179337

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Assessment of different mouthwashes on cannabis oral fluid concentrations.

Ana de Castro et al.

Drug testing and analysis, 6(10), 1011-1019 (2014-01-24)

Since the implementation of mandatory drug testing in drivers' oral fluid, several solutions to avoid an onsite positive result can be found on drug users' forums, especially for marijuana, including the use of different mouthwashes. Recently, a product for personal

Surface behavior of peptides from E1 GBV-C protein: Interaction with anionic model membranes and importance in HIV-1 FP inhibition.

R Galatola et al.

Biochimica et biophysica acta, 1848(2), 392-407 (2014-12-03)

The interaction between a peptide sequence from GB virus C E1 protein (E1P8) and its structural analogs (E1P8-12), (E1P8-13), and (E1P8-21) with anionic lipid membranes (POPG vesicles and POPG, DPPG or DPPC/DPPG (2:1) monolayers) and their association with HIV-1 fusion

Natural occurrence of four Alternaria mycotoxins in tomato- and citrus-based foods in China.

Kai Zhao et al.

Journal of agricultural and food chemistry, 63(1), 343-348 (2014-12-19)

A total of 70 tomato-based and 86 citrus-based products collected in China were analyzed for alternariol, alternariol monomethyl ether, tentoxin, and tenuazonic acid by ultraperformance liquid chromatography–electrospray ionization–tandem mass spectrometry. No toxins were found in any fresh tomato or citrus

Prevalence of heroin markers in urine for pain management patients.

Julie Knight et al.

Forensic science international, 243, 79-83 (2014-05-27)

Surveys of current trends indicate heroin abuse is associated with nonmedical use of pain relievers. Consequently, there is an interest in evaluating the presence of heroin-specific markers in chronic pain patients who are prescribed controlled substances. A total of 926,084

Antibacterial compounds from Salvia adenophora Fernald (Lamiaceae).

Angela Bisio et al.

Phytochemistry, 110, 120-132 (2014-12-02)

From the aerial parts of Salvia adenophora Fernald four derivatives of 12-oxo-phytodienoic acid (1-4) together with five clerodane diterpenoids (5, 6, 8-10), and one known diterpene (7) have been isolated. Compounds 1-6 and 8-10 are described for the first time.

Simvastatin attenuates rhinovirus-induced interferon and CXCL10 secretion from monocytic cells in vitro.

Lisa E Wickert et al.

Journal of leukocyte biology, 95(6), 951-959 (2014-02-18)

RV infections frequently trigger exacerbations of respiratory diseases, such as asthma, yet treatment and intervention options remain limited. Statin drugs are the treatment of choice for dyslipidemia and can also modulate immune cell function. To determine whether statin drugs modify

ERVK polyprotein processing and reverse transcriptase expression in human cell line models of neurological disease.

Mamneet Manghera et al.

Viruses, 7(1), 320-332 (2015-01-23)

Enhanced expression of the reverse transcriptase (RT) protein encoded by human endogenous retrovirus-K (ERVK) is a promising biomarker for several inflammatory and neurological diseases. However, unlike RT enzymes encoded by exogenous retroviruses, little work has been done to identify ERVK

Evaluation of bone repair of critical size defects treated with simvastatin-loaded poly(lactic-co-glycolic acid) microspheres in rat calvaria.

Lorraine B Ferreira et al.

Journal of biomaterials applications, 29(7), 965-976 (2014-09-12)

Statins are hypolipemiant drugs with osteoinductive effect. We evaluated the potential of simvastatin loaded into poly(lactic-co-glycolic acid) (PLGA) microspheres to heal critical size defects in rat calvaria. PLGA scaffolds (50:50 ratio) were synthesized as pure membranes or as microspheres loaded

Extraction parameters for metabolomics from cultured cells.

Zheng Ser et al.

Analytical biochemistry, 475, 22-28 (2015-01-24)

The successful extraction of metabolites is a critical step in metabolite profiling. By optimizing metabolite extraction, the range and quantitative capacity of metabolomics studies can be improved. We considered eight separate extraction protocols for the preparation of a metabolite extract

Simple and accurate quantitative analysis of 20 anti-tuberculosis drugs in human plasma using liquid chromatography-electrospray ionization-tandem mass spectrometry.

Hyo-Ji Kim et al.

Journal of pharmaceutical and biomedical analysis, 102, 9-16 (2014-09-15)

A simple and accurate liquid chromatography (LC)-tandem mass spectrometry (MS/MS) method for the quantitation of 20 anti-tuberculosis (anti-TB) drugs in human plasma, was developed as a tool for therapeutic drug monitoring. Two protein precipitation methods were adopted; one using methanol

Determination of lipid content of oleaginous microalgal biomass by NMR spectroscopic and GC-MS techniques.

Amarijt S Sarpal et al.

