1043003

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Critical period for dopaminergic neuroprotection by hormonal replacement in menopausal rats.

Ana I Rodriguez-Perez et al.

Neurobiology of aging, 36(2), 1194-1208 (2014-11-30)

The neuroprotective effects of menopausal hormonal therapy in Parkinson's disease have not yet been clarified, and it is not known whether there is a critical period. Estrogen induced significant protection against 6-hydroxydopamine-induced dopaminergic degeneration when administered immediately or 6 weeks

Morphological behaviour and metabolic capacity of cryopreserved human primary hepatocytes cultivated in a perfused multiwell device.

Aurelie Vivares et al.

Xenobiotica; the fate of foreign compounds in biological systems, 45(1), 29-44 (2014-07-30)

1. The quantitative prediction of the pharmacokinetic parameters of a drug from data obtained using human in vitro systems remains a significant challenge i.e. prediction of metabolic clearance in humans and estimation of the relative contribution of enzymes involved in

Osseointegration improvement by plasma electrolytic oxidation of modified titanium alloys surfaces.

Mónica Echeverry-Rendón et al.

Journal of materials science. Materials in medicine, 26(2), 72-72 (2015-01-30)

Titanium (Ti) is a material frequently used in orthopedic applications, due to its good mechanical properties and high corrosion resistance. However, formation of a non-adherent fibrous tissue between material and bone drastically could affect the osseointegration process and, therefore, the

Nutrients value and antioxidant content of indigenous vegetables from Southern Thailand.

Ratchanee Kongkachuichai et al.

Food chemistry, 173, 838-846 (2014-12-04)

Evidence from epidemiological studies has strongly suggested that diets rich in fruits and vegetables play a vital role in disease prevention. The aim of this study was to determine nutrient and antioxidant content for 15 varieties of indigenous vegetables and

DNA double-strand breaks by Cr(VI) are targeted to euchromatin and cause ATR-dependent phosphorylation of histone H2AX and its ubiquitination.

Zachary DeLoughery et al.

Toxicological sciences : an official journal of the Society of Toxicology, 143(1), 54-63 (2014-10-08)

Hexavalent chromium is a human respiratory carcinogen that undergoes intracellular activation in vivo primarily via reduction with ascorbate. Replication of Cr-adducted DNA triggers mismatch repair that generates toxic DNA double-strand breaks (DSBs) as secondary lesions. Here, we examined the intranuclear distribution

Studies of the humoral factors produced by layered chondrocyte sheets.

K Hamahashi et al.

Journal of tissue engineering and regenerative medicine, 9(1), 24-30 (2012-11-21)

The authors aimed to repair and regenerate articular cartilage with layered chondrocyte sheets, produced using temperature-responsive culture dishes. The purpose of this study was to investigate the humoral factors produced by layered chondrocyte sheets. Articular chondrocytes and synovial cells were

In vitro antioxidant and anti-inflammatory activities of Radix Isatidis extract and bioaccessibility of six bioactive compounds after simulated gastro-intestinal digestion.

Ping Xiao et al.

Journal of ethnopharmacology, 157, 55-61 (2014-09-27)

Radix Isatidis called "Ban-Lan-Gen" is one of the most commonly-used traditional Chinese medicines for antiviral, anti-inflammatory, antioxidant and antipyretic purposes. Investigate the bioaccessibility of uridine, epigoitrin, adenosine, clemastanin B, indigoticoside A and isolariciresinol as well as the antioxidant and anti-inflammatory

Mechanically stimulated bone cells secrete paracrine factors that regulate osteoprogenitor recruitment, proliferation, and differentiation.

Robert T Brady et al.

Biochemical and biophysical research communications, 459(1), 118-123 (2015-02-28)

Bone formation requires the recruitment, proliferation and osteogenic differentiation of mesenchymal progenitors. A potent stimulus driving this process is mechanical loading, yet the signalling mechanisms underpinning this are incompletely understood. The objective of this study was to investigate the role

Aptamer-conjugated gold nanorod for photothermal ablation of epidermal growth factor receptor-overexpressed epithelial cancer.

Jihye Choi et al.

Journal of biomedical optics, 19(5), 051203-051203 (2013-12-04)

Biomarker-specific photothermal nanoparticles that can efficiently sense markers that are overexpressed in distinguished adenocarcinomas have attracted much interest in an aspect of efficacy increase of cancer treatment. We demonstrated a promising prospect of a smart photothermal therapy agent employing anti-epidermal

Radioactive 198Au-doped nanostructures with different shapes for in vivo analyses of their biodistribution, tumor uptake, and intratumoral distribution.

Kvar C L Black et al.

ACS nano, 8(5), 4385-4394 (2014-04-29)

With Au nanocages as an example, we recently demonstrated that radioactive (198)Au could be incorporated into the crystal lattice of Au nanostructures for simple and reliable quantification of their in vivo biodistribution by measuring the γ radiation from (198)Au decay

Levodopa-induced dyskinesias are associated with transient down-regulation of cAMP and cGMP in the caudate-putamen of hemiparkinsonian rats: reduced synthesis or increased catabolism?

