154903

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Identification and quantification of antitumor thioproline and methylthioproline in Korean traditional foods by a liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry.

Sun Hyo Kim et al.

Journal of pharmaceutical and biomedical analysis, 100, 58-63 (2014-08-17)

A liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometric method (LC-APCI-MS/MS) has been developed for the sensitive determination of antitumor thioproline and methylthioproline from fermented foods. Thioproline and methylthioproline were derivatized in one step with ethyl chloroformate at room temperature. These

Assessment of (poly)phenols in grape (Vitis vinifera L.) stems by using food/pharma industry compatible solvents and Response Surface Methodology.

R Domínguez-Perles et al.

Food chemistry, 164, 339-346 (2014-07-06)

A Box-Behnken design of Response Surface Methodology (RSM) was conducted to analyse the effect of time (10-30 min), temperature (25-95°C), and solvents concentration (5-90%) on the extraction of total phenolics, flavonoids, ortho-diphenols, and anthocyanins as well as to assess the

Neuropharmcological potential of methanolic extract and a triterpene isolated from Madhuca longifolia L leaves in mice.

Triveni S Inganakal et al.

Indian journal of experimental biology, 50(12), 862-866 (2013-08-31)

The methanolic extract of M. longifolia (MLME) and a compound a triterpene, derivative of madhucic acid (dMA) isolated from the leaves of M. longifolia, were investigated for their possible neuropharmacological activities in mice using phenobarbitone induced sleeping time, spontaneous motor

DNA double-strand breaks by Cr(VI) are targeted to euchromatin and cause ATR-dependent phosphorylation of histone H2AX and its ubiquitination.

Zachary DeLoughery et al.

Toxicological sciences : an official journal of the Society of Toxicology, 143(1), 54-63 (2014-10-08)

Hexavalent chromium is a human respiratory carcinogen that undergoes intracellular activation in vivo primarily via reduction with ascorbate. Replication of Cr-adducted DNA triggers mismatch repair that generates toxic DNA double-strand breaks (DSBs) as secondary lesions. Here, we examined the intranuclear distribution

Direct determination of the binding sites of cisplatin on insulin-like growth factor-1 by top-down mass spectrometry.

Ningbo Zhang et al.

Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 20(1), 1-10 (2014-10-26)

Cisplatin has been widely used in the chemotherapy of a variety of tumors, and the interactions of cisplatin with proteins play very important roles in its side effects and drug resistance, as well as its pharmacokinetics and the biodistribution. Insulin-like

Oxidative stress and altered lipid homeostasis in the programming of offspring fatty liver by maternal obesity.

Maria Z Alfaradhi et al.

American journal of physiology. Regulatory, integrative and comparative physiology, 307(1), R26-R34 (2014-05-03)

Changes in the maternal nutritional environment during fetal development can influence offspring's metabolic risk in later life. Animal models have demonstrated that offspring of diet-induced obese dams develop metabolic complications, including nonalcoholic fatty liver disease. In this study we investigated

Implementation of design of experiments for optimization of forced degradation conditions and development of a stability-indicating method for furosemide.

Moolchand Kurmi et al.

Journal of pharmaceutical and biomedical analysis, 96, 135-143 (2014-04-20)

The study involved optimization of forced degradation conditions and development of a stability-indicating method (SIM) for furosemide employing the design of experiment (DoE) concept. The optimization of forced degradation conditions, especially hydrolytic and oxidative, was done by application of 2(n)

Transcriptional expression of myelin basic protein in oligodendrocytes depends on functional syntaxin 4: a potential correlation with autocrine signaling.

Marjolein Bijlard et al.

Molecular and cellular biology, 35(4), 675-687 (2014-12-17)

Myelination of axons by oligodendrocytes is essential for saltatory nerve conduction. To form myelin membranes, a coordinated synthesis and subsequent polarized transport of myelin components are necessary. Here, we show that as part of the mechanism to establish membrane polarity

Antioxidant, antidiabetic and hypolipidemic effects of Tulbaghia violacea Harv. (wild garlic) rhizome methanolic extract in a diabetic rat model.

Kogi Moodley et al.

BMC complementary and alternative medicine, 15, 408-408 (2015-11-19)

The prevalence of diabetes mellitus (DM) continues to rise alarmingly despite years of intensive research. The need to explore alternative remedies such as traditional phytotherapy has therefore become increasingly important in the management and treatment of DM. Diabetes was induced

Formulation and in vitro characterization of thermosensitive liposomes for the delivery of irinotecan.

Ana Casadó et al.

Journal of pharmaceutical sciences, 103(10), 3127-3138 (2014-08-06)

The effect of the lipid composition on the physicochemical properties of a liposomal carrier containing irinotecan (CPT-11) and its in vitro antitumoral activity on a colon cancer cell line has been investigated. The paper describes the procurement of a novel

Development of a new cucumber reference material for pesticide residue analysis: feasibility study for material processing, homogeneity and stability assessment.

