07596

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Showing 1-30 of 75 results for "07596" within Papers

The NKG2D ligand ULBP2 is specifically regulated through an invariant chain-dependent endosomal pathway.

Franziska Uhlenbrock et al.

Journal of immunology (Baltimore, Md. : 1950), 193(4), 1654-1665 (2014-07-16)

Soluble ULBP2 is a marker for poor prognosis in several types of cancer. In this study we demonstrate that both soluble and cell surface-bound ULBP2 is transported via a so far unrecognized endosomal pathway. ULBP2 surface expression, but not MICA/B

Differentiation of human limbal-derived induced pluripotent stem cells into limbal-like epithelium.

Dhruv Sareen et al.

Stem cells translational medicine, 3(9), 1002-1012 (2014-07-30)

Limbal epithelial stem cell (LESC) deficiency (LSCD) leads to corneal abnormalities resulting in compromised vision and blindness. LSCD can be potentially treated by transplantation of appropriate cells, which should be easily expandable and bankable. Induced pluripotent stem cells (iPSCs) are

Chromatin status of apoptosis genes correlates with sensitivity to chemo-, immune- and radiation therapy in colorectal cancer cell lines.

Anne Benard et al.

Apoptosis : an international journal on programmed cell death, 19(12), 1769-1778 (2014-10-09)

The apoptosis pathway of programmed cell death is frequently deregulated in cancer. An intact apoptosis pathway is required for proper response to anti-cancer treatment. We investigated the chromatin status of key apoptosis genes in the apoptosis pathway in colorectal cancer

Sodium Butyrate Induces NIH3T3 cells to senescence-like state and enhances promoter activity of p21WAF/CIP1in p53-Independent manner.

Xiao H, et al.

Biochemical and Biophysical Research Communications, 237(2), 457-460 (1997)

Endogenous CCL2 neutralization restricts HIV-1 replication in primary human macrophages by inhibiting viral DNA accumulation.

Michela Sabbatucci et al.

Retrovirology, 12, 4-4 (2015-01-23)

Macrophages are key targets of HIV-1 infection. We have previously described that the expression of CC chemokine ligand 2 (CCL2) increases during monocyte differentiation to macrophages and it is further up-modulated by HIV-1 exposure. Moreover, CCL2 acts as an autocrine

Combination of SAHA and bortezomib up-regulates CDKN2A and CDKN1A and induces apoptosis of Epstein-Barr virus-positive Wp-restricted Burkitt lymphoma and lymphoblastoid cell lines.

Kwai Fung Hui et al.

British journal of haematology, 167(5), 639-650 (2014-08-27)

Epstein-Barr virus (EBV) latent proteins exert anti-apoptotic effects on EBV-transformed lymphoid cells by down-regulating BCL2L11 (BIM), CDKN2A (p16(INK4A) ) and CDKN1A (p21(WAF1) ). However, the potential therapeutic effects of targeting these anti-apoptotic mechanisms remain unexplored. Here, we tested both in

Human IP10-scFv and DC-induced CTL synergistically inhibit the growth of glioma in a xenograft model.

Xuan Wang et al.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(8), 7781-7791 (2014-05-13)

The epidermal growth factor receptor (EGFR) mutant of EGFRvIII is highly expressed in glioma cells, and the EGFRvIII-specific dendritic cell (DC)-induced tumor antigen-specific CD8(+) cytotoxic T lymphocytes (CTLs) may hold promise in cancer immunotherapy. Interferon (IFN)-γ-inducible protein (IP)-10 (IP-10) is

A novel in vitro method for detecting undifferentiated human pluripotent stem cells as impurities in cell therapy products using a highly efficient culture system.

Keiko Tano et al.

PloS one, 9(10), e110496-e110496 (2014-10-28)

Innovative applications of cell therapy products (CTPs) derived from human pluripotent stem cells (hPSCs) in regenerative medicine are currently being developed. The presence of residual undifferentiated hPSCs in CTPs is a quality concern associated with tumorigencity. However, no simple in

The effect of organic anion-transporting polypeptides 1B1, 1B3 and 2B1 on the antitumor activity of flavopiridol in breast cancer cells.

Stefan Brenner et al.

International journal of oncology, 46(1), 324-332 (2014-10-30)

The contribution of organic anion transporting polypeptides (OATPs) to the cellular uptake of flavopiridol was investigated in OATP1B1-, OATP1B3- and OATP2B1-expressing Chinese hamster ovary (CHO) cells. Uptake of flavopiridol into these cells showed typical Michaelis-Menten kinetics with much higher transport

The interplay between histone deacetylases and c-Myc in the transcriptional suppression of HPP1 in colon cancer.

Jian Wang et al.

