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Showing 31-60 of 978 results for "02487" within Papers
Taylor R Jay et al.
The Journal of experimental medicine, 212(3), 287-295 (2015-03-04)
Variants in triggering receptor expressed on myeloid cells 2 (TREM2) confer high risk for Alzheimer's disease (AD) and other neurodegenerative diseases. However, the cell types and mechanisms underlying TREM2's involvement in neurodegeneration remain to be established. Here, we report that
Maja Lozić et al.
British journal of pharmacology, 171(19), 4385-4398 (2014-05-20)
The paraventricular nucleus (PVN) of the hypothalamus is an important integrative site for neuroendocrine control of the circulation. We investigated the role of oxytocin receptors (OT receptors) in PVN in cardiovascular homeostasis. Experiments were performed in conscious male Wistar rats
Porkodi Kadhirvel et al.
Journal of chromatography. A, 1358, 93-101 (2014-07-22)
Straightforward crushing and sieving bulk polymeric R-aminoglutethimide-imprinted materials were prepared by classical free radical polymerization, whereas nano thin walled grafted imprinted materials were prepared using RAFT mediated control polymerization technique. A stoichiometric non-covalent approach based on a triply hydrogen bonding
Taylor Callicrate et al.
BMC genomics, 15, 1098-1098 (2014-12-17)
The Hawaiian honeycreepers are an avian adaptive radiation containing many endangered and extinct species. They display a dramatic range of phenotypic variation and are a model system for studies of evolution, conservation, disease dynamics and population genetics. Development of a
Yoshiko Kaku et al.
Cancer chemotherapy and pharmacology, 75(3), 527-535 (2015-01-09)
Naftopidil is clinically for treatment of benign prostate hyperplasia, and emerging evidence has pointed to its anticancer effect. To obtain the anticancer drug with the potential greater than that of naftopidil, we have newly synthesized the naftopidil analogue HUHS1015. The
Chunhua Han et al.
Cell cycle (Georgetown, Tex.), 14(7), 1103-1115 (2014-12-09)
Xeroderma pigmentosum group G (XPG) protein is a structure-specific repair endonuclease, which cleaves DNA strands on the 3' side of the DNA damage during nucleotide excision repair (NER). XPG also plays a crucial role in initiating DNA repair synthesis through
Arfat Idrees et al.
Acta poloniae pharmaceutica, 71(2), 287-295 (2014-10-03)
This study was aimed to determine effects of penetration enhancers and plasticizers on drug release from rationally designed formulations of flurbiprofen based transdermal drug delivery system. Matrix type transdermal patches were formulated with ethyl cellulose (EC) as a polymer by
Tanmoy Sadhukha et al.
AAPS PharmSciTech, 15(4), 1029-1038 (2014-05-17)
Poor cellular uptake contributes to high dose requirement and limited therapeutic efficacy of the platinum-based anticancer drug carboplatin. Delivery systems that can improve the cellular accumulation of carboplatin will, therefore, likely improve its therapeutic potential. The objective of this study
Caroline G Walker et al.
Physiological genomics, 47(4), 89-101 (2015-01-22)
Postpartum uterine inflammation (endometritis) in the dairy cow is associated with lower fertility at both the time of infection and after the inflammation has resolved. We hypothesized that aberrant DNA methylation may be involved in the subfertility associated with uterine
M C Cela-Pérez et al.
Talanta, 135, 58-66 (2015-02-03)
A water compatible molecularly imprinted polymer (MIP), synthesized using theophylline (TPH) as dummy-template and acrylamide (AM) as functional monomer, has been employed as supporting material in matrix solid-phase dispersion combined with ultra performance liquid chromatography-photodiode array detection (MSPD-UPLC-PDA) for selective
Hajer Ayari-Jeridi et al.
PloS one, 10(1), e0116615-e0116615 (2015-01-21)
Retinoblastoma, an embryonic neoplasm of retinal origin, is the most common primary intraocular malignancy in children. Somatic inactivation of both alleles of the RB1 tumor suppressor gene in a retinal progenitor cell through diverse mechanisms including genetic and epigenetic modifications
Carsten Schwarz et al.
Nucleic acids research, 37(10), 3215-3229 (2009-03-27)
Despite being plagued by heavily degraded DNA in palaeontological remains, most studies addressing the state of DNA degradation have been limited to types of damage which do not pose a hindrance to Taq polymerase during PCR. Application of serial qPCR
Shigeo Hayashi et al.
Journal of enzyme inhibition and medicinal chemistry, 29(6), 846-867 (2014-02-13)
Because of the pivotal role of cyclooxygenase (COX) in the inflammatory processes, non-steroidal anti-inflammatory drugs (NSAIDs) that suppress COX activities have been used clinically for the treatment of inflammatory diseases/syndromes; however, traditional NSAIDs exhibit serious side-effects such as gastrointestinal damage
Christian Marsching et al.
Journal of lipid research, 55(11), 2354-2369 (2014-10-01)
Mammalian kidneys are rich in sulfatides. Papillary sulfatides, especially, contribute to renal adaptation to chronic metabolic acidosis. Due to differences in their cer-amide (Cer) anchors, the structural diversity of renal sulfatides is large. However, the underling biological function of this
Sebastian Puhl et al.
International journal of pharmaceutics, 477(1-2), 273-281 (2014-12-03)
Nonwoven scaffolds consisting of poly-ε-caprolactone (PCL), poly(lactic-co-glycolic acid) (PLGA) and polidocanol (PD), and loaded with lysozyme crystals were prepared by electrospinning. The composition of the matrix was varied and the effect of PD content in binary mixtures, and of PD
Amina R Gani et al.
