130915

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Showing 1-30 of 41 results for "130915" within Papers

Formation of bromochlorodibenzo-p-dioxins and furans from the high-temperature pyrolysis of a 2-chlorophenol/2-bromophenol mixture.

Catherine S Evans et al.

Environmental science & technology, 39(20), 7940-7948 (2005-11-22)

The homogeneous, gas-phase pyrolytic thermal degradation of a 50:50 mixture of 2-bromophenol and 2-chlorophenol was studied in a 1 cm i.d., fused silica flow reactor at a total concentration of 88 ppm, reaction time of 2.0 s, and temperatures from

Mechanisms of dioxin formation from the high-temperature pyrolysis of 2-bromophenol.

Catherine S Evans et al.

Environmental science & technology, 37(24), 5574-5580 (2004-01-14)

Brominated hydrocarbons are the most commonly used flame retardants. Materials containing brominated hydrocarbons are frequently disposed in municipal and hazardous waste incinerators as well as being subjected to thermal reaction in accidental fires. This results in the potential for formation

Development and evaluation of methods for starch dissolution using asymmetrical flow field-flow fractionation. Part I: Dissolution of amylopectin.

Daysi Perez-Rea et al.

Analytical and bioanalytical chemistry, 407(15), 4315-4326 (2015-05-01)

We have investigated methods of starch dissolution with the aim of finding an optimum method to completely dissolve starch granules to form a molecularly dissolved starch solution without degradation of the polymers. Glycogen was used as a model molecule for

Changes in protein expression in two cholangiocarcinoma cell lines undergoing formation of multicellular tumor spheroids in vitro.

Carlo Mischiati et al.

PloS one, 10(3), e0118906-e0118906 (2015-03-11)

Epithelial-to-Mesenchymal Transition (EMT) is relevant in malignant growth and frequently correlates with worsening disease progression due to its implications in metastases and resistance to therapeutic interventions. Although EMT is known to occur in several types of solid tumors, the information

Comparative proteomic analysis of extracellular proteins expressed by various clonal types of Staphylococcus aureus and during planktonic growth and biofilm development.

Salman S Atshan et al.

Frontiers in microbiology, 6, 524-524 (2015-06-20)

Staphylococcus aureus is well known for its biofilm formation with rapid emergence of new clones circulating worldwide. The main objectives of the study were (1) to identify possible differences in protein expression among various and closely related clonal types of

Detection and characterization of a dehalogenating microorganism by terminal restriction fragment length polymorphism fingerprinting of 16S rRNA in a sulfidogenic, 2-bromophenol-utilizing enrichment.

Donna E Fennell et al.

Applied and environmental microbiology, 70(2), 1169-1175 (2004-02-10)

Terminal restriction fragment length polymorphism analysis of reverse-transcribed 16S rRNA during periods of community flux was used as a tool to delineate the roles of the members of a 2-bromophenol-degrading, sulfate-reducing consortium. Starved, washed cultures were amended with 2-bromophenol plus

Mechanism and direct kinetics study on the homogeneous gas-phase formation of PBDD/Fs from 2-BP, 2,4-DBP, and 2,4,6-TBP as precursors.

Wanni Yu et al.

Environmental science & technology, 45(5), 1917-1925 (2011-02-12)

This study investigated the homogeneous gas-phase formation of polybrominated dibenzo-p-dioxin/dibenzofurans (PBDD/Fs) from 2-BP, 2,4-DBP, and 2,4,6-TBP as precursors. First, density functional theory (DFT) calculations were carried out for the formation mechanism. The geometries and frequencies of the stationary points were

Time-dependent effects of hydrophobic amine-containing drugs on lysosome structure and biogenesis in cultured human fibroblasts.

Randall Logan et al.

Journal of pharmaceutical sciences, 103(10), 3287-3296 (2014-07-22)

Many weakly basic amine-containing drugs are known to be extensively sequestered in acidic lysosomes by an ion trapping-type mechanism. The entrapment of drugs in lysosomes has been shown to influence drug activity, cancer cell selectivity, and pharmacokinetics and can cause

Distribution of bromophenols in species of marine polychaetes and bryozoans from eastern Australia and the role of such animals in the flavor of edible ocean fish and prawns (shrimp).

F B Whitfield et al.

Journal of agricultural and food chemistry, 47(11), 4756-4762 (1999-12-20)

Sixteen species (44 samples) of marine polychaetes and 10 species (14 samples) of bryozoans from eastern Australia were analyzed by GC/MS for the key seafood flavor components 2- and 4-bromophenol, 2, 4- and 2,6-dibromophenol, and 2,4,6-tribromophenol. All five bromophenols were

Biodegradation of brominated aromatics by cultures and laccase of Trametes versicolor.

