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Showing 31-60 of 4287 results for "154903" within Papers
S M Illamola et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 965, 216-223 (2014-07-23)
Lopinavir is an HIV protease inhibitor with high protein binding (98-99%) in human plasma. This study was designed to develop an ultrafiltration method to measure the unbound concentrations of lopinavir overcoming the non-specific binding issue. A liquid chromatography-tandem mass spectrometry
Francesco Ballestriero et al.
PloS one, 9(10), e109201-e109201 (2014-10-09)
The purple pigment violacein is well known for its numerous biological activities including antibacterial, antiviral, antiprotozoan, and antitumor effects. In the current study we identify violacein as the antinematode agent produced by the marine bacterium Microbulbifer sp. D250, thereby extending
Irina Vyazunova et al.
PloS one, 9(11), e113489-e113489 (2014-11-26)
Genomic studies of human high-grade gliomas have discovered known and candidate tumor drivers. Studies in both cell culture and mouse models have complemented these approaches and have identified additional genes and processes important for gliomagenesis. Previously, we found that mobilization
Han Han et al.
Journal of pharmaceutical and biomedical analysis, 117, 266-275 (2015-09-24)
A rapid and sensitive liquid chromatography/electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) method was developed and validated for determining protostemonine, a new anti-tussive agent isolated from Radix Stemonae. Separation was performed on a C18 column with mass detection in positive selected
Margret I Moré et al.
Advances in therapy, 31(12), 1247-1262 (2014-11-22)
We report previously unpublished, early pilot studies performed with a brain-health food supplement containing a proprietary blend of 100 mg phosphatidylserine (PS) and 80 mg phosphatidic acid (PA) produced from soy lecithin. Serum analysis after single PS+PA ingestion was performed in healthy
Q Q He et al.
Organic & biomolecular chemistry, 13(13), 4070-4079 (2015-03-05)
This study investigated the unexpected decomposition and associated intermediates of compound 1, a specific member of a drug discovery library based on a monosaccharide scaffold. LC/MS and NMR spectroscopic analyses indicated that, under acidic conditions, 1 can be converted into
Federica Ianni et al.
Journal of chromatography. A, 1363, 101-108 (2014-04-15)
While aliphatic 2-hydroxyalkanoic acids have been more or less successfully enantioseparated with various chiral stationary phases by HPLC and GC, analogous applications on underivatized aliphatic 3-hydroxyalkanoic acids are completely absent in the scientific literature. With the aim of closing this
Weiquan Zhao et al.
Journal of separation science, 37(17), 2300-2306 (2014-06-14)
Silymarin extracted from Silybum marianum (L.) Gaertn consists of a large number of flavonolignans, of which diastereoisomeric flavonolignans including silybin A and silybin B, and isosilybin A and isosilybin B are the main bioactive components, whose preparation from the crude
Sara Rodriguez-Mozaz et al.
Journal of hazardous materials, 282, 165-173 (2014-10-02)
Water reuse is becoming a common practice in several areas in the world, particularly in those impacted by water scarcity driven by climate change and/or by rising human demand. Since conventional wastewater treatment plants (WWTPs) are not able to efficiently
Benito F García et al.
Molecules (Basel, Switzerland), 20(11), 20079-20106 (2015-11-13)
The citrus by-products released from citrus processing plants may contain high levels of potentially bioactive compounds such as flavonoids, which are a widely distributed group of polyphenolic compounds with health-related properties based on their antioxidant activity. In the study reported
Gyeong Jin Lee et al.
Macromolecular bioscience, 15(11), 1595-1604 (2015-07-18)
Crosslinked bioreducible polypropylenimine-cystaminebisacrylamides (PPI-CBAs) were synthesized for gene delivery systems. They formed nano-sized polyplexes with high stability even in reducing condition probably due to the re-crosslinking. PPI-CBAs displayed high transfection efficiency comparable to PEI25k in serum condition. However, cytotoxicity increase
Xiaoyu Zhou et al.
Journal of bioscience and bioengineering, 118(4), 420-425 (2014-04-22)
Lysozyme acts as an important defensive factor in innate immunity due to its well-recognized bacteriolytic activity. Here we describe the production and performance of human lysozyme-like 6 (LYZL6), a novel human c-type lysozyme homolog. A synthetic codon-optimized cDNA encoding the
Jinping Cao et al.
Food chemistry, 173, 855-863 (2014-12-04)
The physicochemical characteristics of four cherry species (Prunus avium, Prunus cerasus, Prunus pseudocerasus and Prunus tomentosa) were evaluated. Inter-species variability was greater than intra-species differences. Glucose and fructose were the main sugars, and malic acid was the main organic acid
Keerthi B Jayasundera et al.
Analytical chemistry, 86(13), 6363-6371 (2014-06-07)
Engagement of the B cell receptor for antigen (BCR) leads to immune responses through a cascade of intracellular signaling events. Most studies to date have focused on the BCR and protein tyrosine phosphorylation. Because spleen tyrosine kinase, Syk, is an
Rui Huang et al.
Bioresource technology, 200, 738-743 (2015-11-13)
The polarities of the cytoplasm and reactants were measured through dielectric spectroscopy, contact angle test, NMR, and FTIR to investigate the mechanisms underlying acid-catalyzed lipid transesterification in wet microalgal cells subjected to microwave irradiation. Organics with apolar functional groups in
Nizam Uddin et al.