Archives of biochemistry and biophysics, 568, 8-15 (2015-01-13)
Tauroursodeoxycholic acid (TUDCA) a bile salt and chemical chaperone reduces stress-induced aggregation of proteins; activates PERK [PKR (RNA-dependent protein kinase)-like ER (endoplasmic reticulum) kinase] or EIF2AK3, one of the hall marks of ER stress induced unfolded protein response (UPR) in
Flavia Badoud et al.
Journal of proteome research, 13(7), 3455-3466 (2014-06-17)
A subgroup of obese individuals, referred to as metabolically healthy obese (MHO), have preserved insulin sensitivity and a normal lipid profile despite being obese. The molecular basis for this improved cardiometabolic profile remains unclear. Our objective was to integrate metabolite
Elisabeth Kastner et al.
The Journal of pharmacy and pharmacology, 67(3), 450-463 (2015-02-14)
In this study, we have used a chemometrics-based method to correlate key liposomal adjuvant attributes with in-vivo immune responses based on multivariate analysis. The liposomal adjuvant composed of the cationic lipid dimethyldioctadecylammonium bromide (DDA) and trehalose 6,6-dibehenate (TDB) was modified
R J Golden et al.
Regulatory toxicology and pharmacology : RTP, 26(2), 142-155 (1997-11-14)
Risk assessment methodology, particularly pertaining to potential human carcinogenic risks from exposures to environmental chemicals, is undergoing intense scrutiny from scientists, regulators, and legislators. The current practice of estimating human cancer risk is based almost exclusively on extrapolating the results
Soheil Zorofchian Moghadamtousi et al.
PloS one, 10(4), e0122288-e0122288 (2015-04-11)
Annona muricata has been used in folk medicine for the treatment of cancer and tumors. This study evaluated the chemopreventive properties of an ethyl acetate extract of A. muricata leaves (EEAML) on azoxymethane-induced colonic aberrant crypt foci (ACF) in rats.
Geetha Durairaj et al.
Journal of molecular biology, 426(16), 2928-2941 (2014-06-10)
Sus1p is a common component of transcriptional co-activator, SAGA (Spt-Ada-Gcn5-Acetyltransferase), and mRNA export complex, TREX-2 (Transcription-export 2), and is involved in promoting transcription and mRNA export. However, it is not clearly understood how Sus1p promotes transcription. Here, we show that
Jadwiga C Wojtowicz et al.
Experimental eye research, 127, 261-269 (2014-08-26)
The aim of this prospective study was to conduct histopathologic and lipidomic analyses of chalazia, in order to evaluate time-dependent changes in the lesion. Samples of surgically excised chalazia were collected over a period of 12 months from 10 patients (mean age
Aysegul Kutluay et al.
Analytica chimica acta, 839, 59-66 (2014-07-30)
Multi-walled carbon nanotubes (MWCNTs) functionalized by cobalt nanoparticles were obtained using a single step chemical deposition method in an ultrasonic bath. The composite material was characterized using scanning electron microscopy (SEM) and energy dispersive X-ray analysis (EDX). The electroactivity of
Variations in pH sensitivity, acid stability, and fusogenicity of three influenza virus H3 subtypes.
Deirdre A Costello et al.
Journal of virology, 89(1), 350-360 (2014-10-17)
Influenza A virus strains adapt to achieve successful entry into host species. Entry is mediated by the viral membrane protein hemagglutinin (HA), which triggers membrane fusion and genome release under acidic conditions in the endosome. In addition to changes in
Yigit Ocal et al.
Journal of pharmaceutical sciences, 103(8), 2396-2405 (2014-06-19)
In this study, injectable microspheres were developed for the local treatment of joint degeneration in rheumatoid arthritis (RA). Microspheres loaded with triamcinolone (TA), a corticosteroid drug, and/or raloxifene (Ral), a cartilage regenerative drug, were prepared with a biodegradable and biocompatible
Adriana F Lubambo et al.
Carbohydrate polymers, 93(1), 240-245 (2013-03-08)
Self-assembled nano-arrays have a potential application as solid-phase diagnostics in many biomedical devices. The easiness of its production is directly connected to manufacture cost reduction. In this work, we present self-assembled structures starting from spin coated thin films of carboxylated
Darren W Gray et al.
Veterinary research, 46, 7-7 (2015-04-02)
Vaccination procedures within the cattle industry are important disease control tools to minimize economic and welfare burdens associated with respiratory pathogens. However, new vaccine, antigen and carrier technologies are required to combat emerging viral strains and enhance the efficacy of
Xingguo Cheng et al.
Toxicology and applied pharmacology, 278(1), 65-71 (2014-04-29)
The toxic effects of dioxins, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), mainly through activation of the aryl hydrocarbon receptor (AhR) are well documented. Fibroblast growth factor (Fgf) 21 plays critical roles in metabolic adaptation to fasting by increasing lipid oxidation and ketogenesis
Natassa Pippa et al.
Journal of liposome research, 24(3), 223-229 (2014-03-04)
The major advance of mixed liposomes (the so-called chimeric systems) is to control the size, structure, and morphology of these nanoassemblies, and therefore, system colloidal properties, with the aid of a large variety of parameters, such as chemical architecture and
Jun-Hye Shin et al.
PLoS genetics, 10(9), e1004612-e1004612 (2014-09-12)
The exosome complex functions in RNA metabolism and transcriptional gene silencing. Here, we report that mutations of two Arabidopsis genes encoding nuclear exosome components AtRRP6L1 and AtRRP6L2, cause de-repression of the main flowering repressor FLOWERING LOCUS C (FLC) and thus
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