B Uhnáková et al.

Chemosphere, 76(6), 826-832 (2009-05-16)

2-Bromophenol (1), 4-bromophenol (2), 2,4-dibromophenol (3), 2,6-dibromophenol (4), 2,4,6-tribromophenol (5) and tetrabromobisphenol A (6) (1 mM each) added to growing submerged cultures of Trametes versicolor CCBAS 612 were eliminated by 65-85% from the culture medium within 4d. Extracellular laccase activity

Developing structure-activity relationships for the prediction of hepatotoxicity.

Nigel Greene et al.

Chemical research in toxicology, 23(7), 1215-1222 (2010-06-18)

Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential

A predictive ligand-based Bayesian model for human drug-induced liver injury.

Sean Ekins et al.

Drug metabolism and disposition: the biological fate of chemicals, 38(12), 2302-2308 (2010-09-17)

Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predictive in vivo, in vitro, and in silico models to identify compounds

Discovery and mapping of genomic regions governing economically important traits of Basmati rice.

Lakshminarayana R Vemireddy et al.

BMC plant biology, 15, 207-207 (2015-08-22)

Basmati rice, originated in the foothills of Himalayas, commands a premium price in the domestic and international markets on account of its unique quality traits. The complex genetic nature of unique traits of Basmati as well as tedious screening methodologies

Seasonal distribution of bromophenols in selected Hong Kong seafood.

Hau Yin Chung et al.

Journal of agricultural and food chemistry, 51(23), 6752-6760 (2003-10-30)

Selected seafood including rabbitfish (Siganus canaliculatus), brown-spotted grouper (Epinephelus areolatus), clam (Tapes philippinarum), oyster (Ostrea rivularis), shrimp (Penaeus japonicus), and crab (Charybdis feriatus), commonly found in the Hong Kong wet market, was monitored for their distribution and seasonal variations of

Synthesis of dibenzofurans directly from aryl halides and ortho-bromophenols via one-pot consecutive SNAr and intramolecular palladium-catalyzed aryl-aryl coupling reactions.

Hui Xu et al.

Chemical & pharmaceutical bulletin, 56(10), 1496-1498 (2008-10-02)

A series of dibenzofurans were efficiently and conveniently synthesized via one-pot consecutive C(sp(2))-O bond formation reaction (SNAr) in the presence of anhydrous K(2)CO(3), followed by C(sp(2))-C(sp(2)) bond formation reaction (intramolecular palladium-catalyzed aryl-aryl coupling reaction) between aryl halides and ortho-bromophenols. The

cIEF for rapid pKa determination of small molecules: a proof of concept.

Stéphanie Romand et al.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 63, 14-21 (2014-07-06)

A capillary isoelectric focusing (cIEF) method was developed for the determination of the ionization constants (pKa) of small molecules. Two approaches used to decrease the electroosmotic flow (EOF) were compared: (i) a hydroxypropylcellulose (HPC) coated capillary in aqueous medium and

Surface-mediated formation of polybrominated dibenzo-p-dioxins and dibenzofurans from the high-temperature pyrolysis of 2-bromophenol on a CuO/silica surface.

Catherine S Evans et al.

Environmental science & technology, 39(13), 4857-4863 (2005-08-02)

We studied the surface-mediated pyrolytic thermal degradation of 2-bromophenol, a model brominated hydrocarbon that may form brominated dioxins in combustion and thermal processes, on silica-supported copper oxide in a 1 mm i.d., fused silica flow reactor at a constant concentration

Cellular apoptosis and cytotoxicity of phenolic compounds: a quantitative structure-activity relationship study.

Cynthia D Selassie et al.

Journal of medicinal chemistry, 48(23), 7234-7242 (2005-11-11)

In this comprehensive study on the caspase-mediated apoptosis-inducing effect of 51 substituted phenols in a murine leukemia cell line (L1210), we determined the concentrations needed to induce caspase activity by 50% (I50) and utilized these data to develop the following

Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).

Giulia Caron et al.

Journal of medicinal chemistry, 48(9), 3269-3279 (2005-04-29)

Growing interest in the use of both the logarithm of the partition coefficient of the neutral species in the alkane/water system (log P(N)(alk)) and the difference between log P(N)(oct) (the logarithm of the partition coefficient of the neutral species in

Development of a FRET biosensor with high specificity for Akt.

Haruko Miura et al.

Cell structure and function, 39(1), 9-20 (2013-11-12)

The serine/threonine kinase Akt plays a critical role in cell proliferation, survival, and tumorigenesis. As a central kinase in the phosphatidylinositol 3-kinase pathway, its activation mechanism at the plasma membrane has been well characterized. However, the subcellular Akt activity in

Decomposition of 2-bromophenol in NaOH solution at high temperature.

