137-17-7

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Showing 1-16 of 16 results for "137-17-7" within Papers

Quantitative trait locus mapping of airway responsiveness to chromosomes 6 and 7 in inbred mice.

G T De Sanctis et al.

The American journal of physiology, 277(6 Pt 1), L1118-L1123 (1999-12-22)

Quantitative trait locus (QTL) mapping was used to identify chromosomal regions contributing to airway hyperresponsiveness in mice. Airway responsiveness to methacholine was measured in A/J and C3H/HeJ parental strains as well as in progeny derived from crosses between these strains.

A sequence variation scan of the coagulation factor VIII (FVIII) structural gene and associations with plasma FVIII activity levels.

Kevin R Viel et al.

Blood, 109(9), 3713-3724 (2007-01-09)

Plasma factor VIII coagulant activity (FVIII:C) level is a highly heritable quantitative trait that is strongly correlated with thrombosis risk. Polymorphisms within only 1 gene, the ABO blood-group locus, have been unequivocally demonstrated to contribute to the broad population variability

A Role of Caveolae in Trabecular Meshwork Mechanosensing and Contractile Tone.

Michael L De Ieso et al.

Frontiers in cell and developmental biology, 10, 855097-855097 (2022-04-05)

Polymorphisms in the CAV1/2 gene loci impart increased risk for primary open-angle glaucoma (POAG). CAV1 encodes caveolin-1 (Cav1), which is required for biosynthesis of plasma membrane invaginations called caveolae. Cav1 knockout mice exhibit elevated intraocular pressure (IOP) and decreased outflow

Clinical features predictive of high-risk retinoblastoma in 403 Asian Indian patients: a case-control study.

Swathi Kaliki et al.

Ophthalmology, 122(6), 1165-1172 (2015-04-07)

To identify the clinical features predictive of high-risk retinoblastoma on histopathology. Case-control study. A total of 145 cases with histopathologic high-risk features of retinoblastoma and 258 controls without high-risk features. Enucleation and adjuvant chemotherapy. High-risk features on histopathology were defined

[Relationship of epidermal growth factor receptor gene mutations, clinicopathologic features and prognosis in patients with non-small cell lung cancer].

Miao-jing Fan et al.

Zhonghua bing li xue za zhi = Chinese journal of pathology, 40(10), 679-682 (2012-02-11)

To investigate epidermal growth factor receptor (EGFR) gene mutations in exons 19 and 21 of patients with non-small cell lung cancer (NSCLC) and to analyze the relationship of EGFR mutations with clinicopathological features and prognosis. The EGFR gene exons 19

Mass spectrometric determination of disulfide bonds in the biologically active recombinant HBx protein of hepatitis B virus.

Kaveri Sidhu et al.

Biochemistry, 53(28), 4685-4695 (2014-06-28)

Many proteins rely on disulfide bonds formed between pairs of cysteines for the stability of their folded state and to keep regulatory control over their functions. The hepatitis B virus-encoded HBx oncoprotein is known to perform an overwhelming array of

Neonatal Isoflurane Anesthesia or Disruption of Postsynaptic Density-95 Protein Interactions Change Dendritic Spine Densities and Cognitive Function in Juvenile Mice.

Michele L Schaefer et al.

Anesthesiology, 133(4), 812-823 (2020-08-11)

Experimental evidence shows postnatal exposure to anesthesia negatively affects brain development. The PDZ2 domain, mediating protein-protein interactions of the postsynaptic density-95 protein, serves as a molecular target for several inhaled anesthetics. The authors hypothesized that early postnatal disruption of postsynaptic

Activation of the brain melanocortin system is required for leptin-induced modulation of chemorespiratory function.

M Bassi et al.

Acta physiologica (Oxford, England), 213(4), 893-901 (2014-09-11)

Melanocortin receptors (MC3/4R) mediate most of the metabolic and cardiovascular actions of leptin. Here, we tested if MC4R also contributes to leptin's effects on respiratory function. After control measurements, male Holtzman rats received daily microinjections of leptin, SHU9119 (MC3/4R antagonist)

Prognostic significance of p53 codon 72 polymorphism differs with race in colorectal adenocarcinoma.

