107-13-1

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Showing 1-30 of 108 results for "107-13-1" within Papers

C-terminal parathyroid hormone-related protein inhibits proliferation and differentiation of human osteoblast-like cells.

M E Martínez et al.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 12(5), 778-785 (1997-05-01)

Parathyroid hormone-related protein (PTHrP) is synthesized by osteoblasts, although its local role in bone is not completely understood. The C-terminal (107-111) region of PTHrP seems to be a potent inhibitor of osteoblastic bone resorption. We studied the effect of this

Modulation of oxidative and nitrosative stress attenuates microvascular hyperpermeability in ovine model of Pseudomonas aeruginosa sepsis.

Satoshi Fukuda et al.

Scientific reports, 11(1), 23966-23966 (2021-12-16)

In sepsis, microvascular hyperpermeability caused by oxidative/nitrosative stress (O&NS) plays an important role in tissue edema leading to multi-organ dysfunctions and increased mortality. We hypothesized that a novel compound R-107, a modulator of O&NS, effectively ameliorates the severity of microvascular

Frequency of Pro475Ser polymorphism of ADAMTS13 gene and its association with ADAMTS-13 activity in the Korean population.

Mun Ju Jang et al.

Yonsei medical journal, 49(3), 405-408 (2008-06-27)

The in vitro study suggested that proline to serine polymorphism in codon 475 (C1423T) of the A Disintegrin and Metalloprotease with ThromboSpondin type 1 repeats-13 (ADAMTS-13) gene is related to reduced activity of ADAMTS-13. In this study, the frequency of

Significance of phospho-vascular endothelial growth factor receptor-2 expression in pancreatic cancer.

Yosuke Doi et al.

Cancer science, 101(6), 1529-1535 (2010-04-07)

Vascular endothelial growth factor receptors (VEGFRs) are mainly expressed by endothelial cells, but they are also expressed by some cancer cells, including pancreatic cancer. The objective of this study was to evaluate the significance of VEGFRs expression in pancreatic cancer

Upregulation of miR-107 expression following hyperbaric oxygen treatment suppresses HMGB1/RAGE signaling in degenerated human nucleus pulposus cells.

Chi-Chien Niu et al.

Arthritis research & therapy, 21(1), 42-42 (2019-02-02)

The expression of both high-mobility group box 1 (HMGB1) and receptor for advanced glycation end-products (RAGE) is upregulated in degenerated discs. HMGB1 is known to function as a coupling factor between hypoxia and inflammation in arthritis, and this inflammatory response

Parathyroid hormone-related protein-(107-139) inhibits bone resorption in vivo.

J Cornish et al.

Endocrinology, 138(3), 1299-1304 (1997-03-01)

PTH-related protein-(107-139) [PTHrP-(107-139)] has been reported previously to be a potent inhibitor of osteoclast activity. However, this finding has not been reproduced in other in vitro models. We have now examined the effects of this peptide in an in vivo

K Semba et al.

Proceedings of the National Academy of Sciences of the United States of America, 82(19), 6497-6501 (1985-10-01)

From a human genomic library, we obtained six v-erbB-related DNA clones. A DNA probe prepared from one of the clones, lambda 107, hybridized to EcoRI fragments of 6.4 and 13 kilobase pairs of human DNA. Neither of these fragments was

PIK3CA alterations in primary (de novo) and secondary glioblastomas.

Daisuke Kita et al.

Acta neuropathologica, 113(3), 295-302 (2007-01-20)

We assessed alterations in the EGFR/PTEN/PI3K pathway in 107 primary (de novo) glioblastomas and 32 secondary glioblastomas that progressed from low-grade or anaplastic astrocytomas. SSCP followed by DNA sequencing in exons 9 and 20 of the PIK3CA gene revealed missense

Genetic association of paraoxonase-1 polymorphisms and chronic hepatitis C virus infection.

Natàlia Ferré et al.

Clinica chimica acta; international journal of clinical chemistry, 361(1-2), 206-210 (2005-07-05)

Hepatitis C virus infection is associated with hepatic free radical formation and enhanced lipid peroxidation and an individual's antioxidant status may play an important role. Paraoxonase-1 is an esterase that degrades oxidised lipids. In the present study, we investigated the

Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): a randomised multicentre, open-label, phase 2 trial.

Luca Gianni et al.

The Lancet. Oncology, 13(1), 25-32 (2011-12-14)

Studies with pertuzumab, a novel anti-HER2 antibody, show improved efficacy when combined with the established HER2-directed antibody trastuzumab in breast cancer therapy. We investigated the combination of pertuzumab or trastuzumab, or both, with docetaxel and the combination of pertuzumab and

52-kDa Ro/SSA epitopes preferentially recognized by antibodies from mothers of children with neonatal lupus and congenital heart block.