Giuseppe Sancesario et al.

Neurochemistry international, 79, 44-56 (2014-12-03)

Second messenger cAMP and cGMP represent a key step in the action of dopamine that modulates directly or indirectly their synthesis. We aimed to verify whether levodopa-induced dyskinesias are associated with changes of the time course of levodopa/dopamine stimulated cAMP

Influence of cassette design on three-dimensional perfusion culture of artificial bone.

Dajiang Du et al.

Journal of biomedical materials research. Part B, Applied biomaterials, 103(1), 84-91 (2014-04-26)

Media perfusion is often required to maintain cell viability within topographically complex 3-dimensional scaffold cultures. Osteoblast-seeded scaffolds for bone regeneration require robust cell proliferation and survival both within the scaffold and over the exterior for optimal osteogenic capacity. Conventional press-fitting

Binary release of ascorbic acid and lecithin from core-shell nanofibers on blood-contacting surface for reducing long-term hemolysis of erythrocyte.

Qiang Shi et al.

Colloids and surfaces. B, Biointerfaces, 125, 28-33 (2014-12-02)

There is an urgent need to develop blood-contacting biomaterials with long-term anti-hemolytic capability. To obtain such biomaterials, we coaxially electrospin [ascorbic acid (AA) and lecithin]/poly (ethylene oxide) (PEO) core-shell nanofibers onto the surface of styrene-b-(ethylene-co-butylene)-b-styrene elastomer (SEBS) that has been

Chondrogenesis of infrapatellar fat pad derived adipose stem cells in 3D printed chitosan scaffold.

Ken Ye et al.

PloS one, 9(6), e99410-e99410 (2014-06-12)

Infrapatellar fat pad adipose stem cells (IPFP-ASCs) have been shown to harbor chondrogenic potential. When combined with 3D polymeric structures, the stem cells provide a source of stem cells to engineer 3D tissues for cartilage repair. In this study, we

Neurotrophic requirements of human motor neurons defined using amplified and purified stem cell-derived cultures.

Nuno Jorge Lamas et al.

PloS one, 9(10), e110324-e110324 (2014-10-23)

Human motor neurons derived from embryonic and induced pluripotent stem cells (hESCs and hiPSCs) are a potentially important tool for studying motor neuron survival and pathological cell death. However, their basic survival requirements remain poorly characterized. Here, we sought to

Human adipose-derived mesenchymal stromal cells increase endogenous neurogenesis in the rat subventricular zone acutely after 6-hydroxydopamine lesioning.

Anne Schwerk et al.

Cytotherapy, 17(2), 199-214 (2014-12-03)

In Parkinson's disease (PD), neurogenesis in the subventricular zone (SVZ)-olfactory bulb (OB) axis is affected as the result of the lack of dopaminergic innervations reaching the SVZ. This aberrant network has been related to the hyposmia of PD patients, which

Large-scale high-quality 2D silica crystals: dip-drawing formation and decoration with gold nanorods and nanospheres for SERS analysis.

Vitaly A Khanadeev et al.

Nanotechnology, 25(40), 405602-405602 (2014-09-13)

High-quality colloidal crystals (CCs) are important for use in photonic research and as templates for large-scale plasmonic SERS substrates. We investigated how variations in temperature, colloid concentration, and dip-drawing parameters (rate, incubation time, etc) affect the structure of 2D CCs

Effects of combined treatment of α-tocopherol, L-ascorbic acid, selenium and zinc on bleomycin, etoposide and cisplatin-induced alterations in testosterone synthesis pathway in rats.

Narayana Kilarkaje

Cancer chemotherapy and pharmacology, 74(6), 1175-1189 (2014-09-23)

To investigate the effects of therapeutically relevant dose levels of bleomycin, etoposide and cisplatin (BEP) on testicular steroidogenic enzymes, and possible protective effects of an antioxidant cocktail (AC). Adult Sprague-Dawley rats received BEP with or without the AC (α-tocopherol, L-ascorbic

Effect of CTGF/CCN2 on osteo/cementoblastic and fibroblastic differentiation of a human periodontal ligament stem/progenitor cell line.

Asuka Yuda et al.

Journal of cellular physiology, 230(1), 150-159 (2014-06-07)

Appropriate mechanical loading during occlusion and mastication play an important role in maintaining the homeostasis of periodontal ligament (PDL) tissue. Connective tissue growth factor (CTGF/CCN2), a matricellular protein, is known to upregulate extracellular matrix production, including collagen in PDL tissue.

A tissue engineering approach for periodontal regeneration based on a biodegradable double-layer scaffold and adipose-derived stem cells.

João F Requicha et al.

