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Showing 1-30 of 4182 results for "03609" within Papers
Roberta Rizzo et al.
Molecular and cellular biochemistry, 381(1-2), 243-255 (2013-06-06)
Human leukocyte antigen-G (HLA-G) molecules are non-classical HLA class I antigens with an important role in pregnancy immune regulation and inflammation control. Soluble HLA-G proteins can be generated through two mechanisms: alternative splicing and proteolytic release, which is known to
Yuliang Xie et al.
ACS nano, 8(12), 12175-12184 (2014-11-18)
In this work, we develop an in situ method to grow highly controllable, sensitive, three-dimensional (3D) surface-enhanced Raman scattering (SERS) substrates via an optothermal effect within microfluidic devices. Implementing this approach, we fabricate SERS substrates composed of Ag@ZnO structures at
Mijeong Jeon et al.
Archives of oral biology, 59(10), 1013-1023 (2014-06-25)
Stem cells from human exfoliated deciduous teeth (SHED) are a good source of dental tissue for regeneration therapy, and can be obtained using different primary culture methods. The aim of this study was to determine the differences in the in
Ki-Hong Jung et al.
Molecular plant, 8(2), 276-289 (2015-01-28)
Genes that are expressed ubiquitously throughout all developmental stages are thought to be necessary for basic biological or cellular functions. Therefore, determining their biological roles is a great challenge. We identified 4034 of these genes in rice after studying the
Kyung-Ha Ryu et al.
Experimental cell research, 326(1), 143-154 (2014-06-24)
Acute liver failure, the fatal deterioration of liver function, is the most common indication for emergency liver transplantation, and drug-induced liver injury and viral hepatitis are frequent in young adults. Stem cell therapy has come into the limelight as a
Xi Chen et al.
Clinica chimica acta; international journal of clinical chemistry, 444, 289-292 (2015-03-10)
Previous reports have shown that the ERG gene is hypermethylated in the placenta and hypomethylated in maternal blood cells. In this study, we explore the feasibility of hypermethylated ERG as a cell-free fetal (cff) DNA biomarker for non-invasive prenatal testing
Jing Cao et al.
Small (Weinheim an der Bergstrasse, Germany), 10(24), 5126-5136 (2014-08-08)
Loading and release mechanisms of Red clover necrotic mosaicvirus (RCNMV) derived plant viral nanoparticle (PVN) are shown for controlled delivery of the anticancer drug, doxorubicin (Dox). Previous studies demonstrate that RCNMV's structure and unique response to divalent cation depletion and
Mingjia Tan et al.
Neoplasia (New York, N.Y.), 17(1), 114-123 (2015-01-28)
Our recent study showed that SAG/RBX2 E3 ubiquitin ligase regulates apoptosis and vasculogenesis by promoting degradation of NOXA and NF1, and co-operates with Kras to promote lung tumorigenesis by activating NFκB and mTOR pathways via targeted degradation of tumor suppressive
P Edward Purdue et al.
Scientific reports, 4, 7595-7595 (2014-12-24)
As the only cells capable of efficiently resorbing bone, osteoclasts are central mediators of both normal bone remodeling and pathologies associates with excessive bone resorption. However, despite the clear evidence of interplay between osteoclasts and the bone surface in vivo
Miklos Guttman et al.
Nature communications, 6, 6144-6144 (2015-02-06)
HIV's envelope glycoprotein (Env) is the sole target for neutralizing antibodies. The structures of many broadly neutralizing antibodies (bNAbs) in complex with truncated Env subunits or components have been reported. However, their interaction with the intact Env trimer, and the
Yusuke Sakota et al.
Biological & pharmaceutical bulletin, 37(6), 1014-1020 (2014-06-03)
Collagen gel contraction assay is a method for evaluating contraction of cells embedded in collagen gel matrices through measuring the gel size. In the present study, we established a protocol for collagen gel contraction assay using human bronchial smooth muscle
Ousseynou Sarr et al.
PloS one, 9(6), e98433-e98433 (2014-06-14)
Uteroplacental insufficiency (UPI)-induced intrauterine growth restriction (IUGR) predisposes individuals to adult visceral obesity. We postulated that low birth weight (LBW) offspring, from UPI-induced IUGR pregnancies, would display a visceral adipose lipogenic molecular signature involving altered gene expression, phosphorylation status of
Seth S Martin et al.
Atherosclerosis, 239(1), 67-72 (2015-01-13)
Higher serum leptin levels have been associated with a modestly higher incidence of cardiovascular disease in studies involving mostly Caucasian men. We aimed to assess the hypothesis that higher baseline levels of serum leptin are associated with higher risk of
Reeta Tiwari et al.
Cancer investigation, 32(8), 402-408 (2014-07-16)
Betulinic acid (BA) has been shown to cause apoptosis in neuroblastoma and melanoma cell lines. We evaluated the cytotoxicity of BA in two breast cancer cell lines MCF-7 and T47D differing in their p53 status. Treatment with BA resulted in
Christian Krug et al.
Cancer immunology, immunotherapy : CII, 63(10), 999-1008 (2014-06-19)
Chimeric antigen receptors (CARs), which combine an antibody-derived binding domain (single chain fragment variable) with T-cell-activating signaling domains, have become a promising tool in the adoptive cellular therapy of cancer. Retro- and lenti-viral transductions are currently the standard methods to
Ana C Mestre-Citrinovitz et al.
