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Showing 1-30 of 42 results for "188174" within Papers
G Tibolla et al.
Atherosclerosis, 210(1), 78-87 (2009-12-01)
Atherosclerosis is associated with Alzheimer's disease (AD) in humans, but the nature of this link is still elusive. Aim of this study was to investigate aortic atherosclerosis development in a mouse model with central nervous system (CNS) restricted beta-amyloid precursor
Petr Chytil et al.
Molecular pharmaceutics, 15(9), 3654-3663 (2018-03-16)
Herein, the biodegradable micelle-forming amphiphilic N-(2-hydroxypropyl) methacrylamide (HPMA)-based polymer conjugates with the anticancer drug doxorubicin (Dox) designed for enhanced tumor accumulation were investigated, and the influence of their stability in the bloodstream on biodistribution, namely, tumor uptake, and in vivo
Palraj Kalimuthu et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 24(30), 7710-7717 (2018-03-25)
The electrochemically driven catalysis of the complex molybdoenzyme steroid C25 dehydrogenase (S25DH) from the β-Proteobacterium Sterolibacterium denitrificans is reported. S25DH catalyses the oxygen-independent regioselective hydroxylation of the tertiary C25 atom of sterols and also their derivatives. Cholest-4-en-3-one is a native
Daniel L Motola et al.
Cell, 124(6), 1209-1223 (2006-03-15)
In response to environmental and dietary cues, the C. elegans orphan nuclear receptor, DAF-12, regulates dauer diapause, reproductive development, fat metabolism, and life span. Despite strong evidence for hormonal control, the identification of the DAF-12 ligand has remained elusive. In
Dzung H Nguyen et al.
Blood, 99(12), 4298-4306 (2002-05-31)
The chemokine receptor, CCR5, is used as a human immunodeficiency virus coreceptor in combination with CD4 during transmission and early infection. CCR5 has been shown to be palmitoylated and targeted to cholesterol- and sphingolipid-rich membrane microdomains termed "lipid rafts." However
Kwang-wook Ahn et al.
Biochemistry, 43(3), 827-836 (2004-01-21)
We investigated the dependence of cholesterol oxidase catalytic activity and membrane affinity on lipid structure in model membrane bilayers. The binding affinities of cholesterol oxidase to 100-nm unilamellar vesicles composed of mixtures of DOPC or DPPC and cholesterol are not
Dzung H Nguyen et al.
Experimental cell research, 291(1), 36-45 (2003-11-05)
Membrane cholesterol is required to maintain chemokine receptor conformation and function for CXCR4 and CCR5. We previously demonstrated that chemokines preferentially bind to receptors within lipid rafts, which are cholesterol- and sphingolipid-rich membrane microdomains. To further elucidate the role of
On the substrate specificity of human CYP27A1: implications for bile acid and cholestanol formation.
Maria Norlin et al.
Journal of lipid research, 44(8), 1515-1522 (2003-06-05)
The mitochondrial sterol 27-hydroxylase (CYP27A1) is required for degradation of the C27-sterol side chain in bile acid biosynthesis. CYP27A1 seems, however, to have roles beyond this, as illustrated by patients with a deficient sterol 27-hydroxylase due to mutations of the
Christian H Grün et al.
Journal of chromatography. A, 1439, 74-81 (2016-01-18)
During thermal processing of sterols, complex mixtures of sterol oxidation products may be formed. Here, a new method for the separation and detection of such products is described. The method is based on normal-phase liquid chromatography (NPLC) for separation and
B Zipser et al.
Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology, 120(2), 269-282 (1998-11-25)
Steroids were isolated from the blood-sucking leech species Hirudo medicinalis and their structure was studied with one- and two-dimensional NMR spectroscopy (DQF-COSY and HMQC), GC-MS and ESI-MS spectrometry. Fractionating leech lipid using silicic acid chromatography led to the isolation of
Arati B Deshmukh et al.
Molecular bioSystems, 13(11), 2338-2349 (2017-09-20)
Methylglyoxal (MG) is a highly reactive dicarbonyl known to be elevated under the hyperglycemic conditions of diabetes and is implicated in the development of diabetic complications. Therefore, the current study investigates the role of MG in exacerbating insulin resistance at
L Pang et al.
Biochemistry, 38(37), 12003-12011 (1999-10-03)
The neuropeptide galanin mediates a number of diverse physiological and pathophysiological actions via interaction with membrane-bound receptors. The role that membrane cholesterol plays in modulating the interaction between galanin and one of the three cloned galanin receptor subtypes (GalR2) expressed
Hua Tang et al.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 30(6), 655-657 (2007-10-09)
Seven compounds were isolated from the marine bryozoan Bugula neritina L. Their chemical structures were identified by NMR and MS spectroscopies as follows: cholesterol (I), cholest-4-en-3-one (II), cholesteryl myristate (III), 3beta,5alpha,9alpha-trihydrox-y-(22E,24R)-ergosta-,22-dien-6-one (IV), 3beta,5alpha,6beta-trihydroxy-(22E,24R)-ergosta-7,22-dien (V), uracil (VI), thymine (VII). Compounds II-VII
Yorio Maeda et al.
Steroids, 67(5), 333-338 (2002-04-18)
Radioimmunoassay (RIA) is the most prevalent method for measuring small amounts of hormones, peptides, and other compounds in human body fluids. The method, however, has several problems, such as cross reactions or non-specific reactions of the antibody used. In order
Tadashi Fujii et al.
Bioscience, biotechnology, and biochemistry, 73(4), 805-810 (2009-04-09)
We report here some efficient biotransformations using Escherichia coli strains with disruptions for the AcrAB-TolC efflux pump system. Biotransformations of compactin into pravastatin (6alpha-hydroxy-iso-compactin) were performed using E. coli strains with tolC and/or acrAB mutations expressing a cytochrome P450 (P450)
H P Bartram et al.
