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Showing 1-30 of 75 results for "100-01-6" within Papers
Muhammad Anzar et al.
Journal of andrology, 30(6), 661-668 (2009-05-30)
Assessing semen quality is crucially important for the exploitation of genetically superior sires in an artificial insemination (AI) program. In this study, we compare modern and conventional techniques to estimate bovine sperm concentration and membrane integrity. First, the NucleoCounter SP-100
Fang Fang et al.
Zhonghua nan ke xue = National journal of andrology, 18(9), 777-782 (2012-12-01)
To explore the correlation of low-dose radiation with endoplasmic reticulum stress and the activation of the PERK-CHOP signaling pathway in mouse testicular cells. Healthy Kunming mice were randomly assigned to time-effect (0, 3, 6, 12 and 24 h of irradiation
Winona W Wu et al.
Journal of vascular surgery, 69(5), 1452-1460 (2019-03-12)
Transcarotid artery revascularization (TCAR) has emerged as an alternative to transfemoral carotid artery stenting (tfCAS). We investigated the proportion of carotid arteries undergoing revascularization procedures that would be eligible for TCAR based on anatomic criteria and how many arteries at
Timothy B Nguyen et al.
Journal of neurovirology, 15(5-6), 434-438 (2009-08-19)
Glycogen synthase kinase-3beta (GSK3beta) role in human immunodeficiency virus(HIV)-associated neurodegeneration has been evidenced by previous investigations. In this study, we investigated the specificity of two GSK3beta-specific inhibitors, AR-A014418 (A) and B6B30 (B) to prevent direct neurotoxicity in primary human neurons
Harini Jogiraju et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 963, 83-89 (2014-06-21)
NGP1-01 (8-benzylamino-8,11-oxapentacyclo[5.4.0.0(2,6).0(3,10).0(5,9)]undecane) is a heterocyclic cage compound with multifunctional calcium channel blocking activity that has been demonstrated to be neuroprotective in several neurodegenerative models. A sensitive internal standard LC-MS/MS method was developed and validated to quantify NGP1-01 in mouse serum.
Cynthia X Ma et al.
Breast cancer research and treatment, 137(2), 483-492 (2012-12-18)
Mutations in TP53 lead to a defective G1 checkpoint and the dependence on checkpoint kinase 1 (Chk1) for G2 or S phase arrest in response to DNA damage. In preclinical studies, Chk1 inhibition resulted in enhanced cytotoxicity of several chemotherapeutic
R M Cleale et al.
Journal of animal science, 76(7), 1849-1858 (1998-08-05)
We studied the effects of alpha2-adrenoceptor antagonists (A2AA) on nitrogen (N) partitioning. The diets fed contained 19.8% CP and 1.15% lysine. Pigs were fed the diet as a percentage of BW equaling approximately 90% of voluntary intake. In Trial 1
Meng Li et al.
Zhen ci yan jiu = Acupuncture research, 38(2), 123-128 (2013-07-04)
To observe the effect of electroacupuncture (EA) of "Neiguan" (PC 6) and "Xinshu" (BL 15) on levels of serum total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL) and low-density lipoprotein (LDL) and expression of T cell CD 40 L
Tracey L Weissgerber et al.
The Journal of clinical endocrinology and metabolism, 99(3), 978-987 (2014-01-16)
Research examining the source of excess soluble fms-like tyrosine kinase 1 (sFLT1) in preeclampsia has focused on the placenta. The potential contribution of the releasable store of sFLT1 in the systemic vasculature is unknown. We asked whether the nonplacental releasable
Mark A Turner et al.
Journal of the Society for Gynecologic Investigation, 11(3), 141-148 (2004-03-31)
To determine whether prostanoids, nonsteroidal anti-inflammatory drugs (NSAIDs), and members of the tumor necrosis factor superfamily can regulate placental secretion of interleukin-6 (IL-6) and whether labor influences any such effects. Villous fragments of term, human placenta were kept in culture
Kirsten Schultz et al.
Metabolism: clinical and experimental, 54(3), 287-295 (2005-03-01)
An increased amount of hyaluronan (HA) in the arterial wall is a feature of the diabetic macroangiopathy. The functional consequences of accumulated HA are mediated through binding to CD44. The regulation of this receptor by diabetic metabolic and hormonal factors
Jan Lewis Brandes et al.
JAMA, 291(8), 965-973 (2004-02-26)
Small open-label and controlled trials suggest that the antiepileptic drug topiramate is effective for migraine prevention. To assess the efficacy and safety of topiramate for migraine prevention in a large controlled trial. A 26-week, randomized, double-blind, placebo-controlled study was conducted
J H Wang et al.
Clinical pharmacology and therapeutics, 70(1), 42-47 (2001-07-14)
Our objective was to evaluate the relationship between the disposition of sertraline and the presence of the CYP2C19 gene and to define the contribution of cytochrome P450 2C19 (CYP2C19) to sertraline N-demethylation. A single oral 100-mg dose of sertraline was
Patrick Couture et al.
Metabolism: clinical and experimental, 52(11), 1454-1459 (2003-11-19)
The purpose of this study was to assess the contribution of the apolipoprotein E (apoE) polymorphism and factors, such as age and waist circumference, to variations in plasma low-density lipoprotein-cholesterol (LDL-C) response following ad libitum consumption of a diet rich
Su Han Lum et al.
Blood, 135(12), 954-973 (2020-01-15)
MHC class II deficiency is a rare, but life-threatening, primary combined immunodeficiency. Hematopoietic cell transplantation (HCT) remains the only curative treatment for this condition, but transplant survival in the previously published result was poor. We analyzed the outcome of 25
S Suzuki et al.
