151-21-3

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Showing 1-17 of 17 results for "151-21-3" within Papers

High EGFR gene copy number predicts poor outcome in triple-negative breast cancer.

Heae Surng Park et al.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 27(9), 1212-1222 (2014-01-11)

Epidermal growth factor receptor (EGFR) is frequently overexpressed in triple-negative breast cancer and is emerging as a therapeutic target. EGFR gene copy number alteration and mutation are highly variable and scientists have been challenged to define their prognostic significance in

A phase 2, open-label, multi-center study of amuvatinib in combination with platinum etoposide chemotherapy in platinum-refractory small cell lung cancer patients.

Lauren Averett Byers et al.

Oncotarget, 8(46), 81441-81454 (2017-11-09)

Amuvatinib (MP-470) is a multi-targeted kinase inhibitor with potent activity against c-Kit, synergistic with DNA-damaging agents. We evaluated amuvatinib in combination with platinum-etoposide (EP) chemotherapy by objective response rate, survival, and tolerability in platinum-refractory small cell lung cancer (SCLC) patients.

Signal transducer and activator of transcription 3 is involved in cell growth and survival of human rhabdomyosarcoma and osteosarcoma cells.

Chun-Liang Chen et al.

BMC cancer, 7, 111-111 (2007-06-30)

Stat3 has been classified as a proto-oncogene and constitutive Stat3 signaling appears to be involved in oncogenesis of human cancers. However, whether constitutive Stat3 signaling plays a role in the survival and growth of osteosarcomas, rhabdomyosarcomas, and soft-tissue sarcomas is

Size of FLT3 internal tandem duplication has prognostic significance in patients with acute myeloid leukemia.

Derek L Stirewalt et al.

Blood, 107(9), 3724-3726 (2005-12-22)

FLT3 internal tandem duplications (FLT3/ITDs) in the juxtamembrane domain are found in approximately 25% of acute myeloid leukemia (AML) patients, ranging in size from 3 to hundreds of nucleotides. We examined whether the sizes of FLT3/ITDs were associated with clinical

Therapeutic effects of cantharidin analogues without bridging ether oxygen on human hepatocellular carcinoma cells.

Chao-Bin Yeh et al.

European journal of medicinal chemistry, 45(9), 3981-3985 (2010-08-10)

Previous research indicates that cantharidin, norcantharidin and their analogues exhibit anticancer activity due to their inhibition of cancer cell lines such as HL60, HT29 and L1210. The anticancer activities of cantharidin, norcantharidin and their analogues involve the suppression of serine/threonine

Candida africana vulvovaginitis: Prevalence and geographical distribution.

H Fakhim et al.

Journal de mycologie medicale, 30(3), 100966-100966 (2020-04-23)

Candida africana has been recovered principally as a causative agent of vulvovaginal candidiasis (VVC) from different countries, which is likely to be misidentified as the typical Candida albicans or Candida dubliniensis. The current study aimed to characterize C. albicans species complex obtained from

Preparation and pharmacological characterization of trans-2-amino-5(6)-fluoro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as D2-like dopamine receptor agonists.

Antonio Di Stefano et al.

Journal of medicinal chemistry, 48(7), 2646-2654 (2005-04-02)

The present work reports the synthesis of trans-2-amino-5(6)-fluoro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes (4a-f, 5a-f) as a continuation of our studies to better understand the significance of the halo substituent in the trans-1-phenyl-2-aminoindane series and to extend knowledge of the monophenolic ligands of DA receptors.

Promoter hypermethylation of death-associated protein kinase and p16 genes in vulvar lichen sclerosus.

Susana Aidé et al.

Journal of lower genital tract disease, 16(2), 133-139 (2012-03-01)

The purpose of this study was to discuss our investigation of the hypermethylation of promoter regions of tumor suppressor genes, such as death-associated protein kinase (DAPK) and p16, in vulvar lichen sclerosus (LS), in comparison with a control group. Promoter

Effect of transdermal estradiol therapy on bone mineral density of amenorrheic female athletes.

Sayaka Nose-Ogura et al.

