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Showing 1-30 of 488 results for "168149" within Papers
Christopher M Jenkins et al.
Biochemistry, 52(24), 4250-4263 (2013-05-25)
The multifaceted roles of calcium-independent phospholipase A2β (iPLA2β) in numerous cellular processes have been extensively examined through utilization of the iPLA2-selective inhibitor (E)-6-(bromomethylene)-3-(1-naphthalenyl)-2H-tetrahydropyran-2-one (BEL). Herein, we employed accurate mass/high resolution mass spectrometry to demonstrate that the active site serine (S465)
A F Vanin et al.
Biofizika, 58(1), 126-136 (2013-05-09)
Current notions and new experimental data of the authors on physico-chemical features of dinitrosyl iron complexes with natural thiol-containing ligands (glutathione or cysteine), underlying the ability of the complexes to act as NO molecule and nitrosonium ion donors, are considered.
Taka-Aki Ichu et al.
BMC developmental biology, 14, 5-5 (2014-02-06)
After completion of embryogenesis, many organisms experience an additional obligatory developmental transition to attain a substantially different juvenile or adult form. During anuran metamorphosis, the aquatic tadpole undergoes drastic morphological changes and remodelling of tissues and organs to become a
Janardan N Gavade et al.
STAR protocols, 3(4), 101797-101797 (2022-11-04)
Simple genetic screens in budding yeast have identified many conserved meiotic regulators. However, the identification of genes involved in specific steps of meiosis may require a more complex genetic screen that allows visualization of meiosis. Here, we describe a high-throughput
Surya P Manandhar et al.
The Journal of biological chemistry, 289(16), 11431-11442 (2014-03-13)
Palmitoylation at cysteine residues is the only known reversible form of lipidation and has been implicated in protein membrane association as well as function. Many palmitoylated proteins have regulatory roles in dynamic cellular processes, including membrane fusion. Recently, we identified
Ravindra V Badhe et al.
Carbohydrate polymers, 130, 213-221 (2015-06-17)
A new chitosan-based tri-block conjugate, O-PEG-chitosan-N-cysteine was synthesized using microwave irradiation. For synthesis of this derivative, chitosan was modified to a PEG-chitosan conjugate followed by PEG-chitosan-cysteine using 6-O PEGylation and 2-N-thiolation, respectively. The synthesized derivative was characterized using various analytical
Kimberly L W Schultz et al.
Journal of virology, 89(1), 48-60 (2014-10-17)
Susceptibility to alphavirus infection is age dependent, and host maturation is associated with decreased virus replication and less severe encephalitis. To identify factors associated with maturation-dependent restriction of virus replication, we studied AP-7 rat olfactory bulb neuronal cells, which can
Frank J Piscotta et al.
Cell reports, 36(12), 109746-109746 (2021-09-23)
The human microbiota plays a critical role in host health. Proper development of the infant microbiome is particularly important. Its dysbiosis leads to both short-term health issues and long-term disorders lasting into adulthood. A central way in which the microbiome interacts
Claudia Simon et al.
The Journal of biological chemistry, 289(15), 10411-10418 (2014-02-26)
VP1 is the major coat protein of murine polyomavirus and forms virus-like particles (VLPs) in vitro. VLPs consist of 72 pentameric VP1 subunits held together by a terminal clamp structure that is further stabilized by disulfide bonds and chelation of
Qingqing Wang et al.
Biochimica et biophysica acta, 1844(7), 1201-1207 (2014-04-22)
As a potential hemoglobin (Hb)-based oxygen carrier (HBOC), the PEGylated Hb has received much attention for its non-nephrotoxicity. However, PEGylation can adversely alter the structural and functional properties of Hb. The site of PEGylation is an important factor to determine
Hailong Li et al.
Cell calcium, 56(6), 457-466 (2014-12-03)
Mitochondrial Ca(2+) plays a critical physiological role in cellular energy metabolism and signaling, and its overload contributes to various pathological conditions including neuronal apoptotic death in neurological diseases. Live cell mitochondrial Ca(2+) imaging is an important approach to understand mitochondrial
Pål A Olsvik et al.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 165, 17-27 (2014-06-01)
This study aimed to investigate whether dioxin (TCDD) and methylmercury (MeHg) pose a threat to offspring of fish exposed to elevated concentrations of these chemicals via epigenetic-based mechanisms. Adult female zebrafish were fed diets added either 20 μg/kg 2,3,7,8 TCDD
John W Steinke et al.
Journal of immunology (Baltimore, Md. : 1950), 193(1), 41-47 (2014-06-04)
Reactions to aspirin and nonsteroidal anti-inflammatory drugs in patients with aspirin-exacerbated respiratory disease (AERD) are triggered when constraints upon activated eosinophils, normally supplied by PGE2, are removed secondary to cyclooxygenase-1 inhibition. However, the mechanism driving the concomitant cellular activation is
John B Jonnalagadda et al.
Journal of biomaterials science. Polymer edition, 26(7), 401-419 (2015-02-12)
In this study, poly(e-caprolactone)/polyglycolic acid (PCL/PGA) scaffolds for repairing articular cartilage were fabricated via solid-state cryomilling along with compression molding and porogen leaching. Four distinct scaffolds were fabricated using this approach by four independent cryomilling times. These scaffolds were assessed
J Correa-Betanzo et al.