PloS one, 10(4), e0124756-e0124756 (2015-04-22)
Progesterone receptor and estrogen receptor participate in growth and differentiation of the different rat decidual regions. Steroid hormone receptor antagonists were used to study steroid regulation of decidualization. Here we describe a suppressive interaction between progesterone receptor (onapristone) and estrogen
Sylvain Lefort et al.
Autophagy, 10(12), 2122-2142 (2014-11-27)
The triple-negative breast cancer (TN BC) subtype is the most aggressive form of invasive BC. Despite intensive efforts to improve BC treatments, patients with TN BC continue to exhibit poor survival, with half developing resistance to chemotherapy. Here we identify
Michael Schaller-Schönitz et al.
PloS one, 9(5), e97243-e97243 (2014-05-20)
Signal transducers and activators of transcription (STATs) are latent cytoplasmic transcription factors linking extracellular signals to target gene transcription. Hematopoietic cells express two highly conserved STAT5-isoforms (STAT5A/STAT5B), and STAT5 is directly activated by JAK2 downstream of several cytokine receptors and
John E Baatz et al.
In vivo (Athens, Greece), 28(4), 411-423 (2014-07-02)
Clinical trials are currently used to test therapeutic efficacies for lung cancer, infections and diseases. Animal models are also used as surrogates for human disease. Both approaches are expensive and time-consuming. The utility of human biospecimens as models is limited
Anna Otte et al.
International journal of oncology, 45(3), 1151-1158 (2014-06-28)
A recently established cellular model for the rare small cell carcinoma of the ovary hypercalcemic type (SCCOHT-1) was characterized in comparison to ovarian adenocarcinoma cells (NIH:OVCAR-3 and SK-OV-3). The different cancer populations exhibited a common sensitivity in acidic pH milieu
Christopher J Pappas et al.
Applied and environmental microbiology, 81(9), 3176-3181 (2015-03-01)
Leptospirosis, an emerging zoonotic disease, remains poorly understood because of a lack of genetic manipulation tools available for pathogenic leptospires. Current genetic manipulation techniques include insertion of DNA by random transposon mutagenesis and homologous recombination via suicide vectors. This study
M Fujiya et al.
Oncogene, 33(40), 4847-4856 (2013-10-30)
It is well known that microRNAs (miRs) are abnormally expressed in various cancers and target the messenger RNAs (mRNAs) of cancer-associated genes. While (miRs) are abnormally expressed in various cancers, whether miRs directly target oncogenic proteins is unknown. The present
Yaíma L Lightfoot et al.
The EMBO journal, 34(7), 881-895 (2015-02-11)
Intestinal immune regulatory signals govern gut homeostasis. Breakdown of such regulatory mechanisms may result in inflammatory bowel disease (IBD). Lactobacillus acidophilus contains unique surface layer proteins (Slps), including SlpA, SlpB, SlpX, and lipoteichoic acid (LTA), which interact with pattern recognition
Karina Fischer et al.
The American journal of clinical nutrition, 101(4), 794-807 (2015-04-04)
Visceral (VAT) and subcutaneous abdominal (SAAT) and trunk (STRAT) adipose tissue (AT) have been suggested to be differentially influenced by diet. We investigated whether and to what extent usual patterns of nutrient intake are associated with VAT, SAAT, and STRAT
Metin Ekinci et al.
Current eye research, 39(8), 853-858 (2014-02-08)
To evaluate the toxic effects of chronic lead (Pb) exposure on retinal nerve fiber layer thickness (RNFLT), macular thickness (MT) and choroidal thickness (CT) in battery industry workers. Male factory workers (n = 50) and healthy non-employees (n = 20) participated in the study.
Yu-Jing Li et al.
Journal of neuroimmunology, 278, 239-246 (2014-12-04)
While follicular helper T (Tfh) cells have been shown to be involved in many autoimmune diseases, the association of Tfh cells with the disease activity of neuromyelitis optica spectrum disorders (NMOSDs) remains unclear. In this study, the CD4(+)CXCR5(+)PD-1(+) Tfh cell
Nai-Jung Chiang et al.
Clinical and experimental pharmacology & physiology, 41(10), 830-837 (2014-06-10)
Membrane electroporation (MEP) increases the electrical conductivity of the plasma membrane by addition of an external electrical field. Combining MEP-induced current (IMEP ) with antineoplastic agents has been increasingly considered as a new therapeutic manoeuvre, especially in the treatment of
Kostas C Nikolaou et al.
The EMBO journal, 34(4), 430-447 (2014-12-18)
PR-SET7-mediated histone 4 lysine 20 methylation has been implicated in mitotic condensation, DNA damage response and replication licensing. Here, we show that PR-SET7 function in the liver is pivotal for maintaining genome integrity. Hepatocyte-specific deletion of PR-SET7 in mouse embryos
Dunja Aksentijević et al.
Journal of molecular and cellular cardiology, 75, 76-87 (2014-07-30)
Inhibition of malonyl-coenzyme A decarboxylase (MCD) shifts metabolism from fatty acid towards glucose oxidation, which has therapeutic potential for obesity and myocardial ischemic injury. However, ~40% of patients with MCD deficiency are diagnosed with cardiomyopathy during infancy. To clarify the
Mai Matsushita et al.
The Journal of experimental medicine, 212(4), 555-568 (2015-04-01)
The selenoenzyme glutathione peroxidase 4 (Gpx4) is a major scavenger of phospholipid hydroperoxides. Although Gpx4 represents a key component of the reactive oxygen species-scavenging network, its relevance in the immune system is yet to be defined. Here, we investigated the
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