179973

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Solid-state properties and dissolution behaviour of tablets containing co-amorphous indomethacin-arginine.

Elisabeth Lenz et al.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 96, 44-52 (2015-07-22)

Co-amorphous drug formulations provide the possibility to stabilize a drug in its amorphous form by interactions with low molecular weight compounds, e.g. amino acids. Recent studies have shown the feasibility of spray drying as a technique to manufacture co-amorphous indomethacin-arginine

Enhanced nonpeptidergic intraepidermal fiber density and an expanded subset of chloroquine-responsive trigeminal neurons in a mouse model of dry skin itch.

Manouela V Valtcheva et al.

The journal of pain : official journal of the American Pain Society, 16(4), 346-356 (2015-02-03)

Chronic pruritic conditions are often associated with dry skin and loss of epidermal barrier integrity. In this study, repeated application of acetone and ether followed by water (AEW) to the cheek skin of mice produced persistent scratching behavior with no

Determination of 3-methylhistidine and 1-methylhistidine in untreated urine samples by capillary electrophoresis.

Petr Tůma et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 821(1), 53-59 (2005-05-19)

Capillary electrophoretic (CE) method was developed for the determination of urinary 3-methylhistidine (3MH) and 1-methylhistidine (1MH) indicating the extent of degradation of skeletal muscle proteins and thereby the state of human health. 3MH, 1MH and histidine can be separated in

Autotaxin produced by stromal cells promotes LFA-1-independent and Rho-dependent interstitial T cell motility in the lymph node paracortex.

Tomoya Katakai et al.

Journal of immunology (Baltimore, Md. : 1950), 193(2), 617-626 (2014-06-18)

T cells exhibit high-speed migration within the paracortical T zone of lymph nodes (LNs) as they scan cognate Ags displayed by dendritic cells in the tissue microenvironment supported by the network of stromal cells. Although intranodal T cell migration is

Preparation and preliminary evaluation of 63Zn-zinc citrate as a novel PET imaging biomarker for zinc.

Timothy R DeGrado et al.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 55(8), 1348-1354 (2014-07-23)

Abnormalities of zinc homeostasis are indicated in many human diseases. A noninvasive imaging method for monitoring zinc in the body would be useful to understand zinc dynamics in health and disease. To provide a PET imaging agent for zinc, we

Mechanisms of chemical cooperative carcinogenesis by epidermal Langerhans cells.

Julia M Lewis et al.

The Journal of investigative dermatology, 135(5), 1405-1414 (2014-09-19)

Cutaneous squamous cell carcinoma (SCC) is the most prevalent invasive malignancy with metastatic potential. The epidermis is exposed to a variety of environmental DNA-damaging chemicals, principal among which are polyaromatic hydrocarbons (PAHs) ubiquitous in the environment, tobacco smoke, and broiled

Meloxicam and buprenorphine treatment after ovarian transplantation does not affect estrous cyclicity and follicular integrity in aged CBA/J mice.

Anna H Le et al.

PloS one, 9(8), e106013-e106013 (2014-08-26)

Angiogenesis, the formation of new blood vessels, is important for the survival of ovarian transplants and the restoration of ovarian functions. Without angiogenesis, transplanted ovarian tissue becomes more susceptible to tissue damage and necrosis. Administration of analgesics for pain management

Natural killer T cells are essential for the development of contact hypersensitivity in BALB/c mice.

Chihiro Shimizuhira et al.

The Journal of investigative dermatology, 134(11), 2709-2718 (2014-04-24)

Contact hypersensitivity (CHS) has been widely used to study cutaneous immune responses, as a prototype of delayed-type hypersensitivity. Although natural killer T (NKT) cells have been assumed to have an important role in CHS, their role is controversial. Here, we

Retrospective monitoring of long-term recreational and dependent cocaine use in toenail clippings/scrapings as an alternative to hair.

Milena M Madry et al.

Bioanalysis, 6(23), 3183-3196 (2014-12-23)

Toenails were assessed as an alternative matrix to hair for retrospective monitoring of cocaine consumption of recreational and dependent users. Results/methodology: Toenail clippings, scrapings and hair samples from recreational and dependent cocaine users were analyzed for cocaine and metabolites. Dependent

Self-assembled hybrid metal oxide base catalysts prepared by simply mixing with organic modifiers.

Masazumi Tamura et al.

Nature communications, 6, 8580-8580 (2015-10-06)

Multidentate materials formed by simply mixing heterogeneous and homogeneous components are promising for construction of versatile active sites on the surface of heterogeneous compounds, however, to the best of our knowledge, there are no reports on such materials. Self-assembly of

Annexin-A1 restricts Th17 cells and attenuates the severity of autoimmune disease.

