136-60-7

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Showing 1-22 of 22 results for "136-60-7" within Papers

SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 1: cellular pharmacology, in vitro and initial in vivo antitumor activity.

John A Hartley et al.

Cancer research, 64(18), 6693-6699 (2004-09-18)

SJG-136 (NSC 694501) is a rationally designed pyrrolobenzodiazepine dimer that binds in the minor groove of DNA. It spans 6 bp with a preference for binding to purine-GATC-pyrimidine sequences. The agent has potent activity in the National Cancer Institute (NCI)

Discovery of Bioactive Indole-Diketopiperazines from the Marine-Derived Fungus Penicillium brasilianum Aided by Genomic Information.

Ya-Hui Zhang et al.

Marine drugs, 17(9) (2019-09-05)

Identification and analysis of the whole genome of the marine-derived fungus Penicillium brasilianum HBU-136 revealed the presence of an interesting biosynthetic gene cluster (BGC) for non-ribosomal peptide synthetases (NRPS), highly homologous to the BGCs of indole-diketopiperazine derivatives. With the aid

[Radiation protective effect of beta-ketoanalogs of hydroxyphenyl ethanolamines].

V I Kulinskiĭ et al.

Radiatsionnaia biologiia, radioecologiia, 37(6), 914-917 (1998-02-19)

Experiments are carried out on 3400 mice, irradiated in dose 8 Gy (LD97/30). beta-Ketoanalogs of adrenaline (adrenalone, 50-150 mumol/kg), m,p-dipivaloyladrenaline (20 mumol/kg) and phenylephrine (but at 2070 mumol/kg) have the high radioprotective effect (survival is 60-100%), beta-ketoanalogs of isoprenaline and

Humoral immune response to keyhole limpet haemocyanin, the protein carrier in cancer vaccines.

A Kantele et al.

Clinical & developmental immunology, 2011, 614383-614383 (2011-07-01)

Keyhole limpet haemocyanin (KLH) appears to be a promising protein carrier for tumor antigens in numerous cancer vaccine candidates. The humoral immune response to KLH was characterized at the single-cell level with ELISPOT combined with separations of cell populations according

Serum levels of G-CSF and IL-7 in Iranian breast cancer patients.

Elahe Bordbar et al.

Asian Pacific journal of cancer prevention : APJCP, 13(10), 5307-5312 (2012-12-19)

Breast cancer cells and tumor stroma produce different cytokines and soluble factors. Cytokines, while playing crucial roles in immune responses to tumors, also favour tumor growth and progression. IL-7 and G-CSF are two cytokines that may exert influences on the

Effect of oral and parenteral administration of metanil yellow on some hepatic and intestinal biochemical parameters.

S Ramchandani et al.

Journal of applied toxicology : JAT, 17(1), 85-91 (1997-01-01)

Metanil yellow, a non-permitted colour for food commodities, is used in the leather, paper and textile industries. In this paper the effect of oral and parenteral administration of Metanil yellow on hepatic and intestinal biochemical parameters was investigated. Oral administration

Impact of embryo number and maternal undernutrition around the time of conception on insulin signaling and gluconeogenic factors and microRNAs in the liver of fetal sheep.

Shervi Lie et al.

American journal of physiology. Endocrinology and metabolism, 306(9), E1013-E1024 (2014-02-06)

This study aimed to determine whether exposure of the oocyte and/or embryo to maternal undernutrition results in the later programming of insulin action in the liver and factors regulating gluconeogenesis. To do this, we collect livers from singleton and twin

Progressive change of optical coherence tomography scans in retinal degeneration slow mice.

N Horio et al.

Archives of ophthalmology (Chicago, Ill. : 1960), 119(9), 1329-1332 (2001-09-27)

To study whether optical coherence tomography (OCT) scans correlate retinal histologic findings with the progression of retinal degeneration in retinal degeneration slow (rds) mice. Sensory retinal thickness (SRT) and outer retinal thickness (ORT), representing photoreceptor cell layer, in temporal retina

Expression of CXCR-1 and CXCR-2 chemokine receptors on synovial neutrophils in inflammatory arthritides: does persistent or increasing expression of CXCR-2 contribute to the chronic inflammation or erosive changes?

Salih Pay et al.

Joint, bone, spine : revue du rhumatisme, 73(6), 691-696 (2006-09-22)

To analyze the CXCR-1 and CXCR-2 chemokine receptor expression on peripheral blood neutrophils (PBN) and synovial fluid neutrophils (SFN) of patients with rheumatoid arthritis (RA) and Behçet's disease (BD) (characterized by erosive and non-erosive arthritis, respectively), and to compare them

The effects of repeated minimal electroconvulsive shock exposure on levels of mRNA encoding fibroblast growth factor-2 and nerve growth factor in limbic regions.

A Kondratyev et al.

Neuroscience, 114(2), 411-416 (2002-09-03)

Chronic, but not acute, exposure to minimal electroconvulsive shock (ECS) has been shown to decrease vulnerability to neuronal cell death, without itself causing neuronal damage. One potential mechanism for the neuroprotective effect of ECS is the increase in fibroblast growth

Incidence and antimicrobial resistance profiling of Campylobacter in retail chicken livers and gizzards.

Aneesa Noormohamed et al.

Foodborne pathogens and disease, 9(7), 617-624 (2012-05-02)

Campylobacter species are one of the leading causes of foodborne disease in the United States. Campylobacter jejuni and Campylobacter coli are the two main species that are of concern to human health, and they cause approximately 95% of human infections.

miR-143 decreases COX-2 mRNA stability and expression in pancreatic cancer cells.

