139742

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Phenethyl isothiocyanate suppresses receptor activator of NF-kappaB ligand (RANKL)-induced osteoclastogenesis by blocking activation of ERK1/2 and p38 MAPK in RAW264.7 macrophages.

Akira Murakami et al.

BioFactors (Oxford, England), 30(1), 1-11 (2008-01-17)

Osteoclastogenesis is induced by differentiation of hemopoietic cells of monocyte-macrophage lineage into bone-resorbing osteoclasts. The process is initiated by receptor activator of NF-kappaB ligand (RANKL) and resultant activation of mitogen-activated protein kinases (MAPK), including extracellular signal-regulated kinase (ERK)1/2, as well

Pathway and time-resolved benzo[a]pyrene toxicity on Hepa1c1c7 cells at toxic and subtoxic exposure.

Stefan Kalkhof et al.

Journal of proteome research, 14(1), 164-182 (2014-11-05)

Benzo[a]pyrene (B[a]P) is an environmental contaminant mainly studied for its toxic/carcinogenic effects. For a comprehensive and pathway orientated mechanistic understanding of the effects directly triggered by a toxic (5 μM) or a subtoxic (50 nM) concentration of B[a]P or indirectly

UV-visible and (1)H-(15)N NMR spectroscopic studies of colorimetric thiosemicarbazide anion sensors.

Kristina N Farrugia et al.

Organic & biomolecular chemistry, 13(6), 1662-1672 (2014-12-03)

Four model thiosemicarbazide anion chemosensors containing three N-H bonds, substituted with phenyl and/or 4-nitrophenyl units, were synthesised and studied for their anion binding abilities with hydroxide, fluoride, acetate, dihydrogen phosphate and chloride. The anion binding properties were studied in DMSO

Integration of high accuracy N-terminus identification in peptide sequencing and comparative protein analysis via isothiocyanate-based isotope labeling reagent with ESI ion-trap TOF MS.

Jiapeng Leng et al.

Journal of the American Society for Mass Spectrometry, 22(7), 1204-1213 (2011-09-29)

A multifunctional isothiocyanate-based isotope labeling reagent, [d (0)]-/[d (6)]-4,6-dimethoxy pyrimidine-2-isothiocyanate (DMPITC), has been developed for accurate N-terminus identification in peptide sequencing and comparative protein analysis by ESI Ion-trap TOF mass spectrometry. In contrast with the conventional labeling reagent phenyl isothiocyanate

A synthetic decursin analog with increased in vivo stability suppresses androgen receptor signaling in vitro and in vivo.

Yong Zhang et al.

Investigational new drugs, 30(5), 1820-1829 (2011-08-27)

Targeting androgen receptor (AR) signaling with agents distinct from current antagonist drugs remains a rational approach to the prevention and treatment of prostate cancer (PCa). Our previous studies have shown that decursin and isomer decursinol angelate (DA), isolated from the

Pharmacokinetics of tranexamic acid in neonates, infants, and children undergoing cardiac surgery with cardiopulmonary bypass.

Mark C Wesley et al.

Anesthesiology, 122(4), 746-758 (2015-01-15)

Tranexamic acid (TXA) is one of the most commonly used antifibrinolytic medications in children undergoing repair of congenital heart defects. However, a pharmacokinetics analysis of TXA has never been performed in neonates or young children undergoing complex cardiac surgeries using

Developing structure-activity relationships for the prediction of hepatotoxicity.

Nigel Greene et al.

Chemical research in toxicology, 23(7), 1215-1222 (2010-06-18)

Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential

Removal of N-terminal blocking groups from proteins.

Joseph W Leone et al.

Current protocols in protein science, Chapter 11, Unit11-Unit11 (2011-03-15)

Two enzymatic methods commonly used in N-terminal sequence analysis of blocked proteins are presented: one uses pyroglutamate aminopeptidase for N(α)-pyrrolidone carboxyl-proteins in solution or blotted onto a membrane, and the other uses acylaminoacyl-peptide hydrolase for N(α)-acyl-proteins blocked with other acyl

Organic bulk heterojunction photovoltaic devices based on polythiophene-graphene composites.

Minas M Stylianakis et al.

ACS applied materials & interfaces, 4(9), 4864-4870 (2012-08-18)

A solution-processed graphene content was synthesized by treatment of graphite oxide (GO) with phenyl isothiocyanate (PITC) by taking advantage of the functional carboxyl groups of graphene oxide. The GO was prepared by the oxidation of natural graphite powder and was

Catalytic behaviour in the ring-opening polymerisation of organoaluminiums supported by bulky heteroscorpionate ligands.

Jose A Castro-Osma et al.

