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Showing 1-30 of 118 results for "04599" within Papers
Andrew P Ambrosy et al.
Journal of the American College of Cardiology, 63(18), 1823-1832 (2014-03-13)
Digoxin is the oldest cardiac drug still in contemporary use, yet its role in the management of patients with heart failure (HF) remains controversial. A purified cardiac glycoside derived from the foxglove plant, digoxin increases ejection fraction, augments cardiac output
Yike Cai et al.
Journal of pharmacological and toxicological methods, 70(2), 175-181 (2014-07-19)
Monolayers of Caco-2 cells have been widely accepted as one of the well-established in vitro models to predict intestinal drug permeability and absorption in humans. However, the procedure for culturing the traditional 21-day Caco-2 model is labor intensive and time
Xinxin Li et al.
BMC genomics, 15, 723-723 (2014-08-29)
Most biological nitrogen fixation is catalyzed by the molybdenum nitrogenase. This enzyme is a complex which contains the MoFe protein encoded by nifDK and the Fe protein encoded by nifH. In addition to nifHDK, nifHDK-like genes were found in some
Jiake He et al.
Biopharmaceutics & drug disposition, 35(5), 253-263 (2014-01-18)
An unusual, but clinically significant, digoxin (DIG)-bupropion (BUP) drug interaction (DDI), in which BUP increased DIG renal clearance by 80% is reported. To investigate the mechanism(s) of this unusual DDI, first the effect of BUP, its circulating metabolites or their
Ming Ji Jin et al.
Journal of agricultural and food chemistry, 62(40), 9632-9636 (2014-09-27)
This study investigated the effects of intestinal microbiota on the metabolism of geniposide by using a rat model treated with a mixture of antibiotics. The plasma concentration of geniposide was determined after oral administration in control and antibiotics-treated rats by
Claudia S López et al.
Virology, 462-463, 126-134 (2014-06-28)
The HIV-1 Gag proteins are translated from the full-length HIV-1 viral RNA (vRNA), whereas the envelope (Env) protein is translated from incompletely spliced Env mRNAs. Nuclear export of vRNAs and Env mRNAs is mediated by the Rev accessory protein which
Roger Soll et al.
The Cochrane database of systematic reviews, (1)(1), CD001080-CD001080 (2011-01-21)
Lendrum 1955 suggested that pulmonary edema secondary to congestive heart failure may contribute to neonatal respiratory distress syndrome (RDS). Based on this hypothesis, investigators began to use digitalis glycosides to improve myocardial contractility and decrease congestive heart failure. The first
Aline Lauda Freitas Chaves et al.
Anticancer research, 34(10), 5397-5403 (2014-10-03)
The present study evaluated the expression of α1 and β1 Na,K-ATPase, as well as the effects of digoxin (DGX) on oral squamous cell carcinomas (OSCCs). Immunohistochemical expression of α1 and β1 Na,K-ATPase were evaluated in 60 patients who underwent treatment
When 'digoxin use' is not the same as 'digoxin use': lessons from the AFFIRM trial.
Sabina A Murphy
European heart journal, 34(20), 1465-1467 (2013-04-18)
Chang Gong et al.
Cancer research, 74(16), 4341-4352 (2014-07-02)
Phyllodes tumors of breast, even histologically diagnosed as benign, can recur locally and have metastatic potential. Histologic markers only have limited value in predicting the clinical behavior of phyllodes tumors. It remains unknown what drives the malignant progression of phyllodes
Shuangyuan Wang et al.
Analytical and bioanalytical chemistry, 407(1), 331-341 (2014-11-21)
A method based on stop-flow two-dimensional liquid chromatography coupled with electrospray ionization mass spectrometry (2D LC-ESI MS) was established and applied to analyze triterpenoid saponins from the main root of ginseng. Due to the special structure of triterpenoid saponins (they
Nuggehally R Srinivas et al.
Bioanalysis, 1(1), 97-113 (2009-04-01)
Digoxin is an important therapeutic agent for the treatment of congestive cardiac failure. In spite of its narrow therapeutic index, digoxin has been used extensively by the medical community and, lately, the use of digoxin as a mechanistic probe for
Sibylle Neuhoff et al.
Journal of pharmaceutical sciences, 102(9), 3161-3173 (2013-05-21)
Digoxin is the recommended substrate for assessment of P-glycoprotein (P-gp)-mediated drug-drug interactions (DDIs) in vivo. The overall aim of our study was to investigate the inhibitory potential of both verapamil and norverapamil on the P-gp-mediated efflux of digoxin in both
Acute rate control in atrial fibrillation with left ventricular dysfunction.
Shin-ichi Momomura
Circulation journal : official journal of the Japanese Circulation Society, 77(4), 893-894 (2013-03-19)
Prescrire international, 22(137), 98-98 (2013-05-11)
Several epidemiological studies, some of which included several thousand women, have shown a link between digoxin exposure and the risk of breast cancer. A cohort study of women with angina, identified in the Danish Prescription Registry, showed a statistically significant
Maor Sauler et al.
