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Showing 1-30 of 128 results for "146064" within Papers
Craig Sale et al.
Amino acids, 39(2), 321-333 (2010-01-22)
High-intensity exercise results in reduced substrate levels and accumulation of metabolites in the skeletal muscle. The accumulation of these metabolites (e.g. ADP, Pi and H(+)) can have deleterious effects on skeletal muscle function and force generation, thus contributing to fatigue.
Anticoagulation without monitoring.
Wayne L Chandler
American journal of clinical pathology, 140(5), 606-607 (2013-10-15)
Massive left atrial thrombus in a patient with rheumatic mitral stenosis and atrial fibrillation while anticoagulated with dabigatran.
Sushil Allen Luis et al.
Circulation. Cardiovascular imaging, 6(3), 491-492 (2013-05-23)
Ramin Artang et al.
The American journal of cardiology, 112(12), 1973-1979 (2013-10-01)
Dabigatran has been associated with greater risk of myocardial infarction (MI) than warfarin. It is unknown whether the increased risk is unique to dabigatran, an adverse effect shared by other oral direct thrombin inhibitors (DTIs), or the result of a
Wilson I Gonsalves et al.
Mayo Clinic proceedings, 88(5), 495-511 (2013-05-04)
Vitamin K antagonists were the only class of oral anticoagulants available to clinicians for decades. However, with the US Food and Drug Administration approval of new oral anticoagulants, such as dabigatran, rivaroxaban, and apixaban, clinicians now have a broader choice.
Wilma Potze et al.
British journal of haematology, 163(5), 666-673 (2013-11-14)
There is increasing recognition that thrombotic complications may occur in patients with cirrhosis, and literature on antithrombotic treatment in these patients is rapidly emerging. Due to extensive haemostatic changes in patients with cirrhosis, careful monitoring of anticoagulant therapy may be
W L Baker et al.
Clinical pharmacology and therapeutics, 96(1), 17-19 (2014-06-20)
For patients requiring long-term anticoagulation, oral vitamin K antagonists (VKAs) such as warfarin have overwhelming efficacy data and present significant challenges. In addition to the potential exposure to numerous drug-drug and drug-food interactions, patients receiving warfarin require frequent monitoring. It
Thomas V Magee et al.
Journal of medicinal chemistry, 56(12), 5079-5093 (2013-06-06)
We report novel polymyxin analogues with improved antibacterial in vitro potency against polymyxin resistant recent clinical isolates of Acinetobacter baumannii and Pseudomonas aeruginosa . In addition, a human renal cell in vitro assay (hRPTEC) was used to inform structure-toxicity relationships
[Dabigatran and risk of bleeding].
Susann Hasler
Praxis, 104(3), 157-158 (2015-01-30)
Additional events in the RE-LY trial.
Stuart J Connolly et al.
The New England journal of medicine, 371(15), 1464-1465 (2014-09-25)
Waleed Ghanima et al.
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 133(18), 1940-1945 (2013-10-03)
Dabigatran, rivaroxaban and apixaban are three new oral anticoagulants that have recently been approved in Norway. The aim of this article is to provide an overview of the mechanisms of action, the most important indications and practical advice on the
Dabigatran, bleeding, and the regulators.
Thomas J Moore et al.
BMJ (Clinical research ed.), 349, g4517-g4517 (2014-07-25)
Adriano A Truffa et al.
Postgraduate medicine, 125(2), 146-157 (2013-07-03)
Stroke is the most feared complication among patients with atrial fibrillation. Oral anticoagulation therapy with vitamin K antagonists (VKAs) has been the gold standard for stroke prevention for the past 60 years. However, VKA therapy has many downsides, including risk
Inmaculada Hernandez et al.
JAMA internal medicine, 175(1), 18-24 (2014-11-05)
It remains unclear whether dabigatran etexilate mesylate is associated with higher risk of bleeding than warfarin sodium in real-world clinical practice. To compare the risk of bleeding associated with dabigatran and warfarin using Medicare data. In this retrospective cohort study
Y Chen et al.
Acta oto-laryngologica, 114(2), 193-198 (1994-03-01)
The cellular localization of the enzyme carnosinase in human nasal mucosa was investigated using immunoperoxidase and double-staining immunoflourescence techniques. In the olfactory mucosa, carnosinase immunoreactivity was localized in the sustentacular cells, the acinar cells of Bowman's glands, and the perinuclear
Concerns over data in key dabigatran trial.
