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Showing 1-30 of 56 results for "141-24-2" within Papers
Diana M Morales-Prieto et al.
American journal of reproductive immunology (New York, N.Y. : 1989), 66 Suppl 1, 57-62 (2011-07-08)
Starting from the peri-implantation period, leukemia inhibitory factor (LIF) is a major regulator of trophoblast functions. Micro-RNAs (miRNA) are short non-coding RNA sequences, which regulate expression of genes at post-transcriptional level. The influence of LIF on miRNA expression in trophoblastic
M T M van Jaarsveld et al.
Oncogene, 32(36), 4284-4293 (2012-10-10)
Epithelial ovarian cancer is the most lethal gynecological malignancy in the Western world. A major impediment for the successful treatment is the development of drug resistance. The molecular processes that contribute to resistance have been extensively studied; however, there is
K L Moulder et al.
Journal of neurochemistry, 72(3), 1069-1080 (1999-02-26)
The apolipoprotein E (apoE)-derived peptide (141-155)2 has a neurotoxic effect, implying that apoE itself could be a source of toxicity in Alzheimer's disease brain. We characterized the toxicity of this peptide on superior cervical ganglion (SCG) neurons and compared the
C-W Pyo et al.
Tissue antigens, 63(4), 376-377 (2004-03-11)
We report here a new HLA-B*56 allele, B*560502, identified by sequencing-based typing in the Korean population. HLA-B*560502 differs from B*560501 by a single nucleotide at position 141 in exon 2 (T(r)C). This single nucleotide substitution may not result in an
Shunichi Toki et al.
Histopathology, 73(4), 645-652 (2018-06-20)
Ewing sarcoma is a small round cell tumour that affects bone and soft tissues. Although the detection of the specific fusion gene is a robust method of its diagnosis, immunohistochemistry may serve as a practical surrogate. Recent tissue microarray studies
K S Blum et al.
Vox sanguinis, 97(1), 69-76 (2009-03-27)
The genes encoding the Fcgamma receptors (FcgammaR) IIIa and IIIb (FCGR3A and FCGR3B) are clustered on chromosome 1 band q23-24 and exhibit allelic polymorphism. We investigated the molecular basis of additional new FCGR3 genomic variation. A segment shared by FCGR3A
Rodolfo Assis Lisboa et al.
In vitro cellular & developmental biology. Animal, 45(10), 614-621 (2009-09-18)
Orthodontic force compresses the periodontal ligament promoting the expression of pro-inflammatory mediators and matrix metalloproteinases responsible for tooth movement. The extent in time while periodontal cells are being treated and the increment in the amount of mechanical stress caused by
Markus Riegersperger et al.
Transplantation, 95(11), 1338-1345 (2013-04-19)
Endothelial progenitor cell (EPC) counts are proposed surrogate markers for vascular function and cardiovascular risk. The effect of tacrolimus (TAC) on EPC is unknown. In this randomized controlled trial, we assigned 148 stable long-term kidney transplant recipients (KTR) to maintaining
Parco M Siu et al.
Life sciences, 84(13-14), 468-481 (2009-03-24)
Apoptotic signaling proteins were evaluated in postmitotic skeletal myotubes to test the hypothesis that oxidative stress induced by H(2)O(2) activates both caspase-dependent and caspase-independent apoptotic proteins in differentiated C2C12 myotubes. We hypothesized that oxidative stress would decrease anti-apoptotic protein levels
Marina Lanciotti Campanini et al.
Hormones & cancer, 1(4), 187-196 (2010-01-01)
Genes involved in formation/development of the adenohypophysis, CTNNB1 gene, and microRNAs might be implicated in the craniopharyngioma pathogenesis. The objective of this study is to perform the molecular analysis of HESX1, PROP1, POU1F1, and CTNNB1 genes and evaluate a panel
Kevin J Harrington et al.
The Lancet. Oncology, 18(8), 1104-1115 (2017-06-28)
Patients with platinum-refractory recurrent or metastatic squamous cell carcinoma of the head and neck have few treatment options and poor prognosis. Nivolumab significantly improved survival of this patient population when compared with standard single-agent therapy of investigator's choice in Checkmate
Patrick T Fueger et al.
The Journal of physiology, 566(Pt 2), 533-541 (2005-05-10)
Hexokinase (HK) II content is elevated in fatigue resistant muscle fibres and exercise trained muscle. The aim of this study was to determine if exercise capacity is dependent on muscle HK protein content. C57Bl/6 mice with a 50% HK knockout
F C Wardenaar et al.
The British journal of nutrition, 114(12), 2083-2092 (2015-10-06)
Information on dietary composition is vitally important for elite athletes to optimise their performance and recovery, which requires valid tools. The aim of the present study was to investigate the validity of assessing protein intake using three web-based 24-h recalls
Wenxia Jiang et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(8), 2988-2994 (2013-04-23)
The membrane receptor TCblR/CD320 binds transcobalamin (TC) saturated with vitamin B12 [cobalamin (Cbl)] and mediates cellular uptake of the vitamin. The specificity of TC for Cbl and of the receptor for TC-Cbl ensures efficient uptake of Cbl into cells. The
Chantal Henry et al.
BMC psychiatry, 13, 79-79 (2013-03-21)
One of the major issues in clinical practice is the accurate differential diagnosis between mixed states and depression, often leading to inappropriate prescriptions of antidepressants in mixed states, and as a consequence, increasing the risk of manic switch and suicide.
Rama D Mittal et al.
