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Showing 1-30 of 88 results for "163678" within Papers
Pedro Elias Marques et al.
Hepatology (Baltimore, Md.), 61(1), 348-360 (2014-05-16)
Drug-induced liver injury (DILI) is an important cause of acute liver failure, with limited therapeutic options. During DILI, oncotic necrosis with concomitant release and recognition of intracellular content amplifies liver inflammation and injury. Among these molecules, self-DNA has been widely
Jie Yu et al.
Theranostics, 5(9), 931-945 (2015-07-15)
The ability to selectively destroy cancer cells while sparing normal tissue is highly desirable during the cancer therapy. Here, magnetic targeted photothermal therapy was demonstrated by the integration of MoS2 (MS) flakes and Fe3O4 (IO) nanoparticles (NPs), where MoS2 converted
Kang Sun et al.
Biochimica et biophysica acta, 1840(7), 2105-2111 (2014-03-13)
Mammalian thioredoxin reductases (TrxR) are selenoproteins with important roles in antioxidant defense and redox regulation, principally linked to functions of their main substrates thioredoxins (Trx). All major forms of TrxR are intracellular while levels in serum are typically very low.
Jing Yu et al.
Scientific reports, 5, 17109-17109 (2015-12-01)
Ternary metal dichalcogenides alloys exhibit compositionally tunable optical properties and electronic structure, and therefore, band gap engineering by controllable doping would provide a powerful approach to promote their physical and chemical properties. Herein we obtained ternary SnS(2-x)Se(x) alloys with tunable
Synthesis and characterization of CdS quantum dots with carboxylic-functionalized poly (vinyl alcohol) for bioconjugation
Mansur HS, et al.
Polymer, 52(4), 1045-1054 (2011)
Hong Ling et al.
PloS one, 8(1), e54499-e54499 (2013-01-26)
Considerable evidence has demonstrated that transforming growth factor β (TGF-β) plays a key role in hepatic fibrosis, the final common pathway for a variety of chronic liver diseases leading to liver insufficiency. Although a few studies have reported that blocking
Hyeon Tae Kang et al.
Digestive diseases and sciences, 64(3), 781-791 (2018-11-14)
Injecting MSCs via blood vessel is most commonly used method, which has a major drawback of safety. The aim of our study was to evaluate efficacy using scaffold-loaded MSCs in acute liver failure model. Acute liver failure was induced in
Dan-Dan Wei et al.
Journal of pharmaceutical and biomedical analysis, 98, 334-338 (2014-07-06)
Thioacetamide (TAA) is a well-known toxicant and its long term exposure could induce liver fibrosis and cirrhosis. A liver fibrosis rat model was established by consecutive injection of TAA solution for 7 weeks. Serum and urine samples were collected weekly
Synthesis of copper sulfide nanowhisker via sonochemical way and its characterization
Xu C, et al
Chemistry Letters (Jpn), 32(2), 198-199 (2003)
Synthesis of nickel sulfide powders by thioacetamide in the presence of urea.
Grau J and Akinc M.
Journal of the American Ceramic Society. American Ceramic Society, 80(4), 941-951 (1997)
Michael Römer et al.
PloS one, 9(5), e97640-e97640 (2014-05-17)
In the area of omics profiling in toxicology, i.e. toxicogenomics, characteristic molecular profiles have previously been incorporated into prediction models for early assessment of a carcinogenic potential and mechanism-based classification of compounds. Traditionally, the biomarker signatures used for model construction
Veronika M Berghold et al.
Histochemistry and cell biology, 143(4), 381-396 (2014-11-05)
A crucial factor for effective villous trophoblast fusion in the human placenta is the transient deregulation of plasma membrane phospholipid asymmetry leading to externalization of phosphatidylserine to the outer membrane leaflet. Screening of scramblase family members implicated in the collapse
D Mladenovic et al.
Human & experimental toxicology, 32(1), 90-100 (2012-11-01)
Thioacetamide (TAA) is widely used as a model of hepatic encephalopathy (HE). The aim of our study was to investigate the effects of TAA on electroencephalographic (EEG) changes in rats and to compare them with human HE. Male Wistar rats
Hajime Abe et al.
Toxicology and applied pharmacology, 280(3), 467-474 (2014-08-26)
Thioacetamide (TAA) has been used to develop a rodent model for hepatocarcinogenesis. To determine the genes with epigenetic modifications in early hepatocarcinogenesis, we did a genome-wide scan for hypermethylated promoter regions using CpG island microarrays in TAA-promoted rat liver tissue.
Carmel T Chan et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(37), E2476-E2485 (2012-08-17)
Up-regulation of the folding machinery of the heat-shock protein 90 (Hsp90) chaperone protein is crucial for cancer progression. The two Hsp90 isoforms (α and β) play different roles in response to chemotherapy. To identify isoform-selective inhibitors of Hsp90(α/β)/cochaperone p23 interactions
Yoon Mee Yang et al.
