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Showing 1-30 of 137 results for "194123" within Papers
J F Humbert et al.
Veterinary parasitology, 101(3-4), 405-414 (2001-11-15)
Molecular techniques are of growing importance in the study of anthelmintic resistance in trichostrongylid worm populations. A knowledge of the genetic determinants of benzimidazole (BZ) resistance has made it possible to construct a molecular tool for genotyping individual worms, in
Magdalena J Mazur et al.
Plant physiology, 179(1), 168-183 (2018-11-06)
Attachment of the small ubiquitin-like modifier (SUMO) to substrate proteins modulates their turnover, activity, or interaction partners. However, how this SUMO conjugation activity concentrates the proteins involved and the substrates into uncharacterized nuclear bodies (NBs) remains poorly understood. Here, we
Mohammad Azadbakht et al.
Experimental parasitology, 213, 107902-107902 (2020-05-01)
Natural compounds played an important role for prevention and treatment of the disease as well as are the important compounds for the design of the new bioactive compounds. In this study, eight tropolone alkaloids were isolated from Colchicum kurdicum including
Aïssatou Diawara et al.
The American journal of tropical medicine and hygiene, 88(6), 1052-1061 (2013-03-06)
In endemic countries with soil-transmitted helminths mass drug administration with albendazole or mebendazole are being implemented as a control strategy. However, it is well known in veterinary helminths that the use of the same benzimidazole drugs can place selection on
Benjamin W Roose et al.
Biochemistry, 58(30), 3232-3242 (2019-06-30)
Indole prenyltransferases catalyze the prenylation of l-tryptophan (l-Trp) and other indoles to produce a diverse set of natural products in bacteria, fungi, and plants, many of which possess useful biological properties. Among this family of enzymes, CymD from Salinispora arenicola
Chun-Yu Chang et al.
Toxicology and applied pharmacology, 279(3), 351-363 (2014-07-16)
Oxidized LDL (oxLDL) induces a pro-oxidative environment and promotes apoptosis, causing the progression of renal diseases in humans. Taurine is a semi-essential amino acid in mammals and has been shown to be a potent endogenous antioxidant. The kidney plays a
Zsolt Székelyhidi et al.
Bioorganic & medicinal chemistry letters, 15(13), 3241-3246 (2005-06-01)
SR protein-specific kinase-1 (SRPK-1) has been identified as a validated target for hepatitis B virus (HBV). A series of novel tricyclic quinoxaline derivatives was designed and synthesised as potential kinase inhibitory antiviral agents and was found to be active and
Michela Maestrini et al.
Molecules (Basel, Switzerland), 25(2) (2020-01-16)
Gastrointestinal strongyle nematodes (GIS) are included among the most important parasites of small ruminants. The widespread drug resistance and drug residues in products of animal origin have increased the interest in the search for natural compounds with anthelmintic activity as
Laila Arzuman et al.
Anticancer research, 34(10), 5453-5464 (2014-10-03)
In the present study, synergism in activity from the sequenced combinations of monofunctional platinum tris(benzimidazole)monochloroplatinum(II) chloride (coded as LH4) with capsaicin, quercetin, curcumin and cisplatin was investigated as a function of sequence of administration in a number of human ovarian
Zhaoyang Li et al.
The Journal of clinical investigation, 125(3), 1081-1097 (2015-02-03)
Signaling via the MyD88/IRAK pathway in T cells is indispensable for cell survival; however, it is not known whether this pathway functions in the progression of T acute lymphoblastic leukemia (T-ALL). Here, we determined that compared with thymic and peripheral
Mohammad Sajid et al.
Cancer medicine, 8(1), 246-260 (2018-12-24)
Cancer is one of the major health problem globally, responsible for high morbidity and mortality. Exposure of humans to xenobiotics is associated with the development of cancer. Further, these xenobiotics may combine with the body proteins and can act as
Jingshuai Yang et al.
ChemSusChem, 6(2), 275-282 (2013-01-11)
Covalently cross-linked polymer membranes were fabricated from poly(aryl sulfone benzimidazole) (SO(2)PBI) and poly(vinylbenzyl chloride) (PVBCl) as electrolytes for high-temperature proton-exchange-membrane fuel cells. The cross-linking imparted organo insolubility and chemical stability against radical attack to the otherwise flexible SO(2)PBI membranes. Steady
Docking investigation and binding interaction of benzimidazole derivative with bovine serum albumin.