PloS one, 9(11), e111101-e111101 (2014-11-05)
Citrus macroptera Montr. (C. macroptera) is locally known as Satkara. The fruit of this plant is used as appetite stimulant and in the treatment of fever. This study therefore aimed to evaluate the toxic effects of the fruit extract using
Péter Monostori et al.
Hormone research in paediatrics, 84(5), 311-318 (2015-09-24)
Newborn screening for congenital adrenal hyperplasia (CAH) is generally performed using 17- hydroxyprogesterone dissociation-enhanced, lanthanide fluorescence immunoassay (DELFIA®). The primary screening results must be confirmed due to high false-positive rates; however, the need to obtain a separate specimen can hamper
H Singh et al.
Molecular human reproduction, 21(1), 81-94 (2014-09-23)
Implantation failure is one of the major causes of infertility and remains a major barrier to assisted reproduction success. Initial receptivity to implantation is regulated by the endometrial luminal epithelium under maternal hormonal control. Identification of epithelial cell surface components
Michael Kuncewitch et al.
Shock (Augusta, Ga.), 43(3), 268-275 (2014-12-17)
Renal ischemia-reperfusion (IR) injury (IRI) after shock states or transplantation causes tissue damage and delayed graft function, respectively. The Wnt/β-catenin signaling pathway plays a critical role in nephrogenesis. We therefore hypothesized that pharmacological activation of the Wnt/β-catenin signaling by the
Mahmoud Seifi et al.
International journal of pharmaceutics, 471(1-2), 37-44 (2014-05-06)
In the present work a series of tramadole imprinted micro- and nanoparticles were prepared and study their recognition properties. Methacrylic acid (MAA), as a functional monomer, ethylene glycol dimethacrylate (EGDMA) as a cross-linker and different solvents (chloroform, toluene and acetonitrile
Yueming Zhou et al.
The Analyst, 139(21), 5387-5392 (2014-08-26)
Better sensitivity and interface of ambient sampling/ionization mass spectrometry remain a challenge. Herein, a novel, plasma-based, ambient sampling/ionization/transmission (PASIT) integrated source in a pin-to-funnel configuration was developed for the sensitive analysis of complex samples. With the funnel sleeve directly affected
Rosanna T Basting et al.
Journal of ethnopharmacology, 157, 257-267 (2014-10-15)
An ethnopharmacological survey indicated that leaves from Eugenia punicifolia (Kunth) DC. (Myrtaceae) are popularly used as a natural therapeutic agent to treat pain and inflammation. The overall objective of the present study was to evaluate the antinociceptive, anti-inflammatory and gastroprotective
Zhitao Liang et al.
Journal of pharmaceutical and biomedical analysis, 105, 121-133 (2014-12-30)
The root and rhizome of Panax ginseng C.A. Mey, known as ginseng, is a commonly used medicinal plant. Ginsenosides are the major active components responsible for the tonic effects of this herb. Here, the combination of laser microdissection and ultra-high
Chongjiao Li et al.
Nuclear medicine communications, 36(5), 452-460 (2015-01-16)
The aim of this study was to explore the targeting ability and metabolic characteristics of the technetium-99m-labeled single-domain antibody (⁹⁹mTc-sdAb) EG2 targeting epidermal growth factor receptor (EGFR) through an in-vitro and in-vivo study. The sdAb EG2 was radiolabeled with Tc
Elżbieta Sikora et al.
Colloids and surfaces. B, Biointerfaces, 126, 541-545 (2015-01-27)
The skin permeation of forskolin, a diterpene isolated from Coleus forsholii, was studied using oil in water (O/W) emulsions as delivery formulations and also an oil solution for comparative purposes. Two forskolin-loaded emulsions of water/Brij 72:Symperonic A7/Miglyol 812:Isohexadecane, at 0.075
Chloe Townley et al.
European journal of mass spectrometry (Chichester, England), 21(3), 433-442 (2015-08-27)
A new and more reliable method is reported for distinguishing the equatorial and axial epimers of oleanolic and ursolic acids and related triterpenoids based primarily on the relative abundance of the [M+H](+) and [M+-H(2)O](+) signals in their positive mode atmospheric
Nattayaporn Apaijai et al.
PloS one, 9(7), e102374-e102374 (2014-07-19)
Obese-insulin resistance caused by long-term high-fat diet (HFD) consumption is associated with left ventricular (LV) dysfunction and increased risk of myocardial infarction. Metformin and vildagliptin have been shown to exert cardioprotective effects. However, the effect of these drugs on the
Suresh B Lakshminarayana et al.
Antimicrobial agents and chemotherapy, 59(2), 1200-1210 (2014-12-10)
Limited information is available on the pharmacokinetic (PK) and pharmacodynamic (PD) parameters driving the efficacy of antimalarial drugs. Our objective in this study was to determine dose-response relationships of a panel of related spiroindolone analogs and identify the PK-PD index
Ferda Ari et al.
Cytotechnology, 67(3), 531-543 (2014-03-29)
Plants are still to be explored for new anti-cancer compounds because overall success in cancer treatment is still not satisfactory. As a new possible source for such compounds, the lichens are recently taking a great attention. We, therefore, explored both
Lin Guo et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 986-987, 108-114 (2015-03-01)
A liquid chromatography-tandem mass spectrometry method (LC-MS/MS) was developed to quantify ezetimibe (EZM) and its major glucuronide (ezetimibe glucuronide, EZM-G) in human plasma simultaneously. The analytes were purified by solid phase extraction (SPE) without hydrolysis. Separation of the analytes was
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