11022AST

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Showing 1-30 of 41 results for "11022AST" within Papers

Transforming chiral liquid chromatography methodologies into more sensitive liquid chromatography-electrospray ionization mass spectrometry without losing enantioselectivity.

Meera J Desai et al.

Journal of chromatography. A, 1035(2), 203-210 (2004-05-06)

LC-electrospray ionization (ESI) MS conditions were optimized for the individual chiral separation of 19 compounds of pharmaceutical interest using the macrocyclic glycopeptide-based chiral stationary phases in both polar organic and reversed-phase modes (RPM). The influence of mobile phase composition and

Comparison of the factors that contribute to retention on immobilized polysaccharide-based chiral stationary phases and macrocyclic glycopeptide chiral stationary phases with the Abraham model

Mitchell, Clifford R., et al.

Journal of Chromatography. B, Biomedical Sciences and Applications, 875 (1), 65-71 (2008)

Mechanistic insights on chaotropic interactions of liophilic ions with basic pharmaceuticals in polar ionic mode liquid chromatography.

Edmond Sanganyado et al.

Journal of chromatography. A, 1368, 82-88 (2014-10-15)

We report for the first time the effect of liophilic mobile phase additives on the mechanism of chiral recognition of basic chiral pharmaceutical on a vancomycin based chiral stationary phase (CSP). Using methanol as the mobile phase and 0.005% formic

Chromatographic Separations and Analysis: Macrocyclic Glycopeptide Chiral Stationary Phases

Berthod, A.

Comprehensive Chirality, 8, 227-262 (2012)

[The enantioselective pharmacokinetic study of desvenlafaxine sustained release tablet in Chinese healthy male volunteers after oral administration].

Yin-xia Chen et al.

Yao xue xue bao = Acta pharmaceutica Sinica, 50(4), 486-491 (2015-08-01)

A chiral LC-MS/MS method for the simultaneous analysis of desvenlafaxine (DVS) enantiomers in human plasma was developed and applied to a pharmacokinetic study on 12 Chinese healthy volunteers. d6-Desvenlafaxine was used as internal standard (IS). Chromatographic separation was performed on

HPLC?atmospheric pressure chemical ionization mass spectrometric method for enantioselective determination of R,S-propranolol and R,S-hyoscyamine in human plasma

Siluk, Danuta,et al.

Journal of Chromatography. B, Biomedical Sciences and Applications, 859 (2), 213-221 (2007)

Validation and Application of a Simple UHPLC-MS-MS Method for the Enantiospecific Determination of Warfarin in Human Urine.

Osama Y Alshogran et al.

Journal of chromatographic science, 54(4), 554-560 (2015-12-15)

A simple and rapid liquid chromatographic-tandem mass spectrometric method has been developed and validated for the enantiospecific determination of R- and S-warfarin in human urine. Warfarin enantiomers were extracted from urine using methyl tert-butyl ether. Chromatographic separation of warfarin enantiomers

Enantiomeric fraction evaluation of pharmaceuticals in environmental matrices by liquid chromatography-tandem mass spectrometry.

Ana Rita Ribeiro et al.

Journal of chromatography. A, 1363, 226-235 (2014-07-23)

The interest for environmental fate assessment of chiral pharmaceuticals is increasing and enantioselective analytical methods are mandatory. This study presents an enantioselective analytical method for the quantification of seven pairs of enantiomers of pharmaceuticals and a pair of a metabolite.

Determination of molindone enantiomers in human plasma by high-performance liquid chromatography-tandem mass spectrometry using macrocyclic antibiotic chiral stationary phases.

Hongliang Jiang et al.

Journal of chromatography. A, 1192(2), 230-238 (2008-04-09)

A sensitive and selective bioanalytical assay was developed and validated for the determination of enantiomeric molindone in human plasma using high-performance liquid chromatography-tandem mass spectrometry along with supported liquid extraction procedures. The chiral separation was evaluated and optimized on macrocyclic

Simultaneous measurement of S-warfarin, R-warfarin, S-7-hydroxywarfarin and R-7-hydroxywarfarin in human plasma by liquid chromatography-tandem mass spectrometry.

Zhong Zuo et al.

Journal of pharmaceutical and biomedical analysis, 52(2), 305-310 (2010-02-06)

Clinically used anticoagulant warfarin is usually available as a racemic mixture of S- and R-warfarin that are both metabolized mainly by cytochrome P450 isoenzymes. Determination of warfarin enantiomers and their enantiomeric 7-hydroxywarfarin (7-OH-warfarin) metabolites in the human plasma sample allows

Enantioselective biodegradation of pharmaceuticals, alprenolol and propranolol, by an activated sludge inoculum.

Ana R Ribeiro et al.

