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Showing 1-30 of 187 results for "03970590" within Papers
Suiyi Tan et al.
FEBS letters, 588(9), 1515-1522 (2014-03-25)
Amyloid fibrils play important roles in HIV-1 infection. We found peptides derived from the HIV-1 gp120 co-receptor binding region, which are defined as enhancing peptides (EPs), could form amyloid fibrils and remarkably enhance HIV-1 infection. EPs bound to the virus
Ha-Young Park et al.
Bioscience, biotechnology, and biochemistry, 79(1), 130-137 (2014-09-02)
We investigated the effect of theaflavins (TFs) on membrane barrier of Caco-2 cells. For fluorescein-transport experiments, the apparent permeability (Papp) of fluorescein in Caco-2 cells pretreated with 20 μM TFs were significantly decreased compared with that in untreated cells. Although the
Ester Casanova et al.
Biochimica et biophysica acta, 1837(6), 783-791 (2014-02-04)
Skeletal muscle is a key organ of mammalian energy metabolism, and its mitochondria are multifunction organelles that are targets of dietary bioactive compounds. The goal of this work was to examine the regulation of mitochondrial dynamics, functionality and cell energy
Rafael De la Torre et al.
Molecular nutrition & food research, 58(2), 278-288 (2013-09-17)
Trisomy for human chromosome 21 results in Down syndrome (DS), which is among the most complex genetic perturbations leading to intellectual disability. Accumulating data suggest that overexpression of the dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A), is a critical pathogenic mechanisms
Takahiro Kochi et al.
Cancer letters, 342(1), 60-69 (2013-08-29)
Non-alcoholic steatohepatitis (NASH), which involves hepatic inflammation and fibrosis, is associated with liver carcinogenesis. The activation of the renin-angiotensin system (RAS), which plays a key role in blood pressure regulation, promotes hepatic fibrogenesis. In this study, we investigated the effects
Chisa Matsumoto et al.
Scandinavian journal of clinical and laboratory investigation, 73(3), 245-252 (2013-04-03)
We established a novel method to analyze cells collected by fluorescence-activated cell sorting (FACS) named mRNA quantification after FACS (FACS-mQ) in which cells are labeled with a fluorescence dye in a manner that minimizes RNA degradation, and then cells sorted
Katherine A Thompson-Witrick et al.
Journal of agricultural and food chemistry, 62(41), 10181-10191 (2014-09-18)
Polyphenols and maturity parameters were determined in 20 apple cultivars with potential for hard cider production grown in Virginia, U.S.A. Concentrations of five classes of polyphenols were significantly different across cultivar for both peel and flesh. Total polyphenol concentration ranged
Helgi I Ingólfsson et al.
ACS chemical biology, 9(8), 1788-1798 (2014-06-06)
A wide variety of phytochemicals are consumed for their perceived health benefits. Many of these phytochemicals have been found to alter numerous cell functions, but the mechanisms underlying their biological activity tend to be poorly understood. Phenolic phytochemicals are particularly
Yong Zhang et al.
Journal of neuro-oncology, 121(1), 41-52 (2014-09-01)
Combination therapy to inhibit cancer stem cells may have important clinical implications. Here, we examine the molecular mechanisms by which epigallocatechin gallate (EGCG), a bioactive polyphenol in green tea, inhibits the stem cell characteristics of glioma stem-like cells (GSLCs) and
H Fujiki et al.
Preventive medicine, 21(4), 503-509 (1992-07-01)
Our research objective is to develop nontoxic cancer chemopreventive agents and to apply these agents in treating humans. We are identifying agents that inhibit the process of tumor promotion in two-stage carcinogenesis experiments on mouse skin. We review (a) the
Piwen Wang et al.
RSC advances, 4(66), 35242-35250 (2014-09-23)
The low bioavailability of most flavonoids limits their application as anti-carcinogenic agents in humans. A novel approach of treatment with a mixture of bioactive compounds that share molecular anti-carcinogenic targets may enhance the effect on these targets at low concentrations
Hsien-Tsung Yao et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 70, 120-127 (2014-05-13)
The effect of commercially available green tea (GT) and black tea (BT) drinks on drug metabolizing enzymes (DME) and oxidative stress in rats was investigated. Male Wistar rats were fed a laboratory chow diet and GT or BT drink for
Steve Harakeh et al.
International journal of oncology, 45(5), 2159-2166 (2014-09-06)
Experimental and clinical studies have revealed the effectiveness of a specific nutrient synergy (SNS) mixture composed of ascorbic acid (AA), lysine, proline, arginine, epigallocatechin gallate (EGCG) and other micronutrients in targeting crucial physiological mechanisms involved in cancer progression and metastasis.
Xuli Wu et al.
Journal of agricultural and food chemistry, 61(37), 8829-8835 (2013-08-27)
Understanding the interaction of (-)-epigallocatechin-3-gallate (EGCG) and lipase is important for understanding EGCG's inhibition of lipase. In this paper, the interaction of EGCG and porcine lipase was characterized by fluorescence spectroscopy, circular dichroism (CD), isothermal titration calorimetry, and molecular docking.
Franziska Mußbach et al.
Journal of cancer research and clinical oncology, 141(5), 813-825 (2014-11-07)
There is growing evidence for a role of proteinase-activated receptors (PARs), a subfamily of G protein-coupled receptors, in cancer. We have previously shown that PAR1 and PAR4 are able to promote the migration of hepatocellular carcinoma (HCC) cells suggesting a
Haiqiang Wu et al.
