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Showing 1-30 of 1236 results for "179124" within Papers
Sara J Tallaksen-Greene et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(47), 15658-15668 (2014-11-21)
The common neurodegenerative syndromes exhibit age-related incidence, and many Mendelian neurodegenerative diseases exhibit age-related penetrance. Mutations slowing aging retard age related pathologies. To assess whether delayed aging retards the effects of a mutant allele causing a Huntington's disease (HD)-like syndrome
Pieter Glibert et al.
Journal of proteome research, 14(2), 839-849 (2014-12-17)
The ability to distinguish between phosphopeptides of high and low stoichiometry is essential to discover the true extent of protein phosphorylation. We here extend the strategy whereby a peptide sample is briefly split in two identical parts and differentially labeled
Christian Erbel et al.
Innate immunity, 21(3), 255-265 (2014-03-26)
Macrophage heterogeneity in human atherosclerotic plaques has been recognized; however, markers for unequivocal identification of some subtypes are lacking. We found that the platelet chemokine CXCL4 induces a unique macrophage phenotype, which we proposed to call 'M4'. Here, we sought
Salah Khanahmadzadeh et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 972, 6-13 (2014-10-13)
A new process was developed for the selective extraction and pre-concentration of amitriptyline (AT) from human plasma using nano-sized molecularly imprinted polymer (MIP) with ultrasound-assisted extraction (UAE). The nano-sized AT imprinted polymer particles were synthesized using suspension polymerization in silicon
Ryan J Wade et al.
Nature communications, 6, 6639-6639 (2015-03-24)
Electrospun nanofibres are promising in biomedical applications to replicate features of the natural extracellular matrix (ECM). However, nearly all electrospun scaffolds are either non-degradable or degrade hydrolytically, whereas natural ECM degrades proteolytically, often through matrix metalloproteinases. Here we synthesize reactive
Ingebjørg H Nymo et al.
Comparative immunology, microbiology and infectious diseases, 37(3), 195-204 (2014-02-19)
Brucellosis, a worldwide zoonosis, is linked to reproductive problems in primary hosts. A high proportion of Brucella-positive hooded seals (Cystophora cristata) have been detected in the declined Northeast Atlantic stock. High concentrations of polychlorinated biphenyls (PCBs) have also been discovered
Sinisa Bjelic et al.
Journal of molecular biology, 426(1), 256-271 (2013-10-29)
Designed retroaldolases have utilized a nucleophilic lysine to promote carbon-carbon bond cleavage of β-hydroxy-ketones via a covalent Schiff base intermediate. Previous computational designs have incorporated a water molecule to facilitate formation and breakdown of the carbinolamine intermediate to give the
B W Sykes et al.
Journal of veterinary pharmacology and therapeutics, 38(2), 130-136 (2014-10-02)
The objectives were to document the pharmacokinetics of intravenous, enteric-coated oral and plain oral omeprazole in fasted horses and to investigate the impact of feeding on the bioavailability of an enteric-coated omeprazole. Twelve horses received four treatments: intravenous omeprazole (0.5 mg/kg)
Matilde Durán-Lobato et al.
Biomacromolecules, 15(7), 2725-2734 (2014-06-24)
Oral drug delivery is a route of choice for vaccine administration because of its noninvasive nature and thus efforts have focused on efficient delivery of vaccine antigens to mucosal sites. An effective oral vaccine delivery system must protect the antigen
O Campollo et al.
Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion, 44(4), 483-490 (1992-10-01)
Several toxic factors have been implicated in the pathogenesis of hepatic encephalopathy (PSE) among which ammonia plays a dominant role. More recently, the gamma-aminobutyric acid (GABA) hypothesis in which an increase in the GABA-ergic tone and the presence of one
Sameh K Wasseff et al.
Neurobiology of disease, 82, 86-98 (2015-06-09)
Oligodendrocyte:oligodendrocyte (O:O) gap junction (GJ) coupling is a widespread and essential feature of the CNS, and is mediated by connexin47 (Cx47) and Cx32. Loss of function mutations affecting Cx47 results in a severe leukodystrophy, Pelizeus-Merzbacher-like disease (also known as Hypomyelinating
Jae-Min Jeong et al.
Langmuir : the ACS journal of surfaces and colloids, 29(10), 3474-3481 (2013-02-15)
An effective polymeric thin film deposited by initiated chemical vapor deposition (iCVD) process was presented and its application as a barrier film on the PDMS micromold blocking the penetration of oxygen and organic solvents was investigated. With this barrier film
Atsuki Matsubara et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 969, 199-204 (2014-09-03)
The potential of supercritical fluid extraction (SFE) as a preparation method for mass spectrometry of dried blood spots (DBS) was examined. SFE is generally used for the extraction of hydrophobic compounds, but hydrophilic metabolites such as amino acids, amines, and
Sergei Likhodii et al.
Epilepsia, 49 Suppl 8, 83-86 (2008-12-17)
Recent interest in the anticonvulsant effects of acetone has stemmed from studies related to the ketogenic diet (KD). The KD, a high-fat diet used to treat drug-resistant seizures, raises blood and brain levels of three ketones: beta-hydroxybutyrate, acetoacetate, and acetone.
Guangfeng Zhao et al.
Scientific reports, 5, 7647-7647 (2015-01-07)
Chemotherapy treatment in women can frequently cause damage to the ovaries, which may lead to primary ovarian insufficiency (POI). In this study, we assessed the preventative effects of hyaluronic acid (HA) in immunosuppressive drug-induced POI-like rat models and investigated the
Abd Almonem Doolaanea et al.
