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Showing 31-60 of 466 results for "114391" within Papers
Bengyella Louis et al.
Gene, 574(2), 255-264 (2015-08-12)
Bamboo species are the fastest-growing plants having a long vegetative cycle. Abrupt switching from the vegetative phase to the reproductive phase via sporadic flowering boom, occasionally leads to death of bamboo clumps, and threatens the existence of many bamboo species.
Morten A Nielsen et al.
PloS one, 10(9), e0135406-e0135406 (2015-09-04)
The disease caused by Plasmodium falciparum (Pf) involves different clinical manifestations that, cumulatively, kill hundreds of thousands every year. Placental malaria (PM) is one such manifestation in which Pf infected erythrocytes (IE) bind to chondroitin sulphate A (CSA) through expression
Myoung Woo Lee et al.
Biochemical and biophysical research communications, 463(4), 894-899 (2015-06-16)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), either alone or in combination with other anti-cancer agents, is a promising new strategy for the treatment of cancer. However, aberrant PI3K/Akt/mTOR survival signaling may confer TRAIL resistance by altering the balance between pro-
Xiaojiao Chen et al.
Archives of toxicology, 89(4), 635-646 (2014-06-01)
Triclosan (TCS) poses potential risks to reproduction and development due to its endocrine-disrupting properties. However, the mechanism of TCS's effects on early embryonic development is little known. Embryonic stem cells (ESC) and zebrafish embryos provide valuable models for testing the
Chun Yang et al.
Acta neuropsychiatrica, 27(5), 312-316 (2015-05-29)
Accumulating evidences suggest that pro-inflammatory cytokines such as interleukin-6 (IL-6) play a role in the pathophysiology of depression. In the learned helplessness (LH) paradigm, ~35% rats are resilient to inescapable stress. Levels of IL-6 in the serum and medial prefrontal
Birgit Steinmetz et al.
Cell cycle (Georgetown, Tex.), 13(18), 2931-2943 (2014-12-09)
The product of the ecotropic virus integration site 1 (EVI1) gene, whose overexpression is associated with a poor prognosis in myeloid leukemias and some epithelial tumors, regulates gene transcription both through direct DNA binding and through modulation of the activity
Clara Andrea Solari et al.
The Biochemical journal, 462(3), 567-579 (2014-06-21)
PKA (cAMP-dependent protein kinase) activity, as well as that of other AGC members, is regulated by multiple phosphorylations of its catalytic subunits. In Saccharomyces cerevisiae, the PKA regulatory subunit is encoded by the gene BCY1, and the catalytic subunits are
Christina Michailidi et al.
Cancer prevention research (Philadelphia, Pa.), 8(3), 208-221 (2015-01-15)
Exposure to toxicants leads to cumulative molecular changes that overtime increase a subject's risk of developing urothelial carcinoma. To assess the impact of arsenic exposure at a time progressive manner, we developed and characterized a cell culture model and tested
Peter Joseph Durcan et al.
BMC physiology, 14, 11-11 (2014-12-10)
Multiple cell types including trophoblasts, osteoclasts and myoblasts require somatic cell fusion events as part of their physiological functions. In Drosophila Melanogaster the paralogus type 1 transmembrane receptors and members of the immunoglobulin superfamily Kin of Irre (Kirre) and roughest
Kamila Chughtai et al.
Analytical chemistry, 84(4), 1817-1823 (2012-01-31)
Mass spectrometric imaging (MSI) has become widely used in the analysis of a variety of biological surfaces. Biological samples are spatially, morphologically, and metabolically complex. Multimodal molecular imaging is an emerging approach that is capable of dealing with this complexity.
Donatella Tesei et al.
Journal of proteomics, 128, 39-57 (2015-07-21)
The black yeast Exophiala dermatitidis is a worldwide distributed agent of primary and secondary diseases in both immunocompromised and healthy humans, with a high prevalence in human-made environments. Since thermo-tolerance has a crucial role in the fungus persistence in man-dominated
Victoria N Stone et al.
PloS one, 10(11), e0141126-e0141126 (2015-11-07)
Species-specific antimicrobial therapy has the potential to combat the increasing threat of antibiotic resistance and alteration of the human microbiome. We therefore set out to demonstrate the beginning of a pathogen-selective drug discovery method using the periodontal pathogen Porphyromonas gingivalis
Pablo Emiliano Canton et al.
BMC genomics, 16, 1042-1042 (2015-12-10)
Although much is known about the mechanism of action of Bacillus thuringiensis Cry toxins, the target tissue cellular responses to toxin activity is less understood. Previous transcriptomic studies indicated that significant changes in gene expression occurred during intoxication. However, most
Iman Chouikha et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(52), 18709-18714 (2014-12-03)
The arthropod-borne transmission route of Yersinia pestis, the bacterial agent of plague, is a recent evolutionary adaptation. Yersinia pseudotuberculosis, the closely related food-and water-borne enteric species from which Y. pestis diverged less than 6,400 y ago, exhibits significant oral toxicity
Vinko Besic et al.
PloS one, 10(3), e0119270-e0119270 (2015-03-06)
Type 2 diabetes mellitus (T2DM) results from a combination of progressive insulin resistance and loss of pancreatic beta cell function and/or mass. Insulin signalling occurs through the insulin receptor, (INSR) which is alternatively spliced into two isoforms: INSRA (-exon 11)
Benshui Shu et al.