Ecotoxicology and environmental safety, 87, 108-114 (2012-11-08)

Biodegradation of chiral pharmaceuticals in the environment can be enantioselective. Thus quantification of enantiomeric fractions during the biodegradation process is crucial for assessing the fate of chiral pollutants. This work presents the biodegradation of alprenolol and propranolol using an activated

Development and validation of an UFLC-MS/MS method for enantioselectivity determination of d,l-thero-methylphenidate, d,l-thero-ethylphenidate and d,l-thero-ritalinic acid in rat plasma and its application to pharmacokinetic study.

Chenghao Zhang et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1011, 45-52 (2016-01-12)

A chiral UFLC-MS/MS method was established and validated for quantifying d-threo-methylphenidate (d-threo-MPH), l-threo-methylphenidate (l-threo-MPH), d-threo-ethylphenidate (d-threo-EPH), l-threo-ethylphenidate (l-threo-EPH) and d,l-threo-ritalinic acid (d,l-threo-RA) in rat plasma over the linearity range of 1-500ng/mL. Chiral separation was performed on an Astec Chirobiotic V2

Comparative HPLC methods for β-blockers separation using different types of chiral stationary phases in normal phase and polar organic phase elution modes. Analysis of propranolol enantiomers in natural waters.

Sonia Morante-Zarcero et al.

Journal of pharmaceutical and biomedical analysis, 62, 33-41 (2012-01-24)

The enantioselectivities of β-blockers (propranolol, metoprolol, atenolol and pindolol) on four different types of chiral stationary phases (CSPs): Chiralpak AD-H, Lux Cellulose-1, Chirobiotic T and Sumichiral OA-4900 were compared using polar organic (PO) elution mode and normal phase (NP) elution

High-performance liquid chromatographic enantioseparation of unusual isoxazoline-fused 2-aminocyclopentanecarboxylic acids on macrocyclic glycopeptide-based chiral stationary phases.

László Sipos et al.

Journal of chromatography. A, 1232, 142-151 (2011-12-20)

The enantiomers of four unusual isoxazoline-fused 2-aminocyclopentanecarboxylic acids were directly separated on chiral stationary phases containing macrocyclic glycopeptide antibiotics teicoplanin (Astec Chirobiotic T and T2), teicoplanin aglycone (Chirobiotic TAG), vancomycin (Chirobiotic V) and vancomycin aglycone (Chirobiotic VAG) as chiral selectors.

Enantioselective high-performance liquid chromatographic separation of N-methyloxycarbonyl unsaturated amino acids on macrocyclic glycopeptide stationary phases.

J M M Boesten et al.

Journal of chromatography. A, 1108(1), 26-30 (2006-01-31)

This paper describes the enantiomeric resolution of a series of unsaturated N-methyloxycarbonyl-alpha-H-alpha-amino acids (N-MOC-alpha-amino acids) on macrocyclic glycopeptide stationary phases by means of high-performance liquid chromatography (HPLC). Three types of glycopeptide phases, i.e. Chirobiotic T, V and R, were evaluated

Recent advances in the direct and indirect liquid chromatographic enantioseparation of amino acids and related compounds: a review.

István Ilisz et al.

Journal of pharmaceutical and biomedical analysis, 69, 28-41 (2012-02-22)

Amino acids are essential for life, and have many functions in metabolism. One particularly important function is to serve as the building blocks of peptides and proteins, giving rise to complex three dimensional structures through disulfide bonds or crosslinked amino

Stereoisomer analysis of wastewater-derived beta-blockers, selective serotonin re-uptake inhibitors, and salbutamol by high-performance liquid chromatography-tandem mass spectrometry.

Sherri L MacLeod et al.

Journal of chromatography. A, 1170(1-2), 23-33 (2007-10-05)

A reversed-phase enantioselective liquid chromatography-tandem mass spectrometry (HPLC-MS-MS) method was developed to measure enantiomer fractions (EF) and concentrations of pharmaceuticals in wastewater. Enantiomer resolution of six beta-blockers (atenolol, metoprolol, nadolol, pindolol, propranolol, and sotalol) along with two selective serotonin re-uptake

Using chiral liquid chromatography quadrupole time-of-flight mass spectrometry for the analysis of pharmaceuticals and illicit drugs in surface and wastewater at the enantiomeric level.

J P Bagnall et al.

Journal of chromatography. A, 1249, 115-129 (2012-07-04)

This paper presents and compares for the first time two chiral LC-QTOF-MS methodologies (utilising CBH and Chirobiotic V columns with cellobiohydrolase and vancomycin as chiral selectors) for the quantification of amphetamine, methamphetamine, MDA (methylenedioxyamphetamine), MDMA (methylenedioxymethamphetamine), propranolol, atenolol, metoprolol, fluoxetine

Comparison of vancomycin-based stationary phases with different chiral selector coverage for enantioselective separation of selected drugs in high-performance liquid chromatography.