Cancer biology & therapy, 15(9), 1198-1207 (2014-06-12)

HPP1 (hyperplastic polyposis protein 1), a tumor suppressor gene, is downregulated by promoter hypermethylation in a number of tumor types including colon cancer. c-Myc is also known to play a role in the suppression of HPP1 expression via binding to

Human muscle fibre type-specific regulation of AMPK and downstream targets by exercise.

Dorte E Kristensen et al.

The Journal of physiology, 593(8), 2053-2069 (2015-02-03)

AMP-activated protein kinase (AMPK) is a regulator of energy homeostasis during exercise. Studies suggest muscle fibre type-specific AMPK expression. However, fibre type-specific regulation of AMPK and downstream targets during exercise has not been demonstrated. We hypothesized that AMPK subunits are

In vitro ischemia decreases histone H4K16 acetylation in neural cells.

Ruslan I Dmitriev et al.

FEBS letters, 589(1), 138-144 (2014-12-06)

Inhibitors of histone deacetylases are frequently used against ischemia-induced injury, but the specific mechanisms of their action are poorly understood. Here, we report that following a 5-7-h oxygen-glucose deprivation (OGD) acetylation of histone H4 at residue K16 (H4K16Ac) decreases by

Upregulation of STAT3 marks Burkitt lymphoma cells refractory to Epstein-Barr virus lytic cycle induction by HDAC inhibitors.

Derek Daigle et al.

Journal of virology, 84(2), 993-1004 (2009-11-06)

A fundamental problem in studying the latent-to-lytic switch of Epstein-Barr virus (EBV) and the viral lytic cycle itself is the lack of a culture system fully permissive to lytic cycle induction. Strategies to target EBV-positive tumors by inducing the viral

Macitentan does not interfere with hepatic bile salt transport.

Alexander Treiber et al.

The Journal of pharmacology and experimental therapeutics, 350(1), 130-143 (2014-04-29)

Treatment of pulmonary arterial hypertension with the endothelin receptor antagonist bosentan has been associated with transient increases in liver transaminases. Mechanistically, bosentan inhibits the bile salt export pump (BSEP) leading to an intrahepatic accumulation of cytotoxic bile salts, which eventually

Histone deacetylase inhibitors SAHA and sodium butyrate block G1-to-S cell cycle progression in neurosphere formation by adult subventricular cells.

Qiong Zhou et al.

BMC neuroscience, 12, 50-50 (2011-05-28)

Histone deacetylases (HDACs) are enzymes that modulate gene expression and cellular processes by deacetylating histones and non-histone proteins. While small molecule inhibitors of HDAC activity (HDACi) are used clinically in the treatment of cancer, pre-clinical treatment models suggest they also

Phytanic acid induces Neuro2a cell death via histone deacetylase activation and mitochondrial dysfunction.

Kaoru Nagai

Neurotoxicology and teratology, 48, 33-39 (2015-01-27)

Phytanic acid is a branched fatty acid that is a metabolic intermediate of chlorophyll. In this study, the effects of phytanic acid on Histone deacetylase (Hdac) activity were examined in an in vitro enzyme assay and in neuronal Neuro2a cells.

Transgenerational stress memory is not a general response in Arabidopsis.

Ales Pecinka et al.

PloS one, 4(4), e5202-e5202 (2009-04-22)

Adverse conditions can trigger DNA damage as well as DNA repair responses in plants. A variety of stress factors are known to stimulate homologous recombination, the most accurate repair pathway, by increasing the concentration of necessary enzymatic components and the

Short-chain fatty acids enhance adipocyte differentiation in the stromal vascular fraction of porcine adipose tissue.

Genlai Li et al.

The Journal of nutrition, 144(12), 1887-1895 (2014-10-17)

Short-chain fatty acids (SCFAs), including acetate, propionate, and butyrate, are the main products of microbial fermentation in the gut and might mediate some of the effects of gut microbiota and nutrition on development, metabolism, and pathogenesis of obesity and other

The PHD finger of p300 influences its ability to acetylate histone and non-histone targets.

Johannes G M Rack et al.

Journal of molecular biology, 426(24), 3960-3972 (2014-08-27)

In enzymes that regulate chromatin structure, the combinatorial occurrence of modules that alter and recognise histone modifications is a recurrent feature. In this study, we explored the functional relationship between the acetyltransferase domain and the adjacent bromodomain/PHD finger (bromo/PHD) region

DAP12-based activating chimeric antigen receptor for NK cell tumor immunotherapy.

Katrin Töpfer et al.

Journal of immunology (Baltimore, Md. : 1950), 194(7), 3201-3212 (2015-03-06)

NK cells are emerging as new effectors for immunotherapy of cancer. In particular, the genetic engraftment of chimeric Ag receptors (CARs) in NK cells is a promising strategy to redirect NK cells to otherwise NK cell-resistant tumor cells. On the

Membrane-bound complement regulatory proteins are prognostic factors of operable breast cancer treated with adjuvant trastuzumab: a retrospective study.

