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Showing 1-30 of 813 results for "1043003" within Papers
S Cyboran et al.
Life sciences, 126, 1-9 (2015-02-24)
This study was undertaken to determine the biological activity of a green tea supplement with respect to cells and erythrocyte membranes and the molecular mechanism of that activity. The extract's activity was evaluated on the basis of its hemolytic, antioxidant
Masato Yuasa et al.
PloS one, 10(2), e0116462-e0116462 (2015-02-07)
We evaluated whether dexamethasone augments the osteogenic capability of bone marrow-derived stromal cells (BMSCs) and muscle tissue-derived stromal cells (MuSCs), both of which are thought to contribute to ectopic bone formation induced by bone morphogenetic protein-2 (BMP-2), and determined the
Sivaprakash Ramalingam et al.
Current gene therapy, 14(6), 461-472 (2014-09-24)
Generation and precise genetic correction of patient-derived hiPSCs have great potential in regenerative medicine. Such targeted genetic manipulations can now be achieved using gene-editing nucleases. Here, we report generation of cystic fibrosis (CF) and Gaucher's disease (GD) hiPSCs respectively from
Stephen Flowers et al.
Bone, 69, 47-54 (2014-09-04)
The retinoblastoma protein family is intimately involved in the regulation of tissue specific gene expression during mesenchymal stem cell differentiation. The role of the following proteins, pRB, p107 and p130, is particularly significant in differentiation to the osteoblast lineage, as
Sawsan Aboul-Fotouh
Psychopharmacology, 232(6), 1095-1105 (2014-10-16)
Several studies have pointed to the nicotinic acetylcholine receptor (nAChR) antagonists, such as mecamylamine (MEC), as a potential therapeutic target for the treatment of depression. The present study evaluated the behavioral and neurochemical effects of chronic administration of MEC (1
Lusine Danielyan et al.
Cell transplantation, 23 Suppl 1, S123-S139 (2014-10-11)
In view of the rapid preclinical development of cell-based therapies for neurodegenerative disorders, traumatic brain injury, and tumors, the safe and efficient delivery and targeting of therapeutic cells to the central nervous system is critical for maintaining therapeutic efficacy and
Fei Xu et al.
FEMS microbiology letters, 358(1), 98-105 (2014-07-24)
This study investigated inactivation of bacteria with ultraviolet light A irradiation in combination with vitamin K3 as a photosensitizer. Six bacteria including Bacillus cereus, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis, Klebsiella pneumoniae, and Escherichia coli suspended in vitamin K3 aqueous
Ana Freitas et al.
Journal of the science of food and agriculture, 95(1), 44-52 (2014-05-24)
The industrial processing of pineapple generates a high quantity of by-products. To reduce the environmental impact of these by-products and the inherent cost of their treatment, it is important to characterise and valorise these products, converting them into high added
Holly R Harris et al.
European journal of cancer (Oxford, England : 1990), 50(7), 1223-1231 (2014-03-13)
The association between dietary vitamin C intake and breast cancer survival is inconsistent and few studies have specifically examined vitamin C supplement use among women with breast cancer. The purpose of this study was to summarise results from prospective studies
Claire E Schaar et al.
PLoS genetics, 11(2), e1004972-e1004972 (2015-02-12)
Reactive oxygen species (ROS) are highly reactive, oxygen-containing molecules that can cause molecular damage within the cell. While the accumulation of ROS-mediated damage is widely believed to be one of the main causes of aging, ROS also act in signaling
Diane C Forbes et al.
Macromolecular bioscience, 14(8), 1096-1105 (2014-04-23)
This work investigates the interactions of a polycationic nanocarrier with siRNA and with cells in order to better understand the capabilities and limitations of the carrier. The polycationic nanocarriers are cross-linked copolymer nanoparticles synthesized in a single-step reaction using ARGET
Niels Schlichting et al.
Molecular pharmaceutics, 11(7), 2092-2105 (2014-03-19)
In vitro tissue models are useful tools for the development of novel therapy strategies in cartilage repair and care. The limited availability of human primary tissue and high costs of animal models hamper preclinical tests of innovative substances and techniques.
Yoshitaka Kondo et al.
Journal of agricultural and food chemistry, 62(38), 9286-9295 (2014-09-03)
Potato chips (PC) contain abundant amounts of the free radical scavenger ascorbic acid (AA) due to the rapid dehydration of potato tubers (Solanum tuberosum) that occurs during frying. To evaluate the antioxidant activity of PC, this study examined reactive oxygen
Ji-Won Lee et al.
Molecular nutrition & food research, 59(3), 386-400 (2014-11-08)
Bone homeostasis is ensured by the balance between bone formation and resorption. Thus, control of the recruitment, proliferation, and differentiation of bone cells is essential to maintain bone mass. The aim of this study was to elucidate the effects of
Vrunda Patel et al.
Pain practice : the official journal of World Institute of Pain, 12(6), 476-484 (2011-12-14)
Nonsteroidal anti-inflammatory drugs (NSAIDs), including aspirin, have been associated with the damage to the gastrointestinal tract. One proposed mechanism of injury to the gastrointestinal mucosa by NSAIDs is oxygen radical-dependent microvascular injury. There is reasonable evidence to support the benefit
Kosei Nakajima et al.
