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Showing 1-30 of 75 results for "07596" within Papers
Letizia Polito et al.
Journal of Alzheimer's disease : JAD, 42(3), 851-864 (2014-06-26)
Environmental enrichment (EE) is a non-pharmacological intervention reported to counteract pathological signs in models of Alzheimer's disease (AD). We developed EE protocols in APP23 mice and evaluated how they influenced cognitive decline and brain amyloid-β (Aβ) burden. We also investigated
Hai-Ying Li et al.
Journal of cellular biochemistry, 116(2), 287-298 (2014-09-05)
Honokiol, a constituent of Magnolia officinalis, has been reported to possess potent anti-cancer activity through targeting multiple signaling pathways in numerous malignancies including acute myeloid leukemia (AML). However, the underlying mechanisms remain to be defined. Here, we report that honokiol
Karen J Humphreys et al.
PloS one, 9(11), e112288-e112288 (2014-11-08)
The miR-17-92 cluster of microRNAs is elevated in colorectal cancer, and has a causative role in cancer development. Of the six miR-17-92 cluster members, miR-19a and b in particular are key promoters of cancer development and cell proliferation, while preliminary
Marisa Granato et al.
Journal of virology, 88(21), 12715-12726 (2014-08-22)
Autophagy is a catabolic pathway that helps cells to survive under stressful conditions. Cells also use autophagy to clear microbiological infections, but microbes have learned how to manipulate the autophagic pathway for their own benefit. The experimental evidence obtained in
Anastasia Gelgor et al.
Journal of virology, 89(10), 5298-5307 (2015-03-06)
The Kaposi's sarcoma-associated herpesvirus (KSHV) open reading frame 16 (orf16) encodes a viral Bcl-2 (vBcl-2) protein which shares sequence and functional homology with the Bcl-2 family. Like its cellular homologs, vBcl-2 protects various cell types from apoptosis and can also
Petra van der Lelij et al.
The EMBO journal, 33(22), 2643-2658 (2014-09-27)
Although splicing is essential for the expression of most eukaryotic genes, inactivation of splicing factors causes specific defects in mitosis. The molecular cause of this defect is unknown. Here, we show that the spliceosome subunits SNW1 and PRPF8 are essential
Bing Yan et al.
PloS one, 9(10), e110718-e110718 (2014-10-21)
Activated macrophages play an important role in both innate and adaptive immune responses, and aberrant activation of macrophages often leads to inflammatory and immune disorders. However, the molecular mechanisms of how macrophages are activated are not fully understood. In this
Modelling Fanconi anemia pathogenesis and therapeutics using integration-free patient-derived iPSCs.
Guang-Hui Liu et al.
Nature communications, 5, 4330-4330 (2014-07-08)
Fanconi anaemia (FA) is a recessive disorder characterized by genomic instability, congenital abnormalities, cancer predisposition and bone marrow (BM) failure. However, the pathogenesis of FA is not fully understood partly due to the limitations of current disease models. Here, we
Mariza G Santos et al.
BioMed research international, 2014, 787465-787465 (2014-07-24)
Despite the increasing understanding of female reproduction, the molecular diagnosis of primary ovarian insufficiency (POI) is seldom obtained. The RNA-binding protein NANOS3 poses as an interesting candidate gene for POI since members of the Nanos family have an evolutionarily conserved
Jing Jiang et al.
Scientific reports, 5, 9191-9191 (2015-03-18)
Epithelial barrier integrity is critical to maintain the homeostasis in the body. The regulatory mechanism of the epithelial barrier function has not been fully understood. This study aims to elucidate the role of the TWIK-related potassium channel-1 (Trek1) in the
Alicja J Copik et al.
PloS one, 10(1), e0115701-e0115701 (2015-01-22)
The α1A-AR is thought to couple predominantly to the Gαq/PLC pathway and lead to phosphoinositide hydrolysis and calcium mobilization, although certain agonists acting at this receptor have been reported to trigger activation of arachidonic acid formation and MAPK pathways. For
Elisabetta Gerace et al.
Neuropharmacology, 92, 125-134 (2015-01-28)
Ischemic tolerance is an endogenous defense program in which exposure to a subtoxic preconditioning insult results in resistance to a subsequent, otherwise lethal, episode of ischemia. Herein, we evaluated the role of histone acetylation/deacetylation in an in vitro model of
G Csikó et al.
Journal of veterinary pharmacology and therapeutics, 37(4), 406-412 (2014-03-19)
Butyrate, a commonly applied feed additive in poultry nutrition, can modify the expression of certain genes, including those encoding cytochrome P450 (CYP) enzymes. In comparative in vitro and in vivo experiments, the effect of butyrate on hepatic CYP genes was
T K Greene et al.
Journal of thrombosis and haemostasis : JTH, 12(12), 2102-2112 (2014-10-08)
Ectopically expressed B-domainless factor VIII in megakaryocytes is stored in α-granules, is effective in a number of murine hemostatic models, and is protected from circulating inhibitors. However, this platelet (p) FVIII has different temporal-spatial availability from plasma FVIII, with limited efficacy
Joshua J Malago et al.
Journal of Zhejiang University. Science. B, 16(3), 224-234 (2015-03-07)
Intrarectal infusion of butyrate improves colorectal disorders including ulcerative colitis (UC). However, it is not established whether systemically administered butyrate benefits such patients. The current study aimed at exploring and comparing the potential of intraperitoneally, intrarectally, and orally administered butyrate
Andrew J Linsenbardt et al.