Mei Liu et al.

Oncology reports, 32(6), 2619-2627 (2014-09-23)

Complement-dependent cytotoxicity (CDC) is an important antitumor mechanism of monoclonal antibodies (mAbs). However, trastuzumab, an anti-HER2 mAb, exerts only minor CDC. Overexpression of membrane-bound complement regulatory proteins (mCRPs), which suppress CDC, have been implicated in various malignant tumors. Here, we

A chimeric EBV gp350/220-based VLP replicates the virion B-cell attachment mechanism and elicits long-lasting neutralizing antibodies in mice.

Javier Gordon Ogembo et al.

Journal of translational medicine, 13, 50-50 (2015-04-18)

Epstein-Barr virus (EBV), an oncogenic gammaherpesvirus, causes acute infectious mononucleosis (AIM) and is linked to the development of several human malignancies. There is an urgent need for a vaccine that is safe, prevents infection and/or limits disease. Unique among human

A feasibility study of an in vitro differentiation potential toward insulin-producing cells by dental tissue-derived mesenchymal stem cells.

Chenphop Sawangmake et al.

Biochemical and biophysical research communications, 452(3), 581-587 (2014-09-03)

Dental tissue-derived mesenchymal stem cells have been proposed as an alternative source for mesenchymal stem cells. Here, we investigated the differentiation ability toward insulin producing cells (IPCs) of human dental pulp stem cells (hDPSCs) and human periodontal ligament stem cells

Sodium butyrate, a histone deacetylase Inhibitor, ameliorates SIRT2-induced memory impairment, reduction of cell proliferation, and neuroblast differentiation in the dentate gyrus.

Dae Young Yoo et al.

Neurological research, 37(1), 69-76 (2014-06-26)

Histone deacetylases (HDACs) play a key role in synaptic plasticity and learning and memory. Sirtuin 2 (SIRT2), a class III HDAC, is abundantly expressed in neurons and functions as a mitotic exit regulator in dividing cells. In this study, we

Proteome-wide lysine acetylation profiling of the human pathogen Mycobacterium tuberculosis.

Longxiang Xie et al.

The international journal of biochemistry & cell biology, 59, 193-202 (2014-12-03)

N(ɛ)-Acetylation of lysine residues represents a pivotal post-translational modification used by both eukaryotes and prokaryotes to modulate diverse biological processes. Mycobacterium tuberculosis is the causative agent of tuberculosis, one of the most formidable public health threats. Many aspects of the

Fight Cancer with Vitamins and Supplements: A Guide to Prevention and Treatment (2001)

Nuclear factor of activated T-cells 5 increases intestinal goblet cell differentiation through an mTOR/Notch signaling pathway.

Yuning Zhou et al.

Molecular biology of the cell, 25(18), 2882-2890 (2014-07-25)

The intestinal mucosa undergoes a continual process of proliferation, differentiation, and apoptosis that is regulated by multiple signaling pathways. Previously, we have shown that the nuclear factor of activated T-cells 5 (NFAT5) is involved in the regulation of intestinal enterocyte

Establishment of B-cell lines latently infected with reactivation-competent murine gammaherpesvirus 68 provides evidence for viral alteration of a DNA damage-signaling cascade.

J Craig Forrest et al.

Journal of virology, 82(15), 7688-7699 (2008-05-23)

Gammaherpesvirus 68 (gammaHV68, or MHV68) is a naturally occurring rodent pathogen that replicates to high titer in cell culture and is amenable to in vivo experimental evaluation of viral and host determinants of gammaherpesvirus disease. However, the inability of MHV68

Colon cancer cell apoptosis is induced by combined exposure to the n-3 fatty acid docosahexaenoic acid and butyrate through promoter methylation.

Youngmi Cho et al.

Experimental biology and medicine (Maywood, N.J.), 239(3), 302-310 (2014-02-06)

DNA methylation and histone acetylation contribute to the transcriptional regulation of genes involved in apoptosis. We have demonstrated that docosahexaenoic acid (DHA, 22:6 n-3) and butyrate enhance colonocyte apoptosis. To determine if DHA and/or butyrate elevate apoptosis through epigenetic mechanisms thereby

Valnoctamide, a non-teratogenic amide derivative of valproic acid, inhibits arachidonic acid activation in vitro by recombinant acyl-CoA synthetase-4.

Hiren R Modi et al.

Bipolar disorders, 16(8), 875-880 (2014-07-22)

Valproic acid (VPA), a mood stabilizer used for treating bipolar disorder (BD), uncompetitively inhibits acylation of arachidonic acid (AA) by recombinant AA-selective acyl-CoA synthetase 4 (Acsl4) at an enzyme inhibition constant (Ki ) of 25 mM. Inhibition may account for

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