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The Effective Use of Protein Kinase Inhibitors
89 116
SAPK4/p38δ 105 95 103 130 110 111 98 94 93 87 79 94 103 82 84 99 104 113 133
MAPKAP-K1a
MAPKAP-K1b 16 72 37 79 89 88 86 93 83 95 92 70 20
Quality Control Ranges: MILLIPLEX® MAP Human Cytokine/ Chemokine Magnetic Bead Panel
mL
Control 2 507 - 1053 pg/mL Control 2 513 - 1065 pg/mL
IL-10 Control 1 100 - 208 pg/mL IL-1 Control
NovAseptic®Valve Pneumatic Stainless Steel Actuator, Normally Closed, ATEX
Pressure
AX12 AX18 AX25 AX38 AX51 AX76
Max bar(g) 6.0 6.0 6.0 6.0 6.0 3.0
(psi(g)) (87) (87) (87) (87) (87) (43)
Min bar(g) –1.0 –1.0 –1.0 –1.0 –1.0 –1.0
(psi(g)) (–14) (–14) (–14) (–14)
Specification sheet: NovAseptic® Valve, Pneumatic Plastic Actuator, Normally Closed, NC
Pressure
PA12 PA18 PA25 PA38 PA51 PA76
Max
bar(g) 6.0 6.0 6.0 6.0 6.0 3.0
(psi(g)) (87) (87) (87) (87) (87) (43)
Min
bar(g) –1.0 –1.0 –1.0 –1.0 –1.0 –1.0
(psi(g)) (–14) (–14) (–14) (–14) (–14
Specification sheet: NovAseptic® Valve, Pneumatic Stainless Steel Actuator, Normally Closed, NC
Pressure
PA12 PA18 PA25 PA38 PA51 PA76
Max
bar(g) 6.0 6.0 6.0 6.0 6.0 3.0
(psi(g)) (87) (87) (87) (87) (87) (43)
Min
bar(g) –1.0 –1.0 –1.0 –1.0 –1.0 –1.0
(psi(g)) (–14) (–14) (–14) (–14) (–14
The Effective Use of Protein Kinase Inhibitors
89 116
SAPK4/p38δ 105 95 103 130 110 111 98 94 93 87 79 94 103 82 84 99 104 113 133
MAPKAP-K1a
MAPKAP-K1b 16 72 37 79 89 88 86 93 83 95 92 70 20
MILLIPLEX®MAP Human Myokine Panel is an optimized quantitative immunoassay that simultaneously measures 15 novel muscle-secreted factors
:8 dil 123 84 48 108 98 91 94 63 87 105 70 110 66 84 111
1:16 dil 129 84 42 108 87 90 94 61 83 100 64 114 61 75 116
Average 121 84 49
Specification Sheet: NovAseptic® Mixer Drive Unit, HS ATEX
Hz Quadratic Torque 5–50 Hz Quadratic Torque 5–50 Hz
Thermostat 2 (PTC 110 °C) (PTC 120 °C) 2 (PTC 110 °C) (PTC 120 °C) 2 (PTC 110 °C) (PTC 120 °C)
Color White White White
Specification Sheet
Monitoring low dose API blend uniformity with Parteck® M
values.
0 1 2 3 6 7 84 9 10 11
130
90
100
110
120
80
70
D
ru
g
co
nt
en
t
[%
]
5
Data Sheet - A2262 - Lot 106H94251
Ionization Mass Spectrum
40 50 60 70 80 90 100 110 120 130 140
0
5000
10000
15000
20000
Abundance
42
44
51 59
65
77 87
91
103 106
NovAseptic® ATEX Valve User Guide
Description
Dimension (mm)
L G1
AX12/110
Actuator
pneumatic,
normally
closed, SS
47 87
AX18/100 62 100
AX25/110 85 120
AX38/110 95 134
AX51/110 120 180
AX76/110 125 220
Air Supply
Specification
Product Information Sheet - O8801
Ger. Offen. 2,554,148 (1977); Chem. Abstr., 87, 117683n (1977).
39 J.W. Scott, D.R. Parrish, and G. Saucy, U.S. Patent 4,018, 799 (1977); Chem. Abstr., 87, 68154e (1977).
MultiScreen Ultracel-10 filter plate: Protein retention, recovery, volume recovery and guidelines for concentrating and desalting
plates (n=96).
Cytochrome c FITC-BSA
Plate 1 85% 88%
Plate 2 92% 87%
Part 2: Protein Recovery
4
Table 2. Well-to-well reproducibility of Cytochrome c recovery.
Product Information Sheet - N7132
for Biochemical
Compounds, 3rd ed., National Academy of
Sciences (Washington, DC: 1972), p. 87.
