122 705-93-5

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Showing 1-14 of 14 results for "122 705-93-5" within Papers

Identification of arginine-700 as the residue that binds the C-5 carboxyl group of 2-oxoglutarate in human lysyl hydroxylase 1.

K Passoja et al.

FEBS letters, 434(1-2), 145-148 (1998-09-17)

Lysyl hydroxylase catalyzes the formation of hydroxylysine in collagens by a reaction that involves oxidative decarboxylation of 2-oxoglutarate. Its binding site can be divided into two main subsites: subsite I consists of a positively charged side-chain which binds the C-5

Functions of MutLalpha, replication protein A (RPA), and HMGB1 in 5'-directed mismatch repair.

Jochen Genschel et al.

The Journal of biological chemistry, 284(32), 21536-21544 (2009-06-12)

A purified system comprised of MutSalpha, MutLalpha, exonuclease 1 (Exo1), and replication protein A (RPA) (in the absence or presence of HMGB1) supports 5'-directed mismatch-provoked excision that terminates after mismatch removal. MutLalpha is not essential for this reaction but enhances

Excitotoxicity and metabolic changes in association with infarct progression.

Johannes Woitzik et al.

Stroke, 45(4), 1183-1185 (2014-03-20)

We investigated to what extent excitotoxicity and metabolic changes in the peri-infarct region of patients with malignant hemispheric stroke are associated with delayed infarct progression. In 18 patients with malignant hemispheric stroke, 2 microdialysis probes were implanted within the peri-infarct

Identification and characterization of a novel cyclic nucleotide phosphodiesterase gene (PDE9A) that maps to 21q22.3: alternative splicing of mRNA transcripts, genomic structure and sequence.

M Guipponi et al.

Human genetics, 103(4), 386-392 (1998-12-18)

Cyclic nucleotide-specific phosphodiesterases (PDEs) play an essential role in signal transduction by regulating the intracellular concentration of second messengers (cAMP and cGMP). We have identified and made an initial characterization of a full-length cDNA encoding a novel human cyclic nucleotide

Hyperosmolality in vivo upregulates aquaporin 2 water channel and Na-K-2Cl co-transporter in Brattleboro rats.

Chunling Li et al.

Journal of the American Society of Nephrology : JASN, 17(6), 1657-1664 (2006-05-05)

There are considerable experimental results that indicate that arginine vasopressin (AVP)-independent factors are involved in urinary concentration. This study examined the role of hyperosmolality in vivo to modulate aquaporin 2 (AQP2) and Na-K-2Cl co-transporter (NKCC2), pivotal factors in urinary concentration

Patient demographics and cardiovascular risk factors differentially influence geometric remodeling of the aorta compared with the peripheral arteries.

Alexey Kamenskiy et al.

Surgery, 158(6), 1617-1627 (2015-06-23)

Detailed knowledge of the dimensions and shape of the main arteries of the body and how they change with age and disease is important for understanding arterial pathophysiology and improving minimally invasive devices to treat arterial diseases. Our goal was

Expression of PAX8 in normal and neoplastic tissues: a comprehensive immunohistochemical study.

David Tacha et al.

Applied immunohistochemistry & molecular morphology : AIMM, 19(4), 293-299 (2011-02-03)

PAX8 is a nephric-lineage transcription factor and is a crucial transcription factor for organogenesis of the thyroid gland, kidney, and Müllerian system. PAX8 is shown to be expressed in a high percentage of kidney and ovarian carcinomas. Limited information is

The codon 72 polymorphic variants of p53 in Italian rheumatoid arthritis patients.

P Macchioni et al.

Clinical and experimental rheumatology, 25(3), 416-421 (2007-07-17)

The p53 tumor suppressor protein plays an important role in cell apoptosis. The wild type p53 protein presents a common polymorphism at position 72 resulting in either a proline or an arginine residue at this position, leading to differences between

Lack of S100A1 in mice confers a gender-dependent hypertensive phenotype and increased mortality after myocardial infarction.

Jean-Francois Desjardins et al.

American journal of physiology. Heart and circulatory physiology, 296(5), H1457-H1465 (2009-03-17)

S100A1 is a small Ca(2+)-binding protein expressed in the myocardium and blood vessels that is downregulated in the diseased heart and plays a role in the regulation of cardiac muscle Ca(2+) homeostasis and contractility. To understand its physiological role under

The -112G>A polymorphism of the secretoglobin 3A2 (SCGB3A2) gene encoding uteroglobin-related protein 1 (UGRP1) increases risk for the development of Graves' disease in subsets of patients with elevated levels of immunoglobulin E.

Dimitry A Chistiakov et al.

Journal of applied genetics, 52(2), 201-207 (2010-12-21)

The human secretoglobin 3A2 (SCGB3A2) gene encoding secretory uteroglobin-related protein 1 (UGRP1) resides on the chromosome region 5q31-33 that harbors a susceptibility locus to several autoimmune and inflammatory diseases, including asthma and Graves' disease (GD). Recently, association between the marker

Diagnosing primary and metastatic renal cell carcinoma: the use of the monoclonal antibody 'Renal Cell Carcinoma Marker'.

D K McGregor et al.

The American journal of surgical pathology, 25(12), 1485-1492 (2001-11-22)

The diagnosis of primary or metastatic renal cell carcinoma (RCC) can be difficult, especially in small biopsies, because of the wide variety of histologic appearances and clinical presentations that RCC can assume. An immunomarker specific for RCC is currently not

Ectopic Pax2 expression in chick ventral optic cup phenocopies loss of Pax2 expression.

Rachna Sehgal et al.

Developmental biology, 319(1), 23-33 (2008-05-20)

Pax2 is essential for the development of the urogenital system, neural tube, otic vesicle, optic cup and optic tract [Dressler, G.R., Deutsch, U., et al., 1990. PAX2, a new murine paired-box-containing gene and its expression in the developing excretory system.

Effect of early neonatal vitamin A supplementation on mortality during infancy in Ghana (Neovita): a randomised, double-blind, placebo-controlled trial.

Karen M Edmond et al.

Lancet (London, England), 385(9975), 1315-1323 (2014-12-17)

Results of randomised controlled trials of newborn (age 1-3 days) vitamin A supplementation have been inconclusive. The WHO is coordinating three large randomised trials in Ghana, India, and Tanzania (Neovita trials). We present the findings of the Neovita trial in

Effectiveness of rifaximin in prevention of diarrhoea in individuals travelling to south and southeast Asia: a randomised, double-blind, placebo-controlled, phase 3 trial.

Philipp Zanger et al.

The Lancet. Infectious diseases, 13(11), 946-954 (2013-09-10)

Travellers' diarrhoea causes substantial acute and long-term morbidity. Chemoprophylaxis with fluoroquinolones or rifaximin is effective in prevention of diarrhoea in individuals travelling to Latin America and Africa. Little evidence is available to support the protective effect of antimicrobial drugs in

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