PloS one, 9(10), e109438-e109438 (2014-10-03)
Inhibition of β-amyloid (Aβ) aggregation is an attractive therapeutic and preventive strategy for the discovery of disease-modifying agents in Alzheimer's disease (AD). Phomopsis occulta is a new, salt-tolerant fungus isolated from mangrove Pongamia pinnata (L.) Pierre. We report here the
John T Barr et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(1), 34-41 (2014-10-19)
The mechanistic understanding of interactions between diet-derived substances and conventional medications in humans is nascent. Most investigations have examined cytochrome P450-mediated interactions. Interactions mediated by other phase I enzymes are understudied. Aldehyde oxidase (AO) is a phase I hydroxylase that
Calli A Davison et al.
Cancer research, 73(12), 3704-3715 (2013-06-19)
Metastasis by cancer cells relies upon the acquisition of the ability to evade anoikis, a cell death process elicited by detachment from extracellular matrix (ECM). The molecular mechanisms that ECM-detached cancer cells use to survive are not understood. Striking increases
Susanne M Henning et al.
The Journal of nutrition, 136(7), 1839-1843 (2006-06-15)
Green and black tea have shown promise in the chemoprevention of prostate cancer. The objective of this study was to determine the bioavailability and bioactivity of tea polyphenols (PP) and theaflavins in human serum and human and mouse tissues. A
Simona Martinotti et al.
Toxicology and applied pharmacology, 274(1), 35-41 (2013-11-10)
Malignant mesothelioma (MMe) is a poor-prognosis tumor in need of innovative therapies. In a previous in vivo study, we showed synergistic anti-MMe properties of the ascorbate/epigallocatechin-3-gallate/gemcitabine combination. We have now focused on the mechanism of action, showing the induction of
Lan Yi et al.
Oncotarget, 5(19), 8924-8936 (2014-09-23)
The p53 protein ensures cellular fidelity by suppressing or killing cells under stresses that enhance the mutation rate. Evidence suggests that the p53 protein may also ensure the fidelity of the epigenome. In this study a group of drugs that
Ming Chen et al.
Medical mycology, 53(2), 194-198 (2015-01-22)
In this study, we investigate the susceptibility of Candida albicans, Candida glabrata, Candida krusei, Candida parapsilosis, Candida tropicalis, and Aspergillus fumigatus using the EUCAST microdilution minimum inhibitory concentration (MIC) method (final tea supernatant concentration range 5.0-0.005 mg/ml) to 23 different
Satiesh Kumar Ramadass et al.
Colloids and surfaces. B, Biointerfaces, 125, 65-72 (2014-12-02)
Matrix metalloproteinases (MMPs) have been investigated as a potential target for treating invasive breast cancers. The chemotherapy for breast cancer is often prescribed as a combination of drugs. The present study investigates a novel strategy of combining a MMP inhibitor
Yuko Iida et al.
Molecular medicine reports, 10(3), 1383-1388 (2014-07-26)
(‑)‑Epigallocatechin gallate (EGCG) is a major component of green tea. It has been demonstrated that EGCG has an antithrombotic effect by inhibiting platelet aggregation. However, the detailed mechanisms underlying the effects of EGCG remain to be elucidated. The present study
Ling Tao et al.
Molecular nutrition & food research, 59(2), 203-211 (2014-10-21)
We have previously reported that the green tea catechin, (-)-epigallocatechin-3-gallate (EGCG), can induce oxidative stress in oral cancer cells but exerts antioxidant effects in normal cells. Here, we report that these differential prooxidative effects are associated with sirtuin 3 (SIRT3)
Vivian Caetano Bochi et al.
Food chemistry, 176, 234-243 (2015-01-28)
Ceylon gooseberry is a deep-purple exotic berry that is being produced in Brazil with great market potential. This work aimed to determine major phenolic compounds in this specie by HPLC-PDA-ESI/MS. Samples were collected in two different seasons. Pulp and skin
Dong-ke Yu et al.
Acta pharmacologica Sinica, 36(4), 473-482 (2015-04-04)
(-)-Epigallocatechin-3-gallate (EGCG) is one of the most abundant polyphenols in green tea with strong antioxidant activity and various therapeutic effects. In this study, we investigated the anti-fibrotic effects of EGCG and underlying mechanisms in bile duct-ligated (BDL) rats and a
Emma C Stuart et al.
Life sciences, 79(25), 2329-2336 (2006-09-02)
Green tea and its major constituent epigallocatechin gallate (EGCG) have been extensively studied as a potential treatment for a variety of diseases, including cancer. Epidemiological data have suggested that EGCG may provide protective effects against hormone related cancers, namely breast
H Fujiki et al.
Cancer detection and prevention, 24(1), 91-99 (2000-04-11)
The study of tumor promotion in rodent carcinogenesis using chemical tumor promoters has revealed various tumor promotion pathways, such as the 12-O-tetradecanoylphorbol-13-acetate (TPA) pathway mediated through activation of protein kinase C, and the okadaic acid pathway mediated through inhibition of
Hirota Fujiki et al.
Journal of cancer research and clinical oncology, 139(10), 1603-1614 (2013-06-13)
The classic two-stage chemical carcinogenesis in rodents is not directly linked to multistage carcinogenesis in humans. In light of our findings that tumor necrosis factor-α (TNF-α) is an endogenous tumor promoter and that TNF-α-inducing protein (Tipα) of Helicobacter pylori stimulates
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