175633

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Showing 1-9 of 9 results for "175633" within Papers

A mechanistic modelling approach for the determination of the mechanisms of inhibition by cyclosporine on the uptake and metabolism of atorvastatin in rat hepatocytes using a high throughput uptake method.

Simon J Carter et al.

Xenobiotica; the fate of foreign compounds in biological systems, 50(4), 415-426 (2019-08-08)

Determine the inhibition mechanism through which cyclosporine inhibits the uptake and metabolism of atorvastatin in fresh rat hepatocytes using mechanistic models applied to data generated using a high throughput oil spin method.Atorvastatin was incubated in fresh rat hepatocytes (0.05-150 nmol/ml) with

Contemporaneous 3D characterization of acute and chronic myocardial I/R injury and response.

Simon F Merz et al.

Nature communications, 10(1), 2312-2312 (2019-05-28)

Cardioprotection by salvage of the infarct-affected myocardium is an unmet yet highly desired therapeutic goal. To develop new dedicated therapies, experimental myocardial ischemia/reperfusion (I/R) injury would require methods to simultaneously characterize extent and localization of the damage and the ensuing

Colloidal ordering from phase separation in a liquid-crystalline continuous phase.

Loudet J-C, et al.

Nature, 407(6804), 611-613 (2000)

Close temporal coupling of neuronal activity and tissue oxygen responses in rodent whisker barrel cortex.

Jennifer Li et al.

The European journal of neuroscience, 34(12), 1983-1996 (2011-12-14)

Neuronal activity elicits metabolic and vascular responses, during which oxygen is first consumed and then supplied to the tissue via an increase in cerebral blood flow. Understanding the spatial and temporal dynamics of blood and tissue oxygen (To₂) responses following

Viscous liquid film flows over a periodic surface.

Trifonov YY.

International Journal of Multiphase Flow, 24(7), 1139-1161 (1999)

Implementation of permeation rules leads to a FabI inhibitor with activity against Gram-negative pathogens.

Erica N Parker et al.

Nature microbiology, 5(1), 67-75 (2019-11-20)

Gram-negative bacterial infections are a significant public health concern, and the lack of new drug classes for these pathogens is linked to the inability of most drug leads to accumulate inside Gram-negative bacteria1-7. Here, we report the development of a

hFRUIT: An optimized agent for optical clearing of DiI-stained adult human brain tissue.

Sven Hildebrand et al.

Scientific reports, 10(1), 9950-9950 (2020-06-21)

Here, we describe a new immersion-based clearing method suitable for optical clearing of thick adult human brain samples while preserving its lipids and lipophilic labels such as 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate (DiI). This clearing procedure is simple, easy to implement, and allowed

A quality comparison of protein crystals grown under containerless conditions generated by diamagnetic levitation, silicone oil and agarose gel.

Hui-Ling Cao et al.

Acta crystallographica. Section D, Biological crystallography, 69(Pt 10), 1901-1910 (2013-10-09)

High-quality crystals are key to obtaining accurate three-dimensional structures of proteins using X-ray diffraction techniques. However, obtaining such protein crystals is often a challenge. Several containerless crystallization techniques have been reported to have the ability to improve crystal quality, but

Synthesis of bicyclo[5.3.0]azulene derivatives.

Donald D Nolting et al.

Nature protocols, 4(8), 1113-1117 (2009-07-21)

Azulene has been recognized for its application in medicinal therapy against inflammation. Recently, azulene analogs have been used in optical technology. Nevertheless, synthesis of this family of compounds is always associated with multiple challenges. In this protocol, we describe a

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