Miho Uchida et al.

Journal of hazardous materials, 101(3), 231-238 (2003-08-26)

2-Bromophenol was reacted in aqueous sodium hydroxide at 200-250 degrees C. The decomposition rate was remarkably faster at 250 degrees C than at 225 or 200 degrees C, and the percentage debromination reached almost 100% in 1M NaOH at 250

Study of the photodegradation of 2-bromophenol under UV and sunlight by spectroscopic, chromatographic and chemometric techniques.

Anusha Jayaraman et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 910, 138-148 (2012-04-24)

This work is focused on the study of the photodegradation of 2-bromophenol under the action of UV light and sunlight. The photodegradation process has been monitored using UV-Vis spectroscopy and High Performance Liquid Chromatography coupled to diode array and mass

Rotavirus increases levels of lipidated LC3 supporting accumulation of infectious progeny virus without inducing autophagosome formation.

Francesca Arnoldi et al.

PloS one, 9(4), e95197-e95197 (2014-04-17)

Replication of many RNA viruses benefits from subversion of the autophagic pathway through many different mechanisms. Rotavirus, the main etiologic agent of pediatric gastroenteritis worldwide, has been recently described to induce accumulation of autophagosomes as a mean for targeting viral

Synthesis of polybrominated diphenyl ethers via symmetrical tetra- and hexabrominated diphenyliodonium salts.

Daniel Teclechiel et al.

Chemosphere, 74(3), 421-427 (2008-11-11)

Polybrominated diphenyl ethers (PBDEs) are a class of brominated flame retardants (BFRs) which have become widespread environmental pollutants due to their persistence and bioaccumulativeness. Pure authentic PBDE congeners are required for chemical analysis, assessments of their chemical/physical properties and toxicological

Pathways of formation of 2-, 3- and 4-bromophenol from bromobenzene. Proposed mechanism for C-S lyase reactions of cysteine conjugates.

K Lertratanangkoon et al.

Research communications in chemical pathology and pharmacology, 80(3), 259-282 (1993-06-01)

Bromobenzene is metabolized by the rat and guinea pig to 2-, 3- and 4-bromophenol. 3-Bromophenol is formed through the sulfur-series pathway to phenols. This route involves the enterohepatic circulation; the key intermediate is the S-(2-hydroxy-4-bromocyclohexa-3,5-dienyl)-L-cysteine derived from the 4-S-glutathione conjugate

Acute and subacute nephrotoxicity of 2-bromophenol in rats.

Elzbieta Bruchajzer et al.

Toxicology letters, 134(1-3), 245-252 (2002-08-23)

The present report aims at providing broader information on the acute nephrotoxicity of 2-bromophenol (2-BP) (a bromobenzene (BB) metabolite), due to its action on the kidneys, after repeated administration. Investigations were performed on female rats. Following a single dose, the

One-pot synthesis of benzofurans via palladium-catalyzed enolate arylation with o-bromophenols.

Christian Eidamshaus et al.

Organic letters, 10(19), 4211-4214 (2008-08-30)

A one-pot synthesis of benzofurans which utilizes a palladium-catalyzed enolate arylation is described. The process demonstrates broad substrate scope and provides differentially substituted benzofurans in moderate to excellent yields. The utility of the method is further demonstrated by the synthesis

Mechanisms of dioxin formation from the high-temperature oxidation of 2-bromophenol.

Catherine S Evans et al.

Environmental science & technology, 39(7), 2128-2134 (2005-05-06)

The homogeneous, gas-phase oxidative thermal degradation of 2-bromophenol was studied in a 1 cm i.d., fused silica flow reactor at a concentration of 88 ppm, reaction time of 2.0 s, over a temperature range from 300 to 1000 degrees C.

Formation of bromochlorodibenzo-p-dioxins and dibenzofurans from the high-temperature oxidation of a mixture of 2-chlorophenol and 2-bromophenol.

Catherine S Evans et al.

Environmental science & technology, 40(9), 3036-3042 (2006-05-25)

The homogeneous, gas-phase oxidative thermal degradation of a 50:50 mixture of 2-bromophenol and 2-chlorophenol was studied in a 1 cm i.d., fused silica flow reactor at a concentration of 88 ppm, with a reaction time of 2.0 s, over a

Tamoxifen in combination with temozolomide induce a synergistic inhibition of PKC-pan in GBM cell lines.

Joana Balça-Silva et al.

Biochimica et biophysica acta, 1850(4), 722-732 (2015-01-03)

Glioblastoma (GBM) is a highly proliferative, angiogenic grade IV astrocytoma that develops resistance to the alkylating agents used in chemotherapy, such as temozolomide (TMZ), which is considered the gold standard. The mean survival time for GBM patients is approximately 12

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