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Showing 1-30 of 4168 results for "03620" within Papers
Takumi Murakami et al.
FEMS microbiology ecology, 91(3) (2015-03-13)
The glacier ice worm, Mesenchytraeus solifugus, is a unique annelid, inhabiting only snow and ice in North American glaciers. Here, we analyzed the taxonomic composition of bacteria associated with M. solifugus based on the 16S rRNA gene. We analyzed four
Jae Eun Lee et al.
Biochemical and biophysical research communications, 459(1), 161-165 (2015-02-26)
N-myc Downstream Regulated Gene 1 (NDRG1) is a metastasis suppressor protein which suppresses metastasis without affecting primary tumorigenesis. There have been many reports about the anti-metastatic function of NDRG1 in various cancers. However, the regulatory mechanism of NDRG1 at the
Yang Chen et al.
Biochimica et biophysica acta, 1853(2), 396-408 (2014-12-03)
Inflammasomes play a critical role in the development of vascular diseases. However, the molecular mechanisms activating the inflammasome in endothelial cells and the relevance of this inflammasome activation is far from clear. Here, we investigated the mechanisms by which an
Payal Agarwal et al.
Pharmaceutical research, 31(12), 3404-3414 (2014-06-15)
To develop a live oral delivery system of Glucagon like peptide-1 (GLP-1), for the treatment of Type-2 Diabetes. LL-pUBGLP-1, a recombinant Lactococcus lactis (L. lactis)) transformed with a plasmid vector encoding GLP-1 cDNA was constructed and was used as a
Soon Woo Nam et al.
Clinical science (London, England : 1979), 127(8), 519-526 (2014-04-10)
Cirrhotic cardiomyopathy is defined as systolic and diastolic dysfunctions, electrophysiological changes and macroscopic structural changes. However, the underlying mechanisms of this syndrome remain unclear. A possible role of myocardial apoptosis in the pathogenesis has not been previously examined. We hypothesized
Yu Matsukura et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 33(2), 246-253 (2014-11-19)
Even though mouse studies have various advantages, harvesting an adequate number of synovial mesenchymal stem cells (MSCs) is difficult in mice. We investigated whether the total yield of MSCs increased in synovium with inflammation in mice. Infrapatellar fat pads (IFPs)
Mai Sato et al.
Oncotarget, 6(5), 3292-3305 (2015-02-12)
MYC deregulation is a driver of many human cancers. Altering the balance of MYC protein levels at the level of transcription, protein stability, or turnover is sufficient to transform cells to a tumorigenic phenotype. While direct targeting of MYC is
Dilara Kaman et al.
Bosnian journal of basic medical sciences, 15(1), 9-13 (2015-03-01)
The cholesteryl ester transfer protein (CETP) plays a crucial role in high-density lipoprotein (HDL) metabolism. Genetic variants that alter CETP concentration may cause significant alterations in HDL-cholesterol (HDL-C) concentration. In this case-control study, we analyzed the genotype frequencies of CETP
Mariano Sánchez-Siles et al.
International journal of dermatology, 53(12), 1454-1459 (2014-06-06)
A study is made of DNA damage and apoptosis in a group of patients with oral leukoplakia (OL) with mild dysplasia. The study comprised 30 patients with a clinicopathological diagnosis of OL with mild dysplasia and 30 controls. Both samples
Kazime Gonca Akbulut et al.
Biogerontology, 16(1), 99-108 (2014-11-29)
The protein family of sirtuins and FoXO1 transcription factor have been shown to play significant roles in the aging process. In this study we aimed to investigate the changes in the levels of SIRT2, NFκB and FoXO1 and oxidative parameters
Soo Min Cho et al.
Scientific reports, 4, 6777-6777 (2014-10-28)
Amyloid-β (Aβ) is one of the few neuropathological biomarkers associated with transporters of the blood-brain barrier (BBB). Despite the well-characterized clinical indication of decreasing Aβ levels in the cerebrospinal fluid (CSF) during the development of Alzheimer's disease (AD), the link
Seri Jeong et al.
PloS one, 9(5), e98284-e98284 (2014-05-30)
Human leukocyte antigen-G (HLA-G) is known to be implicated in a tumor-driven immune escape mechanism in malignancies. The purpose of this study was to investigate HLA-G polymorphism and expression in breast cancer. HLA-G alleles were determined by direct DNA sequencing
Anni E Sorkio et al.
Biomaterials, 51, 257-269 (2015-03-17)
The environmental cues received by the cells from synthetic substrates in vitro are very different from those they receive in vivo. In this study, we applied the Langmuir-Schaefer (LS) deposition, a variant of Langmuir-Blodgett technique, to fabricate a biomimetic microenvironment
Denis G Knyazev et al.
The Journal of biological chemistry, 289(35), 24611-24616 (2014-07-13)
While engaged in protein transport, the bacterial translocon SecYEG must maintain the membrane barrier to small ions. The preservation of the proton motif force was attributed to (i) cation exclusion, (ii) engulfment of the nascent chain by the hydrophobic pore
Wynne Q Zhang et al.
Neuropharmacology, 90, 1-8 (2014-12-03)
Clinical evidence indicates brain serotonin (5-HT) stores and neurotransmission may be inadequate in subpopulations of individuals with autism, and this may contribute to characteristically impaired social behaviors. Findings that depletion of the 5-HT precursor tryptophan (TRP) worsens autism symptoms support
Bin Lou et al.
