13767

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Showing 1-12 of 12 results for "13767" within Papers

Holger Erfle et al.

Methods in molecular biology (Clifton, N.J.), 785, 277-287 (2011-09-09)

Endocytosis is one of the most essential cellular processes, which enables cells to internalise diverse -material. It is crucial for regulation of receptor activity and signalling, cell polarisation, attachment and motility, and a great number of other cellular functions. A

Kynurenine regulates NLRP2 inflammasome in astrocytes and its implications in depression.

Qingyu Zhang et al.

Brain, behavior, and immunity, 88, 471-481 (2020-04-14)

Increased kynurenine (Kyn) metabolized from tryptophan (Try) is a biomarker in the immune dysfunction of depression. However, the mechanism by which Kyn change promotes depression is poorly defined. Astrocytes are involved in the neuroinflammation of depression. Among the numerous inflammatory

Preparation of xylenol orange functionalized silica gel as a selective solid phase extractor and its application for preconcentration?separation of mercury from waters

Fan J, et al.

Journal of Hazardous Materials, 145(1), 323-330 (2007)

Work flow for multiplexing siRNA assays by solid-phase reverse transfection in multiwell plates.

Holger Erfle et al.

Journal of biomolecular screening, 13(7), 575-580 (2008-07-05)

Solid-phase reverse transfection on cell microarrays is a high-throughput method for the parallel transfection of mammalian cells. However, the cells transfected in this way have been restricted so far to microscopy-based analyses. Analysis methods such as reverse transcriptase-polymerase chain reaction

Reverse transfection on cell arrays for high content screening microscopy.

Holger Erfle et al.

Nature protocols, 2(2), 392-399 (2007-04-05)

Here, we describe a robust protocol for the reverse transfection of cells on small interfering (siRNA) arrays, which, in combination with multi-channel immunofluorescence or time-lapse microscopy, is suitable for genome-wide RNA interference (RNAi) screens in intact human cells. The automatic

Leonurine Exerts Antidepressant-Like Effects in the Chronic Mild Stress-Induced Depression Model in Mice by Inhibiting Neuroinflammation.

Miaomiao Jia et al.

The international journal of neuropsychopharmacology, 20(11), 886-895 (2017-10-11)

Leonurine is an active alkaloid that is extracted from Traditional Chinese Medicine Herba leonuri. Emerging evidence indicates that leonurine produces neuroprotective effects in ischemic stroke, Parkinson's disease, and Alzheimer's disease. However, the effect of leonurine in neuropsychiatric disorders, especially in

Metal ion enrichment with Amberlite XAD-2 functionalized with Tiron: analytical applications

Kumar M, et al.

Analyst, 125(6), 1221-1226 (2000)

Texture analysis of protein deposits produced by droplet evaporation.

Yojana J P Carreón et al.

Scientific reports, 8(1), 9580-9580 (2018-06-27)

The deposit patterns derived from droplet evaporation allow current development of medical tests and new strategies for diagnostic in patients. For such purpose, the development and implementation of algorithms capable of characterizing and differentiating deposits are crucial elements. We report

Metformin improves depressive-like symptoms in mice via inhibition of peripheral and central NF-κB-NLRP3 inflammation activation.

Ren-Wei Du et al.

Experimental brain research, 238(11), 2549-2556 (2020-09-02)

Emerging evidence indicates that NLRP3 inflammasome-induced inflammation plays a crucial role in the pathogenesis of depression. Thus, inhibition of NLRP3 inflammasome activation may offer a therapeutic benefit in the treatment of depression. Metformin has been shown to have potential anti-inflammatory

Drd2 biased agonist prevents neurodegeneration against NLRP3 inflammasome in Parkinson's disease model via a β-arrestin2-biased mechanism.

Jialei Zhu et al.

Brain, behavior, and immunity, 90, 259-271 (2020-08-31)

Activated astrocytes secrete inflammatory cytokines such as interleukin-1β (IL-1β) into the extracellular milieu, damaging surrounding neurons and involving in the pathogenesis of neurodegenerative diseases, such as Parkinson's disease (PD). Dopamine receptor D2 (Drd2) expresses both in neurons and astrocytes, and

Dopamine D2 receptor restricts astrocytic NLRP3 inflammasome activation via enhancing the interaction of β-arrestin2 and NLRP3.

Jialei Zhu et al.

Cell death and differentiation, 25(11), 2037-2049 (2018-05-23)

Astrocytes are involved in the neuroinflammation of neurodegenerative diseases, such as Parkinson's disease (PD). Among the numerous inflammatory cytokines, interleukin-1β (IL-1β) produced by astrocytic Nod-like receptor protein (NLRP) inflammasome is crucial in the pathogenesis of PD. β-arrestin2-mediated dopamine D2 receptor

Disulfide cross-links reveal conserved features of DNA topoisomerase I architecture and a role for the N terminus in clamp closure.

Komaraiah Palle et al.

The Journal of biological chemistry, 283(41), 27767-27775 (2008-08-12)

In eukaryotes, DNA topoisomerase I (Top1) catalyzes the relaxation of supercoiled DNA by a conserved mechanism of transient DNA strand breakage, rotation, and religation. The unusual architecture of the monomeric human enzyme comprises a conserved protein clamp, which is tightly

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