Christine Fritsch et al.

Arthritis research & therapy, 8(1), R4-R4 (2005-12-17)

Neonatal lupus erythematosus is a rare disorder caused by the transplacental passage of maternal autoantibodies. The 52-kDa Ro/SSA antigen (Ro52) ribonucleoprotein represents an antigenic target strongly associated with the autoimmune response in mothers whose children have neonatal lupus and cardiac

MUTYH exon 7 and 13 mutations associated with colorectal cancer (MAP syndrome) are not commonly associated with sporadic pancreatic cancer.

Lauren M Smith et al.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 9(6), 793-796 (2010-01-30)

Biallelic MUTYH exon 7 and 13 mutations are associated with a high frequency of somatic K-ras gene guanine to thymine transversion mutations at codon 12 position 1 in MUTYH-associated polyposis patients who have increased risk of colon cancer. The purpose

HNF4A immunohistochemistry facilitates distinction between primary and metastatic breast and gastric carcinoma.

R S van der Post et al.

Virchows Archiv : an international journal of pathology, 464(6), 673-679 (2014-04-09)

The distinction between primary gastric adenocarcinoma and gastric metastatic breast carcinoma can be difficult. Expression of hepatocyte nuclear factor 4A (HNF4A) has been described as being specific to distinguish between neoplastic gastric and breast epithelial cells. The aim of this

Two polymorphic microsatellites in a coding segment of the canine androgen receptor gene.

H Shibuya et al.

Animal genetics, 24(5), 345-348 (1993-10-01)

A 0.6-kb segment of exon 1 of the canine androgen receptor gene contains two polymorphic CAG tandem repeats which encode strings of glutamine homopolymers. The number of CAGs in each tandem repeat was determined by (1) polymerase chain reaction (PCR)

Effect of polymorphisms of the MTHFR and APOE genes on susceptibility to diabetes and severity of diabetic retinopathy in Brazilian patients.

F I V Errera et al.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 39(7), 883-888 (2006-07-25)

Diabetes mellitus (DM) is a highly prevalent complex genetic disorder. There has been a worldwide effort in the identification of susceptibility genes for DM and its complications, and the 5-10-methylenetetrahydrofolate reductase (MTHFR) and apolipoprotein-E (APOE) genes have been considered good

Influence of α-adrenergic vasoconstriction on the blunted skeletal muscle contraction-induced rapid vasodilation with aging.

Darren P Casey et al.

Journal of applied physiology (Bethesda, Md. : 1985), 113(8), 1201-1212 (2012-09-11)

We tested the hypothesis that elevated sympathetic tone is responsible for lower peak vasodilation after single muscle contractions in older adults. Young (n = 13, 7 men and 6 women, age: 27 ± 1 yr) and older (n = 13

Chimeric L1-L2 virus-like particles as potential broad-spectrum human papillomavirus vaccines.

Christina Schellenbacher et al.

Journal of virology, 83(19), 10085-10095 (2009-07-31)

The amino (N) terminus of the human papillomavirus (HPV) minor capsid protein L2 can induce low-titer, cross-neutralizing antibodies. The aim of this study was to improve immunogenicity of L2 peptides by surface display on highly ordered, self-assembled virus-like particles (VLP)

Chimeric L1-L2 virus-like particles as potential broad-spectrum human papillomavirus vaccines.

Christina Schellenbacher et al.

Journal of virology, 83(19), 10085-10095 (2009-07-31)

Equilibrium and kinetic analysis of human interleukin-13 and IL-13 receptor alpha-2 complex formation.

Eilyn R Lacy

Journal of molecular recognition : JMR, 25(3), 184-191 (2012-03-13)

Interleukin 13 (IL-13) is a pleiotropic cytokine secreted by activated T cells. Both IL-13 and its polymorphic variant (IL-13-R110Q) have been shown to be associated with multiple diseases such as asthma and allergy. Two IL-13 receptors have been identified, IL-13R

[The relationship between gene polymorphism of catechol-O-methyltransferase and survival of oral pesticides suicide attempters].

Wen-wei Cheng et al.

Zhonghua nei ke za zhi, 45(5), 403-405 (2006-06-20)

To understand the association between gene polymorphism of catechol-O-methyltransferase (COMT) and suicide attempters taking pesticides orally and to provide a scientific base for the prevention of suicidal behavior. 107 suicide attempters taking pesticides orally were collected from The People's Hospitals

Single nucleotide polymorphisms act as modifiers and correlate with the development of medullary and simultaneous medullary/papillary thyroid carcinomas in 2 large, non-related families with the RET V804M proto-oncogene mutation.

Alexander L Shifrin et al.

