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Showing 1-30 of 4287 results for "154903" within Papers
Mamatha Garige et al.
Biochemical and biophysical research communications, 467(2), 275-281 (2015-10-10)
The molecular basis for nutraceutical properties of the polyphenol curcumin (Curcuma longa, Turmeric) is complex, affecting multiple factors that regulate cell signaling and homeostasis. Here, we report the effect of curcumin on cellular and developmental mechanisms in the eukaryotic model
Yan Zhou et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 89, 107-115 (2014-12-08)
Combination therapies have been investigated to address the current challenges of anti-cancer therapeutics. In particular, a novel paradigm of combination therapy targeting both cancer stem/progenitor cells and bulk tumor cells is promising to improve the long-term therapeutic benefit against prostate
Valentino Ruggieri et al.
BMC plant biology, 14, 337-337 (2014-12-04)
Genome Wide Association Studies (GWAS) have been recently used to dissect complex quantitative traits and identify candidate genes affecting phenotype variation of polygenic traits. In order to map loci controlling variation in tomato marketable and nutritional fruit traits, we used
Eun Ju Choi et al.
Chemistry & biology, 22(9), 1270-1279 (2015-08-25)
Low-nutrient media and long incubation times facilitated the cultivation of 20 taxonomically diverse Gram-negative marine bacteria within the phyla Bacteroidetes and Proteobacteria. These strains comprise as many as three new families and include members of clades that had only been
Eva Gorrochategui et al.
Analytica chimica acta, 854, 20-33 (2014-12-07)
A lipidomic study was developed in a human placental choriocarcinoma cell line (JEG-3) exposed to tributyltin (TBT) and to a mixture of perfluorinated chemicals (PFCs). The method was based on the application of multivariate curve resolution-alternating least squares (MCR-ALS) to
Fengxia Wu et al.
Aquatic toxicology (Amsterdam, Netherlands), 155, 43-51 (2014-06-30)
We studied the effects of endocrine disrupting compounds nonylphenol (NP) and letrozole (LE) on the male goldfish Carassius aumtus. Exposure to NP (20 μg l(-1)) alone caused a significant up-regulation in the expression of aromatase, estrogen receptors and vitellogenin (VTG)
Weihao Wang et al.
Steroids, 95, 51-65 (2015-01-13)
Dioscorea panthaica is a traditional Chinese medicinal herb used in the treatment of various physiological conditions, including cardiovascular disease, gastropathy and hypertension. Steroidal saponins (SS) are the main active ingredients of this herb and have effects on myocardial ischemia and
Ana R Ribeiro et al.
Journal of chromatography. A, 1418, 140-149 (2015-10-04)
The fate and removal of organic micropollutants in the environment is a demanding issue evidenced by the recent European policy. This work presents an analytical method for the trace quantification of 37 micropollutants including Priority Substances (Directive 2013/39/EU), substances of
Martin Göttle et al.
Annals of neurology, 76(1), 95-107 (2014-06-04)
Lesch-Nyhan disease (LND) is caused by congenital deficiency of the purine recycling enzyme, hypoxanthine-guanine phosphoribosyltransferase (HGprt). Affected patients have a peculiar neurobehavioral syndrome linked with reductions of dopamine in the basal ganglia. The purpose of the current studies was to
Sergey Kosourov et al.
Applied and environmental microbiology, 80(18), 5807-5817 (2014-07-13)
We have investigated two approaches to enhance and extend H2 photoproduction yields in heterocystous, N2-fixing cyanobacteria entrapped in thin alginate films. In the first approach, periodic CO2 supplementation was provided to alginate-entrapped, N-deprived cells. N deprivation led to the inhibition
Jessica A Cottrell et al.
Analytical biochemistry, 469, 34-42 (2014-12-03)
This article describes a new method for extracting RNA, protein, and lipid mediators from a single tissue specimen. Specifically, mouse bone fracture callus specimens were extracted into a single solution that was processed using three different procedures to measure messenger
Meei-Hua Lin et al.
The Journal of investigative dermatology, 135(2), 462-470 (2014-09-04)
Fatty acid transport protein (FATP) 4 is one of a family of six FATPs that facilitate long- and very-long-chain fatty acid uptake. Mice lacking FATP4 are born with tight, thick skin and a defective barrier; they die neonatally because of
Er-Bao Zhang et al.
Medical oncology (Northwood, London, England), 31(5), 914-914 (2014-03-29)
Gastric cancer (GC) is one of the most frequent cancers worldwide. Recent studies have shown that long noncoding RNAs (lncRNAs) play critical roles in multiple biological processes, including oncogenesis. The present study aimed to evaluate the potential role of lncRNA
Ritwika Ray et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 20(47), 15618-15624 (2014-10-07)
The present article describes novel oxidative protocols for direct esterification of alcohols. The protocols involve successful demonstrations of both "cross" and "self" esterification of a wide variety of alcohols. The cross-esterification proceeds under a simple transition-metal-free condition, containing catalytic amounts
Teresa Ferreira et al.
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada, 21(1), 2-14 (2014-11-13)
A 16th century liturgical cope belonging to D. Teotónio of Braganza (collection of the Museum of Évora, ME 172/1) was selected for a material study. The cope is made of a variety of materials that include two different types of
Johanna Sápi et al.
