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Showing 1-30 of 118 results for "04599" within Papers
Konstanze Steiner et al.
Toxicology and applied pharmacology, 280(3), 534-542 (2014-09-15)
Cyanobacterial blooms have an impact on the aquatic ecosystem due to the production of toxins (e.g. microcystins, MCs), which constrain fish health or even cause fish death. However the toxicokinetics of the most abundant toxin, microcystin-LR (MC-LR), are not yet
Wesley Palatnick et al.
Emergency medicine practice, 16(2), 1-19 (2014-06-03)
While it is relatively uncommon, an overdose of calcium-channel blockers, beta blockers, or digoxin has a significant morbidity and mortality rate, and its management can be complex. Digoxin toxicity can present with an acute overdose or as chronic toxicity while
A patient with systolic dysfunction and an alternating axis.
P Elliott Miller et al.
JAMA internal medicine, 174(12), 2027-2028 (2014-10-28)
Georg Petschenka et al.
Proceedings. Biological sciences, 280(1759), 20123089-20123089 (2013-03-22)
Because cardenolides specifically inhibit the Na(+)K(+)-ATPase, insects feeding on cardenolide-containing plants need to circumvent this toxic effect. Some insects such as the monarch butterfly rely on target site insensitivity, yet other cardenolide-adapted lepidopterans such as the oleander hawk-moth, Daphnis nerii
Chunbo Zhang et al.
Epilepsia, 54(7), 1154-1160 (2013-04-05)
Antiepileptic drugs (AEDs) do not effectively treat 30-40% of patients with epilepsy. Export of AEDs by P-glycoprotein (Pgp, ABCB1, or MDR1), which is overexpressed in the blood-brain barrier in drug-resistant patients, may be a mechanism for resistance to AEDs. For
Haiping Yang et al.
Oncology letters, 8(3), 1043-1050 (2014-08-15)
Breast cancer is one of the most common malignancies worldwide and is the second leading cause of cancer-related mortality among females. miRNAs are a class of small noncoding RNAs that are aberrantly expressed in human cancers. Due to their small
Julie Master et al.
Cardiology journal, 16(5), 483-486 (2009-09-16)
Digoxin remains one of the most frequently prescribed drugs in the management of atrial fibrillation. The main indications for digoxin in atrial fibrillation are restoration of sinus rhythm, prevention of recurrence and slowing of the ventricular rate. However, none of
Yan Liang et al.
PloS one, 9(6), e98717-e98717 (2014-06-13)
Phytochemical-mediated alterations in P-glycoprotein (P-gp) activity may result in herb-drug interactions by altering drug pharmacokinetics. Shengmai-san, a traditional Chinese herbal medicine composed by Panax Ginseng, Ophiopogon Japonicus, and Schisandra Chinensis, is routinely being used for treating various coronary heart diseases.
Kenji Tsuji et al.
Biochemical and biophysical research communications, 447(1), 108-114 (2014-04-03)
The kidneys are exposed to hypoxic conditions during development. Hypoxia-inducible factor (HIF), an important mediator of the response to hypoxia, is believed to have an important role in development. However, the relationship between HIF and branching morphogenesis has not been
Prescrire international, 19(106), 68-70 (2010-06-24)
Digoxin has a narrow therapeutic margin and potentially life-threatening cardiac adverse effects. Gastrointestinal disorders, neuropsychological disorders and bradycardia are warning signs. Some drug combinations can aggravate the cardiac adverse effects of digoxin, or reduce its efficacy. We reviewed the literature
Digoxin for patients with atrial fibrillation and heart failure: paradise lost or not?
Dirk J van Veldhuisen et al.
European heart journal, 34(20), 1468-1470 (2013-01-18)
Vanita Suri et al.
Indian journal of medical sciences, 63(9), 411-414 (2009-10-07)
Sustained fetal supraventricular tachycardia (SVT) with a heart rate of approximately 210 bpm may lead to increased atrial and venous pressures and congestive heart failure. There is no clear consensus regarding the best drug-treatment regimens for fetal SVT. However, considerable
Ali Ahmed et al.
The American journal of medicine, 127(1), 61-70 (2013-11-22)
Heart failure is the leading cause for hospital readmission, the reduction of which is a priority under the Affordable Care Act. Digoxin reduces 30-day all-cause hospital admission in chronic systolic heart failure. Whether digoxin is effective in reducing readmission after
Lingtak-Neander Chan et al.
Pharmacotherapy, 35(4), 361-369 (2015-03-12)
To evaluate the effect of Roux-en-Y gastric bypass surgery (RYGB) on the pharmacokinetics of midazolam (a CYP3A4 substrate) and digoxin (a P-glycoprotein substrate). Prospective, nonblinded, longitudinal, single-dose pharmacokinetic study in three phases: presurgery baseline and postoperative assessments at 3 and
Judy W M Cheng et al.