Scandinavian journal of medicine & science in sports, 30(8), 1379-1386 (2020-04-15)

The effects of transdermal estradiol treatment (HT) in amenorrheic athletes (AA) with low body weight (BW) and low bone mineral density (BMD) are unknown. To investigate whether HT increases BMD in AA with low BW and to compare the results

Role of 20-HETE in the antihypertensive effect of transfer of chromosome 5 from Brown Norway to Dahl salt-sensitive rats.

Jan M Williams et al.

American journal of physiology. Regulatory, integrative and comparative physiology, 302(10), R1209-R1218 (2012-03-24)

This study examined whether substitution of chromosome 5 containing the CYP4A genes from Brown Norway rat onto the Dahl S salt-sensitive (SS) genetic background upregulates the renal production of 20-HETE and attenuates the development of hypertension. The expression of CYP4A

Selective interactions of spinophilin with the C-terminal domains of the δ- and μ-opioid receptors and G proteins differentially modulate opioid receptor signaling.

Danai-Dionysia Fourla et al.

Cellular signalling, 24(12), 2315-2328 (2012-08-28)

Previous studies have shown that the intracellular domains of opioid receptors serve as platforms for the formation of a multi-component signaling complex consisting of various interacting partners (Leontiadis et al., 2009, Cell Signal. 21, 1218-1228; Georganta et al., 2010, Neuropharmacology

Beta2-adrenoceptor Thr164Ile polymorphism is associated with markedly decreased vasodilator and increased vasoconstrictor sensitivity in vivo.

Victor Dishy et al.

Pharmacogenetics, 14(8), 517-522 (2004-07-31)

The uncommon Thr164Ile polymorphism of the beta2-adrenoceptor is associated with profoundly altered responses to agonist in vitro; however its effects on vascular responses in vivo are not known. Altered adrenergic vascular sensitivity may contribute to the decreased survival observed in

Dissemination of Trimethoprim-Sulfamethoxazole Drug Resistance Genes Associated with Class 1 and Class 2 Integrons Among Gram-Negative Bacteria from HIV Patients in South India.

Marimuthu Ragavan Ramesh Kumar et al.

Microbial drug resistance (Larchmont, N.Y.), 23(5), 602-608 (2016-11-18)

The antibiotic, trimethoprim-sulfamethoxazole (TMP-SMX), is generally used for prophylaxis in HIV individuals to protect them from Pneumocystis jiroveci infection. Long-term use of TMP-SMX develops drug resistance among bacteria in HIV patients. The study was aimed to detect the TMP-SMX resistance

The pathway not taken: understanding 'omics data in the perinatal context.

Andrea G Edlow et al.

American journal of obstetrics and gynecology, 213(1), 59-59 (2015-03-17)

'Omics analysis of large datasets has an increasingly important role in perinatal research, but understanding gene expression analyses in the fetal context remains a challenge. We compared the interpretation provided by a widely used systems biology resource (ingenuity pathway analysis

FDG uptake observed around the lumbar spinous process: relevance to Baastrup disease.

Kayo Nishimatsu et al.

Annals of nuclear medicine, 29(9), 766-771 (2015-07-15)

In positron emission tomography (PET) with F-18-fluorodeoxyglucose (FDG), non-tumorous focal uptake is often observed around the lumbar spinous processes (LSPs). Close approximation of LSPs with sclerosis is often seen, which is called Baastrup disease. The aim of this study was

Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase binding.

M C Brown et al.

The Journal of cell biology, 135(4), 1109-1123 (1996-11-01)

Paxillin is a 68-kD focal adhesion phosphoprotein that interacts with several proteins including members of the src family of tyrosine kinases, the transforming protein v-crk, and the cytoskeletal proteins vinculin and the tyrosine kinase, focal adhesion kinase (FAK). This suggests

Sequential paclitaxel followed by tegafur and uracil (UFT) or S-1 versus UFT or S-1 monotherapy as adjuvant chemotherapy for T4a/b gastric cancer (SAMIT): a phase 3 factorial randomised controlled trial.

Akira Tsuburaya et al.

The Lancet. Oncology, 15(8), 886-893 (2014-06-24)

The prognosis for locally advanced gastric cancer is poor despite advances in adjuvant chemotherapy. We did the Stomach cancer Adjuvant Multi-Institutional group Trial (SAMIT) to assess the superiority of sequential treatment (paclitaxel then tegafur and uracil [UFT] or paclitaxel then

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