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Showing 1-30 of 49 results for "11207741910" within Papers
Jill M Brown et al.
Nature protocols, 17(5), 1306-1331 (2022-04-06)
DNA fluorescence in situ hybridization (FISH) has been a central technique in advancing our understanding of how chromatin is organized within the nucleus. With the increasing resolution offered by super-resolution microscopy, the optimal maintenance of chromatin structure within the nucleus
Ashley M Wood et al.
Nature communications, 5, 5467-5467 (2014-11-18)
Telomeres protect the ends of linear genomes, and the gradual loss of telomeres is associated with cellular ageing. Telomere protection involves the insertion of the 3' overhang facilitated by telomere repeat-binding factor 2 (TRF2) into telomeric DNA, forming t-loops. We
Vicky Roslinsky et al.
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 134(10), 3167-3181 (2021-07-17)
Disomic alien chromosome addition Brassica carinata lines with super-high erucic acid content were developed through interspecific hybridization with B. juncea and characterized using molecular, cytological and biochemical techniques. Brassica carinata [A.] Braun (BBCC, 2n = 34) is a climate-resilient oilseed.
James D P Rhodes et al.
Cell reports, 30(3), 820-835 (2020-01-23)
How chromosome organization is related to genome function remains poorly understood. Cohesin, loop extrusion, and CCCTC-binding factor (CTCF) have been proposed to create topologically associating domains (TADs) to regulate gene expression. Here, we examine chromosome conformation in embryonic stem cells
Sabine A Hartlieb et al.
Nature communications, 12(1), 1269-1269 (2021-02-26)
Telomere maintenance by telomerase activation or alternative lengthening of telomeres (ALT) is a major determinant of poor outcome in neuroblastoma. Here, we screen for ALT in primary and relapsed neuroblastomas (n = 760) and characterize its features using multi-omics profiling. ALT-positive tumors
Seda Kilinc et al.
Nucleus (Austin, Tex.), 5(4), 318-330 (2014-12-09)
Mouse olfaction depends on specialized olfactory sensory neurons (OSNs) that each express only one olfactory receptor protein from among a family of >1000 olfactory receptor (OR) genes encoded in the genome. To investigate epigenetic mechanisms underlying monogenic OR expression, we
Yu-Hang Zhong et al.
Frontiers in plant science, 12, 816946-816946 (2022-02-15)
Interploidy cross commonly results in complex chromosome number and structural variations. In our previous study, a progeny with segregated ploidy levels was produced by an interploidy cross between diploid female parent Populus tomentosa × Populus bolleana clone TB03 and triploid
Ichiro Hiratani et al.
PLoS biology, 6(10), e245-e245 (2008-10-10)
DNA replication in mammals is regulated via the coordinate firing of clusters of replicons that duplicate megabase-sized chromosome segments at specific times during S-phase. Cytogenetic studies show that these "replicon clusters" coalesce as subchromosomal units that persist through multiple cell
Julia Truch et al.
Nature communications, 13(1), 3485-3485 (2022-06-18)
The chromatin remodeller ATRX interacts with the histone chaperone DAXX to deposit the histone variant H3.3 at sites of nucleosome turnover. ATRX is known to bind repetitive, heterochromatic regions of the genome including telomeres, ribosomal DNA and pericentric repeats, many
Caroline Scott et al.
Haematologica, 106(11), 2960-2970 (2020-10-31)
The investigation of inherited disorders of erythropoiesis has elucidated many of the principles underlying the production of normal red blood cells and how this is perturbed in human disease. Congenital Dyserythropoietic Anaemia type 1 (CDA-I) is a rare form of
Julieta Saba et al.
Journal of neurochemistry, 146(6), 686-702 (2018-06-01)
Astrocytes are glial cells that help maintain brain homeostasis and become reactive in neurodegenerative processes releasing both harmful and beneficial factors. We have demonstrated that brain-derived neurotrophic factor (BDNF) expression is induced by melanocortins in astrocytes but BDNF actions in
J Chen et al.
Cytogenetic and genome research, 122(2), 169-174 (2008-12-20)
Karyotypes and chromosomal characteristics of two species of bullhead catfish of the genus Liobagrus, namely L. marginatus and L. styani were examined by means of conventional (Giemsa and CMA(3) staining) and molecular (FISH with telomeric, 5S and 18S rDNA probes
Olesya Sokolova et al.
Development (Cambridge, England), 150(12) (2023-06-15)
Insulators are architectural elements implicated in the organization of higher-order chromatin structures and transcriptional regulation. However, it is still unknown how insulators contribute to Drosophila telomere maintenance. Although the Drosophila telomeric retrotransposons HeT-A and TART occupy a common genomic niche
Moloy T Goswami et al.
Oncotarget, 6(27), 23445-23461 (2015-07-04)
Cancer cells exhibit altered metabolism including aerobic glycolysis that channels several glycolytic intermediates into de novo purine biosynthetic pathway. We discovered increased expression of phosphoribosyl amidotransferase (PPAT) and phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) enzymes of de novo purine biosynthetic
Peng Wang et al.
Nature communications, 13(1), 6502-6502 (2022-11-02)
The mechanisms underlying fibrogenic responses after injury are not well understood. Epithelial cell cycle arrest in G2/M after injury is a key checkpoint for determining wound-healing leading to either normal cell proliferation or fibrosis. Here, we identify a kidney- and
Devon A Lukow et al.