Nutrition and cancer, 25(1), 71-78 (1996-01-01)
Diet-induced changes in fecal excretion of secondary bile acids, certain neutral sterols, and bacterial enzyme activities are known to play a role in colon cancer development. Dietary fish oil (FO) has been implicated as a protective agent in colon carcinogenesis.
Liang-Bin Xiong et al.
Microbial cell factories, 19(1), 80-80 (2020-04-02)
The bioconversion of phytosterols into high value-added steroidal intermediates, including the 9α-hydroxy-4-androstene-3,17-dione (9-OHAD) and 22-hydroxy-23,24-bisnorchol-4-ene-3-one (4-HBC), is the cornerstone in steroid pharmaceutical industry. However, the low transportation efficiency of hydrophobic substrates into mycobacterial cells severely limits the transformation. In this
Luigi Puglielli et al.
The Journal of clinical investigation, 115(9), 2556-2563 (2005-08-30)
The abnormal accumulation of amyloid beta-peptide (Abeta) in the form of senile (or amyloid) plaques is one of the main characteristics of Alzheimer disease (AD). Both cholesterol and Cu2+ have been implicated in AD pathogenesis and plaque formation. Abeta binds
Yin-Ru Chiang et al.
Applied and environmental microbiology, 74(1), 107-113 (2007-11-13)
The anoxic metabolism of cholesterol was studied in the denitrifying bacterium Sterolibacterium denitrificans, which was grown with cholesterol and nitrate. Cholest-4-en-3-one was identified before as the product of cholesterol dehydrogenase/isomerase, the first enzyme of the pathway. The postulated second enzyme
Oswald Quehenberger et al.
Journal of lipid research, 51(11), 3299-3305 (2010-07-31)
The focus of the present study was to define the human plasma lipidome and to establish novel analytical methodologies to quantify the large spectrum of plasma lipids. Partial lipid analysis is now a regular part of every patient's blood test
Hugues Ouellet et al.
Molecular microbiology, 77(3), 730-742 (2010-06-16)
The infectivity and persistence of Mycobacterium tuberculosis requires the utilization of host cell cholesterol. We have examined the specific role of cytochrome P450 CYP125A1 in the cholesterol degradation pathway using genetic, biochemical and high-resolution mass spectrometric approaches. The analysis of
Douglas J Kenny et al.
Cell host & microbe, 28(2), 245-257 (2020-06-17)
The human microbiome encodes extensive metabolic capabilities, but our understanding of the mechanisms linking gut microbes to human metabolism remains limited. Here, we focus on the conversion of cholesterol to the poorly absorbed sterol coprostanol by the gut microbiota to
P Liu et al.
The Journal of biological chemistry, 275(41), 31648-31654 (2000-08-05)
Platelet-derived growth factor receptor beta (PDGFRbeta) in fibroblasts is concentrated in caveolae where it controls the tyrosine phosphorylation of multiple proteins. Caveolae are enriched in cholesterol and sphingolipids, but the role of these lipids in PDGFR signal transduction is unknown.
A M Wolfreys et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 40(4), 461-470 (2002-03-15)
Phytosterol esters are phytosterols derived from vegetable oils following esterification to fatty acids. When phytosterols are added to foods, they inhibit the absorption of dietary and endogenous cholesterol and thereby reduce blood cholesterol concentrations. As part of a comprehensive programme
Xiao-Chuan Liu et al.
Biotechnology and bioengineering, 82(7), 858-863 (2003-04-18)
A novel approach for regioselective synthesis is described. The approach uses the unique binding properties of protein as a guide to achieve regioselectivity. Specifically, steroids, e.g., 4-androstene-3,17-dione, were reduced selectively at carbon 17 using bovine serum albumin (BSA) as a
Jinben Ma et al.
Cell death & disease, 7(9), e2372-e2372 (2016-12-03)
Metastasis is a great challenge in lung adenocarcinoma (ADC) therapy. Cholesterol has been implicated in ADC metastasis. 4-cholesten-3-one, as cholesterol metabolite and analog, can substitute membrane cholesterol and increase membrane fluidity. In this study, we explored the possibility that 4-cholesten-3-one
Jenna K Capyk et al.
The Journal of biological chemistry, 284(51), 35534-35542 (2009-10-23)
Cyp125 (Rv3545c), a cytochrome P450, is encoded as part of the cholesterol degradation gene cluster conserved among members of the Mycobacterium tuberculosis complex. This enzyme has been implicated in mycobacterial pathogenesis, and a homologue initiates cholesterol catabolism in the soil
J A Weststrate et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 37(11), 1063-1071 (1999-11-24)
A study was conducted in 12 healthy males and 12 females (mean age 36 years) to assess the impact of a margarine enriched with phytosterol esters on faecal concentrations of bile acids and sterols. During the run-in period, volunteers consumed
J P Slotte
Biochimica et biophysica acta, 1259(2), 180-186 (1995-11-16)
The oxidation of monolayer cholesterol by cholesterol oxidase has been visualized using monolayer fluorescence microscopy. A direct microscopic visualization was possible because the lateral distribution of a lipid fluorophore, tetramethylrhodamine (TRITC)-labeled phosphatidylethanolamine, was very different in a cholesterol containing monolayer
Jonathan B Johnston et al.
The Journal of biological chemistry, 285(47), 36352-36360 (2010-09-17)
One challenge to the development of new antitubercular drugs is the existence of multiple virulent strains that differ genetically. We and others have recently demonstrated that CYP125A1 is a steroid C(26)-monooxygenase that plays a key role in cholesterol catabolism in
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