Dalton transactions (Cambridge, England : 2003), 44(27), 12388-12400 (2014-12-24)

A series of alkyl organoaluminium complexes based on bulky heteroscorpionate ligands were designed as catalysts for the ring-opening polymerisation of cyclic esters. Thus, the treatment of AlX3 (X = Me, Et) with bulky acetamide or thioacetamide heteroscorpionate ligands nbptamH (1)

Synthesis of a molecularly imprinted polymer to isolate glucosamine from plant extracts by an ionic-non-covalent dual approach.

N Henry et al.

International journal of cosmetic science, 37(2), 196-206 (2014-11-18)

The objective of this study was to synthesize a novel glucosamine-imprinted sorbent based on ionic and non-covalent dual approach to purify glucosamine from chicory root extracts. The synthesis of the molecularly imprinted polymer was optimized in terms of choice of

The anti-inflammatory secoiridoid glycosides from gentianae scabrae radix: the root and rhizome of Gentiana scabra.

Yu-Min He et al.

Journal of natural medicines, 69(3), 303-312 (2015-03-10)

Gentianae Scabrae Radix is a well-known traditional medicine that is used for the treatment of hepatitis, cholecystitis and inflammatory diseases. It consists mainly of secoiridoid glycosides, with representatives of gentiopicroside, sweroside and swertiamarin. In the present study, a chemical investigation

Combining [13C6]-phenylisothiocyanate and the Edman degradation reaction: a possible breakthrough for absolute quantitative proteomics together with protein identification.

Tomoyuki Oe et al.

Rapid communications in mass spectrometry : RCM, 24(2), 173-179 (2009-12-17)

This manuscript describes the results of a preliminary experiment performed as 'proof of concept' of a novel approach to absolute quantitation of proteins without the use of standard proteins. Absolute quantitation remains a challenging issue in the proteomics field. Therefore

Removal of N-terminal blocking groups from proteins.

E Fowler et al.

Current protocols in protein science, Chapter 11, Unit 11-Unit 11 (2008-04-23)

Two enzymatic methods commonly used in N-terminal sequence analysis of blocked proteins are presented in this unit; one uses pyroglutamate aminopeptidase for N(alpha)-pyrrolidone carboxyl-proteins in solution or blotted onto a membrane, and the other uses acylaminoacyl-peptide hydrolase for N(alpha)-acyl-proteins blocked

Inhibition of endothelial cell differentiation and proinflammatory cytokine production during angiogenesis by allyl isothiocyanate and phenyl isothiocyanate.

P Thejass et al.

Integrative cancer therapies, 6(4), 389-399 (2007-12-01)

Angiogenesis is a crucial step in the growth and metastasis of cancers. The activation of endothelial cells and their further behavior are very critical during angiogenesis. The authors analyze the effect of allyl isothiocyanate (AITC) and phenyl isothiocyanate (PITC) on

Development of a method for the determination of glycine in human cerebrospinal fluid using pre-column derivatization and LC-MS/MS.

Sarah F Wilson et al.

Journal of pharmaceutical and biomedical analysis, 56(2), 315-323 (2011-06-21)

An LC-MS/MS method using pre-column derivatization with phenylisothiocyanate (PITC) was developed to quantify glycine in human cerebrospinal fluid (CSF) and applied to the determination of glycine in human samples collected during clinical testing. The calibration curve range for the assay

A predictive ligand-based Bayesian model for human drug-induced liver injury.

Sean Ekins et al.

Drug metabolism and disposition: the biological fate of chemicals, 38(12), 2302-2308 (2010-09-17)

Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predictive in vivo, in vitro, and in silico models to identify compounds

Implication of novel thiazolo-thiophene derivative (MCD-KV-10) for management of asthma.

Dhiraj Patil et al.

Journal of enzyme inhibition and medicinal chemistry, 30(2), 229-239 (2014-06-19)

Asthma is multifaceted disease where many targets contribute towards its development and progression. Among these, adenosine receptor subtypes play a major role. MCD-KV-10, a novel thiazolo-thiophene was designed and evaluated pre-clinically for its implication in management of asthma. This compound

Characterization of amino acids in silk sericin protein from Gonometa rufobrunnae by MEKC with phenyl isothiocyanate derivatization.

Simiso Dube et al.

Journal of separation science, 29(9), 1245-1250 (2006-07-13)

An MEKC method was developed for the separation and characterization of phenyl-isothiocyanate (PITC)-labeled amino acids derived from Gonometa rufobrunnae silkworm after microdialysis sample cleanup. The influence of the buffer and SDS concentration on the resolution of the amino acids was

Allyl isothiocyanate induces replication-associated DNA damage response in NSCLC cells and sensitizes to ionizing radiation.

