Search Within
13438
Applied Filters:
Keyword:'13438'
Showing 1-30 of 886 results for "13438" within Papers
Aline Pertile Remor et al.
Molecular neurobiology, 56(3), 1539-1557 (2018-06-28)
Chronic metabolic alterations may represent a risk factor for the development of cognitive impairment, dementia, or neurodegenerative diseases. Hyperglycemia and obesity are known to imprint epigenetic markers that compromise the proper expression of cell survival genes. Here, we showed that
O Kebir et al.
Molecular psychiatry, 22(4), 512-518 (2016-04-27)
The onset of psychosis is the consequence of complex interactions between genetic vulnerability to psychosis and response to environmental and/or maturational changes. Epigenetics is hypothesized to mediate the interplay between genes and environment leading to the onset of psychosis. We
Methylation analysis of SHOX2 and RASSF1A in bronchoalveolar lavage fluid for early lung cancer diagnosis.
Minpu Ren et al.
Annals of diagnostic pathology, 27, 57-61 (2017-03-23)
Hiroko Sugawara et al.
Progress in neuro-psychopharmacology & biological psychiatry, 56, 117-121 (2014-09-10)
Epigenetic regulation may be involved in the pathophysiology of mental disorders, such as schizophrenia and bipolar disorder, and in the pharmacological action of drugs. Characterizing the epigenetic effects of drugs is an important step to optimal treatment. We performed comprehensive
Chih-Hsiung Hsu et al.
World journal of gastroenterology, 26(2), 154-167 (2020-01-29)
It is evident that current clinical criteria are suboptimal to accurately estimate patient prognosis. Studies have identified epigenetic aberrant changes as novel prognostic factors for colorectal cancer (CRC). To estimate whether a methylation gene panel in different clinical stages can
David Kingsley et al.
Virology journal, 15(1), 117-117 (2018-08-02)
Previous work indicated that an ultrashort pulse (USP) 425 nm laser is capable of inactivating murine norovirus (MNV: Virol. J. 11:20), perhaps via an impulsive stimulated Raman scattering (ISRS) mechanism, and does not substantially damage human plasma proteins (PLOS One 9:11).
Matlock A Jeffries et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(10), 2804-2815 (2014-07-02)
To perform a genome-wide DNA methylation study to identify DNA methylation changes in osteoarthritic (OA) cartilage tissue. The contribution of differentially methylated genes to OA pathogenesis was assessed by bioinformatic analysis, gene expression analysis, and histopathologic severity correlation. Genome-wide DNA
Xiao-bin Lv et al.
Scientific reports, 5, 17940-17940 (2015-12-15)
SUN2, a key component of LINC (linker of nucleoskeleton and cytoskeleton) complex located at the inner nuclear membrane, plays unknown role in lung cancer. We found that SUN2 expression was decreased in lung cancer tissue compared with paired normal tissues
Guan-di Chen et al.
Cell biochemistry and function, 35(8), 488-496 (2017-11-17)
Cervical cancer is one of the most common malignancies of the female reproductive system. Therefore, it is critical to investigate the molecular mechanisms involved in the development and progression of cervical cancer. In this study, we stimulated cervical cancer cells
Ruiping Zhang et al.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 38(12), 2153-2164 (2017-10-06)
Neural tube defects (NTDs) are a complex trait associated with gene-environment interactions. Folic acid deficiency and planar cell polarity gene mutations account for some NTD cases; however, the etiology of NTDs is still little understood. In this study, in three
Tina Haase et al.
Biomolecules, 8(3) (2018-08-22)
Smoking is a major risk factor for cardiovascular diseases and has been implicated in the regulation of the G protein-coupled receptor 15 (GPR15) by affecting CpG methylation. The G protein-coupled receptor 15 is involved in angiogenesis and inflammation. An effect
Masaki Nagaya et al.
The Journal of surgical research, 227, 119-129 (2018-05-29)
The present study aimed to evaluate whether bioengineered mouse islet cell sheets can be used for the treatment of diabetes mellitus. Isolated mouse pancreatic islets were dispersed, and cells were plated on temperature-responsive culture plates coated with iMatrix-551. On day
Hiroki Nakata et al.
Journal of anatomy, 235(2), 271-280 (2019-05-31)
The aim of the present study was to clarify the detailed morphology of efferent and epididymal ducts in adult mice using three-dimensional (3D) analysis. We reconstructed efferent and epididymal ducts in three adult mice using serial paraffin sections and high-performance
Yuri An et al.
Developmental biology, 446(1), 43-55 (2018-12-12)
Teratomas are tumors consisting of components of the three germ layers that differentiate from pluripotent stem cells derived from germ cells. In the normal mouse testis, teratomas rarely form, but a deficiency in Dead-end1 (Dnd1) in mice with a 129/Sv
Feng Zeng et al.
Breast cancer research and treatment, 180(1), 237-245 (2020-01-27)
Deficiency or silence of TP53 is an early event in breast tumorigenesis. Aberrant methylation and mutation in regulatory regions were considered as crucial regulators of gene expression. Using multiplex-PCR and next-generation sequencing technology, we analyzed TP53 mutation spectrum in its
Jing Wang et al.
