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Showing 1-30 of 45 results for "120-74-1" within Papers
Changsong Zhang et al.
International journal of cancer, 123(5), 998-1004 (2008-06-12)
CpG island methylator phenotype (CIMP) involves the targeting of multiple genes by promoter hypermethylation. Telomerase plays an important role in the development of cellular immortality and oncogenesis. To gain insight into the role of epigenetic aberration of telomerase-related genes in
Lin Sun et al.
Journal of medicinal chemistry, 63(9), 4790-4810 (2020-04-17)
The HIV-1 CA protein has gained remarkable attention as a promising therapeutic target for the development of new antivirals, due to its pivotal roles in HIV-1 replication (structural and regulatory). Herein, we report the design and synthesis of three series
Israfil Kucuk et al.
International journal of pharmaceutics, 472(1-2), 339-346 (2014-06-20)
Itraconazole is widely used as an anti-fungal drug to treat infections. However, its poor aqueous solubility results in low bioavailability. The aim of the present study was to improve the drug release profile by preparing surface itraconazole adsorbed polymethylsilsesquioxane (PMSQ)
Thapanan Putta et al.
Journal of environmental management, 92(9), 2272-2276 (2011-05-21)
Tungsten doping and hydrothermal treatment were found to significantly improve the visible-light photoactivity of TiO(2) synthesized by the sol-gel method. It was observed that TiO(2) doped with a 0.5% W:Ti mole ratio and treated with 4 h of hydrothermal curing
Angelo J Trapani et al.
Journal of cardiovascular pharmacology, 44 Suppl 1, S211-S215 (2005-04-20)
CGS 35601 is a potent triple inhibitor of endothelin-converting enzyme-1, neutral endopeptidase 24.11, and angiotensin-converting enzyme. It inhibited the activities of these three enzymes with IC50 values of 55, 2 and 22 nM, respectively. In conscious rats, CGS 35601 suppressed
V Sanna et al.
Haemophilia : the official journal of the World Federation of Hemophilia, 14(4), 796-803 (2008-05-08)
Haemophilia A (HA) is an X-linked recessive haemorrhagic disorder caused by a deficiency of coagulation factor VIII. Disease causative mutations are heterogeneous and spread all over the F8 gene sequence, with the exception of intron 22 inversion occurring in about
R Mahfouz et al.
Tissue antigens, 68(1), 66-71 (2006-06-16)
This study represents the first report on the distribution of 16 Killer cell Immunoglobulin-like Receptors (KIR) genes in 120 unrelated healthy Lebanese individuals. We observed that 2DL2 frequency (61%) comes second highest after South Asians (64%) and 2DL5 frequency (58.3%)
Toni Llorente-Mirandes et al.
Food chemistry, 194, 849-856 (2015-10-17)
The present study reports arsenic analysis in Lentinula edodes, Agaricus bisporus and Pleurotus ostreatus before and after being cooked. Furthermore, arsenic in raw and cooked mushroom was determined in the gastric and gastrointestinal bioaccessible fractions obtained after simulating human digestion
Hsiang-Chih Lu et al.
Oncotarget, 9(33), 23018-23028 (2018-05-26)
Malignant Peripheral Nerve Sheath Tumors (MPNSTs) are aggressive soft tissue sarcomas that can occur sporadically or in the setting of the Neurofibromatosis type 1 (NF1) cancer predisposition syndrome. These tumors carry a dismal overall survival. Previous work in our lab
T W Hutchens et al.
Pediatric research, 31(3), 239-246 (1992-03-01)
Histidine-rich glycoprotein (HRG) is a 74-kD glycoprotein, originally discovered in plasma, which contains an unusually large amount of histidine (13 mol%) and proline (13 mol%). The specific functions of this protein remain unclear, although it binds (reversibly) transition metal ions
Yuji Tanaka et al.
American journal of physiology. Gastrointestinal and liver physiology, 282(4), G656-G662 (2002-03-19)
Regulation of bilirubin glucuronide transporters during hyperbilirubinemia in hepatic and extrahepatic tissues is not completely clear. In the present study, we evaluated the regulation of the bilirubin glucuronide transporters, multidrug resistance-associated proteins (MRP)2 and 3, in rats with obstructive jaundice.
Ryan Neil Marshall et al.
Frontiers in physiology, 13, 1097988-1097988 (2023-01-24)
Background: Ageing is associated with alterations to skeletal muscle oxidative metabolism that may be influenced by physical activity status, although the mechanisms underlying these changes have not been unraveled. Similarly, the effect of resistance exercise training (RET) on skeletal muscle
Xijun Wang et al.
Arzneimittel-Forschung, 58(7), 336-341 (2008-08-30)
A method for the rapid and simultaneous determination of 6,7-dimethylesculetin (CAS 120-08-1) and geniposide (CAS 24512-63-8) in rat plasma has been developed, using validated high performance liquid chromatography (HPLC) with solid phase extraction (SPE). The HPLC analysis was performed on
Hideo Mizutani et al.
Circulation journal : official journal of the Japanese Circulation Society, 74(1), 120-128 (2009-12-08)
Phosphorylation of the regulatory light chain of myosin (MLC) has roles in cardiac function. In vitro, myosin phosphatase target subunit 2 (MYPT2) is a strongly suspected regulatory subunit of cardiac myosin phosphatase (MP), but there is no in-vivo evidence regarding
Mohamed H Abdel-Wahab et al.
