105449

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Structure-activity studies of fluoroalkyl-substituted gamma-butyrolactone and gamma-thiobutyrolactone modulators of GABA(A) receptor function.

D J Canney et al.

Bioorganic & medicinal chemistry, 6(1), 43-55 (1998-03-21)

Dihydro-2(3H)-furanones (gamma-butyrolactones) and dihydro-2(3H)-thiophenones (gamma-thiobutyrolactones) containing fluoroalkyl groups at positions C-3, C-4, and C-5 of the heterocyclic rings were prepared. The anticonvulsant/convulsant activities of the compounds were evaluated in mice. Brain concentrations of the compounds were determined and the effects

Phytogrowth-inhibitory activities of sulfur-containing compounds. II. The inhibitory activities of thiosalicylic acid and dihydro-2(3H)-thiophenone-related compounds on plant growth.

Y Inamori et al.

Biological & pharmaceutical bulletin, 16(8), 813-816 (1993-08-01)

Thiosalicylic acid (I) showed rather strong inhibitory activity on the growth of roots of all plants treated except Abelmoschus esculentus Moench at the concentration of 5.0 x 10(-4) M. This compound strongly inhibited the growth of the root of Echinochloa

Metabolic response against sulfur-containing heterocyclic compounds by the lignin-degrading basidiomycete Coriolus versicolor.

H Ichinose et al.

Applied microbiology and biotechnology, 58(4), 517-526 (2002-04-17)

The fungal conversions of sulfur-containing heterocyclic compounds were investigated using the lignin-degrading basidiomycete Coriolus versicolor. The fungus metabolized a series of sulfur compounds--25 structurally related thiophene derivatives--via several different pathways. Under primary metabolic conditions, C. versicolor utilized thiophenes, such as

Engineered chitosan for improved 3D tissue growth through Paxillin-FAK-ERK activation.

Md Abdul Kafi et al.

Regenerative biomaterials, 7(2), 141-151 (2020-04-17)

Scaffold engineering has attracted significant attention for three-dimensional (3D) growth, proliferation and differentiation of stem cells in vitro. Currently available scaffolds suffer from issues such as poor ability for cell adhesion, migration and proliferation. This paper addresses these issues with

Tiny droplets make a big splash.

Michael Eisenstein

Nature methods, 3(2), 71-71 (2006-02-14)

Mechanism of hydrolysis and aminolysis of homocysteine thiolactone.

Jonathan Garel et al.

Chemistry (Weinheim an der Bergstrasse, Germany), 12(15), 4144-4152 (2006-02-03)

Homocysteine thiolactone (tHcy) is deemed a risk factor for cardiovascular diseases and strokes, presumably because it acylates the side chain of protein lysine residues ("N-homocysteinylation"), thereby causing protein damage and autoimmune responses. We analysed the kinetics of hydrolysis and aminolysis

Comparative analysis of the metal-dependent structural and functional properties of mouse and human SMP30.

Roshan Kumar Dutta et al.

PloS one, 14(6), e0218629-e0218629 (2019-06-21)

Senescence Marker Protein (SMP30) is a metalloenzyme that shows lactonase activity in the ascorbic acid (AA) biosynthesis pathway in non-primate mammals such as a mouse. However, AA biosynthesis does not occur in the primates including humans. Several studies have shown

One-pot difunctionalization of poly (ω-pentadecalactone) with thiol-thiol or thiol-acrylate groups, catalyzed by Candida antarctica lipase B.

Takwa M, et al.

Macromolecular Rapid Communications, 27(22), 1932-1936 (2006)

Alkyl-substituted gamma-butyrolactones act at a distinct site allosterically linked to the TBPS/picrotoxinin site on the GABAA receptor complex.

K D Holland et al.

Brain research, 615(1), 170-174 (1993-06-25)

Effects of alkyl-substituted gamma-butyrolactones and gamma-thiobutyrolactones on [35S]t-butylbicyclophosphorothionate (35S-TBPS) dissociation from the picrotoxinin receptor were studied. Unlike picrotoxinin, these lactones accelerated the dissociation rate of 35S-TBPS. Thus, previous reports that these lactones change the Kd but not the Bmax of

A Novel Synthesis of Poly(ester-alt-sulfide)s by the Ring-Opening Alternating Copolymerization of Oxiranes with gamma-Thiobutyrolactone Using Quaternary Onium Salts or Crown Ether Complexes as Catalysts.

Nishikubo et al.

Macromolecules, 31(15), 4746-4752 (1998-07-29)

Poly(ester-alt-sulfide) (polymer 1) was synthesized by the alternating copolymerization of glycidyl phenyl ether (GPE) with gamma-thiobutyrolactone (TBL) catalyzed by either quaternary onium salts or crown ether complexes. The copolymerization proceeded to produce polymer 1 with good yields in neat or

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