Hung Pham et al.

Biochemical and biophysical research communications, 439(1), 6-11 (2013-08-27)

Small non-coding RNAs, microRNAs (miRNA), inhibit the translation or accelerate the degradation of message RNA (mRNA) by targeting the 3'-untranslated region (3'-UTR) in regulating growth and survival through gene suppression. Deregulated miRNA expression contributes to disease progression in several cancers

In vitro and in vivo assays for studying histone ubiquitination and deubiquitination.

Heui-Yun Joo et al.

Methods in molecular biology (Clifton, N.J.), 1288, 213-230 (2015-04-02)

Posttranslational histone modifications play important roles in regulating chromatin structure and function (Rando, Curr Opin Genet Dev 22:148-155, 2012; Zentner and Henikoff, Nat Struct Mol Biol 20:259-266, 2013). One example of such modifications is histone ubiquitination, which occurs predominately on

Antibodies directed to protein S in patients with systemic lupus erythematosus: prevalence and clinical significance.

Maria Laura Bertolaccini et al.

Thrombosis and haemostasis, 90(4), 636-641 (2003-09-30)

Antibodies directed against protein S (anti-ProtS) may be involved in the development of thrombosis in patients with the antiphospholipid syndrome. We assessed the prevalence and clinical significance of anti-ProtS and evaluated their immunological characteristics in 184 patients with SLE and

High-resolution solution structure of the inhibitor-free catalytic fragment of human fibroblast collagenase determined by multidimensional NMR.

F J Moy et al.

Biochemistry, 37(6), 1495-1504 (1998-03-04)

The high-resolution solution structure of the inhibitor-free catalytic fragment of human fibroblast collagenase (MMP-1), a protein of 18.7 kDa, which is a member of the matrix metalloproteinase family, has been determined using three-dimensional heteronuclear NMR spectroscopy. A total of 30

Decreased cGMP level contributes to increased contraction in arteries from hypertensive rats: role of phosphodiesterase 1.

Fernanda R Giachini et al.

Hypertension (Dallas, Tex. : 1979), 57(3), 655-663 (2011-02-02)

Recent evidence suggests that angiotensin II (Ang II) upregulates phosphodiesterase (PDE) 1A expression. We hypothesized that Ang II augmented PDE1 activation, decreasing the bioavailability of cyclic guanosine 3' 5'-monophosphate (cGMP), and contributing to increased vascular contractility. Male Sprague-Dawley rats received

Finding a suitable library size to call variants in RNA-Seq.

Anna Quaglieri et al.

BMC bioinformatics, 21(1), 553-553 (2020-12-03)

RNA sequencing allows the study of both gene expression changes and transcribed mutations, providing a highly effective way to gain insight into cancer biology. When planning the sequencing of a large cohort of samples, library size is a fundamental factor

ACE gene polymorphism in children with nephrotic syndrome in the Indonesian population.

Teguh Haryo Sasongko et al.

The Kobe journal of medical sciences, 51(3-4), 41-47 (2006-01-20)

The angiotensin converting enzyme (ACE) gene carries insertion (I) and deletion (D) polymorphism within its intron 16. The presence of D-allele in the ACE gene has been reported as a probable genetic risk factor for idiopathic nephrotic syndrome (INS), especially

The influence of G-protein beta3-subunit gene and endothelial nitric oxide synthase gene in exon 7 polymorphisms on progression of autosomal dominant polycystic kidney disease.

J Reiterová et al.

Renal failure, 26(2), 119-125 (2004-08-04)

A significant phenotypical variability is observed in autosomal dominant polycystic kidney disease (ADPKD). The variability cannot be fully explained by the genetic heterogeneity of the disease. We examined the influence of G-protein beta3-subunit C825T polymorphism and endothelial nitric oxide synthase

Expression analysis of kidney-specific cadherin in a wide spectrum of traditional and newly recognized renal epithelial neoplasms: diagnostic and histogenetic implications.

Adam Kuehn et al.

The American journal of surgical pathology, 31(10), 1528-1533 (2007-09-27)

Kidney-specific cadherin (Ksp-cad) is a membrane-associated cell adhesion glycoprotein expressed by the distal nephron tubular cells in its later developmental stages. Chromophobe renal cell carcinoma and renal oncocytoma are reported to be variably positive for Ksp-cad with some studies suggesting

Efficacy and Safety of Durvalumab in Locally Advanced or Metastatic Urothelial Carcinoma: Updated Results From a Phase 1/2 Open-label Study.

Thomas Powles et al.

JAMA oncology, 3(9), e172411-e172411 (2017-08-18)

The data reported herein were accepted for assessment by the US Food and Drug Administration for Biologics License Application under priority review to establish the clinical benefit of durvalumab as second-line therapy for locally advanced or metastatic urothelial carcinoma (UC)

Neoadjuvant carboplatin in patients with triple-negative and HER2-positive early breast cancer (GeparSixto; GBG 66): a randomised phase 2 trial.

Gunter von Minckwitz et al.

The Lancet. Oncology, 15(7), 747-756 (2014-05-06)

Preclinical data suggest that triple-negative breast cancers are sensitive to interstrand crosslinking agents, and that synergy may exist for the combination of a taxane, trastuzumab, and a platinum salt for HER2-positive breast cancer. We therefore aimed to assess the efficacy

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