Pharmacological research, 46(3), 287-293 (2002-09-11)
Dibromoacetonitrile (DBAN) is a disinfection by-product following chlorination of drinking water. Epidemiological studies indicate that it might present a potential hazard to human health. DBAN was previously found to induce oxidative stress in rat stomach as manifested by perturbation of
Nancy E Lane et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 18(12), 2105-2115 (2003-12-16)
Osteoporosis is a syndrome of excessive skeletal fragility that results from both the loss of trabecular bone mass and trabecular bone connectivity. Recently, bFGF has been found to increase trabecular bone mass in osteoporotic rats. The purpose of this study
D Häfner et al.
American journal of respiratory and critical care medicine, 158(1), 270-278 (1998-07-09)
We have tested two surfactant preparations with the same phospholipid (PL) composition, containing recombinant surfactant protein-C (rSP-C surfactant) and without SP-C (plain PL surfactant). The effects of rSP-C surfactant were compared with the bovine-derived surfactant preparations Alveofact, bLES, and Infasurf
M J Hannon et al.
QJM : monthly journal of the Association of Physicians, 110(5), 277-281 (2017-02-10)
In approximately half of cases of primary aldosteronism (PA), the cause is a surgically-resectable unilateral aldosterone-producing adrenal adenoma. However, long-term data on surgical outcomes are sparse. We report on clinical outcomes post-adrenalectomy in a cohort of patients with PA who
JoAnn Trial et al.
Journal of immunology (Baltimore, Md. : 1950), 173(3), 2190-2198 (2004-07-22)
To identify signals that can alter leukocyte function in patients receiving highly active antiretroviral therapy (HAART), we analyzed single blood samples from 74 HIV-1-infected patients and additional blood was collected at 90-day intervals from 51 HIV-1-infected patients over a 516
Andrea L Fellet et al.
American journal of physiology. Heart and circulatory physiology, 291(3), H1246-H1254 (2006-04-18)
In autonomic-blocked rats treated with NG-nitro-L-arginine methyl ester (L-NAME, 7.5 mg/kg), heart rate increased 18% and mean arterial pressure increased 48%. Thyroidectomy, along with autonomic blockade, hampered the chronotropic response but did not modify the effect on blood pressure. After
Erik Asmussen et al.
Acta odontologica Scandinavica, 60(3), 146-150 (2002-08-09)
A slow contraction may result in reduced gap formation when a restorative resin polymerizes in a dental cavity. It was the aim in the present work to investigate the rate of contraction in relation to composition of experimental light-curing resin
Toshihiro Sato et al.
The Journal of biological chemistry, 278(6), 4314-4321 (2002-11-22)
Previously, we determined the crystal structures of the dimeric ligand binding region of the metabotropic glutamate receptor subtype 1. Each protomer binds l-glutamate within the crevice between the LB1 and LB2 domains. We proposed that the two different conformations of
Anwar A Jammah et al.
Frontiers in endocrinology, 11, 603432-603432 (2021-03-16)
Following total thyroidectomy and radioactive iodine (RAI) ablation, serum thyroglobulin levels should be undetectable to assure that patients are excellent responders and at very low risk of recurrence. To assess the utility of stimulated (sTg) and non-stimulated (nsTg) thyroglobulin levels
Meinolf Suttorp et al.
Leukemia, 32(7), 1657-1669 (2018-06-22)
A total of 156 patients (age range 1.3-18.0 years, median 13.2 years; 91 (58.3%) male) with newly diagnosed CML (N = 146 chronic phase (CML-CP), N = 3 accelerated phase (CML-AP), N = 7 blastic phase (CML-BP)) received imatinib up-front (300, 400, 500 mg/m2, respectively) within a
Kei Hosoda et al.
Anticancer research, 35(1), 419-425 (2015-01-01)
Our objective was to clarify if preoperative chemotherapy was associated with improved survival in Japanese patients with Siewert type II adenocarcinoma of the esophagogastric junction. We retrospectively reviewed the medical records of 86 patients with Siewert type II adenocarcinoma who
Mei Sun et al.
Circulation, 110(20), 3221-3228 (2004-11-10)
We investigated the potential contributions of tumor necrosis factor-alpha (TNF-alpha) on the incidence of acute myocardial rupture and subsequent chronic cardiac dysfunction after myocardial infarction (MI) in TNF knockout (TNF-/-) mice compared with C57/BL wild-type (WT) mice. Animals were randomized
Brett A Dolezal et al.
Journal of addiction medicine, 7(2), 122-128 (2013-04-05)
Physical exercise has been shown to benefit diverse medical and behavioral conditions. This study assesses the feasibility and efficacy of an 8-week endurance and resistance training program on fitness measures in individuals undergoing residential treatment for methamphetamine (MA) dependence. A
Jonathon A Nye et al.
Nuclear medicine and biology, 38(7), 1035-1041 (2011-07-12)
The enantiomerically enriched (ee=90%, enantiomer 1) synthetic amino acid (R,S)-anti-1-amino-2-fluorocyclopentyl-1-carboxylic acid (anti-2-[(18)F]FACPC-1) accumulates in malignant cells by elevated transport through the sodium-independent system-L (leucine preferring) amino acid transporter. The purpose of this study was to evaluate in vivo uptake and
Priscilla Montez et al.
Endocrinology, 153(12), 5746-5759 (2012-10-23)
Metabolic syndrome (MetS) is commonly associated with elevated renin-angiotensin system, oxidative stress, and steatohepatitis with down-regulation of uncoupling proteins (UCPs). However, the mechanisms linking renin-angiotensin system, steatosis, and UCP2 to hepatic oxidative damage during insulin resistance are not described. To
He Wang et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 26(1), 139-147 (2012-08-25)
The molecular pathogenesis of gastroenteropancreatic neuroendocrine tumors is largely unknown. We hypothesize that gastroenteropancreatic neuroendocrine tumors are heterogeneous with regard to these signaling pathways and these differences could have a significant impact on the outcome of clinical trials. We selected
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