Animal science journal = Nihon chikusan Gakkaiho, 88(8), 1113-1119 (2016-12-08)
Castration plays a regulatory role in growth and carcass traits, particularly in fat deposition, but its molecular mechanisms are still not clear. The present study showed that castration significantly reduced the serum growth hormone and the responses of the growth
Jianming He et al.
Oncotarget, 8(40), 67670-67683 (2017-10-06)
Glucocorticoids are effective to treat lymphoma and leukemia. Their effect in colon cancer remains far from clear. Here, we found that glucocorticoid receptor (GR) α protein level was dramatically lower in colon cancer than in lymphoma. Colon cell lines LoVo
Juntao Li et al.
Cell cycle (Georgetown, Tex.), 18(16), 1965-1975 (2019-07-10)
Up to accomplishment of this study, the role of long non-coding RNAs (lncRNAs) in breast cancer has been investigated in several researches. Nevertheless, its association with the chemosensitivity of cancer was little known. Therefore, this study is focused on lncRNA
Bhavana Bhatnagar et al.
Leukemia & lymphoma, 61(2), 387-396 (2019-09-24)
Current treatment options for older and relapsed or refractory (R/R) acute myeloid leukemia (AML) patients are limited and represent an unmet need. Based on preclinical studies showing strong anti-leukemic effects in vivo, this phase I dose-escalation study assessed the safety
DNA methylation in pancreatic cancer: protocols for the isolation of DNA and bisulfite modification.
Katja Biewusch et al.
Methods in molecular biology (Clifton, N.J.), 863, 273-280 (2012-02-24)
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive tumor and still remains a challenge for its lack of effective therapeutic strategies, which is due to the late diagnosis of this disease. Methylation markers might improve early detection and surveillance of PDAC.
Yuan Gao et al.
Environmental science & technology, 53(7), 3689-3696 (2019-03-20)
Recently, it has been reported that the combination of permanganate (Mn(VII)) and bisulfite can lead to a rapid degradation of organic contaminants, where soluble Mn(III) is proposed to be responsible. Interestingly, in this work, we demonstrated the involvement of high-valent
Chien-Feng Li et al.
Molecular cancer therapeutics, 14(11), 2623-2633 (2015-09-12)
Hepatocellular carcinoma (HCC) can arise from chronic inflammation due to viral infection, organ damage, drug toxicity, or alcohol abuse. Moreover, gene desensitization via aberrant CpG island methylation is a frequent epigenetic defect in HCC. However, the details of how inflammation
Z-B Sun et al.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 26(1), 187-197 (2014-08-13)
In this study, we found out a previously undefined function of icariin which restored the dynamic balance between osteogenic and adipogenic differentiation of mesenchymal stem cells (MSCs) in patients with osteonecrosis of femoral head (ONFH) via ABCB1-promoter demethylation. These findings
Fang Han et al.
Cancer management and research, 12, 3389-3399 (2020-06-05)
Ring finger protein 180 (RNF180) is a tumor suppressor gene regulated by promoter methylation. We previously demonstrated that the RNF180 promoter methylation could be a risk factor for gastric cancer (GC); and eight high-frequency hypermethylated CpG sites were associated with
Yufeng Ma et al.
International journal of environmental research and public health, 16(14) (2019-07-25)
Human exposure to polycyclic aromatic hydrocarbons (PAHs) results in adverse health implications. However, the specific impact of paternal preconception PAHs exposure has not been fully studied. In this study, a total of 219 men aged 24-53 were recruited and an
Jung-Hye Choi et al.
The Journal of general virology, 98(11), 2786-2798 (2017-10-27)
All-trans retinoic acid (ATRA), the most biologically active metabolite of vitamin A, is known to activate p14 expression via promoter hypermethylation to induce p53-dependent apoptosis in human hepatocytes. In this study, we found that the oncogenic hepatitis B virus (HBV)
Yui Murata et al.
Progress in neuro-psychopharmacology & biological psychiatry, 99, 109855-109855 (2020-01-09)
Accumulating evidence suggests that aberrant epigenetic regulation is involved in the pathophysiology of major psychiatric disorders such as schizophrenia (SZ) and bipolar disorder (BD). We previously showed that the plasma level of betaine (N,N,N-trimethylglycine), a methyl-group donor, was significantly decreased
Heping Cui et al.
Food chemistry, 246, 442-447 (2018-01-03)
The yield of the Maillard reaction intermediate (MRI), prepared in aqueous medium, is usually unsatisfactory. However, the addition of sodium sulfite could improve the conversion of xylose-phenylalanine (Xyl-Phe) to the MRI (N-(1-deoxy-d-xylulos-1-yl)-phenylalanine) in aqueous medium. Sodium sulfite (Na
Calen P Ryan et al.
Scientific reports, 8(1), 11100-11100 (2018-07-25)
Evolutionary theory predicts that reproduction entails costs that detract from somatic maintenance, accelerating biological aging. Despite support from studies in human and non-human animals, mechanisms linking 'costs of reproduction' (CoR) to aging are poorly understood. Human pregnancy is characterized by
Miyako Yoshida et al.
Chemical & pharmaceutical bulletin, 61(1), 1-7 (2012-11-06)
The purpose of this study was to predict the stability of imipenem in a mixed infusion. The hydrolysis of imipenem in aqueous solution was found to be accelerated by pH, and by increasing concentrations of sodium bisulfite (SBS) and L-cysteine.
Page 1 of 30