Science translational medicine, 11(496) (2019-06-14)
Hyaluronan (HA), a major extracellular matrix glycosaminoglycan, is a biomarker for cirrhosis. However, little is known about the regulatory and downstream mechanisms of HA overproduction in liver fibrosis. Hepatic HA and HA synthase 2 (HAS2) expression was elevated in both
Michaela Granzow et al.
Hepatology (Baltimore, Md.), 60(1), 334-348 (2014-03-13)
Activation of the renin angiotensin system resulting in stimulation of angiotensin-II (AngII) type I receptor (AT1R) is an important factor in the development of liver fibrosis. Here, we investigated the role of Janus kinase 2 (JAK2) as a newly described
Shirley Abramovitch et al.
American journal of physiology. Gastrointestinal and liver physiology, 308(2), G112-G120 (2014-09-13)
1,25(OH)2D3, the active form of vitamin D, has an antiproliferative and antifibrotic effect on hepatic stellate cells. Our aim was to investigate the potential of 1,25(OH)2D3 to inhibit the development of liver fibrosis and to ameliorate established fibrosis in vivo.
Heather Hajovsky et al.
Chemical research in toxicology, 25(9), 1955-1963 (2012-08-08)
The hepatotoxicity of thioacetamide (TA) has been known since 1948. In rats, single doses cause centrolobular necrosis accompanied by increases in plasma transaminases and bilirubin. To elicit these effects, TA requires oxidative bioactivation, leading first to its S-oxide (TASO) and
Montinee Khunvirojpanich et al.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 96 Suppl 1, S71-S77 (2013-06-04)
In order to detoxify ammonia, mammalian livers use carbamoyl phosphate synthetase (CPS) and glutamine synthetase (GS) for conversion into respective non-toxic urea and glutamine. CPS is expressed in the periportal hepatocytes whereas GS is contained in the pericentral hepatocytes. To
Zhaoqiang Ding et al.
Materials science & engineering. C, Materials for biological applications, 48, 469-479 (2015-01-13)
A novel molecularly imprinted optosensing material based on multi-walled carbon nanotube-quantum dots (MWCNT-QDs) has been designed and synthesized for its high selectivity, sensitivity and specificity in the recognition of a target protein bovine serum albumin (BSA). Molecularly imprinted polymer coated
Syed Muhammad Shahid et al.
Pakistan journal of pharmaceutical sciences, 26(5), 853-857 (2013-09-17)
Angiotensin converting enzyme (ACE) is a key player of Renin Angiotensin System (RAS), involved in conversion of active product, angiotensin-II. Alterations in RAS have been implicated in the pathophysiology of various diseases involving heart, kidney, lung and liver. This study
Kate M Dudek et al.
The Biochemical journal, 453(1), 71-82 (2013-04-17)
Recent work has demonstrated the importance of post-transcriptional gene regulation in toxic responses. In the present study, we used two rat models to investigate mRNA translation in the liver following xenobiotic-induced toxicity. By combining polysome profiling with genomic methodologies, we
Infrared Spectra and Normal Vibrations of Thioamides. II. Thioacetamide.
Suzuki I.
Bulletin of the Chemical Society of Japan, 35(9), 1449-1456 (1962)
Journal of the Chemical Society. Perkin Transactions 1, 659-659 (1992)
Zhaobing Ding et al.
Journal of gastroenterology and hepatology, 28(1), 188-201 (2012-09-20)
Hepatic fibrosis is a worldwide healthy burden associated with significant morbidity and mortality. It is caused by a variety of chronic liver injuries. There is currently no effective treatment for liver fibrosis. In this report, we tested an imidazolium salt
Kota Kaneko et al.
Hepatology (Baltimore, Md.), 61(6), 2056-2066 (2015-01-13)
Serving as the center for metabolism and detoxification, the liver is inherently susceptible to a wide variety of damage imposed by toxins or chemicals. Induction of cell populations with biliary epithelial phenotypes, which include progenitor-like cells and are referred to
Ko Omura et al.
The Journal of toxicological sciences, 39(5), 785-794 (2014-09-23)
We previously reported a toxicogenomics-based prediction model for hepatocarcinogens in which the expression patterns of signature genes following repeated doses of either genotoxic or non genotoxic compounds were similar. Based on the results of our prediction model, we hypothesized that
Yong-Jun Dai et al.
Developmental and comparative immunology, 97, 28-37 (2019-03-27)
The aim of this article is to investigate the mechanism of lipotoxicity induced by high-fat diets (HFD) in Megalobrama amblycephala. In the present study, fish (average initial weight 40.0 ± 0.35 g) were fed with two fat levels (6% and 11%) diets with
Feng Hong et al.
Digestive diseases and sciences, 58(1), 257-264 (2012-08-25)
Sorafenib, which is approved for treatment of HCC, has also shown promising antifibrotic activity, and therefore refinement of its dosing requirements and window of efficacy are important goals prior to antifibrotic clinical trials. The purpose of this study was to
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