Analytical and bioanalytical chemistry, 407(13), 3799-3816 (2015-03-25)

Direct methods based on (1)H NMR spectroscopic techniques have been developed for the determination of neutral lipids (triglycerides and free fatty acids) and polar lipids (glyceroglycolipids/phospholipids) in the solvent extracts of oleaginous microalgal biomasses cultivated on a laboratory scale with

Development and validation of a liquid-chromatography high-resolution tandem mass spectrometry approach for quantification of nine cytochrome P450 (CYP) model substrate metabolites in an in vitro CYP inhibition cocktail.

Julia Dinger et al.

Analytical and bioanalytical chemistry, 406(18), 4453-4464 (2014-05-17)

Knowledge about the cytochrome P450 (CYP) inhibition potential of new drug candidates is important for drug development because of its risk of interactions. For novel psychoactive substances (NPS), corresponding data are not available. For developing a general drug inhibition cocktail

Hypo-osmotic shock-induced subclinical inflammation of skin in a rat model of disrupted skin barrier function.

Chihiro Kishi et al.

Biological research for nursing, 17(2), 135-141 (2015-02-15)

Aging disrupts skin barrier function and induces xerosis accompanied by pruritus. In many cases, elderly patients complain of pruritus during skin hygiene care, a condition called aquagenic pruritus of the elderly (APE). To date, the pathophysiology and mechanism of action

Determination of phenolic acids and flavonoids in raw propolis by silica-supported ionic liquid-based matrix solid phase dispersion extraction high performance liquid chromatography-diode array detection.

Zhibing Wang et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 969, 205-212 (2014-09-06)

The silica-supported ionic liquid (S-SIL) was prepared by impregnation and used as the dispersion adsorbent of matrix solid phase dispersion (MSPD) for the simultaneous extraction of eight phenolic acids and flavonoids, including caffeic acid, ferulic acid, morin, luteolin, quercetin, apigenin

Development and Validation of a Stability Indicating RP-HPLC Method for Hydrocortisone Acetate Active Ingredient, Propyl Parahydroxybenzoate and Methyl Parahydroxybenzoate Preservatives, Butylhydroxyanisole Antioxidant, and Their Degradation Products in a Rectal Gel Formulation.

Magda Ascaso et al.

Journal of AOAC International, 98(1), 27-34 (2015-04-11)

A stability indicating method was established through a stress study, wherein different methods of degradation (oxidation, hydrolysis, photolysis, and temperature) were studied simultaneously to determine the active ingredient hydrocortisone acetate, preservatives propyl parahydroxybenzoate, and methyl parahydroxybenzoate, antioxidant butylhydroxyanisole (BHA), and

Methanolic extracts of Solieria robusta inhibits proliferation of oral cancer Ca9-22 cells via apoptosis and oxidative stress.

Yii-Huei Yen et al.

Molecules (Basel, Switzerland), 19(11), 18721-18732 (2014-11-19)

Many red algae-derived natural products are known to have anticancer effects. The biological functions of the red alga Solieria robusta from the Karachi coast (Pakistan) remain unclear. Here, we prepared a methanolic extracts of S. robusta (MESR) to examine its

Isolation and characterization of lignin from the oak wood bioethanol production residue for adhesives.

Soo Jung Lee et al.

International journal of biological macromolecules, 72, 1056-1062 (2014-12-03)

Lignin was isolated from the residue of bioethanol production with oak wood via alkaline and catalyzed organosolv treatments at ambient temperature to improve the purity of lignin for the materials application. The isolated lignins were analyzed for their chemical composition

Fabric phase sorptive extraction: a new sorptive microextraction technique for the determination of non-steroidal anti-inflammatory drugs from environmental water samples.

Inés Racamonde et al.

Analytica chimica acta, 865, 22-30 (2015-03-04)

Fabric phase sorptive extraction (FPSE) is a new, yet very promising member of the sorbent-based sorptive microextraction family. It has simultaneously improved both the extraction sensitivity and the speed of the extraction by incorporating high volume of sol-gel hybrid inorganic-organic

Enhancement of the photovoltaic performance of CH₃NH₃PbI₃ perovskite solar cells through a dichlorobenzene-functionalized hole-transporting material.

Jin-Wook Lee et al.

Chemphyschem : a European journal of chemical physics and physical chemistry, 15(12), 2595-2603 (2014-05-28)

A dichlorobenzene-functionalized hole-transporting material (HTM) is developed for a CH3NH3PbI3-based perovskite solar cell. Notwithstanding the similarity of the frontier molecular orbital energy levels, optical properties, and hole mobility between the functionalized HTM [a polymer composed of 2'-butyloctyl-4,6-dibromo-3-fluorothieno[3,4-b]thiophene-2-carboxylate (TT-BO), 3',4'-dichlorobenzyl-4,6-dibromo-3-fluorothieno[3,4-b]thiophene-2-carboxylate (TT-DCB)

Increasing the dissolution rate and oral bioavailability of the poorly water-soluble drug valsartan using novel hierarchical porous carbon monoliths.

Yanzhuo Zhang et al.