PloS one, 9(7), e102641-e102641 (2014-07-18)
Sphingomyelin synthase (SMS) plays an important role in plasma atherogenic lipoprotein metabolism, inflammation, and the development of atherosclerosis. To understand whether the impaired apoB secretion and inflammation response is a direct result from lack of SMS activity, in this study
Marjan Steppe et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 72, 129-137 (2014-07-11)
Inflammatory bowel disease (IBD) is a chronic inflammation of the digestive tract, characterized by dysbiosis of the intestinal microbiota. Probiotics have been suggested as a strategy to reduce active disease or extend remission. We isolated and characterized the butyrate-producing strain
Somruedee Yorsin et al.
Journal of ethnopharmacology, 156, 162-174 (2014-08-30)
In Thai traditional medicine, rhizomes of Kaempferia parviflora (KP) have been used for treating hypertension and for the promotion of longevity with good health and well being. Ageing is one of the most important risk factors for development of cardiovascular
R Brooks et al.
Stem cells (Dayton, Ohio), 33(3), 848-858 (2014-11-18)
Promoting the expansion of adult stem cell populations offers the potential to ameliorate radiation or chemotherapy-induced bone marrow failure and allows for expedited recovery for patients undergoing these therapies. Previous genetic studies suggested a pivotal role for SH2 domain-containing inositol-5-phosphatase
Emmanuel Breard et al.
Vaccine, 33(4), 512-518 (2014-12-17)
Eradication of bluetongue virus is possible, as has been shown in several European countries. New serotypes have emerged, however, for which there are no specific commercial vaccines. This study addressed whether heterologous vaccines would help protect against 2 serotypes. Thirty-seven
S Weisshaar et al.
Journal of thrombosis and haemostasis : JTH, 12(11), 1850-1860 (2014-09-12)
Patients with acute coronary syndrome and concomitant atrial fibrillation may require antithrombotic triple therapy but clinical evidence of safety and efficacy is poor. We have therefore studied the combination of different antithrombotic medicines for coagulation activation in an in vivo
Qian Guo et al.
Biomedical and environmental sciences : BES, 28(1), 25-35 (2015-01-09)
A PCR-reverse dot blot hybridization (RDBH) assay was developed for rapid detection of rpoB gene mutations in 'hot mutation region' of Mycobacterium tuberculosis (M. tuberculosis). 12 oligonucleotide probes based on the wild-type and mutant genotype rpoB sequences of M. tuberculosis
Indu Upadhyaya et al.
Applied and environmental microbiology, 81(9), 2985-2994 (2015-02-25)
Salmonella enterica serovar Enteritidis is a major foodborne pathogen in the United States, causing gastroenteritis in humans, primarily through consumption of contaminated eggs. Chickens are the reservoir host of S. Enteritidis. In layer hens, S. Enteritidis colonizes the intestine and
Dopamine receptor and Gα(olf) expression in DYT1 dystonia mouse models during postnatal development.
Lin Zhang et al.
PloS one, 10(4), e0123104-e0123104 (2015-04-11)
DYT1 dystonia is a heritable, early-onset generalized movement disorder caused by a GAG deletion (ΔGAG) in the DYT1 gene. Neuroimaging studies and studies using mouse models suggest that DYT1 dystonia is associated with dopamine imbalance. However, whether dopamine imbalance is
Rosalyn R Ram et al.
Molecular and cellular biology, 34(12), 2350-2358 (2014-04-16)
The RASSF1A gene is one of the most frequently inactivated genes in over 30 different types of cancers (H. Donninger, M. D. Vos, and G. J. Clark, J. Cell Sci. 120:3163-3172, 2007, http://dx.doi.org/10.1242/jcs.010389). Despite the prevalence of RASSF1A silencing in
Mamoru Akita et al.
International journal of oncology, 45(5), 1901-1912 (2014-09-02)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising candidate for cancer treatment, but some cancer cell types are resistant to TRAIL cytotoxicity. Therefore, overcoming this resistance is necessary for effective TRAIL therapy. Mitochondrial morphology is important for the maintenance
Q Bao et al.
Targeted oncology, 9(3), 251-261 (2013-08-13)
Fibrosarcomas show a high incidence of recurrence and general resistance to apoptosis. Limiting tumor regrowth and increasing their sensitivity to chemotherapy and apoptosis represent key issues in developing more effective treatments of these tumors. Tissue inhibitor of metalloproteinase 1 (TIMP-1)
Mira Pavkovic et al.
Toxicology, 324, 147-157 (2014-06-01)
Extracellular microRNAs (miRNAs) have emerged as novel biomarkers (BMs) for various pathological states. To evaluate whether urinary miRNAs could serve as biomarkers for drug-induced kidney injury, we performed a nephrotoxicity study in rats with cisplatin (Cp), which is known to
Jiawen Wu et al.
Biochemical and biophysical research communications, 459(1), 87-93 (2015-02-26)
Our recent study has shown that cellular junctions in myelin and in the epi-/perineruium that encase nerve fibers regulate the permeability of the peripheral nerves. This permeability may affect propagation of the action potential. Direct interactions between the PDZ₁ domain
N S Geraci et al.
Parasite immunology, 37(1), 43-51 (2014-11-08)
Leishmania are intracellular protozoa that influence host immune responses eliciting parasite species-specific pathologies. MicroRNAs (miRNAs) are short single-stranded ribonucleic acids that complement gene transcripts to block protein translation and have been shown to regulate immune system molecular mechanisms. Human monocyte-derived
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