Scandinavian journal of gastroenterology, 40(7), 827-831 (2005-08-20)
An association between polymorphism in the gene coding for the anti-inflammatory cytokine interleukin-1-receptor antagonist (IL-1Ra) and ulcerative colitis (UC) has been reported. To date, there is no report from India confirming this association. In the present study the aim was
C Darke et al.
Tissue antigens, 57(5), 478-480 (2001-09-15)
A new HLA-B allele - B*4903 - was detected by the polymerase chain reaction using sequence-specific priming (PCR-SSP), in a Caucasoid bone marrow panel donor, that differs from B*4901 by 8 nucleotides at positions 141, 142, 144, 165, 167, 193
N Shadid et al.
The British journal of surgery, 99(8), 1062-1070 (2012-05-26)
New minimally invasive treatment modalities, such as ultrasound-guided foam sclerotherapy (UGFS), are becoming more popular. In a multicentre randomized controlled non-inferiority trial, the effectiveness and costs of UGFS and surgery for treatment of the incompetent great saphenous vein (GSV) were
A Magenta et al.
Cell death and differentiation, 18(10), 1628-1639 (2011-04-30)
We examined the effect of reactive oxygen species (ROS) on MicroRNAs (miRNAs) expression in endothelial cells in vitro, and in mouse skeletal muscle following acute hindlimb ischemia. Human umbilical vein endothelial cells (HUVEC) were exposed to 200 μM hydrogen peroxide (H(2)O(2))
Emma L Edghill et al.
Diabetes, 57(4), 1034-1042 (2007-12-29)
Insulin gene (INS) mutations have recently been described as a cause of permanent neonatal diabetes (PND). We aimed to determine the prevalence, genetics, and clinical phenotype of INS mutations in large cohorts of patients with neonatal diabetes and permanent diabetes
L Tarnow et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 16(8), 1653-1656 (2001-07-31)
An XbaI polymorphism in the gene encoding the glucose transporter, GLUT-1, is associated with development of diabetic nephropathy in Chinese type 2 diabetic patients. In addition, an amino acid variant (K121Q) in the gene encoding the glycoprotein plasma cell differentiating
Judith A Smith et al.
Arthritis and rheumatism, 58(6), 1640-1649 (2008-06-03)
To determine whether macrophages, a type of cell implicated in the pathogenesis of ankylosing spondylitis (AS), exhibit a characteristic gene expression pattern. Macrophages were derived from the peripheral blood of 8 AS patients (median disease duration 13 years [range <1-43
Tejal Rawal et al.
AAPS PharmSciTech, 19(4), 1894-1907 (2018-04-18)
The elevated blood levels of cholesterol and low-density lipoproteins result in hyperlipidemia. The available expensive prophylactic treatments are kindred with severe side effects. Therefore, we fabricated the polymeric nanoparticles of gamma-oryzanol to achieving the improved efficacy of drug. The nanoparticles
Paul D Fisher et al.
Journal of biomedical materials research. Part A, 103(7), 2365-2373 (2014-11-27)
In situ forming poly(lactic-co-glycolic acid) (PLGA) implants have not been strongly considered for bone applications because of their poor mechanical properties. Here, in situ forming scaffolds containing hydroxyapatite micro- and nanoparticles were characterized to determine their mechanical properties, injectability, and
A Magenta et al.
Cell death and differentiation, 18(10), 1628-1639 (2011-04-30)
We examined the effect of reactive oxygen species (ROS) on MicroRNAs (miRNAs) expression in endothelial cells in vitro, and in mouse skeletal muscle following acute hindlimb ischemia. Human umbilical vein endothelial cells (HUVEC) were exposed to 200 μM hydrogen peroxide (H(2)O(2))
Vahid Asnafi et al.
Blood, 113(17), 3918-3924 (2008-12-26)
Many somatic genetic abnormalities have been identified in T-cell acute lymphoblastic leukemia (T-ALL) but each individual abnormality accounts for a small proportion of cases; therapeutic stratification consequently still relies on classical clinical markers. NOTCH1 and/or FBXW7 mutations both lead to
Hatem A Mousa et al.
Thrombosis and haemostasis, 92(5), 1025-1031 (2004-11-16)
We investigated changes in both thrombin activatable fibrinolysis inhibitor (TAFI) antigen levels and its functional effect on in vitro fibrinolysis in normal pregnancy. 152 pregnant women and 31 women in the immediate postpartum period were studied, with pregnancy divided into
A de Meijer et al.
Clinical pharmacology and therapeutics, 66(4), 425-430 (1999-11-05)
To study the influence of meloxicam, a cyclooxygenase-2 (COX-2) preferential nonsteroidal anti-inflammatory drug, on serum thromboxane and platelet function in healthy volunteers with use of the maximum recommended daily dosage of 15 mg/day. This study used an open, randomized crossover
Sima L Sharara et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 71(8), e331-e337 (2019-12-21)
Limited data exist regarding the efficacy of piperacillin-tazobactam (TZP) for the management of nonbacteremic pyelonephritis caused by extended-spectrum β-lactamase (ESBL)-producing organisms. We conducted a multicenter observational study comparing clinical outcomes of adults hospitalized with ESBL-producing pyelonephritis who were receiving TZP
Yunjie Wang et al.
Antioxidants & redox signaling, 28(2), 141-163 (2017-07-28)
Microglia-mediated neuroinflammation plays an important role in focal ischemic stroke, a disorder with no effective therapeutic agents. Since microglial polarization to the M2 phenotype and reduction of oxidative stress are mediated through AMP-activated protein kinase (AMPK) and nuclear factor erythroid
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