2. Methods of Enzymatic Analysis, Volume 4, Hans
Ulrich Bergmeyer, Academic Press, Inc., (New
York
Product Information Sheet - N8285
for Biochemical
Compounds, 3rd ed., National Academy of
Sciences (Washington, DC: 1972), p. 87.
2. Methods of Enzymatic Analysis, Volume 4, Hans
Ulrich Bergmeyer, Academic Press, Inc., (New
York
Data Sheet - M7067
1993).
2. Izquierdo, M.A., et al., Drug resistance-associated
marker Lrp for prediction of response to chemo-
therapy and prognoses in advanced ovarian
carcinoma. J. Natl. Cancer Inst., 87, 1230-1237
Data Sheet - K1005
Cell Biol., 107, 2657 (1988).
6. Brady, S., et al., Proc. Natl. Acad. Sci. (USA), 87,
1061 (1990).
MG,KAA,PHC 01/08-1
Sigma brand products are sold through Sigma-Aldrich, Inc.
Sigma-Aldrich, Inc
Product Information Sheet - N3014
for Biochemical
Compounds, 3rd ed., National Academy of
Sciences (Washington, DC: 1972), p. 87.
2. Methods of Enzymatic Analysis, Volume 4, Hans
Ulrich Bergmeyer, Academic Press, Inc., (New
York
Product Information Sheet - N8410
for Biochemical
Compounds, 3rd ed., National Academy of
Sciences (Washington, DC: 1972), p. 87.
2. Methods of Enzymatic Analysis, Volume 4, Hans
Ulrich Bergmeyer, Academic Press, Inc., (New
York
Product Information Sheet - N8535
for Biochemical
Compounds, 3rd ed., National Academy of
Sciences (Washington, DC: 1972), p. 87.
2. Methods of Enzymatic Analysis, Volume 4, Hans
Ulrich Bergmeyer, Academic Press, Inc., (New
York
Product Information Sheet - T8133
Adams, D. A. Electrophoresis in
agarose and acrylamide gels. Methods Enzymol.,
152, 61-87 (1987).
2. Electrophoresis: Theory, Techniques, and
Biochemical and Clinical Applications, 2nd ed.
Data Sheet - D9442
changes in dopamine and other
presynaptic dopaminergic markers in human
striatum., J. Neurochem., 87, 574 – 585 (2003).
4. Kahn, R. S., et al., Role of dopamine transporter
genotype and maternal
Data Sheet - J3774
References
1. Aringer, M., et al., Life Sciences, 64, 2173-2186
(1999).
2. Nagy, Z.S., et al., Crit. Rev. Immunol., 24, 87-110
(2004).
3. Ihle, J.N., Nature, 377, 591-594 (1995).
4. Verma, A.
Data Sheet - M7192
1993).
2. Izquierdo, M.A., et al., Drug resistance-associated
marker Lrp for prediction of response to chemo-
therapy and prognoses in advanced ovarian
carcinoma. J. Natl. Cancer Inst., 87, 1230-1237
Data Sheet - L0915
method.
References
1. Gearing, D., et al., EMBO J., 10, 2839 (1991).
2. Bazan, J.F., Proc. Natl. Acad. Sci. USA, 87, 6934
(1990).
3. Gearing, D.P., et al., Proc. Natl. Acad. Sci. USA, 91
Data Sheet - D9567
changes in dopamine and other
presynaptic dopaminergic markers in human
striatum., J. Neurochem., 87, 574 – 585 (2003).
4. Kahn, R. S., et al., Role of dopamine transporter
genotype and maternal
Data Sheet - V6137
vascular endothelial cell mitogen from a rat glioma-
derived cell line, Proc. Natl. Acad. Sci. USA, 87,
1323-1327 (1990).
KAA 05/00
Sigma brand products are sold through Sigma-Aldrich, Inc.
Sigma-Aldrich
Data Sheet - V5764
Brain Res., 110, 126-
139 (2003).
4. Jellali, A. et al., Cellular localization of the vesicular
inhibitory amino acid transporter in the mouse and
human retina. J. Comp. Neurol., 449, 76-87 (2002).
Parteck®ODT Excipient
+ 1% Mg stearate (500 mg final weight)
(Procedure: USP apparatus 2, 900 ml phosphate buffer, pH 7.2, 37ºC, 50 rpm, 221 nm)
110
100
90
80
70
60
50
40
Parteck® ODT Excipient: Right here - Right now
+ 1% Mg stearate (500 mg final weight)
(Procedure: USP apparatus 2, 900 ml phosphate buffer, pH 7.2, 37ºC, 50 rpm, 221 nm)
110
100
90
80
70
60
50
40
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