Developmental cell, 56(17), 2427-2439 (2021-08-06)
Aneuploidy is a ubiquitous feature of human tumors, but the acquisition of aneuploidy typically antagonizes cellular fitness. To investigate how aneuploidy could contribute to tumor growth, we triggered periods of chromosomal instability (CIN) in human cells and then exposed them
Shelly Sorrells et al.
PLoS genetics, 8(8), e1002922-e1002922 (2012-09-07)
DNA double-strand breaks (DSBs) represent one of the most deleterious forms of DNA damage to a cell. In cancer therapy, induction of cell death by DNA DSBs by ionizing radiation (IR) and certain chemotherapies is thought to mediate the successful
D T Gruszka et al.
Science advances, 6(38) (2020-09-20)
During replication, nucleosomes are disrupted ahead of the replication fork, followed by their reassembly on daughter strands from the pool of recycled parental and new histones. However, because no previous studies have managed to capture the moment that replication forks
Rutesh N Vyas et al.
Molecular and cellular neurosciences, 82, 1-11 (2017-04-18)
Function of the mammalian olfactory system depends on specialized olfactory sensory neurons (OSNs) that each express only one allele ("monoallelic") of one odorant receptor (OR) gene ("monogenic"). The lysine-specific demethylase-1 (LSD1) protein removes activating H3K4 or silencing H3K9 methylation marks
Xinyan Zhou et al.
Nature communications, 13(1), 5700-5700 (2022-09-29)
Given the complex nature of ulcerative colitis, combination therapy targeting multiple pathogenic genes and pathways of ulcerative colitis may be required. Unfortunately, current therapeutic strategies are usually based on independent chemical compounds or monoclonal antibodies, and the full potential of
Muhammet Gaffaroglu et al.
Genes, 11(12) (2020-12-10)
Salmonids are extremely important economically and scientifically; therefore, dynamic developments in their research have occurred and will continue occurring in the future. At the same time, their complex phylogeny and taxonomy are challenging for traditional approaches in research. Here, we
Lyndal Kearney et al.
Methods in molecular biology (Clifton, N.J.), 878, 149-174 (2012-06-08)
Cytogenetic analysis of tumour material has been greatly enhanced over the past 30 years by the application of a range of techniques based around fluorescence in situ hybridization (FISH). Fluorescence detection for in situ hybridization has the advantage of including
Byoung-San Moon et al.
Cell death discovery, 9(1), 61-61 (2023-02-14)
Nuclear architecture underlies the transcriptional programs within the cell to establish cell identity. As previously demonstrated, long-range chromatin interactions of the Oct4 distal enhancer (DE) are correlated with active transcription in naïve state embryonic stem cells. Here, we identify and
Monika Wimmer et al.
Cell communication and signaling : CCS, 18(1), 61-61 (2020-04-12)
Cutaneous squamous cell carcinomas (cSCC) are the primary cause of premature deaths in patients suffering from the rare skin-fragility disorder recessive dystrophic epidermolysis bullosa (RDEB), which is in marked contrast to the rarely metastasizing nature of these carcinomas in the
Xueman Chen et al.
Nature communications, 13(1), 7160-7160 (2022-11-24)
Aromatase inhibition is an efficient endocrine therapy to block ectopic estrogen production for postmenopausal estrogen receptor (ER)-positive breast cancer patients, but many develop resistance. Here, we show that aromatase inhibitor (AI)-resistant breast tumors display features of enhanced aerobic glycolysis with
Xiufen Zheng et al.
Oncogenesis, 9(3), 34-34 (2020-03-14)
The underlying mechanisms of long non-coding RNAs (lncRNA) participating in the progression of lung cancers are largely unknown. We found a novel lncRNA, PIK3CD antisense RNA 2 (PIK3CD-AS2), that contributes to lung adenocarcinoma (LUAD) progression. The expression characteristics of PIK3CD-AS2
Evidence of Interspecific Chromosomal Diversification in Rainbowfishes (Melanotaeniidae, Teleostei).
Zuzana Majtánová et al.
Genes, 11(7) (2020-07-28)
Rainbowfishes (Melanotaeniidae) are the largest monophyletic group of freshwater fishes occurring in Australia and New Guinea, with 112 species currently recognised. Despite their high taxonomic diversity, rainbowfishes remain poorly studied from a cytogenetic perspective. Using conventional (Giemsa staining, C banding
Ritu Bhalla et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 26(6), 835-848 (2013-01-26)
Identification of new molecular markers has led to the molecular classification of prostate cancer based on driving genetic lesions. The translation of these discoveries for clinical use necessitates the development of simple, reliable and rapid detection systems to screen patients
Emily Brookes et al.
iScience, 26(1), 105695-105695 (2022-12-31)
Brain-derived neurotrophic factor (BDNF) promotes neuronal differentiation and survival and is implicated in the pathogenesis of many neurological disorders. Here, we identified a novel intergenic enhancer located 170 kb from the Bdnf gene, which promotes the expression of Bdnf transcript
Juliane Marie Theiss et al.
PLoS pathogens, 11(7), e1004974-e1004974 (2015-07-29)
Merkel cell polyomavirus (MCPyV) is considered the etiological agent of Merkel cell carcinoma and persists asymptomatically in the majority of its healthy hosts. Largely due to the lack of appropriate model systems, the mechanisms of viral replication and MCPyV persistence
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