Susana Grimalt et al.

Analytical and bioanalytical chemistry, 407(11), 3083-3091 (2015-01-30)

The feasibility of the production of a reference material for pesticide residue analysis in a cucumber matrix was investigated. Cucumber was spiked at 0.075 mg/kg with each of the 15 selected pesticides (acetamiprid, azoxystrobin, carbendazim, chlorpyrifos, cypermethrin, diazinon, (α + β)-endosulfan, fenitrothion, imazalil

Sensitivity improvement in hydrophilic interaction chromatography negative mode electrospray ionization mass spectrometry using 2-(2-methoxyethoxy)ethanol as a post-column modifier for non-targeted metabolomics.

Wendelin Koch et al.

Journal of chromatography. A, 1361, 209-216 (2014-08-28)

The application of ammonia acetate buffered liquid chromatography (LC) eluents is known to concomitantly lead to ion suppression when electrospray ionization mass spectrometry (ESI-MS) detection is used. In negative ESI mode, post column infusion of 2-(2-methoxyethoxy)ethanol (2-MEE) was shown in

Assessment of total phenolic content and antioxidant potential of methanol extract of Peltophorum pterocarpum (DC.) Backer ex K. Heyne.

Madiha Khan et al.

Pakistan journal of pharmaceutical sciences, 26(5), 967-972 (2013-09-17)

Plants are rich in a variety of chemical compounds. Many are secondary metabolites including aromatic substances most of them are phenols or their oxygen substituted derivatives. Medicinal plants are rich in antioxidant constituents such as phenols, tocopherols, ascorbic acid, carotenoids

Localization of sunitinib, its metabolites and its target receptors in tumour-bearing mice: a MALDI-MS imaging study.

S Torok et al.

British journal of pharmacology, 172(4), 1148-1163 (2014-11-05)

The clinical effects of anti-angiogenic agents remain controversial. Therefore, elucidating the pharmacological properties of these compounds is a pivotal issue. The effects of treatment with sunitinib on tumour and normal tissues of mice bearing C-26 adenocarcinoma cells were analysed by

Comparison of everolimus QMS immunoassay on Architect ci4100 and liquid chromatography/mass spectrometry: lack of agreement in organ-transplanted patients.

Erica Hoffer et al.

Therapeutic drug monitoring, 37(2), 214-219 (2014-08-28)

Liquid chromatography with mass spectrometry (LC-MS/MS) is the method of choice for the determination of everolimus whole blood concentrations but is not always available. Therefore, immunoassays have been developed for clinical monitoring of everolimus. In previous studies, the Quantitative Microsphere

RNAi-based functional selection identifies novel cell migration determinants dependent on PI3K and AKT pathways.

Minchul Seo et al.

Nature communications, 5, 5217-5217 (2014-10-29)

Lentiviral short hairpin RNA (shRNA)-mediated genetic screening is a powerful tool for identifying loss-of-function phenotype in mammalian cells. Here, we report the identification of 91 cell migration-regulating genes using unbiased genome-wide functional genetic selection. Individual knockdown or cDNA overexpression of

Optimization on preparation condition of polyunsaturated fatty acids nanoliposome prepared by Mozafari method.

B Rasti et al.

Journal of liposome research, 24(2), 99-105 (2013-10-09)

This study presents the application of the response surface methodology (design) to develop an optimal preparation condition (independent variables) namely shear rate (600-1000 rpm), mixing time (30-60 min), and sonication time (10-20 min) for polyunsaturated fatty acids (docosahexaenoic acid and

Anatomical localization of progenitor cells in human breast tissue reveals enrichment of uncommitted cells within immature lobules.

Lisa M Arendt et al.

Breast cancer research : BCR, 16(5), 453-453 (2014-10-16)

Lineage tracing studies in mice have revealed the localization and existence of lineage-restricted mammary epithelial progenitor cells that functionally contribute to expansive growth during puberty and differentiation during pregnancy. However, extensive anatomical differences between mouse and human mammary tissues preclude

Pharmacological inhibition of dynamin II reduces constitutive protein secretion from primary human macrophages.

Maaike Kockx et al.

PloS one, 9(10), e111186-e111186 (2014-10-28)

Dynamins are fission proteins that mediate endocytic and exocytic membrane events and are pharmacological therapeutic targets. These studies investigate whether dynamin II regulates constitutive protein secretion and show for the first time that pharmacological inhibition of dynamin decreases secretion of

Prion infection of mouse brain reveals multiple new upregulated genes involved in neuroinflammation or signal transduction.

James A Carroll et al.

Journal of virology, 89(4), 2388-2404 (2014-12-17)

Gliosis is often a preclinical pathological finding in neurodegenerative diseases, including prion diseases, but the mechanisms facilitating gliosis and neuronal damage in these diseases are not understood. To expand our knowledge of the neuroinflammatory response in prion diseases, we assessed

Assay of 6-gingerol in CO2 supercritical fluid extracts of ginger and evaluation of its sustained release from a transdermal delivery system across rat skin.