Venkat R Katkoori et al.

Clinical cancer research : an official journal of the American Association for Cancer Research, 15(7), 2406-2416 (2009-04-03)

Several studies have examined the prognostic value of the codon 72 polymorphism of the p53 gene in colorectal adenocarcinoma, but none have addressed patient race/ethnicity. Therefore, this study assessed the prognostic value of this polymorphism in African American and Caucasian

[Characteristics of the airway inflammation and the relationship to interleukin-17 in severe asthma].

Qing-tao Zhou et al.

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 28(9), 630-634 (2005-10-07)

To investigate the characteristics of airway inflammation in severe asthma and the association with interleukin-17 (IL-17). Sixteen patients with mild persistent asthma, 14 patients with moderate persistent asthma and 18 patients with severe persistent asthma, as well as 15 normal

Genomic Predictors of Brisk Walking Are Associated with Elite Sprinter Status.

João Paulo L F Guilherme et al.

Genes, 13(10) (2022-10-28)

Brisk walkers are physically more active, taller, have reduced body fat and greater physical fitness and muscle strength. The aim of our study was to determine whether genetic variants associated with increased walking pace were overrepresented in elite sprinters compared

[Methyl-CpG-binding protein 2 gene and CDKL5 gene mutation in patients with Rett syndrome: analysis of 177 Chinese pediatric patients].

Mei-rong Li et al.

Zhonghua yi xue za zhi, 89(4), 224-229 (2009-06-26)

To study the spectrum of mutations in methyl-CpG-binding protein 2 gene (MECP2) and cyclin-dependent kinase-like 5 gene (CDKL5) in Chinese pediatric patients with Rett syndrome (RTT), and establish a simple, quick, and efficient gene test method as well as screen

Laser capture microdissection coupled mass spectrometry (LCM-MS) for spatially resolved analysis of formalin-fixed and stained human lung tissues.

Jeremy A Herrera et al.

Clinical proteomics, 17, 24-24 (2020-06-23)

Haematoxylin and eosin (H&E)-which respectively stain nuclei blue and other cellular and stromal material pink-are routinely used for clinical diagnosis based on the identification of morphological features. A richer characterization can be achieved by laser capture microdissection coupled to mass

Distribution of keratins in normal endothelial cells and a spectrum of vascular tumors: implications in tumor diagnosis.

M Miettinen et al.

Human pathology, 31(9), 1062-1067 (2000-10-03)

Vascular endothelial cells are specialized mesenchyme-derived epithelial-like lining cells which are the essential participants in benign and malignant vascular tumors. Although endothelia in lower animals often express keratins (K), human endothelia are generally K negative and vimentin-positive. However, K expression

Orteronel plus prednisone in patients with chemotherapy-naive metastatic castration-resistant prostate cancer (ELM-PC 4): a double-blind, multicentre, phase 3, randomised, placebo-controlled trial.

Fred Saad et al.

The Lancet. Oncology, 16(3), 338-348 (2015-02-24)

Orteronel is an investigational, partially selective inhibitor of CYP 17,20-lyase in the androgen signalling pathway, a validated therapeutic target for metastatic castration-resistant prostate cancer. We assessed orteronel in chemotherapy-naive patients with metastatic castration-resistant prostate cancer. In this phase 3, double-blind

Neoadjuvant carboplatin in patients with triple-negative and HER2-positive early breast cancer (GeparSixto; GBG 66): a randomised phase 2 trial.

Gunter von Minckwitz et al.

The Lancet. Oncology, 15(7), 747-756 (2014-05-06)

Preclinical data suggest that triple-negative breast cancers are sensitive to interstrand crosslinking agents, and that synergy may exist for the combination of a taxane, trastuzumab, and a platinum salt for HER2-positive breast cancer. We therefore aimed to assess the efficacy

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