Kaushlendra Tripathi et al.

Oncotarget, 6(7), 5237-5252 (2015-03-07)

Allyl isothiocyanate (AITC), a constituent of many cruciferous vegetables exhibits significant anticancer activities in many cancer models. Our studies provide novel insights into AITC-induced anticancer mechanisms in human A549 and H1299 non-small cell lung cancer (NSCLC) cells. AITC exposure induced

PEGylation of human serum albumin: reaction of PEG-phenyl-isothiocyanate with protein

Meng F, et al.

Bioconjugate Chemistry, 19(7), 1352-1360 (2008)

Determination of theanine in commercial tea by liquid chromatography with fluorescence and diode array ultraviolet detection.

R Thippeswamy et al.

Journal of agricultural and food chemistry, 54(19), 7014-7019 (2006-09-14)

Two liquid chromatographic methods that involve precolumn derivatization with o-phthaladehyde (OPA) and phenylisothiocyanate (PITC) with fluorescence and diode array UV detection for the determination of theanine have been developed. The chromatographic separations were achieved by reverse-phase high-performance liquid chromatography using

A systematic, comparative study on the beneficial health components and antioxidant activities of commercially fermented soy products marketed in China.

Lu Xu et al.

Food chemistry, 174, 202-213 (2014-12-23)

The objectives of this study are to systematically assess the bioactive substances and overall antioxidant capacities of commercially fermented soy products and to find the relationships between the presence of beneficial components in different types of soybean fermented products. The

Subfemtomole level protein sequencing by Edman degradation carried out in a microfluidic chip.

Wenzhang Chen et al.

Chemical communications (Cambridge, England), (24)(24), 2488-2490 (2007-06-15)

A novel microfluidic chip based Edman degradation system is developed, in which Edman degradation can be carried out with peptide at a subfemtomole level; combined with MALDI-TOF-MS detection, the identification specificity of gel-separated protein in low abundance has been drastically

Cardiac taurine and principal amino acids in right and left ventricles of patients with either aortic valve stenosis or coronary artery disease: the importance of diabetes and gender.

Martin Lewis et al.

SpringerPlus, 3, 523-523 (2014-10-04)

Free intracellular taurine and principal α-amino acids (glutamate, glutamine, aspartate, asparagine and alanine) are abundant in human heart. They are cellular regulators and their concentration can change in response to disease and cardiac insults and have been shown to differ

Irreversible binding of a novel phenylisothiocyanate tropane analog to monoamine transporters in rat brain.

Vishakantha Murthy et al.

Biochemical pharmacology, 74(2), 336-344 (2007-06-02)

Irreversible tropane analogs have been useful in identifying binding sites of cocaine on biogenic amine transporters, including transporters for dopamine (DAT), serotonin (SERT) and norepinephrine (NET). The present study characterizes the properties of the novel phenylisothiocyanate tropane HD-205, synthesized from

Investigation of dendriplexes by ion mobility-mass spectrometry.

Emma-Dune Leriche et al.

Molecules (Basel, Switzerland), 19(12), 20731-20750 (2014-12-17)

Highly branched polyamidoamine (PAMAM) dendrimers presenting biological activities have been envisaged as non-viral gene delivery vectors. They are known to associate with nucleic acid (DNA) in non-covalent complexes via electrostatic interactions. Although their transfection efficiency has been proved, PAMAMs present

A New Reactive 1,8-Naphthalimide Derivative for Highly Selective and Sensitive Detection of Hg

Feng Lv et al.

Journal of fluorescence, 27(4), 1285-1292 (2017-03-28)

A 1,8-naphthalimide derivative with a reactive aliphatic hydroxyl was designed and synthesized as a fluorescent probe. Its structure was characterized by IR

Improvement in isolation and identification of food-derived peptides in human plasma based on precolumn derivatization of peptides with phenyl isothiocyanate.

Misako Aito-Inoue et al.

Journal of agricultural and food chemistry, 54(15), 5261-5266 (2006-07-20)

For the isolation and detection of food-derived peptides in blood, an approach based on the derivatization of peptides with phenyl isothiocyanate (PITC) was developed. This approach allows hydrophilic peptides to be resolved and specifically detected by reversed-phase (RP) HPLC. For

Characterization of Jamaican agro-industrial wastes. Part I: characterization of amino acids using HPLC: pre-column derivatization with phenylisothiocyanate.

Y A Bailey-Shaw et al.

Journal of chromatographic science, 47(8), 674-680 (2009-09-24)

Jamaican agro-industries generate large quantities of wastes, which are either discarded or under-utilized. In order to evaluate the possible utilization of these wastes, it is necessary that the profiles of the major biochemical groups be developed. This paper describes the

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