Yan Chen et al.

Die Pharmazie, 69(7), 506-511 (2014-07-31)

Ginger has been widely used as healthy food condiment as well as traditional Chinese medicine since antiquity. Multiple potentials of ginger for treatment of various ailments have been revealed. However, the biological half-life of 6-gingerol (a principal pungent ingredient of

Antitumor activity of an enzyme prodrug therapy targeted to the breast tumor vasculature.

Brent D Van Rite et al.

Cancer investigation, 31(8), 505-510 (2013-10-03)

The L-methioninase-annexin V/selenomethionine enzyme prodrug system, designed to target the tumor vasculature and release the methylselenol anticancer drug in the tumor, was tested in mice with implanted MBA-MB-231 breast tumors. This therapy was able to cause a reduction in the

Multi-targeted interference-free determination of ten β-blockers in human urine and plasma samples by alternating trilinear decomposition algorithm-assisted liquid chromatography-mass spectrometry in full scan mode: comparison with multiple reaction monitoring.

Hui-Wen Gu et al.

Analytica chimica acta, 848, 10-24 (2014-09-30)

β-blockers are the first-line therapeutic agents for treating cardiovascular diseases and also a class of prohibited substances in athletic competitions. In this work, a smart strategy that combines three-way liquid chromatography-mass spectrometry (LC-MS) data with second-order calibration method based on

Chemical profile and biological activities of Veronica thymoides subsp. pseudocinerea.

Abdulselam Ertas et al.

Pharmaceutical biology, 53(3), 334-339 (2014-10-22)

In Turkey, Veronica species (Plantaginaceae) have been used as a diuretic and for wound healing in traditional medicine. To examine the fatty acid and essential oil profiles, the antioxidant, anticholinesterase, antimicrobial, and DNA damage effects of Veronica thymoides P.H. Davis

5-Florouracil-loaded poly(lactic acid)-poly(caprolactone) hybrid scaffold: potential chemotherapeutic implant.

Kamal K Gupta et al.

Journal of biomedical materials research. Part A, 102(8), 2600-2612 (2013-09-17)

Hybrid nanofibers of poly(lactic acid) and polycaprolactone have been developed by embedding cancerous drug through electrospinning technique. The composition of polymer has been varied to check the compositional effect on properties. The quality of nanofibers has been testified through surface

Anti-diabetic and spasmolytic potential of Farsetia hamiltonii Royle from Cholistan desert.

Muhammad Munawar Hayat et al.

Journal of ethnopharmacology, 156, 347-352 (2014-09-16)

Folk herbal practitioners of the Cholistan desert claim Farsetia hamiltonii Royle (Brassicaceae) to treat diabetes, oxidative damages, diarrhea, fever, and abdominal cramps. The aim of this study was to scientifically find the potential of Farsetia hamiltonii in treating diabetes and

Identification of human cytochrome P450 isozymes involved in the metabolism of naftopidil enantiomers in vitro.

Lijun Zhu et al.

The Journal of pharmacy and pharmacology, 66(11), 1534-1551 (2014-06-20)

Naftopidil (NAF) is a chiral compound with two enantiomers (R(+)-NAF and S(-)-NAF) and is used as a racemic mixture in clinical practice. This study aims to investigate the metabolism of NAF enantiomers in pooled human liver microsomes (HLMs) and cytochrome

Enantioselective nano liquid chromatographic separation of racemic pharmaceuticals: a facile one-pot in situ preparation of lipase-based polymer monoliths in capillary format.

Marwa Ahmed et al.

Chirality, 26(11), 754-763 (2014-03-08)

New affinity monolithic capillary columns of 150 µm internal diameter were prepared in situ fused glass capillary via either immobilization or encapsulation of Candida antarctica lipase B (CALB) on or within polymer monoliths, respectively. The immobilized lipase-based monoliths were prepared

Doxorubicin and lapatinib combination nanomedicine for treating resistant breast cancer.

Huiyuan Wang et al.

Molecular pharmaceutics, 11(8), 2600-2611 (2014-01-11)

Our objective was to design a polymeric micelle-based doxorubicin and lapatinib combination therapy for treating multidrug resistant (MDR) breast cancers. Poly(ethylene glycol)-block-poly(2-methyl-2-benzoxycarbonylpropylene carbonate) (PEG-PBC) polymers were synthesized for preparing doxorubicin and lapatinib loaded micelles using a film dispersion method. Micelles

Comprehensive polar lipid identification and quantification in milk by liquid chromatography-mass spectrometry.

Zhiqian Liu et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 978-979, 95-102 (2014-12-23)

Polar lipids (PLs) are a significant functional component of milk that are difficult to quantitate. A simple method for comprehensive identification and quantitative analysis of all essential PL species using bovine milk is described. The lipid fraction was extracted by

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