07-307

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Showing 1-20 of 20 results for "07-307" within Papers

Dual modulation of type I interferon response by bluetongue virus.

Virginie Doceul et al.

Journal of virology, 88(18), 10792-10802 (2014-07-11)

Bluetongue virus (BTV) is a double-stranded RNA (dsRNA) virus that causes an economically important disease in ruminants. BTV infection is a strong inducer of type I interferon (IFN-I) in multiple cell types. It has been shown recently that BTV and

Study of interferon-β antiviral activity against Herpes simplex virus type 1 in neuron-enriched trigeminal ganglia cultures.

Ana Maria Low-Calle et al.

Virus research, 180, 49-58 (2014-01-01)

Herpes simplex virus type 1 (HSV-1) causes a lytic infection in epithelial cells before being captured and moved via retrograde axonal transport to the nuclei of the sensory neurons of the trigeminal ganglion or dorsal root, where it establishes a

The Amino-Terminal Region of Hepatitis E Virus ORF1 Containing a Methyltransferase (Met) and a Papain-Like Cysteine Protease (PCP) Domain Counteracts Type I Interferon Response.

Eugénie Bagdassarian et al.

Viruses, 10(12) (2018-12-21)

Hepatitis E virus (HEV) is responsible for large waterborne epidemics of hepatitis in endemic countries and is an emerging zoonotic pathogen worldwide. In endemic regions, HEV-1 or HEV-2 genotypes are frequently associated with fulminant hepatitis in pregnant women, while with

Basal expression levels of IFNAR and Jak-STAT components are determinants of cell-type-specific differences in cardiac antiviral responses.

Zurney, J; Howard, KE; Sherry, B

Journal of virology null

Enteropathogenic Escherichia coli (EPEC) effector-mediated suppression of antimicrobial nitric oxide production in a small intestinal epithelial model system.

Marc Maresca et al.

Cellular microbiology, 7(12), 1749-1762 (2005-11-29)

In vivo studies with the mouse-specific member of the attaching and effacing (A/E) family of pathogens raised the possibility that these non-invasive enteric pathogens can specifically inhibit inducible nitric oxide synthase (iNOS) expression to prevent the production of antimicrobial nitric

Mapuera virus, a rubulavirus that inhibits interferon signalling in a wide variety of mammalian cells without degrading STATs.

K Hagmaier et al.

The Journal of general virology, 88(Pt 3), 956-966 (2007-02-28)

Mapuera virus (MPRV) is a paramyxovirus that was originally isolated from bats, but its host range remains unknown. It was classified as a member of the genus Rubulavirus on the basis of structural and genetic features. Like other rubulaviruses it

Deciphering the differential response of two human fibroblast cell lines following Chikungunya virus infection.

Vincent G Thon-Hon et al.

Virology journal, 9, 213-213 (2012-09-21)

Chikungunya virus (CHIKV) is an arthritogenic member of the Alphavirus genus (family Togaviridae) transmitted by Aedes mosquitoes. CHIKV is now known to target non hematopoietic cells such as epithelial, endothelial cells, fibroblasts and to less extent monocytes/macrophages. The type I

The anti-interferon activity of conserved viral dUTPase ORF54 is essential for an effective MHV-68 infection.

Ronika Sitapara Leang et al.

PLoS pathogens, 7(10), e1002292-e1002292 (2011-10-15)

Gammaherpesviruses such as KSHV and EBV establish lifelong persistent infections through latency in lymphocytes. These viruses have evolved several strategies to counteract the various components of the innate and adaptive immune systems. We conducted an unbiased screen using the genetically

Infiltrating CD11b+CD11c+ cells have the potential to mediate inducible nitric oxide synthase-dependent cell death in mammary carcinomas of HER-2/neu transgenic mice.

Nirmala Parajuli et al.