Tissue engineering. Part A, 20(17-18), 2483-2492 (2014-03-01)

Human and canine periodontium are often affected by an inflammatory pathology called periodontitis, which is associated with severe damages across tissues, namely, in the periodontal ligament, cementum, and alveolar bone. However, the therapies used in the routine dental practice, often

Roundabout 4 regulates blood-tumor barrier permeability through the modulation of ZO-1, Occludin, and Claudin-5 expression.

Heng Cai et al.

Journal of neuropathology and experimental neurology, 74(1), 25-37 (2014-12-04)

The blood-tumor barrier (BTB) restricts the delivery of chemotherapeutic drug molecules to tumor tissues. We found that the endothelial cell (EC) receptor molecule Roundabout 4 (Robo4) is endogenously expressed in human brain microvascular ECs and that it is upregulated in

Sensory neurons do not induce motor neuron loss in a human stem cell model of spinal muscular atrophy.

Andrew J Schwab et al.

PloS one, 9(7), e103112-e103112 (2014-07-24)

Spinal muscular atrophy (SMA) is an autosomal recessive disorder leading to paralysis and early death due to reduced SMN protein. It is unclear why there is such a profound motor neuron loss, but recent evidence from fly and mouse studies

Repeated folding stress-induced morphological changes in the dermal equivalent.

Koji Y Arai et al.

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 20(4), 399-408 (2014-02-11)

Repeated mechanical stresses applied to the same region of the skin are thought to induce morphological changes known as wrinkle. However, the underlying mechanisms are not fully understood. To study the mechanisms, we examined effects of repeated mechanical stress on

Polyamine-capped gold nanorod as a localized surface Plasmon resonance probe for rapid and sensitive copper(II) ion detection.

Yingshuai Liu et al.

Journal of colloid and interface science, 439, 7-11 (2014-12-03)

Polyamine-capped gold nanorods (AuNRs) were developed as nanoprobes for localized surface Plasmon resonance (LSPR)-based simple, selective, and sensitive detection of Cu(2+) ions. Poly(sodium-4-styrenesulfonate) (PSS) and polyethylenimine (PEI) was successively adsorbed on the positively charged AuNRs via electrostatic adsorption, resulting in

Heterogeneity of peptide adducts with carbonylated lipid peroxidation products.

Ivana Milic et al.

Journal of mass spectrometry : JMS, 50(3), 603-612 (2015-03-25)

Highly reactive lipid peroxidation-derived carbonyls (oxoLPP) modify protein nucleophiles via Michael addition or Schiff base formation. Once formed, Michael adducts can be further stabilized via cyclic hemiacetals with or without loss of water. Depending on the mechanism of their formation

Characterization of rat testicular teratoma and its derived cell lines, with particular reference to possible mesenchymal differentiations.

Jyoji Yamate et al.

Histology and histopathology, 29(9), 1201-1216 (2014-04-12)

The original tumor, 4 cm in diameter, was found in the left testis of a 2-month old SD rat. The tumor consisted of well-differentiated, mature tissues such as bone, cartilage, adipose tissue, smooth and skeletal muscles, skin, hair, glands (salivary

Cosmetic preservatives as therapeutic corneal and scleral tissue cross-linking agents.

Natasha Babar et al.

Investigative ophthalmology & visual science, 56(2), 1274-1282 (2015-01-31)

Previously, aliphatic β-nitroalcohols (BNAs) have been studied as a means to chemically induce tissue cross-linking (TXL) of cornea and sclera. There are a number of related and possibly more potent agents, known as formaldehyde releasers (FARs), that are in commercial

Randomized, double-blind, phase I/II study of intravenous allogeneic mesenchymal stromal cells in acute myocardial infarction.

Anoop Chullikana et al.

Cytotherapy, 17(3), 250-261 (2014-12-09)

Cell therapy is promising as an exploratory cardiovascular therapy. We have recently developed an investigational new drug named Stempeucel (bone marrow-derived allogeneic mesenchymal stromal cells) for patients with acute myocardial infarction (AMI) with ST-segment elevation. A phase I/II randomized, double-blind

The influence of biodegradable magnesium alloys on the osteogenic differentiation of human mesenchymal stem cells.

Rachel W Li et al.

Journal of biomedical materials research. Part A, 102(12), 4346-4357 (2014-03-29)

The postdegradation effect of pure Mg, Mg-1Y, Mg-5Al, and Mg-2Ca alloys on the differentiation, proliferation and gene expression of human mesenchymal stem cells (hMSCs) was investigated. It was revealed that that Mg(2+) ions result in an increase in cell proliferation.

miR-34c regulates the permeability of blood-tumor barrier via MAZ-mediated expression changes of ZO-1, occludin, and claudin-5.

Lini Zhao et al.

Journal of cellular physiology, 230(3), 716-731 (2014-09-10)

The purposes of this study were to investigate the potential roles of miR-34c in regulating blood-tumor barrier (BTB) functions and its possible molecular mechanisms. The over-expression of miR-34c significantly impaired the integrity and increased the permeability of BTB, which were

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