Z Bosáková et al.

Journal of chromatography. A, 1088(1-2), 94-103 (2005-09-01)

Two vancomycin-based chiral stationary phases (CSPs) with different coverage of the chiral selector vancomycin (Chirobiotic V and Chirobiotic V2) were compared. beta-Blockers and profens, as structurally diverse groups of drugs, were chosen as analytes. Retention and enantioseparation of beta-blockers were

Amphetamine concentrations in human urine following single-dose administration of the calcium antagonist prenylamine-studies using fluorescence polarization immunoassay (FPIA) and GC-MS.

Thomas Kraemer et al.

Journal of analytical toxicology, 27(2), 68-73 (2003-04-03)

Prenylamine (R,S-N-(3,3-diphenylpropyl-methyl-2-phenethylamine), a World Health Organization class V calcium antagonist, is known to be metabolized to amphetamine. In this study, amphetamine concentrations after a single-dose administration of prenylamine were determined to check if they reached values that could be of

Effect of the mobile phase on the retention behaviour of optical isomers of carboxylic acids and amino acids in liquid chromatography on bonded Teicoplanin columns.

P Jandera et al.

Journal of chromatography. A, 917(1-2), 123-133 (2001-06-14)

Conditions for separation of enantiomers of underivatized amino acids phenyl glycine and tryptophan and of mandelic acid as test compounds were studied on a Chirobiotic T column packed with amphoteric glycopeptide Teicoplanin covalently bonded to the surface of silica gel.

Analysis of the enantiomers of citalopram and its demethylated metabolites using chiral liquid chromatography

Kosel, M., et al.

Journal of Chromatography. B, Biomedical Applications, 719 (1-2), 234-238 (1998)

Direct and indirect high-performance liquid chromatographic enantioseparation of beta-amino acids.

Antal Péter et al.

Journal of chromatography. A, 1031(1-2), 171-178 (2004-04-03)

Direct and indirect reversed-phase (RP) high-performance liquid chromatographic methods were developed for the separation of enantiomers of 18 unnatural beta-amino acids, including several beta-3-homo amino acids. The direct separations of the underivatized analytes were performed on chiral stationary phases (CSPs)

HPLC separation technique for analysis of bufuralol enantiomers in plasma and pharmaceutical formulations using a vancomycin chiral stationary phase and UV detection

Hefnawy, Mohamed M., et al.

Journal of Chromatography. B, Biomedical Sciences and Applications, 856 (1-2), 328-336 (2007)

Chromatography Liquid Chiral Separations

Xiao, T.L., et al.

Encyclopedia of Separation Science, 1-15 (2000)

Chiral separation by simultaneous use of vancomycin as stationary phase chiral selector and chiral mobile phase additive.

Q Sun et al.

Journal of chromatography. B, Biomedical sciences and applications, 745(1), 159-166 (2000-09-21)

Improved chiral selectivity was observed for numerous compounds when vancomycin was added to the mobile phase on a Chirobiotic-V column. This chiral mobile phase additive (CMPA) is the same chiral selector as that bonded to the stationary phase of this

Enantioselective quantification of fluoxetine and norfluoxetine by HPLC in wastewater effluents.

Ana R Ribeiro et al.

Chemosphere, 95, 589-596 (2013-11-05)

Microbial degradation is the most important process to remove organic pollutants in Waste Water Treatment Plants. Regarding chiral compounds this process is normally enantioselective and needs the suitable analytical methodology to follow the removal of both enantiomers in an accurate

Screening approach, optimisation and scale-up for chiral liquid chromatography of cathinones.

R Wimal H Perera et al.

Journal of chromatography. A, 1269, 189-197 (2012-11-24)

Screening approaches adopted in pharmaceutical companies for chiral LC method development may be quite complicated and sophisticated in order to guarantee a high success rate. However in other environments it may be of more value to assess how simple a

Classification of LC chiral stationary phases: Wainer Types I?V revisited

Lough, W. John

Journal of Chromatography. B, Biomedical Applications, 968, 1-7 (2014)

A validated LC method for the determination of vesamicol enantiomers in human plasma using vancomycin chiral stationary phase and solid phase extraction.

Mohamed M Hefnawy et al.

Journal of pharmaceutical and biomedical analysis, 35(3), 535-543 (2004-05-13)

An enantioseparation high performance liquid chromatographic (HPLC) method was developed and validated to determine D-(+)- and L-(-)-vesamicol in human plasma. The assay involved the use of a solid phase extraction for plasma sample clean up prior to HPLC analysis utilizing

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