International journal of pharmaceutics, 473(1-2), 375-383 (2014-07-23)

In the present study, a novel hierarchical porous carbon monolith (HPCM) with three-dimensionally (3D) ordered macropores (∼ 400 nm) and uniform accessible mesopores (∼ 5.2 nm) was synthesized via a facile dual-templating technique using colloidal silica nanospheres and Poloxamer 407

Coupling of solid phase microextraction with electrospray ionization ion mobility spectrometry and direct analysis of venlafaxine in human urine and plasma.

Mohammad T Jafari et al.

Analytica chimica acta, 853, 460-468 (2014-12-04)

The capability of electrospray ionization-conventional ion mobility spectrometry (ESI-IMS) for direct analysis of the samples extracted by solid phase microextraction (SPME) was investigated and evaluated for the first time. To that end, an appropriate new desorption chamber was designed and

Convenient QSAR model for predicting the complexation of structurally diverse compounds with beta-cyclodextrins.

Alfonso Pérez-Garrido et al.

Bioorganic & medicinal chemistry, 17(2), 896-904 (2008-12-06)

This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoretical molecular descriptors, calculated solely from the molecular structure of the compounds under investigation

Analysis of oxysterols and vitamin D metabolites in mouse brain and cell line samples by ultra-high-performance liquid chromatography-atmospheric pressure photoionization-mass spectrometry.

Linda Ahonen et al.

Journal of chromatography. A, 1364, 214-222 (2014-09-11)

We have developed an ultra-high-performance liquid chromatography-atmospheric pressure photoionization-tandem mass spectrometric (UHPLC-APPI-MS/MS) method for the simultaneous quantitative analyses of several oxysterols and vitamin D metabolites in mouse brain and cell line samples. An UHPLC-APPI-high resolution mass spectrometric (UHPLC-APPI-HRMS) method that

Pharmacokinetic comparison to determine the mechanisms underlying the differential efficacies of cationic diamidines against first- and second-stage human African trypanosomiasis.

Sihyung Yang et al.

Antimicrobial agents and chemotherapy, 58(7), 4064-4074 (2014-05-07)

Human African trypanosomiasis (HAT), a neglected tropical disease, is fatal without treatment. Pentamidine, a cationic diamidine, has been used to treat first-stage (hemolymphatic) HAT since the 1940s, but it is ineffective against second-stage (meningoencephalitic, or central nervous system [CNS]) infection.

Development of 2D and 3D mucus models and their interactions with mucus-penetrating paclitaxel-loaded lipid nanocapsules.

Anne-Claire Groo et al.

Pharmaceutical research, 31(7), 1753-1765 (2014-01-29)

To study, diffusion through mucus (3D model) of different formulations of paclitaxel loaded lipid nanocapsules (Ptx-LNCs), to interpret the results in the light of LNC behavior at air-mucus interface (2D model). LNC surface properties were modified with chitosan or poly(ethylene

An LC-MS/MS method for the simultaneous determination of goserelin and testosterone in rat plasma for pharmacokinetic and pharmacodynamic studies.

Shu Zhang et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 965, 183-189 (2014-07-20)

A liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) method was developed, using testosterone-d3 as a surrogate analyte, for the simultaneous quantification of goserelin and testosterone in rat plasma. According to this method, the pharmacokinetic and pharmacodynamic data were obtained from

Brominated flame retardants in matched serum samples from Swedish first-time mothers and their toddlers.

Leena M O Sahlström et al.

Environmental science & technology, 48(13), 7584-7592 (2014-06-14)

Tri-decabrominated diphenyl ethers and 21 other flame retardants were determined in matched serum samples from 24 Swedish mothers (Uppsala county) and their toddlers (11-15 months of age). The median concentrations of individual polybrominated diphenyl ethers (PBDEs) ranged from 0.036 to

Sustained in vivo signaling by long-lived IL-2 induces prolonged increases of regulatory T cells.

Charles J M Bell et al.

Journal of autoimmunity, 56, 66-80 (2014-12-03)

Regulatory T cells (Tregs) expressing FOXP3 are essential for the maintenance of self-tolerance and are deficient in many common autoimmune diseases. Immune tolerance is maintained in part by IL-2 and deficiencies in the IL-2 pathway cause reduced Treg function and

Development and validation of one-step ultrasound-assisted extraction for simultaneous determination of multiclass fungicides in soils.

Yared Merdassa et al.

Journal of AOAC International, 98(1), 192-200 (2015-04-11)

A rapid, efficient, and simple one-step ultrasound-assisted extraction (UAE) method was developed for the analysis of seven fungicides (cymoxanil, metalaxyl, mandipropamid, folpet, chlorothalonil, kresoxim-methyl, and famoxadone) in horticultural soils. Analytes in the samples were determined by HPLC with variable wavelength

PEGylated-thymoquinone-nanoparticle mediated retardation of breast cancer cell migration by deregulation of cytoskeletal actin polymerization through miR-34a.

Saurav Bhattacharya et al.

Biomaterials, 51, 91-107 (2015-03-17)

Thymoquinone (TQ), a major active constituent of black seeds of Nigella sativa, has potential medical applications including spectrum of therapeutic properties against different cancers. However, little is known about their effect on breast cancer cell migration, which is the cause

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