Neoplasia (New York, N.Y.), 16(11), 939-949 (2014-11-27)
Patients with bone cancer metastasis suffer from unbearable pain and bone fractures due to bone remodeling. This is caused by tumor cells that disturb the bone microenvironment. Here, we have investigated the role of tumor-secreted sugar-binding protein, i.e., galectin-3, on
Bret H Clough et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30(1), 83-94 (2014-08-19)
Although bone has remarkable regenerative capacity, about 10% of long bone fractures and 25% to 40% of vertebral fusion procedures fail to heal. In such instances, a scaffold is employed to bridge the lesion and accommodate osteoprogenitors. Although synthetic bone
Arnold Bolomsky et al.
Journal of hematology & oncology, 8, 10-10 (2015-04-19)
Insulin like growth factor binding protein 7 (IGFBP7) is a secreted protein binding insulin like growth factor 1 (IGF-1), insulin, vascular endothelial growth factor A (VEGFA), and activin A. It antagonizes bone morphogenetic proteins and is involved in the tumour
Gulsen Tel et al.
Pharmaceutical biology, 53(6), 824-830 (2015-02-28)
Recently, mushrooms are interesting natural products to be investigated due to exhibiting various bioactivities. This study determines the antioxidant and anticholinesterase activities of various extracts of five wild mushroom species. In addition, the total bioactive contents, namely, ascorbic acid, β-carotene
Katherine A Brown et al.
ACS nano, 8(10), 10790-10798 (2014-09-23)
Excited state electron transfer (ET) is a fundamental step for the catalytic conversion of solar energy into chemical energy. To understand the properties controlling ET between photoexcited nanoparticles and catalysts, the ET kinetics were measured for solution-phase complexes of CdTe
Jonathan Sagal et al.
Stem cells translational medicine, 3(8), 888-898 (2014-06-07)
Human pluripotent stem cells (PSCs) are a promising cell resource for various applications in regenerative medicine. Highly efficient approaches that differentiate human PSCs into functional lineage-specific neurons are critical for modeling neurological disorders and testing potential therapies. Proneural transcription factors
Hao Guo et al.
Archives of oral biology, 60(1), 199-207 (2014-12-03)
Ubiquitous environmental pollutants such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) cause abnormalities in reproduction and development. TCDD inhibits the development of teeth, and its effects depend on its dose and the developmental stage of the tooth. Our aim here was to investigate the
Phil Jun Kang et al.
Biomaterials, 35(26), 7336-7345 (2014-06-03)
Somatic cells can be reprogrammed to generate induced pluripotent stem cells (iPSCs) by overexpression of four transcription factors, Oct4, Klf4, Sox2, and c-Myc. However, exogenous expression of pluripotency factors raised concerns for clinical applications. Here, we show that iPS-like cells
Daniela Sieghart et al.
Journal of cellular and molecular medicine, 19(1), 187-197 (2014-10-15)
Balneotherapy employing sulphurous thermal water is still applied to patients suffering from diseases of musculoskeletal system like osteoarthritis (OA) but evidence for its clinical effectiveness is scarce. Since the gasotransmitter hydrogen sulphide (H2 S) seems to affect cells involved in
David Tagler et al.
Biotechnology and bioengineering, 111(7), 1417-1429 (2014-01-01)
The in vitro growth of ovarian follicles is an emerging technology for fertility preservation. Various strategies support the culture of secondary and multilayer follicles from various species including mice, non-human primate, and human; however, the culture of early stage (primary
Lubica Horvathova et al.
Journal of neuroimmunology, 278, 255-261 (2014-12-04)
The sympathetic nervous system regulates many immune functions and modulates the anti-tumor immune defense response, too. Therefore, we studied the effect of 6-hydroxydopamine induced sympathectomy on selected hematological parameters and inflammatory markers in rats with Yoshida AH130 ascites hepatoma. We
Ewa Kleszczewska
Postepy higieny i medycyny doswiadczalnej, 56(5), 655-669 (2003-02-18)
L-ascorbic acid is one of the basic vitamins, necessary to the normal growth and behaviour of organisms. The primary of this review is to present the chemical characteristics of this substance and to discuss its relation to various biological functions
Sung Hugh Choi et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 23(2), 235-243 (2014-11-02)
Three type-1 repeat (3TSR) domain of thrombospondin-1 is known to have anti-angiogenic effects by targeting tumor-associated endothelial cells, but its effect on tumor cells is unknown. This study explored the potential of 3TSR to target glioblastoma (GBM) cells in vitro
Dariela Almeda et al.
Biomaterials, 41, 37-44 (2014-12-20)
Liposomes may be engineered to target inflamed endothelium by mimicking ligand-receptor interactions between leukocytes and cytokine-activated endothelial cells (ECs). The upregulation and assembly of vascular cell adhesion molecule-1 (VCAM1) and E-selectin on the cell membrane upon exposure to cytokines have
Li Jiang et al.
Journal of tissue engineering and regenerative medicine, 8(11), 896-905 (2013-01-22)
Osteoarthritis (OA) is the most common form of arthritis, in which cartilage is irreversibly degraded, causing severe pain and disability. Current therapeutic strategies cannot repair damaged cartilage. We evaluated the repair potential of selected chondrogenic clonal MSCs (sC-MSCs) by delivering
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