Samia Yazid et al.

Journal of autoimmunity, 58, 1-11 (2015-01-27)

Annexin-A1 (Anx-A1) is an endogenous anti-inflammatory molecule and while described as a repressor of innate immune responses, the role of Anx-A1 in adaptive immunity, and in particular in T helper (Th) cell responses, remains controversial. We have used a T-cell

Development of a multianalyte method based on micro-matrix-solid-phase dispersion for the analysis of fragrance allergens and preservatives in personal care products.

Maria Celeiro et al.

Journal of chromatography. A, 1344, 1-14 (2014-04-29)

An effective, simple and low cost sample preparation method based on matrix solid-phase dispersion (MSPD) followed by gas chromatography-mass spectrometry (GC-MS) or gas chromatography-triple quadrupole-mass spectrometry (GC-MS/MS) has been developed for the rapid simultaneous determination of 38 cosmetic ingredients, 25

The dissolution enhancement of piroxicam in its physical mixtures and solid dispersion formulations using gluconolactone and glucosamine hydrochloride as potential carriers.

Hiba Al-Hamidi et al.

Pharmaceutical development and technology, 20(1), 74-83 (2014-01-08)

The solid dispersion technique is one of the most effective methods for improving the dissolution rate of poorly water-soluble drugs; however this is reliant on a suitable carrier and solvent being selected. The work presented explores amino sugars (d-glucosamine HCl

Apple polysaccharide reduces NF-Kb mediated colitis-associated colon carcinogenesis.

Dian Zhang et al.

Nutrition and cancer, 67(1), 177-190 (2014-11-21)

Nuclear factor-kappa B (NF-κB) is an important molecule in mediating inflammatory colitis, which can lead to colorectal cancer (CRC). The aim of this study was to evaluate the chemopreventive efficacy of apple polysaccharide extract (AP) in inhibiting NF-κB-mediated inflammation pathways

Exposure of native bees foraging in an agricultural landscape to current-use pesticides.

Michelle L Hladik et al.

The Science of the total environment, 542(Pt A), 469-477 (2015-11-02)

The awareness of insects as pollinators and indicators of environmental quality has grown in recent years, partially in response to declines in honey bee (Apis mellifera) populations. While most pesticide research has focused on honey bees, there has been less

Monitoring breath during oral glucose tolerance tests.

S Ghimenti et al.

Journal of breath research, 7(1), 017115-017115 (2013-03-01)

The evolution of breath composition during oral glucose tolerance tests (OGTTs) was analysed by thermal desorption/gas chromatography/mass spectrometry in 16 subjects and correlated to blood glucose levels. The glucose tolerance tests classified five of the subjects as diabetics, eight as

The vitamin D receptor is required for activation of cWnt and hedgehog signaling in keratinocytes.

Thomas S Lisse et al.

Molecular endocrinology (Baltimore, Md.), 28(10), 1698-1706 (2014-09-03)

Alopecia (hair loss) in vitamin D receptor (VDR)-null mice is due to absence of ligand-independent actions of the VDR that are required for initiation of postmorphogenic hair cycles. Investigations were undertaken to determine whether the VDR is required for the

[Isopropanol and acetone level in serum after preoperative surface disinfection with antiseptics containing isopropanol].

S Wittmann et al.

Blutalkohol, 29(5), 326-335 (1992-09-01)

After preoperative skin disinfection in pediatric surgery, serum levels of isopropanol up to 12.2 mg/l (MW 5.0 mg/l +/- 3.37, n = 26) were found. They result from a rapid and prolonged but uncharacteristic percutaneous resorption of the isopropanol-containing disinfectant.

Aminoacetone oxidase from Streptococcus oligofermentans belongs to a new three-domain family of bacterial flavoproteins.

Gianluca Molla et al.

The Biochemical journal, 464(3), 387-399 (2014-10-01)

The aaoSo gene from Streptococcus oligofermentans encodes a 43 kDa flavoprotein, aminoacetone oxidase (SoAAO), which was reported to possess a low catalytic activity against several different L-amino acids; accordingly, it was classified as an L-amino acid oxidase. Subsequently, SoAAO was demonstrated

Effects of LB broth, naphthalene concentration, and acetone on the naphthalene degradation activities by Pseudomonas putida G7.

Su-Yun Chang et al.

Water environment research : a research publication of the Water Environment Federation, 87(1), 61-67 (2015-01-30)

Luria-Bertani broth and acetone were usually used in naphthalene degradation experiments as nutrient and solvent. However, their effect on the degradation was seldom mentioned. In this work, we investigated the effect of LB, naphthalene concentration, and acetone on the degradation

In vitro cytokines profile and ultrastructural changes of microglia and macrophages following interaction with Leishmania.