Journal of microencapsulation, 31(6), 600-608 (2014-04-05)
The aim of this study is to investigate the cell uptake of Nigella sativa oil (NSO)-PLGA microparticle by neuron-like PC-12 cells in comparison to surfactants; hydrophilic (Tween 80 & Triton X100) and hydrophobic (Span 80). Solvent evaporation was used to
Xiaodan Cao et al.
Journal of proteomics, 130, 221-230 (2015-10-11)
Schistosomiasis remains a serious public health problem, with 200 million people infected and 779 million people at risk worldwide. The schistosomulum is the early stage of the complex lifecycle of Schistosoma japonicum in their vertebrate hosts, and is the main
Gregor Bond et al.
Transplant immunology, 32(1), 40-45 (2014-12-03)
After inflammatory stimulus, mast cells (MC) migrate to secondary lymphoid organs contributing to adaptive immune response. There is growing evidence that MC also contribute to transplant tolerance, but little is known about MC kinetics in the setting of transplant tolerance
Ina Kurth et al.
Oncotarget, 6(33), 34494-34509 (2015-10-16)
Despite recent advances in understanding of the molecular pathogenesis and improvement of treatment techniques, locally advanced head and neck squamous cell carcinoma (HNSCC) remains associated with an unfavorable prognosis. Compelling evidence suggests that cancer stem cells (CSC) may cause tumor
Luiz G Maturana et al.
Brain and behavior, 3(4), 417-430 (2014-01-02)
The purpose of this study was to investigate the influence of implanting collagen with a supramolecular organization on peripheral nerve regeneration, using the sciatic nerve tubulization technique. For this purpose, adult female Sprague Dawley rats were divided into five groups:
Hui Peng et al.
Environmental science & technology, 49(5), 2999-3006 (2015-01-27)
Ultra-High Resolution LC/mass spectrometry (LC-UHRMS; Thermo Fisher Q-Exactive) was used to identify two novel isomers of hydroxylated bis(2-ethylhexyl)-tetrabromophthalate (OH-TBPH) which were unexpectedly observed in a commercial standard of TBPH. By combining ultra-high resolution (UHR) mass spectra (MS(1)), mass errors to
Marwa Ahmed et al.
Journal of chromatography. A, 1360, 100-109 (2014-08-19)
Single-walled carbon nanotubes were encapsulated into different polymer-based monolithic backbones. The polymer monoliths were prepared via the copolymerization of 20% monomers, glycidyl methacrylate, 20% ethylene glycol dimethacrylate and 60% porogens (36% 1-propanol, 18% 1,4-butanediol) or 16.4% monomers (16% butyl methacrylate
D C Riley et al.
Journal of neuroscience research, 93(4), 572-583 (2014-11-27)
Restoration of neuronal functions by outgrowths regenerating at ∼1 mm/day from the proximal stumps of severed peripheral nerves takes many weeks or months, if it occurs at all, especially after ablation of nerve segments. Distal segments of severed axons typically
Shashwati U Atwe et al.
Journal of controlled release : official journal of the Controlled Release Society, 194, 45-52 (2014-08-26)
Oral vaccination can offer a painless and convenient method of vaccination. Furthermore, in addition to systemic immunity it has potential to stimulate mucosal immunity through antigen-processing by the gut-associated lymphoid tissues. In this study we propose the concept that pollen
Weronika Wituszyńska et al.
Plant, cell & environment, 38(2), 315-330 (2014-01-30)
As obligate photoautotrophs, plants are inevitably exposed to ultraviolet (UV) radiation. Because of stratospheric ozone depletion, UV has become more and more dangerous to the biosphere. Therefore, it is important to understand UV perception and signal transduction in plants. In
Ye Ni et al.
Applied microbiology and biotechnology, 83(3), 415-423 (2009-05-12)
China is one of the few countries, which maintained the fermentative acetone-butanol-ethanol (ABE) production for several decades. Until the end of the last century, the ABE fermentation from grain was operated in a few industrial scale plants. Due to the
Tai-Ying Chiou et al.
Journal of oleo science, 62(1), 1-8 (2013-01-30)
Defatted rice bran was treated with water, 50% (v/v) ethanol, ethanol, 50% (v/v) acetone, or acetone. The treatment temperature and time were fixed at 230°C and 5 min, respectively. The treatment with 50% (v/v) acetone produced the highest yield of
Shirley L Zhang et al.
Blood, 124(2), 296-304 (2014-05-31)
Development of T cells in the thymus requires continuous importation of T-lineage progenitors from the bone marrow via the circulation. Following bone marrow transplant, recovery of a normal peripheral T-cell pool depends on production of naïve T cells in the
Seongjin Hong et al.
Environmental pollution (Barking, Essex : 1987), 199, 110-118 (2015-02-04)
The major AhR-active PAHs were identified in crude oil and oil-contaminated sediments by use of effect-directed analysis. As part of the study, an enhanced potency balance analysis was conducted by establishing the novel relative potency values of (alkyl)-PAHs from the
Buyun Ma et al.
Journal of cancer research and clinical oncology, 141(3), 419-429 (2014-09-23)
The potent anticancer efficacy of oncolytic viruses has been verified in Clinic in recent years. Cisplatin (DDP) is one of most common chemotherapeutic drugs, but is accompanied by side effects and drug resistance. Our previous studies have shown the strategy
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