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Showing 1-30 of 466 results for "114391" within Papers
Sarath Vijayakumar et al.
Mammalian genome : official journal of the International Mammalian Genome Society, 26(3-4), 154-172 (2015-02-04)
A/J mice develop progressive hearing loss that begins before 1 month of age and is attributed to cochlear hair cell degeneration. Screening tests indicated that this strain also develops early onset vestibular dysfunction and has otoconial deficits. The purpose of this
John E Buonora et al.
Journal of neurotrauma, 32(22), 1805-1814 (2015-05-06)
Autoimmune profiling in rats revealed the antioxidant enzyme, peroxiredoxin 6 (PRDX6), as a target for autoantibodies evoked in response to traumatic brain injury (TBI). Consistent with this proposal, immunohistochemical analysis of rat cerebral cortex demonstrated that PRDX6 is highly expressed
Adriana María Belén Abiuso et al.
The Journal of endocrinology, 223(3), 241-253 (2014-09-26)
The histamine H4 receptor (HRH4), discovered only 13 years ago, is considered a promising drug target for allergy, inflammation, autoimmune disorders and cancer, as reflected by a steadily growing number of scientific publications and patent applications. Although the presence of
Sameer S Udhane et al.
Scientific reports, 5, 10132-10132 (2015-05-15)
Androgens are essential for sexual development and reproduction. However, androgen regulation in health and disease is poorly understood. We showed that human adrenocortical H295R cells grown under starvation conditions acquire a hyperandrogenic steroid profile with changes in steroid metabolizing enzymes
Giuseppe Fiume et al.
Scientific reports, 5, 13864-13864 (2015-09-08)
Immune activation and chronic inflammation are hallmark features of HIV infection causing T-cell depletion and cellular immune dysfunction in AIDS. Here, we addressed the issue whether HIV-1 Tat could affect T cell development and acute inflammatory response by generating a
Harriet P Lo et al.
The Journal of cell biology, 210(5), 833-849 (2015-09-02)
Dysfunction of caveolae is involved in human muscle disease, although the underlying molecular mechanisms remain unclear. In this paper, we have functionally characterized mouse and zebrafish models of caveolae-associated muscle disease. Using electron tomography, we quantitatively defined the unique three-dimensional
Rachel L Gillespie et al.
Investigative ophthalmology & visual science, 56(2), 883-891 (2015-01-13)
To define the phenotypic manifestation, confirm the genetic basis, and delineate the pathogenic mechanisms underlying an oculoauricular syndrome (OAS). Two individuals from a consanguineous family underwent comprehensive clinical phenotyping and electrodiagnostic testing (EDT). Genome-wide microarray analysis and Sanger sequencing of
David Westover et al.
Molecular cancer, 14, 92-92 (2015-05-01)
Irinotecan is a camptothecin analogue currently used in clinical practice to treat advanced colorectal cancer. However, acquired resistance mediated by the drug efflux pump ABCG2 is a recognized problem. We reported on a novel camptothecin analogue, FL118, which shows anticancer
Leona Daniela Jeffery Daim et al.
Electrophoresis, 36(15), 1699-1710 (2015-05-02)
The basidiomycete fungal pathogen Ganoderma boninense is the causative agent for the incurable basal stem rot (BSR) disease in oil palm. This disease causes significant annual crop losses in the oil palm industry. Currently, there is no effective method for
Birgit Steinmetz et al.
Cell cycle (Georgetown, Tex.), 13(18), 2931-2943 (2014-12-09)
The product of the ecotropic virus integration site 1 (EVI1) gene, whose overexpression is associated with a poor prognosis in myeloid leukemias and some epithelial tumors, regulates gene transcription both through direct DNA binding and through modulation of the activity
Marina Rolo Pinheiro da Rosa et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(11), 11107-11120 (2014-08-08)
Ameloblastoma is an odontogenic tumor characterized by local invasiveness and frequent recurrence. The surrounding stroma, composed of different cell types and extracellular matrix (ECM), may influence ameloblastoma invasive behavior. Furthermore, tumor and stromal cells secrete matrix metalloproteases (MMPs), which, in
Rodrigo W A Souza et al.
PloS one, 9(10), e110020-e110020 (2014-10-21)
Heart failure (HF) is associated with cachexia and consequent exercise intolerance. Given the beneficial effects of aerobic exercise training (ET) in HF, the aim of this study was to determine if the ET performed during the transition from cardiac dysfunction
Stephanie M Knebel et al.
Prostaglandins & other lipid mediators, 116-117, 131-135 (2015-01-27)
Inappropriate platelet aggregation can result in thrombosis and tissue ischemia. When compared to healthy human platelets, those of humans with type 2 diabetes (DM2) exhibit increased aggregation when stimulated. Activation of the platelet prostacyclin receptor (IPR) results in cAMP accumulation
Om Prakash Gupta et al.
Molecular biology reports, 42(1), 43-51 (2014-09-15)
Indulgence of heat defense mechanism is crucial to allay undesirable effects by developing significant heat tolerant plants. Translation of heat stress related genes into proteins is a key tolerance strategy tailored by plants. In order to understand the possible mechanisms
Donatella Tesei et al.
Journal of proteomics, 128, 39-57 (2015-07-21)
The black yeast Exophiala dermatitidis is a worldwide distributed agent of primary and secondary diseases in both immunocompromised and healthy humans, with a high prevalence in human-made environments. Since thermo-tolerance has a crucial role in the fungus persistence in man-dominated
Ying Lin et al.