Archives of insect biochemistry and physiology, 89(3), 153-168 (2015-04-02)
The induction of apoptosis by azadirachtin, a well-known botanical tetranortriterpenoid isolated from the neem tree (Azadirachta indica A. Juss) and other members of the Meliaceae, was investigated in Spodoptera frugiperda cultured cell line (Sf9). Morphological changes in Sf9 cells treated
Siao-Syun Guan et al.
Oncotarget, 5(13), 4868-4880 (2014-06-21)
Colorectal cancer (CRC) is known as a common malignant neoplasm worldwide. The role of EGFR/HER2 in CRC is unclear. Afatinib is an irreversible EGFR/HER2 inhibitor. There were few studies of afatinib on CRC. Here, we investigated the protein levels/expressions of
Mayra Denisse Ramírez-Quijas et al.
Microbial pathogenesis, 87, 1-12 (2015-07-19)
In order for Candida species to adhere and colonize human host cells they must express cell wall proteins (CWP) and adapt to reactive oxygen species (ROS) generated by phagocytic cells of the human host during the respiratory burst. However, how
Lindsay M Reynolds et al.
BMC genomics, 16, 333-333 (2015-04-23)
Transcriptomic studies hold great potential towards understanding the human aging process. Previous transcriptomic studies have identified many genes with age-associated expression levels; however, small samples sizes and mixed cell types often make these results difficult to interpret. Using transcriptomic profiles
Takaya Shimura et al.
Cancer prevention research (Philadelphia, Pa.), 8(3), 240-248 (2015-01-17)
Although the early diagnosis of gastric cancer provides the opportunity for curative endoscopic resection, comprehensive screening endoscopy would be invasive and expensive. To date, there is a complete absence of clinically useful gastric cancer biomarkers. With the goal of discovering
Susanne Mueller et al.
Molecular biology of the cell, 26(14), 2596-2608 (2015-05-23)
Protein degradation is essential for cellular homeostasis. We developed a sensitive approach to examining protein degradation rates in Saccharomyces cerevisiae by coupling a SILAC approach to selected reaction monitoring (SRM) mass spectrometry. Combined with genetic tools, this analysis made it
Shaoping Wu et al.
Gut, 64(7), 1082-1094 (2014-08-01)
Vitamin D and the vitamin D receptor (VDR) appear to be important immunological regulators of inflammatory bowel diseases (IBD). Defective autophagy has also been implicated in IBD, where interestingly, polymorphisms of genes such as ATG16L1 have been associated with increased
Xian-Jun Sun et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 37(2), 707-718 (2015-09-12)
The microRNA (miR) 29 family has been studied extensively for its involvement in several diseases, and aberrant expression of its members is associated with tumorigenesis and cancer progression. Here, we examined the role of miR-29a in pancreatic cancer and the
L Félix-Valenzuela et al.
Letters in applied microbiology, 61(4), 367-373 (2015-07-16)
The fruit juice industry recognizes Alicyclobacillus as a major quality control target micro-organism. In this study, we analysed 19 bacterial isolates to identify Alicyclobacillus species by polymerase chain reaction (PCR) and sequencing analyses. Phenotypic and genomic diversity among isolates were
Heinz Fischer et al.
PloS one, 6(3), e17581-e17581 (2011-03-11)
The cornified layer, the stratum corneum, of the epidermis is an efficient barrier to the passage of genetic material, i.e. nucleic acids. It contains enzymes that degrade RNA and DNA which originate from either the living part of the epidermis
Yaodong Dong et al.
PloS one, 10(8), e0136051-e0136051 (2015-08-22)
Aminoglycoside antibiotics such as gentamicin could cause ototoxicity in mammalians, by inducing oxidative stress and apoptosis in sensory hair cells of the cochlea. Sodium hydrosulfide (NaHS) is reported to alleviate oxidative stress and apoptosis, but its role in protecting aminoglycoside-induced
Alpha hemoglobin stabilizing protein: Its causal relationship with the severity of beta thalassemia.
Chandan S Sagar et al.
Blood cells, molecules & diseases, 55(2), 104-107 (2015-07-05)
Thalassemia major is characterized by anemia, iron overload and cellular damage. The severity of symptoms correlates with the alpha/non-alpha globin imbalance and is proportional to the magnitude of alpha chain excess. Alpha hemoglobin stabilizing protein (AHSP), the erythroid specific alpha
Miroslaw Ksiazek et al.
Biological chemistry, 396(3), 261-275 (2014-11-14)
The genome of Tannerella forsythia, an etiological factor of chronic periodontitis, contains several genes encoding putative proteases. Here, we characterized a subtilisin-like serine protease of T. forsythia referred to as mirolase. Recombinant full-length latent promirolase [85 kDa, without its signal
Ketan S Patil et al.
PloS one, 10(12), e0143969-e0143969 (2015-12-04)
MicroRNAs are key regulators associated with numerous diseases. In HEK293 cells, miR-153-3p and miR-205-5p down-regulate alpha-synuclein (SNCA) and Leucine-rich repeat kinase 2 (LRRK2), two key proteins involved in Parkinson's disease (PD). We have used two-dimensional gel electrophoresis (2D-PAGE) coupled to
Monika Bubka et al.
Biochimie, 103, 37-49 (2014-04-15)
An important role in cancer pathogenesis is attributed to N-glycans with "bisecting" N-acetylglucosamine and beta1-6 branches but the exact mechanisms still remain to be elucidated. Two structures are formed by Golgi beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (EC = 2.4.1.144, GnT-III) and alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase
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