07982

Applied Filters:

Keyword:'07982'

Showing 1-11 of 11 results for "07982" within Papers

Goblet cell-targeting nanoparticles for oral insulin delivery and the influence of mucus on insulin transport.

Yun Jin et al.

Biomaterials, 33(5), 1573-1582 (2011-11-19)

The present study was to demonstrate the effects of goblet cell-targeting nanoparticles on the oral absorption of insulin in vitro, ex vivo and in vivo, and identify the targeting mechanism as well as the influence of mucus. The insulin loaded

Thymoquinone Attenuates Cardiomyopathy in Streptozotocin-Treated Diabetic Rats.

Mustafa S Atta et al.

Oxidative medicine and cellular longevity, 2018, 7845681-7845681 (2018-12-05)

Diabetic cardiomyopathy is a diabetic complication due to oxidative stress injuries. This study examined the protecting influence of thymoquinone (TQ) on diabetes-caused cardiac complications. The intracellular means by which TQ works against diabetes-caused cardiac myopathy in rats is not completely

Targeting zymogen activation to control the matriptase-prostasin proteolytic cascade.

Zhenghong Xu et al.

Journal of medicinal chemistry, 54(21), 7567-7578 (2011-10-05)

Membrane-associated serine protease matriptase has been implicated in human diseases and might be a drug target. In the present study, a novel class of matriptase inhibitors targeting zymogen activation is developed by a combination of the screening of compound library

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Zhichao Liu et al.

PLoS computational biology, 7(12), e1002310-e1002310 (2011-12-24)

Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be translated

Purification and inhibition studies with anions and sulfonamides of an α-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii.

Alessandra Cincinelli et al.

Bioorganic & medicinal chemistry, 19(6), 1847-1851 (2011-03-08)

A high activity α-carbonic anhydrase (CA, EC 4.2.1.1) has been purified from various tissues of the Antarctic seal Leptonychotes weddellii. The new enzyme, denominated lwCA, has a catalytic activity for the physiologic CO(2) hydration to bicarbonate reaction, similar to that

A hydrophobically-modified alginate gel system: utility in the repair of articular cartilage defects.

Mohammad Kazem Ghahramanpoor et al.

Journal of materials science. Materials in medicine, 22(10), 2365-2375 (2011-08-13)

Alginate is a family of natural polysaccharides, widely used in industry and medicine for many applications, with its non toxic nature, gentle sol/gel transition procedure and low cost, alginate inferior biomechanical properties have limited its utility especially in tissue engineering.

Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium.

Daniela Vullo et al.

Bioorganic & medicinal chemistry letters, 21(12), 3591-3595 (2011-05-17)

Two new β-carbonic anhydrases (CAs, EC 4.2.1.1) from the bacterial pathogen Salmonella enterica serovar Typhimurium, stCA 1 and stCA 2, were characterized kinetically. The two enzymes possess appreciable activity as catalysts for the hydration of CO(2) to bicarbonate, with k(cat)

Inhibition of the β-carbonic anhydrase from Streptococcus pneumoniae by inorganic anions and small molecules: Toward innovative drug design of antiinfectives?

Peter Burghout et al.

Bioorganic & medicinal chemistry, 19(1), 243-248 (2010-12-18)

The Gram-positive bacterium Streptococcus pneumoniae is a human respiratory tract pathogen that contributes significantly to global mortality and morbidity. It was recently shown that this bacterial pathogen depends on a conserved β-carbonic anhydrase (CA, EC 4.2.1.1) for in vitro growth

Anion inhibition studies of an α-carbonic anhydrase from the living fossil Astrosclera willeyana.

Anna Ohradanova et al.

Bioorganic & medicinal chemistry letters, 22(3), 1314-1316 (2012-01-10)

An α-carbonic anhydrase (CA, EC 4.2.1.1) isolated from the living fossil sponge Astrosclera willeyana, Astrosclerin, was investigated for its inhibition profile with simple inorganic anions, complex anions and other small molecules known to interact with these zinc enzymes. Astrosclerin is

Overexpression, crystallization and preliminary X-ray crystallographic analysis of the C-terminal cytosolic domain of mouse anoctamin 1.

Sang Ho Park et al.

Acta crystallographica. Section F, Structural biology and crystallization communications, 67(Pt 10), 1250-1252 (2011-11-22)

Transmembrane protein 16A (TMEM16A, also known as anoctamin 1; ANO1) is a bona fide Ca(2+)-activated chloride channel that is activated by intracellular Ca(2+)- and Ca(2+)-mobilizing stimuli and plays important roles in a variety of physiological functions. To elucidate the structural

Developing structure-activity relationships for the prediction of hepatotoxicity.

Nigel Greene et al.

Chemical research in toxicology, 23(7), 1215-1222 (2010-06-18)

Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential

Page 1 of 1