Biomacromolecules, 9(10), 2629-2636 (2008-08-14)
Amphiphilic biodegradable star-shaped polymer was conveniently prepared by the Sn(Oct)2-catalyzed ring opening polymerization of epsilon-caprolactone (CL) with hyperbranched poly(ester amide) (PEA) as a macroinitiator. Various monomer/initiator ratios were employed to vary the length of the PCL arms. (1)H NMR and
Filippa Pettersson et al.
Cancer research, 75(6), 1102-1112 (2015-01-23)
The translation initiation factor eIF4E is an oncogene that is commonly overexpressed in primary breast cancers and metastases. In this article, we report that a pharmacologic inhibitor of eIF4E function, ribavirin, safely and potently suppresses breast tumor formation. Ribavirin administration
Xiangyu Zhou et al.
Molecular medicine reports, 12(5), 7425-7432 (2015-10-16)
The aim of the present study was to investigate the possible role of cytotoxic T lymphocytes (CTL) and mononuclear macrophages in the pathogenic processes of experimental animals. To construct a chronic experimental allergic encephalomyelitis (EAE) model, an artificially synthesized myelin
S Vilain et al.
Electrophoresis, 22(20), 4368-4374 (2002-02-05)
In a new area of postgenomics challenges, the optimization of protein identification has become a central goal in microbiochemistry. In this work, we demonstrate that the substitution of Coomassie Brilliant Blue for bromophenol blue in two-dimensional electrophoresis (2-DE) buffers improves
Youzhi Miao et al.
BMC microbiology, 15, 126-126 (2015-06-24)
Plant biomass, the most abundant natural material on earth, represents a vast source of food and energy in nature. As the main component of plant biomass, xylan is a complex polysaccharide comprising a linear β(1,4)-linked backbone of xylosyl residues substituted
Pablo Emiliano Canton et al.
BMC genomics, 16, 1042-1042 (2015-12-10)
Although much is known about the mechanism of action of Bacillus thuringiensis Cry toxins, the target tissue cellular responses to toxin activity is less understood. Previous transcriptomic studies indicated that significant changes in gene expression occurred during intoxication. However, most
Iman Chouikha et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(52), 18709-18714 (2014-12-03)
The arthropod-borne transmission route of Yersinia pestis, the bacterial agent of plague, is a recent evolutionary adaptation. Yersinia pseudotuberculosis, the closely related food-and water-borne enteric species from which Y. pestis diverged less than 6,400 y ago, exhibits significant oral toxicity
Vinko Besic et al.
PloS one, 10(3), e0119270-e0119270 (2015-03-06)
Type 2 diabetes mellitus (T2DM) results from a combination of progressive insulin resistance and loss of pancreatic beta cell function and/or mass. Insulin signalling occurs through the insulin receptor, (INSR) which is alternatively spliced into two isoforms: INSRA (-exon 11)
Benshui Shu et al.
Archives of insect biochemistry and physiology, 89(3), 153-168 (2015-04-02)
The induction of apoptosis by azadirachtin, a well-known botanical tetranortriterpenoid isolated from the neem tree (Azadirachta indica A. Juss) and other members of the Meliaceae, was investigated in Spodoptera frugiperda cultured cell line (Sf9). Morphological changes in Sf9 cells treated
Mayra Denisse Ramírez-Quijas et al.
Microbial pathogenesis, 87, 1-12 (2015-07-19)
In order for Candida species to adhere and colonize human host cells they must express cell wall proteins (CWP) and adapt to reactive oxygen species (ROS) generated by phagocytic cells of the human host during the respiratory burst. However, how
Agnieszka Rak et al.
Biology of reproduction, 92(6), 142-142 (2015-05-01)
Resistin, a hormone secreted by adipocytes, is thought to be important in reproduction. Our previous study demonstrated resistin expression in porcine ovarian follicles and its direct effect on steroidogenesis. The aim of the current study was to evaluate the effect
Takaya Shimura et al.
Cancer prevention research (Philadelphia, Pa.), 8(3), 240-248 (2015-01-17)
Although the early diagnosis of gastric cancer provides the opportunity for curative endoscopic resection, comprehensive screening endoscopy would be invasive and expensive. To date, there is a complete absence of clinically useful gastric cancer biomarkers. With the goal of discovering
Bengyella Louis et al.
Gene, 574(2), 255-264 (2015-08-12)
Bamboo species are the fastest-growing plants having a long vegetative cycle. Abrupt switching from the vegetative phase to the reproductive phase via sporadic flowering boom, occasionally leads to death of bamboo clumps, and threatens the existence of many bamboo species.
Nilay Yogeshkumar Thakar et al.
Stem cells and development, 24(16), 1888-1900 (2015-03-21)
The molecular mechanisms that orchestrate the exit from pluripotency, cell cycle progression, and lineage-specific differentiation in human pluripotent stem cells (hPSCs) are poorly understood. RELB, a key protein in the noncanonical nuclear factor-kappaB (NFκB) signaling pathway, was previously implicated in
Nikolai B Nordsborg et al.
Journal of applied physiology (Bethesda, Md. : 1985), 119(2), 116-123 (2015-05-30)
The hypothesis that the adaptive capacity is higher in human upper- than lower-body skeletal muscle was tested. Furthermore, the hypothesis that more pronounced adaptations in upper-body musculature can be achieved by "low-volume high-intensity" compared with "high-volume low-intensity" exercise training was
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