Deborah Cohen
BMJ (Clinical research ed.), 349, g4747-g4747 (2014-07-25)
Torben Bjerregaard Larsen et al.
The American journal of medicine, 127(4), 329-336 (2013-12-24)
Dabigatran may provide less protection against myocardial infarction than vitamin K antagonists (VKAs) in patients with atrial fibrillation. This may be particularly evident among "switchers" to dabigatran from VKA, as a result of discontinuation effects. We identified in nationwide Danish
Daniela Billups et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(44), 17429-17434 (2013-11-01)
The mechanisms by which the excitatory neurotransmitter glutamate is recycled at synapses are currently unknown. By examining the functional expression of plasma membrane transporters at presynaptic terminals, we aim to elucidate some of the mechanisms of glutamate recycling. Using whole-cell
The trouble with dabigatran.
Blake Charlton et al.
BMJ (Clinical research ed.), 349, g4681-g4681 (2014-07-25)
David J Graham et al.
Circulation, 131(2), 157-164 (2014-11-02)
The comparative safety of dabigatran versus warfarin for treatment of nonvalvular atrial fibrillation in general practice settings has not been established. We formed new-user cohorts of propensity score-matched elderly patients enrolled in Medicare who initiated dabigatran or warfarin for treatment
Iris Thondorf et al.
Bioorganic & medicinal chemistry, 19(21), 6409-6418 (2011-10-01)
The proton-coupled amino acid transporter hPAT1 has recently gained much interest due to its ability to transport small drugs thereby allowing their oral administration. A three-dimensional quantitative structure-activity relationship (3D QSAR) study has been performed on its natural and synthetic
Ischemic stroke in an obese patient receiving dabigatran.
Lorenz Breuer et al.
The New England journal of medicine, 368(25), 2440-2442 (2013-06-21)
Michael P Miller et al.
The American journal of emergency medicine, 32(4), 375-382 (2014-02-12)
The recent arrival of the target-specific oral anticoagulants (TSOACs) offers potential advantages in the field of anticoagulation. However, there are no rapid and accurate and routinely available laboratory assays to evaluate their contribution to clinical bleeding. With the expanding clinical
John Caruso et al.
Nutrients, 4(7), 585-601 (2012-08-02)
β-alanine is an amino acid that, when combined with histidine, forms the dipeptide carnosine within skeletal muscle. Carnosine and β-alanine each have multiple purposes within the human body; this review focuses on their roles as ergogenic aids to exercise performance
New oral anticoagulants may not be effective to prevent venous thromboembolism in patients with antiphospholipid syndrome.
Khine Win et al.
American journal of hematology, 89(10), 1017-1017 (2014-07-22)
Carolyn M Millar et al.
Blood, 121(18), 3543-3544 (2013-05-04)
In this issue of Blood, Schiele et al report the development of a monoclonal antibody that reverses the anticoagulant effect of the direct thrombin inhibitor dabigatran.
Stuart E Lind et al.
American journal of clinical pathology, 141(5), 665-674 (2014-04-10)
The activated partial thromboplastin time (aPTT) test has been used for years to monitor parenteral direct thrombin inhibitors (DTIs) and unfractionated heparin. Because the aPTT correlates poorly with unfractionated heparin levels, we hypothesized that the aPTT may not be the
[Not Available].
Johann Steurer
Praxis, 103(10), 602-602 (2014-05-08)
J Aznar et al.
Thrombosis research, 27(6), 691-701 (1982-09-15)
The soluble fibrin monomer complexes (SFMC) in 154 obstetric patients with possible disseminated intravascular coagulation (DIC) were evaluated in SDS polyacrylamide gel electrophoresis (PAGE) after precipitation with B-alanine. Other coagulation tests were performed on these patients. The patients were classified
Elena Ashikhmina et al.
The Annals of thoracic surgery, 98(6), 2215-2216 (2014-12-04)
We present a successful case of prevention of postoperative hemorrhage in a 70-year-old male on dabigatran, who developed an acute type A aortic dissection and subsequently underwent an emergent ascending aortic replacement.
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