Neurotoxicology, 30(6), 1030-1035 (2009-07-22)
Parkinson disease is a specific form of neurodegeneration characterized by a loss of nigra-striatal dopaminergic neurons in the midbrain of humans. The disease is also characterized by an increase in oxidative stress and a loss of glutathione in the midbrain
Siyuan Ding et al.
PLoS biology, 12(1), e1001758-e1001758 (2014-01-11)
Type III interferon (IFN-λ) exhibits potent antiviral activity similar to IFN-α/β, but in contrast to the ubiquitous expression of the IFN-α/β receptor, the IFN-λ receptor is restricted to cells of epithelial origin. Despite the importance of IFN-λ in tissue-specific antiviral
M A Torres-Vega et al.
Gene therapy, 22(1), 58-64 (2014-10-24)
Hyperammonemia, a condition present in patients with urea cycle disorders (UCDs) or liver diseases, can cause neuropsychiatric complications, which in the worst cases result in brain damage, coma or death. Diverse treatments exist for the treatment of hyperammonemia, but they
Kazuhiro Takuma et al.
Pharmacology, biochemistry, and behavior, 126, 43-49 (2014-09-23)
We recently showed that prenatal exposure to valproic acid (VPA) in mice causes autism-like behavioral abnormalities, including social interaction deficits, anxiety-like behavior and spatial learning disability, in male offspring. In the present study, we examined the effect of prenatal VPA
Steven C Tsai et al.
American journal of physiology. Cell physiology, 306(12), C1108-C1118 (2014-03-15)
Our knowledge of the molecular mechanisms underlying human embryonic stem cell (hESC) self-renewal and differentiation is incomplete. The level of octamer-binding transcription factor 4 (Oct4), a critical regulator of pluripotency, is precisely controlled in mouse embryonic stem cells. However, studies
Danielle S Stolzenberg et al.
Endocrinology, 155(9), 3674-3683 (2014-06-17)
In many species, including mice, maternal responsiveness is experience-dependent and permanent, lasting for long periods (months to years). We have shown that after brief exposures to pups, virgin female mice continue to respond maternally toward pups for at least one
Kevin Brulois et al.
Journal of virology, 88(16), 9335-9349 (2014-06-06)
The downregulation of immune synapse components such as major histocompatibility complex class I (MHC-I) and ICAM-1 is a common viral immune evasion strategy that protects infected cells from targeted elimination by cytolytic effector functions of the immune system. Kaposi's sarcoma-associated
Sandeep Dayal et al.
PloS one, 6(9), e24571-e24571 (2011-09-29)
Antibodies are assembled by a highly orchestrated series of recombination events during B cell development. One of these events, class switch recombination, is required to produce the IgG, IgE and IgA antibody isotypes characteristic of a secondary immune response. The
Nimisha Singh et al.
Genes, chromosomes & cancer, 53(12), 999-1007 (2014-08-15)
Small cell lung cancer (SCLC) is an aggressive disease with a poor prognosis. These cancers are deficient in glucocorticoid receptor (GR) expression, and therefore, resistant to glucocorticoids. Overexpression of the GR both in vivo and in vitro leads to apoptotic
Wei Gao et al.
PloS one, 9(11), e112698-e112698 (2014-11-14)
Alcohol insult triggers complex events in the liver, promoting fibrogenic/inflammatory signals and in more advanced cases, aberrant matrix deposition. It is well accepted that the regenerative capacity of the adult liver is impaired during alcohol injury. The liver progenitor/stem cells
Hong Geun Park et al.
The international journal of neuropsychopharmacology, 17(9), 1487-1500 (2014-03-13)
The enzymatic activity of histone deacetylases (HDACs) leads to a histone deacetylation-mediated condensed chromatic structure, resulting in transcriptional repression, which has been implicated in the modifications of neural circuits and behaviors. Repeated treatment with electroconvulsive seizure (ECS) induces changes in
Muslima Chowdhury et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(41), 15872-15877 (2008-10-07)
Ig class switch recombination (CSR) is initiated by activation-induced cytidine deaminase (AID) mediated deamination of the switch (S) regions; the resultant mismatch is processed to yield the DNA breaks required for recombination. Whereas many of the pathways involved in the
Kai Liu et al.
PloS one, 9(8), e105309-e105309 (2014-08-30)
Induced pluripotent stem (iPS) cells from somatic cells have great potential for regenerative medicine. The efficiency in generation of iPS cells has been significantly improved in recent years. However, the generation of high-quality iPS cells remains of high interest. Consistently
Dan Huang et al.
Applied microbiology and biotechnology, 99(3), 1399-1413 (2014-12-10)
Lysine acetylation is a dynamic, reversible posttranslational modification that is known to play an important role in regulating the activity of many key enzymes in bacteria. Acetylproteome studies have been performed on some bacteria. However, until now, there have been
Tsung-Hua Hsieh et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 23(4), 656-666 (2014-12-23)
Histone deacetylase inhibitors (HDACi) are novel clinical anticancer drugs that inhibit HDAC gene expression and induce cell apoptosis in human cancers. Nevertheless, the detailed mechanism or the downstream HDAC targets by which HDACi mediates apoptosis in human breast cancer cells
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