes-chitosan (CNT-CHI) composite. To achieve this, acid-functionalized single-walled CNTs were used to prepare CNT-CHI gel and electrodes were
Yiyin Mao et al.
Nature communications, 5, 5532-5532 (2014-11-19)
Porous metal-organic frameworks (MOFs) demonstrate great potential for numerous applications. Although hetero-functional components have been encapsulated within MOF crystalline particles, the uniform incorporation of functional species with different sizes, shapes and functions in MOF thin films with dual properties, especially
Olgica Trenchevska et al.
Journal of proteomics, 116, 15-23 (2015-01-01)
The chemokine RANTES plays a key role in inflammation, cell recruitment and T cell activation. RANTES is heterogenic and exists as multiple variants in vivo. Herein we describe the development and characterization of a fully quantitative mass spectrometric immunoassay (MSIA)
Lars Sejergaard et al.
Biotechnology progress, 30(5), 1057-1064 (2014-05-07)
This study demonstrates how the multimodal Capto adhere resin can be used in concert with calcium chloride or arginine hydrochloride as mobile phase modifiers to create a highly selective purification process for a modified human growth hormone. Importantly, these processes
Yue Xu et al.
International journal of clinical and experimental medicine, 7(12), 4997-5003 (2015-02-11)
Evaluate the behavior and function of human umbilical vein endothelial cells (HUVECs) on decellularized extracellular matrix (ECM) deposited by bone marrow mesenchymal stem cells (BMSCs). Prepared through chemical approach, decellularized ECM was characterized by use of immunofluorescence staining. The morphology
Jing Guo et al.
Journal of chromatography. A, 1356, 129-137 (2014-07-12)
Hydrogen-deuterium exchange mass spectrometry (HX-MS) with proteolytic fragmentation is used to determine patterns of unfolding, as measured by increased solvent exposure, with peptide-level resolution for a glycosylated monoclonal antibody both when eluted from a tentacle-type cation exchange column (Fractogel EMD
Daniel Bury et al.
Biochemical pharmacology, 93(2), 141-150 (2014-12-03)
The glycosyltransferases of family 51 (GT51) catalyze the polymerization of lipid II to form linear glycan chains, which, after cross linking by the transpeptidases, form the net-like peptidoglycan macromolecule. The essential function of the GT makes it an attractive antimicrobial
Jinyang Chung et al.
Biosensors & bioelectronics, 67, 303-308 (2014-09-06)
Fast and accurate pathogen detection in aquatic environments is challenging in many biomedical studies and microbial diagnostic applications. In this study, we developed a real-time, continuous, and non-destructive single cell detection method using target specific aptamer-conjugated fluorescent nanoparticles (A-FNPs) and
Yao-An Shen et al.
Cancer letters, 360(1), 39-47 (2015-02-11)
Currently, epithelial ovarian cancer is viewed as a heterogeneous disease with five major histological subtypes. Clear cell carcinoma represents a specific histological subtype of epithelial ovarian cancer that demonstrates more aggressive clinical behavior and drug resistance compared with other subtypes.
John Gounarides et al.
PloS one, 9(10), e111472-e111472 (2014-10-25)
Proteins that are post-translationally adducted with 2-(ω-carboxyethyl)pyrrole (CEP) have been proposed to play a pathogenic role in age-related macular degeneration, by inducing angiogenesis in a Toll Like Receptor 2 (TLR2)-dependent manner. We have investigated the involvement of CEP adducts in
Sameh Magdeldin et al.
Journal of proteome research, 14(2), 943-952 (2014-11-16)
The purpose of this study is to determine the behavioral and proteomic consequences of shock-induced stress in zebrafish (Danio rerio) as a vertebrate model. Here we describe the behavioral effects of exposure to predictable and unpredictable electric shock, together with
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