International journal of cancer, 126(4), 896-908 (2009-08-05)

The development of autochtonous mammary tumors in HER-2/neu transgenic mice is facilitated by immune tolerance to the neu-transgene. However, appropriate vaccination strategies can initiate immune system-mediated antitumor response by a process that requires IFN-gamma. We investigated the role of inducible

Synergistic transcriptional activation of indoleamine dioxygenase by IFN-gamma and tumor necrosis factor-alpha.

Cory M Robinson et al.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 23(8), 413-421 (2003-09-19)

Interferon-gamma (IFN-gamma)-induced indoleamine 2,3-dioxygenase (IDO) activity inhibits the growth of susceptible intracellular pathogens by catalyzing the oxidative cleavage of the indole ring of L-tryptophan and depleting pools of the essential amino acid. Tumor necrosis factor-alpha (TNF-alpha) synergistically enhances the IDO

Hepatitis C virus core protein differently regulates the JAK-STAT signaling pathway under interleukin-6 and interferon-gamma stimuli.

Hosui, Atsushi, et al.

The Journal of Biological Chemistry, 278, 28562-28571 (2003)

Precision-cut slice cultures of tumors from MMTV-neu mice for the study of the ex vivo response to cytokines and cytotoxic drugs.

Nirmala Parajuli, Wolfgang Doppler

In Vitro Cellular & Developmental Biology. Animal null

Porcine reproductive and respiratory syndrome virus Nsp1? inhibits interferon-activated JAK/STAT signal transduction by inducing karyopherin-?1 degradation.

Wang, Rong, et al.

Journal of virology, 87, 5219-5228 (2013)

Donor T-cell alloreactivity against host thymic epithelium limits T-cell development after bone marrow transplantation.

Hauri-Hohl, MM; Keller, MP; Gill, J; Hafen, K; Pachlatko, E; Boulay, T; Peter et al.

Blood null

STAT2 deficiency and susceptibility to viral illness in humans.

Hambleton, S; Goodbourn, S; Young, DF; Dickinson, P; Mohamad, SM; Valappil, M; McGovern et al.

Proceedings of the National Academy of Sciences of the USA null

Induction of type I interferons by a novel porcine reproductive and respiratory syndrome virus isolate.

Nan, Yuchen, et al.

Virology, 432, 261-270 (2012)

High STAT1 mRNA levels but not its tyrosine phosphorylation are associated with macrophage infiltration and bad prognosis in breast cancer.

Piotr Tymoszuk et al.

BMC cancer, 14, 257-257 (2014-04-15)

STAT1 has been attributed a function as tumor suppressor. However, in breast cancer data from microarray analysis indicated a predictive value of high mRNA expression levels of STAT1 and STAT1 target genes belonging to the interferon-related signature for a poor

RNA helicase DDX5 enables STAT1 mRNA translation and interferon signalling in hepatitis B virus replicating hepatocytes.

Jiazeng Sun et al.

Gut, 71(5), 991-1005 (2021-05-23)

RNA helicase DDX5 is downregulated during HBV replication and poor prognosis HBV-related hepatocellular carcinoma (HCC). The objective of this study is to investigate the role of DDX5 in interferon (IFN) signalling. We provide evidence of a novel mechanism involving DDX5

NF-kappaB-driven STAT2 and CCL2 expression in astrocytes in response to brain injury.

Reza Khorooshi et al.

Journal of immunology (Baltimore, Md. : 1950), 181(10), 7284-7291 (2008-11-05)

Tissue response to injury includes expression of genes encoding cytokines and chemokines. These regulate entry of immune cells to the injured tissue. The synthesis of many cytokines and chemokines involves NF-kappaB and signal transducers and activators of transcription (STAT). Injury

Cytokine receptor signalling.

J N Ihle

Nature, 377(6550), 591-594 (1995-10-19)

Many cell functions are regulated by members of the cytokine receptor superfamily. Signalling by these receptors depends upon their association with Janus kinases (JAKs), which couple ligand binding to tyrosine phosphorylation of signalling proteins recruited to the receptor complex. Among

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