Patricia Karla Santos Ramos et al.

Parasitology, 141(8), 1052-1063 (2014-04-11)

In the present study, we assessed morphological changes and cytokine production after in vitro interaction with causative agents of American cutaneous leishmaniasis and compared the microglia and macrophage immune responses. Cultures of microglia and macrophages infected with stationary-phase promastigotes of

Application of TLC method with video scanning in estimation of daily dietary intake of specific flavonoids--preliminary studies.

Wojciech Koch et al.

Acta poloniae pharmaceutica, 70(4), 611-620 (2013-08-08)

Flavonoids, substances present in foods of plant origin, play an important role in many metabolic processes. Numerous properties of these substances were described, including their anti-allergic, antitumor and antioxidant properties. Therefore, an increased intake of these nutrients may play a

Contribution of 3-hydroxyisobutyrate to the measurement of 3-hydroxybutyrate in human plasma: comparison of enzymatic and gas-liquid chromatography-mass spectrometry assays in normal and in diabetic subjects.

A Avogaro et al.

Journal of lipid research, 30(11), 1811-1817 (1989-11-01)

In this study we employed a capillary gas-liquid chromatographic-mass spectrometric (GLC-MS) method to measure the plasma concentrations of 3-hydroxybutyrate (3-OHB) and 3-hydroxyisobutyrate (3-OHIB) in overnight fasted diabetic subjects and in normal subjects. Plasma contents of 3-hydroxybutyrate measured in this fashion

Nonaggregational shape-persistent cyclo[6]aramide and its macrocyclic effect toward binding secondary ammonium salts in moderately polar media.

Jinchuan Hu et al.

Organic letters, 15(18), 4670-4673 (2013-09-13)

Simply by introducing steric side chains, the shape-persistent cyclo[6]aramides were found to exhibit nonaggregational behavior and strong association (3 × 10(4) M(-1)) ability in acetone for binding secondary ammonium salt. The complexation can be switched in an on-and-off fashion using

Absence of keratin 8 or 18 promotes antimitochondrial autoantibody formation in aging male mice.

Diana M Toivola et al.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(12), 5081-5089 (2015-09-25)

Human mutations in keratin 8 (K8) and keratin 18 (K18), the intermediate filament proteins of hepatocytes, predispose to several liver diseases. K8-null mice develop chronic liver injury and fragile hepatocytes, dysfunctional mitochondria, and Th2-type colitis. We tested the hypothesis that

IL-33 and thymic stromal lymphopoietin mediate immune pathology in response to chronic airborne allergen exposure.

Koji Iijima et al.

Journal of immunology (Baltimore, Md. : 1950), 193(4), 1549-1559 (2014-07-13)

Humans are frequently exposed to various airborne allergens in the atmospheric environment. These allergens may trigger a complex network of immune responses in the airways, resulting in asthma and other chronic airway diseases. In this study, we investigated the immunological

Investigation of the neuroprotective impact of nimodipine on Neuro2a cells by means of a surgery-like stress model.

Eva Herzfeld et al.

International journal of molecular sciences, 15(10), 18453-18465 (2014-10-16)

Nimodipine is well characterized for the management of SAH (subarachnoid hemorrhage) and has been shown to promote a better outcome and less DIND (delayed ischemic neurological deficits). In rat experiments, enhanced axonal sprouting and higher survival of motoneurons was demonstrated

Heart pigmentation in the gray bichir, Polypterus senegalus (Actinopterygii: Polypteriformes).

I Reyes-Moya et al.

Anatomia, histologia, embryologia, 44(6), 475-480 (2014-11-08)

The occurrence of pigment cells in the heart is well documented in amphibians, birds and mammals. By contrast, information on heart pigmentation in fish is extremely sparse. The aim is to report the presence of pigment cells over the entire

The acetone-butanol-ethanol fermentation: recent progress in technology.

I S Maddox

Biotechnology & genetic engineering reviews, 7, 189-220 (1989-01-01)

Integration of phase separation with ultrasound-assisted salt-induced liquid-liquid microextraction for analyzing the fluoroquinones in human body fluids by liquid chromatography.

Huili Wang et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 985, 62-70 (2015-02-11)

Herein, we developed a novel integrated device to perform phase separation based on ultrasound-assisted salt-induced liquid-liquid microextraction for determination of five fluoroquinones (FQs) in human body fluids. The integrated device consisted of three simple HDPE components used to separate the

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