The American journal of geriatric pharmacotherapy, 8(5), 419-427 (2011-02-22)
Digoxin has been reported to improve symptoms and reduce hospitalization in patients with heart failure as well as to control rapid ventricular rate in patients with atrial fibrillation. Both of these are high-prevalence diseases in the elderly, and yet studies
Sihyung Yang et al.
Antimicrobial agents and chemotherapy, 58(7), 4064-4074 (2014-05-07)
Human African trypanosomiasis (HAT), a neglected tropical disease, is fatal without treatment. Pentamidine, a cationic diamidine, has been used to treat first-stage (hemolymphatic) HAT since the 1940s, but it is ineffective against second-stage (meningoencephalitic, or central nervous system [CNS]) infection.
Digoxin: time to reconsider its role in atrial fibrillation?
Mohit K Turagam
Southern medical journal, 106(6), 381-381 (2013-06-06)
Natalia Lampon et al.
Clinical laboratory, 58(11-12), 1301-1304 (2013-01-08)
Although the possible interference of digoxin-like immunoreactive substances (DLIS) on the Architect iDigoxin chemiluminiscent microparticle immunoassay (CMIA) has been emphasized by the manufacturer, a specific study about this subject has still not been carried out. Apparent serum digoxin concentrations were
Seema Saksena et al.
American journal of physiology. Gastrointestinal and liver physiology, 304(6), G615-G622 (2013-01-19)
Intestinal P-glycoprotein (Pgp/multidrug resistance 1), encoded by the ATP-binding cassette B1 gene, is primarily involved in the transepithelial efflux of toxic metabolites and xenobiotics from the mucosa into the gut lumen. Reduced Pgp function and expression has been shown to
[Clinical pharmacist intercepts iatrogenic event through medication reconciliation: a case report].
C Michel et al.
Journal de pharmacie de Belgique, (4)(4), 28-30 (2014-01-24)
Hiroaki Yamaguchi et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 972, 73-80 (2014-12-03)
A liquid chromatography/tandem mass spectrometry method for the determination of intracellular accumulation in addition to transcellular transport of digoxin and ouabain in renal epithelial HK-2 cells was developed. The solid-phase extraction Bond Elut(®) C18 (100mg/1mL) cartridge was used for the
Honokiol inhibits pathological retinal neovascularization in oxygen-induced retinopathy mouse model.
Divya Teja Vavilala et al.
Biochemical and biophysical research communications, 438(4), 697-702 (2013-08-08)
Aberrant activation of the hypoxia inducible factor (HIF) pathway is the underlying cause of retinal neovascularization, one of the most common causes of blindness worldwide. The HIF pathway also plays critical roles during tumor angiogenesis and cancer stem cell transformation.
Robert C Bourge et al.
The American journal of medicine, 126(8), 701-708 (2013-03-16)
Heart failure is a leading cause of hospital admission and readmission in older adults. The new United States healthcare reform law has created provisions for financial penalties for hospitals with higher than expected 30-day all-cause readmission rates for hospitalized Medicare
S Aubrey Stoch et al.
International journal of clinical pharmacology and therapeutics, 51(8), 688-692 (2013-06-21)
This study was conducted in order to assess the effect of multiple doses of odanacatib, a cathepsin (Cat)-K inhibitor, on the pharmacokinetics of digoxin. Twelve healthy male and female subjects received 0.5 mg digoxin and 50 mg odanacatib. This open
Weibin Zha et al.
PloS one, 8(1), e54349-e54349 (2013-02-02)
HIV protease inhibitor (PI)-induced inflammatory response in macrophages is a major risk factor for cardiovascular diseases. We have previously reported that berberine (BBR), a traditional herbal medicine, prevents HIV PI-induced inflammatory response through inhibiting endoplasmic reticulum (ER) stress in macrophages.
Robert J Biggar
Clinical cancer research : an official journal of the American Association for Cancer Research, 18(8), 2133-2137 (2012-03-01)
Digoxin, a phyto-estrogen, binds with estrogen receptors (ER) and can cause gynecomastia. Among women currently using digoxin, breast and uterus cancer incidences are significantly increased (approximate risk ratios, 1.3-1.5). Both cancers are often estrogen sensitive. In contrast, ovary and cervix
The reply.
Ali Ahmed et al.
The American journal of medicine, 128(1), e19-e19 (2015-01-03)
Reference laboratory values for digoxin following publication of Digitalis Investigation Group (DIG) trial data.
Paul J Hauptman et al.
JAMA internal medicine, 173(16), 1552-1554 (2013-06-26)
When 'digoxin use' is not the same as 'digoxin use': lessons from the AFFIRM trial.
Sabina A Murphy
European heart journal, 34(20), 1465-1467 (2013-04-18)
Andrew P Ambrosy et al.
Journal of the American College of Cardiology, 63(18), 1823-1832 (2014-03-13)
Digoxin is the oldest cardiac drug still in contemporary use, yet its role in the management of patients with heart failure (HF) remains controversial. A purified cardiac glycoside derived from the foxglove plant, digoxin increases ejection fraction, augments cardiac output
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