Clinics in chest medicine, 34(4), 799-810 (2013-11-26)
Recent advances in pulmonary arterial hypertension (PAH) research have created a new era of PAH-specific therapies. Although these therapeutics have revolutionized PAH therapy, their innovation was predated by supportive but nonspecific medical therapies adapted from their use in more common
Mihai Gheorghiade et al.
Acute cardiac care, 11(2), 83-87 (2009-04-23)
Digitalis preparations have been used for centuries. Digoxin is an agent that is readily available, can be administered acutely and long-term, intravenously or orally, is safe and may be beneficial in both acute and chronic heart failure (HF). It may
Vanita Suri et al.
Indian journal of medical sciences, 63(9), 411-414 (2009-10-07)
Sustained fetal supraventricular tachycardia (SVT) with a heart rate of approximately 210 bpm may lead to increased atrial and venous pressures and congestive heart failure. There is no clear consensus regarding the best drug-treatment regimens for fetal SVT. However, considerable
Fernando Valiente-Echeverría et al.
Nature communications, 5, 4819-4819 (2014-09-18)
Stress granules (SG) are translationally silent sites of RNA triage induced by environmental stresses including viral infection. Here we show that HIV-1 Gag blocks SG assembly irrespective of eIF2α phosphorylation and even when SG assembly is forced by overexpression of
Chuenjid Kongkaew et al.
Archives of cardiovascular diseases, 105(10), 507-516 (2012-10-16)
Digoxin is highly potent and efficacious for treatment of heart failure (HF) and/or atrial fibrillation (AF) yet compliance is often poor. To examine prevalence rates of non-compliance with digoxin; variations between clinical settings, types of non-compliance and methods of detection;
K Römermann et al.
The Journal of pharmacology and experimental therapeutics, 353(2), 351-359 (2015-03-11)
As a result of the growing availability of genetically engineered mouse lines, the pilocarpine post-status epilepticus (SE) model of temporal lobe epilepsy is increasingly used in mice. A discrepancy in pilocarpine sensitivity in FVB/N wild-type versus P-glycoprotein (PGP)-deficient mice precipitated
Mark Bush et al.
Postgraduate medicine, 124(6), 55-72 (2013-01-17)
Albiglutide is a glucagon-like peptide-1 analog that is currently under investigation for the treatment of type 2 diabetes mellitus as a once-weekly injection. Three open-label phase 1 studies were conducted in healthy human participants to investigate potential pharmacokinetic (PK) and/or
Konstanze Steiner et al.
Toxicology and applied pharmacology, 280(3), 534-542 (2014-09-15)
Cyanobacterial blooms have an impact on the aquatic ecosystem due to the production of toxins (e.g. microcystins, MCs), which constrain fish health or even cause fish death. However the toxicokinetics of the most abundant toxin, microcystin-LR (MC-LR), are not yet
Hiroaki Yamaguchi et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 972, 73-80 (2014-12-03)
A liquid chromatography/tandem mass spectrometry method for the determination of intracellular accumulation in addition to transcellular transport of digoxin and ouabain in renal epithelial HK-2 cells was developed. The solid-phase extraction Bond Elut(®) C18 (100mg/1mL) cartridge was used for the
Robert C Bourge et al.
The American journal of medicine, 126(8), 701-708 (2013-03-16)
Heart failure is a leading cause of hospital admission and readmission in older adults. The new United States healthcare reform law has created provisions for financial penalties for hospitals with higher than expected 30-day all-cause readmission rates for hospitalized Medicare
Natalia Lampon et al.
Clinical laboratory, 58(11-12), 1301-1304 (2013-01-08)
Although the possible interference of digoxin-like immunoreactive substances (DLIS) on the Architect iDigoxin chemiluminiscent microparticle immunoassay (CMIA) has been emphasized by the manufacturer, a specific study about this subject has still not been carried out. Apparent serum digoxin concentrations were
Yan Liang et al.
PloS one, 9(6), e98717-e98717 (2014-06-13)
Phytochemical-mediated alterations in P-glycoprotein (P-gp) activity may result in herb-drug interactions by altering drug pharmacokinetics. Shengmai-san, a traditional Chinese herbal medicine composed by Panax Ginseng, Ophiopogon Japonicus, and Schisandra Chinensis, is routinely being used for treating various coronary heart diseases.
Julie Master et al.
Cardiology journal, 16(5), 483-486 (2009-09-16)
Digoxin remains one of the most frequently prescribed drugs in the management of atrial fibrillation. The main indications for digoxin in atrial fibrillation are restoration of sinus rhythm, prevention of recurrence and slowing of the ventricular rate. However, none of
Weibin Zha et al.
PloS one, 8(1), e54349-e54349 (2013-02-02)
HIV protease inhibitor (PI)-induced inflammatory response in macrophages is a major risk factor for cardiovascular diseases. We have previously reported that berberine (BBR), a traditional herbal medicine, prevents HIV PI-induced inflammatory response through inhibiting endoplasmic reticulum (ER) stress in macrophages.
Wesley Palatnick et al.
Emergency medicine practice, 16(2), 1-19 (2014-06-03)
While it is relatively uncommon, an overdose of calcium-channel blockers, beta blockers, or digoxin has a significant morbidity and mortality rate, and its management can be complex. Digoxin toxicity can present with an acute overdose or as chronic toxicity while
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