Food chemistry, 165, 522-531 (2014-07-21)
Wild blueberries are rich in polyphenols and have several potential health benefits. Understanding the factors that affect the bioaccessibility and bioavailability of polyphenols is important for evaluating their biological significance and efficacy as functional food ingredients. Since the bioavailability of
Brian C Wengerter et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 22(7), 1375-1387 (2014-04-01)
Effective therapeutic vaccines often require activation of T cell-mediated immunity. Robust T cell activation, including CD8 T cell responses, can be achieved using antibodies or antibody fragments to direct antigens of interest to professional antigen presenting cells. This approach represents
Elena Geromichalou et al.
European journal of medicinal chemistry, 96, 47-57 (2015-04-16)
Recent science evidenced the interlinkage of oxidative stress and cancer. Due to the inherent complexity of cancer and its accompanying effect of oxidative stress, novel molecules, containing combinatorial functionalities should be targeted. Herein, we synthesized gemcitabine-5'-O-lipoate derived from a regioselective
Kris M Weigel et al.
Current protocols, 1(7), e209-e209 (2021-07-28)
The gut microbiome is recognized as a critical regulator of human diseases. Constituents of the microbiota and their individual activities can affect a broad range of disease states related to autoimmunity, cancer, infection, metabolism, mental health, and toxicant exposure. A
Guus G H van den Akker et al.
Arthritis research & therapy, 16(3), R135-R135 (2014-06-29)
Relatively little is known about cellular subpopulations in the mature nucleus pulposus (NP). Detailed understanding of the ontogenetic, cellular and molecular characteristics of functional intervertebral disc (IVD) cell populations is pivotal to the successful development of cell replacement therapies and
Daniel Garrido et al.
Scientific reports, 5, 13517-13517 (2015-09-05)
Breast milk enhances the predominance of Bifidobacterium species in the infant gut, probably due to its large concentration of human milk oligosaccharides (HMO). Here we screened infant-gut isolates of Bifidobacterium longum subsp. infantis and Bifidobacterium bifidum using individual HMO, and
Patricia Sanz-Ramos et al.
Cellular & molecular biology letters, 19(4), 659-674 (2014-11-27)
We aim to demonstrate the role of Alk receptors in the response of hydrogel expansion. Chondrocytes from rat knees were cultured onto plastic and hydrogel surfaces. Alk-1 and Alk-5 were overexpressed or silenced and the effects on cells during expansion
Sun-Young Park et al.
Korean journal for food science of animal resources, 35(5), 615-621 (2016-01-14)
Lactobacillus plantarum FH185 was isolated from the feces of healthy adults. In our previous study, L. plantarum FH185 was demonstrated that it has anti-obesity effect in the in vitro and in vivo test. In order to determine its potential for
Mikko T Nieminen et al.
PloS one, 9(5), e97864-e97864 (2014-05-29)
The ability of C. albicans to form biofilms is a major virulence factor and a challenge for management. This is evident in biofilm-associated chronic oral-oesophageal candidosis, which has been shown to be potentially carcinogenic in vivo. We have previously shown
Kazuki Ohno et al.
Biochemical and biophysical research communications, 456(1), 245-249 (2014-12-03)
Hydrogen sulfide (H2S) is a gaseous regulatory factor produced by several enzymes, and plays a pivotal role in processes such as proliferation or vasodilation. Recent reports demonstrated the physiological and pathophysiological functions of H2S in neurons. PTEN is a target
Fiona E Freeman et al.
Tissue engineering. Part A, 21(7-8), 1320-1332 (2015-01-16)
Chondrogenic priming (CP) of mesenchymal stem cells (MSCs) and coculture of MSCs with human umbilical vein endothelial stem cells (HUVECs) both have been shown to significantly increase the potential for MSCs to undergo osteogenic differentiation and mineralization in vitro and
Clayton Gordy et al.
iScience, 25(10), 105165-105165 (2022-10-11)
Gaze stabilization relies on bilateral mirror-symmetric vestibular endorgans, central circuits, and extraocular motor effectors. Embryonic removal of one inner ear before the formation of these structures was used to evaluate the extent to which motor outputs in the presence of
Joana A Santos et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(22), E2251-E2260 (2014-05-23)
Iron-sulfur clusters function as cofactors of a wide range of proteins, with diverse molecular roles in both prokaryotic and eukaryotic cells. Dedicated machineries assemble the clusters and deliver them to the final acceptor molecules in a tightly regulated process. In
Torben Sølbeck Rasmussen et al.
International journal of systematic and evolutionary microbiology, 71(3) (2021-01-30)
A bacterial strain, designated WCA-9-b2T, was isolated from the caecal content of an 18-week-old obese C57BL/6NTac male mouse. According to phenotypic analyses, the isolate was rod-shaped, strictly anaerobic, spore-forming, non-motile and Gram-stain-positive, under the conditions tested. Colonies were irregular and
Jiahua Li et al.
American journal of physiology. Cell physiology, 305(2), C190-C196 (2013-05-17)
Claudins constitute a family of tight junction transmembrane proteins whose first extracellular loop (ECL1) determines the paracellular permeability and ion selectivity in epithelia. There are two cysteines in the ECL1 that are conserved among all claudins. We hypothesized that these
Michał Burmistrz et al.
Journal of bacteriology, 197(16), 2631-2641 (2015-05-28)
The CRISPR-Cas (clustered regularly interspaced short palindromic repeats/CRISPR-associated genes) system provides prokaryotic cells with an adaptive and heritable immune response to foreign genetic elements, such as viruses, plasmids, and transposons. It is present in the majority of Archaea and almost
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