Circulation research, 77(4), 679-683 (1995-10-01)
We report in the present study the effect of intrathecal treatment with antisense oligonucleotides complementary to thyrotropin releasing hormone (TRH) receptor mRNA on the pressor response to intrathecal administration of TRH and on resting arterial blood pressure in Wistar-Kyoto (WKY)
Marc Sanson et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 27(25), 4150-4154 (2009-07-29)
Unexpected mutations affecting the isocitrate dehydrogenase (IDH1) gene at codon 132 have been found in 12% of glioblastomas. IDH1 codon 132 sequencing was performed in a series of 404 patients with glioma (100 grade 2, 121 grade 3, and 183
Yuna C Larrabee et al.
The Laryngoscope, 121(8), 1756-1759 (2011-07-28)
Cleft lip with or without cleft palate (CL/P) is a common birth defect throughout the world. Linkage studies have shown interferon regulatory factor 6 (IRF6) to be associated with CL/P in multiple populations, including one in Honduras. It is unknown
Theodore Wein et al.
PM & R : the journal of injury, function, and rehabilitation, 10(7), 693-703 (2018-01-14)
Poststroke distal lower limb spasticity impairs mobility, limiting activities of daily living and requiring additional caregiver time. To evaluate the efficacy, safety, and sustained benefit of onabotulinumtoxinA in adults with poststroke lower limb spasticity (PSLLS). A multicenter, randomized, double-blind, phase
Mitchell L Jones et al.
The British journal of nutrition, 107(10), 1505-1513 (2011-11-10)
Several studies have reported limited or no reduction in serum cholesterol in response to probiotic formulations. Recently, probiotics have shown promise in treating metabolic disease due to improved strain selection and delivery technologies. The aim of the present study was
Ayodeji O Egunlusi et al.
ChemMedChem, 10(7), 1259-1266 (2015-05-28)
Neurodegenerative disorders are debilitating conditions characterised by progressive dysfunction and death of neuronal cells. Amidst the proposed mechanisms of neurodegeneration, the effects of excitotoxicity via N-methyl-D-aspartate (NMDA) receptor stimulation and activation of voltage-gated calcium channels (VGCC) on neuronal cells are
Renske D M Steenbergen et al.
Journal of the National Cancer Institute, 96(4), 294-305 (2004-02-19)
Cervical carcinogenesis is initiated by infection with high-risk (i.e., carcinogenic) human papillomavirus (HPV) types. The subsequent progression from premalignant cervical intraepithelial neoplasia (CIN) to invasive cancer is driven by both genetic and epigenetic processes. We assessed the role of the
Daniela Lötsch et al.
Neuro-oncology, 15(4), 423-432 (2013-02-09)
Glioblastoma multiforme (GBM) is a heterogeneous, highly aggressive primary brain tumor with strongly variable patient survival. Because reliable prognostic biomarkers are lacking, we investigated the relation between telomerase-associated parameters and the disease course. Telomerase-associated parameters were determined in 100 GBM
T Dhaouadi et al.
Archives de l'Institut Pasteur de Tunis, 87(1-2), 53-59 (2010-01-01)
This study aimed to investigate HLA-DRB1 alleles in rheumatoid arthritis (RA) patients from Tunisia and to examine the effect of these alleles on disease severity. HLA-DRBI alleles and sub-typing of DRBI*04 and *01 were determined in 90 patients and 100
D T Rein et al.
Journal of cancer research and clinical oncology, 129(3), 161-164 (2003-04-25)
Interactions of hyaluronic acid (HA) with its binding protein RHAMM (receptor for HA-mediated motility) have been proposed as being important in promoting tumour progression and dissemination. This comparative study was designed to investigate the RHAMM expression patterns in endometrial carcinoma.
Fariba Akhondzadeh et al.
Journal of cellular physiology, 235(10), 6969-6977 (2020-02-07)
Inflammatory cytokine, interleukin-6 (IL-6), plays an important role in the pathogenesis of cardiac hypertrophy. Recent studies have documented that resveratrol exhibits cardioprotective effects. The present study attempts to explore whether resveratrol suppreses IL-6 in hypertrophied H9c2 cardiomyoblasts through histone deacetylase
Muhammad Abdul Naeem et al.
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 12(2), 223-226 (2006-05-19)
The objective of this study was to determine the prevalence of prothrombin gene mutation in a sample population from Pakistan. Two hundred apparently healthy unrelated adults (older than 18 years) were included in the study. The sample population comprised 100
Julia Kirchheiner et al.
Clinical pharmacology and therapeutics, 76(4), 302-312 (2004-10-08)
In the treatment of heart failure and hypertension with metoprolol, ultrarapid metabolizers (UMs) may not achieve optimal target concentrations with recommended doses. We compared metoprolol pharmacokinetics and effects in UMs with extensive metabolizers (EMs) and with poor metabolizers (PM) as
Mahdi Alamili et al.
Journal of critical care, 29(1), 184-184 (2013-10-22)
Melatonin used as an exogenous drug has been documented to have potent antioxidant and anti-inflammatory effects in animal model. We aimed to examine the effect of melatonin in an experimental human sepsis model. Twelve healthy males were enrolled in a
P Madeddu et al.
Circulation, 96(10), 3570-3578 (1997-12-13)
To evaluate the role of kinins in the regulation of cardiovascular function, we studied the phenotype of a mouse strain with disruption of the bradykinin B2-receptor gene (Bk 2r-/-). Under basal conditions, tail-cuff blood pressure was higher in Bk2r-/- than
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