Surgery, 148(6), 1274-1280 (2010-12-08)

Single nucleotide polymorphisms (SNPs) may function as modifiers of the RET proto-oncogene, resulting in the expression of medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC). We present 2 non-related Italian-American families (Family 1, n = 107; Family 2, n

Chronic autoimmune atrophic gastritis associated with primary hyperparathyroidism: a transversal prospective study.

Sara Massironi et al.

European journal of endocrinology, 168(5), 755-761 (2013-03-01)

The coexistence of chronic autoimmune atrophic gastritis (CAAG) and primary hyperparathyroidism (PHPT) has been described previously, even if its extent and underlying mechanisms remain poorly understood. We therefore prospectively evaluated this association in two series of patients, one with CAAG

Screening of pectinase-producing microorganisms with polygalacturonase activity.

Jamile Zeni et al.

Applied biochemistry and biotechnology, 163(3), 383-392 (2010-07-30)

The aim of this work was to perform the screening of microorganisms, previously isolated from samples of agro-industrial waste and belonging to the culture collection of our laboratory, able to produce polygalacturonases (PG). A total of 107 microorganisms, 92 newly

Efficacy and safety of albendazole plus ivermectin, albendazole plus mebendazole, albendazole plus oxantel pamoate, and mebendazole alone against Trichuris trichiura and concomitant soil-transmitted helminth infections: a four-arm, randomised controlled trial.

Benjamin Speich et al.

The Lancet. Infectious diseases, 15(3), 277-284 (2015-01-16)

Existing anthelmintic drugs (eg, albendazole and mebendazole) have low efficacy against the intestinal nematode species Trichuris trichiura and the drug pipeline is exhausted. We aimed to investigate the strategy of combination chemotherapy with existing drugs to establish whether their efficacy

Tubulovascular nitric oxide crosstalk: buffering of angiotensin II-induced medullary vasoconstriction.

Jeffrey G Dickhout et al.

Circulation research, 91(6), 487-493 (2002-09-21)

Studies were designed to determine the source of NO responsible for buffering of the angiotensin II (Ang II)-mediated decrease of blood flow in the renal medulla. Intracellular Ca2+ concentration ([Ca2+]i) and NO production ([NO]i) of pericytes and endothelium of the

Genetic alterations in the K-Ras gene influence the prognosis in patients with cervical cancer treated by radiotherapy.

Pia Wegman et al.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 21(1), 86-91 (2011-02-19)

A high incidence of K-Ras mutations has been identified in a variety of human cancers, especially in codon 12, 13, and 61. Nevertheless, the presence of K-Ras mutations in cervical cancer remains controversial. The aim of this study was to

Efficacy of human-simulated bronchopulmonary exposures of cefepime, zidebactam and the combination (WCK 5222) against MDR Pseudomonas aeruginosa in a neutropenic murine pneumonia model.

James M Kidd et al.

The Journal of antimicrobial chemotherapy, 75(1), 149-155 (2019-10-24)

WCK 5222 combines cefepime with zidebactam, a β-lactam enhancer that binds PBP2 and inhibits class A and C β-lactamases. The efficacy of human-simulated bronchopulmonary exposures of WCK 5222 against MDR Pseudomonas aeruginosa was investigated in a neutropenic murine pneumonia model.

Study of the use of antidepressants for depression in dementia: the HTA-SADD trial--a multicentre, randomised, double-blind, placebo-controlled trial of the clinical effectiveness and cost-effectiveness of sertraline and mirtazapine.

S Banerjee et al.

Health technology assessment (Winchester, England), 17(7), 1-166 (2013-02-27)

Depression is common in dementia, causing considerable distress and other negative impacts. Treating it is a clinical priority, but the evidence base is sparse and equivocal. This trial aimed to determine clinical effectiveness of sertraline and mirtazapine in reducing depression

Activated EphA2 Processing by MT1-MMP Is Involved in Malignant Transformation of Ovarian Tumours In Vivo.

Yoko Takahashi et al.

Anticancer research, 38(7), 4257-4266 (2018-07-05)

Erythropoietin-producing hepatocellular receptor-2 (EphA2) is overexpressed in ovarian cancer. The N-terminals of EphA2 are processed by membrane-type 1 matrix metalloproteinase (MT1-MMP) and can subsequently induce ligand-independent signal activation to promote motility, invasion, and metastasis. The aim of this study was

Linkage of Nat and Es-1 in the mouse and development of strains congenic for N-acetyltransferase.

S S Mattano et al.

The Journal of heredity, 79(6), 430-433 (1988-11-01)

The human polymorphism in the hepatic enzyme N-acetyltransferase (NAT) affects the rate at which individuals acetylate, and in many cases detoxify, aromatic amine and hydrazine drugs and xenobiotics. Differences in NAT activity are known to affect individual susceptibility to drug

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