PloS one, 10(11), e0142190-e0142190 (2015-11-06)
Bevacizumab is an exogenous inhibitor which inhibits the biological activity of human VEGF. Several studies have investigated the effectiveness of bevacizumab therapy according to different cancer types but these days there is an intense debate on its utility. We have
Long Wang et al.
Molecular medicine reports, 11(4), 2711-2716 (2014-12-18)
Glucocorticoid‑induced osteoporosis (GIOP) is a widespread clinical complication following glucocorticoid therapy. This irreversible damage to bone‑forming and ‑resorbing cells is essential in the pathogenesis of osteoporosis. Autophagy is a physiological process involved in the regulation of cells and their responses
Paul R Elliott et al.
Scientific reports, 5, 16826-16826 (2015-11-21)
This paper proposes a mechanism of controlling the diameter and separation of metallic nanorods from physical vapor deposition through self-organized seeds and experimentally demonstrates the feasibility using Ag as the prototype metal, In as the seed, and Si the substrate.
Elisabetta Bertol et al.
Forensic science international, 243, 149-155 (2014-09-10)
We report on a case of repeated MDPV consumptions that resulted in severe psychosis and agitation prompting the concomitant abuse of benzodiazepines. A 27-year-old man was found irresponsive in his apartment and was brought to the emergency department (ED) of
Ottmar Golf et al.
Journal of the American Society for Mass Spectrometry, 26(1), 44-54 (2014-11-09)
Here we present a proof of concept cross-platform normalization approach to convert raw mass spectra acquired by distinct desorption ionization methods and/or instrumental setups to cross-platform normalized analyte profiles. The initial step of the workflow is database driven peak annotation
Mohammad Asif Iqbal et al.
Journal of chromatography. A, 1373, 149-158 (2014-12-04)
In the analysis of biogenic volatile organic compounds (BVOCs) in ambient air, preparation of a sub-ppb level standard is an important factor. This task is very challenging as most BVOCs (e.g., monoterpenes) are highly volatile and reactive in nature. As
Martina Bolechová et al.
Food chemistry, 170, 265-270 (2014-10-13)
Alkaloids known as secondary metabolites are grouped by typical structural characteristics into large families such as pyrrolizidine alkaloids (PAs) comprising more than 350 individual heterocyclic compounds. The PAs present a serious health risk to human and livestock; hence there is
Dafni Dimakopoulou-Papazoglou et al.
Food microbiology, 53(Pt B), 76-81 (2015-12-19)
The effect of pH and water activity (aw) on the formation of biofilm by Salmonella enterica ser. Newport, previously identified as a strong biofilm producer, was assessed. Biofilm formation was evaluated in tryptone soy broth at 37 °C and at different
Laura Jaime et al.
Journal of the science of food and agriculture, 95(4), 722-729 (2014-06-17)
In this work three different techniques were applied to extract dry leaves of spinach (Spinacia oleracea): solid-liquid extraction (SLE), pressurised liquid extraction (PLE) and supercritical fluid extraction (SFE) to investigate the influence of extraction solvent and technique on extracts composition
Milena M Madry et al.
Bioanalysis, 6(23), 3183-3196 (2014-12-23)
Toenails were assessed as an alternative matrix to hair for retrospective monitoring of cocaine consumption of recreational and dependent users. Results/methodology: Toenail clippings, scrapings and hair samples from recreational and dependent cocaine users were analyzed for cocaine and metabolites. Dependent
Masazumi Tamura et al.
Nature communications, 6, 8580-8580 (2015-10-06)
Multidentate materials formed by simply mixing heterogeneous and homogeneous components are promising for construction of versatile active sites on the surface of heterogeneous compounds, however, to the best of our knowledge, there are no reports on such materials. Self-assembly of
Chang-Seob Seo et al.
Molecular medicine reports, 12(5), 7789-7795 (2015-09-24)
Aucklandia lappa Decne, a well-known traditional herbal medicine, is used for the treatment of asthma, rheumatism, coughs, tuberculosis and numerous other diseases. The present study evaluated the inhibitory effects of the three sesquiterpene lactones costunolide, dehydrocostus lactone, and alantolactone, isolated
Amandeep Kaur et al.
Zeitschrift fur Naturforschung. C, Journal of biosciences, 69(3-4), 110-116 (2014-05-31)
The antileishmanial activity of extracts and phytoconstituents of Moringa oleifera Lam. was investigated in vitro against promastigotes of Leishmania donavani. The 70% ethanolic extract of roots and the methanolic extract of leaves showed moderate inhibitory activity with IC50 values of
Tânia Petta et al.
Enzyme and microbial technology, 58-59, 36-43 (2014-04-16)
Lipid mediators such as the leukotrienes, resolvins and protectins have been considered excellent models for the development of new anti-inflammatory drugs, due to their high potentiality. Nevertheless, only tiny amounts are available from natural sources and they have to be
Tam T T N Nguyen et al.
Analytical and bioanalytical chemistry, 407(28), 8497-8503 (2015-09-04)
An analytical method based on capillary electrophoresis (CE) and inductively coupled plasma mass spectrometry (ICP-MS) detection was developed for studies on the interaction of gold-containing drugs and plasma proteins using auranofin as example. A detection limit of 18 ng/mL of
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