J Jayabharathi et al.
Journal of photochemistry and photobiology. B, Biology, 117, 27-32 (2012-10-03)
(1)H NMR, (13)C NMR and Mass spectral analysis have been made for 1-(4-fluorobenzyl)-2-(4-fluorophenyl)-1H-benzo[d]imidazole (FBFPB). The mutual interaction of FBFPB with bovine serum albumin (BSA) was investigated using absorption, fluorescence and synchronous fluorescence spectral studies. The binding distance has been determined
Lyara Ferreira Pereira et al.
Ultrasonics sonochemistry, 69, 105275-105275 (2020-08-02)
In this work, Zn-based coordination polymer [Zn2(1,3-bdc)bzim2]n was successfully synthesized by the sonochemical method using a 13 mm probe-type ultrasound operating at 20 kHz and amplitudes of 30, 40 and 50% corresponding to an acoustic power of 5.5, 8.6, and 10.3 W, respectively.
Haitao Liu et al.
Anti-cancer drugs, 26(6), 667-677 (2015-03-27)
Coumarins are a large family of compounds derived from a wide range of plants, fungi, and bacteria, and coumarin derivatives can have extremely variable structures and consequently diverse biological properties including antitumor activity. Compounds that bear a benzimidazole moiety are
Venkatasubramanian Ulaganathan et al.
Journal of the American Chemical Society, 135(6), 2263-2272 (2013-01-12)
Human kinesin Eg5 is a target for drug development in cancer chemotherapy with compounds in phase II clinical trials. These agents bind to a well-characterized allosteric pocket involving the loop L5 region, a structural element in kinesin-5 family members thought
Eko Aditya Rifai et al.
Journal of computer-aided molecular design, 32(1), 239-249 (2017-09-11)
Computational protein binding affinity prediction can play an important role in drug research but performing efficient and accurate binding free energy calculations is still challenging. In the context of phase 2 of the Drug Design Data Resource (D3R) Grand Challenge
Lihua Shii et al.
Molecular immunology, 88, 20-31 (2017-06-05)
The SERPINB2 gene is strongly upregulated in inflammatory states. In monocytes, it can constitute up to 1% of total cellular protein. It functions in protection from proteotoxic stress and plays a role in angioedema. The purpose of this study was
Nour T Abdel-Ghani et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 104, 134-142 (2012-12-26)
[NiL(1,2)Cl(2)(OH(2))(3)]·zH(2)O and [ZnL(1,2)(CH(3)CO(2))(2)] (L(1)=(1H-benzimidazol-2-ylmethyl)-N-phenyl amine, z=0 and L(2)=2-[(1H-Benzimidazol-2-ylmethyl)-amino]-benzoic acid methyl ester, z=1) complexes have been synthesized and characterized by a variety of physico-chemical techniques. The central Ni(II) ion is coordinated by only the pyridine-type nitrogen (N(py)) of benzimidazole ring, three
Dan Zhao et al.
ACS nano, 13(1), 125-133 (2019-01-04)
Marine mussel inspired polydopamine (PDA) has received increased attention due to its good thermal and chemical stability as well as strong adhesion on most materials. In this work, high-performance nanofiltration membranes based on interpenetrating polymer networks (IPN) incorporating PDA and
Fabian López-Vallejo et al.
Bioorganic & medicinal chemistry, 15(2), 1117-1126 (2006-11-01)
Comparative molecular field analysis (CoMFA) was performed on a set of 1H-benzimidazole derivatives. Molecular modeling and 3D-QSAR were employed to determine the tautomeric form that would probably fit a target receptor in Entamoeba histolytica. CoMFA results suggest that the antiamoebic
Tamara Muñoz-Caro et al.
Parasites & vectors, 8, 607-607 (2015-11-28)
Polymorphonuclear neutrophil (PMN) and eosinophil extracellular trap (ETs) formation has recently been described as an important host effector mechanism against invading pathogens. So far, scarce evidence on metazoan-triggered ET formation has been published. We here describe for the first time
Anna Martínez-Villalba et al.
Journal of chromatography. A, 1313, 119-131 (2013-09-17)
In this work the atmospheric pressure ionization behavior and the tandem mass spectrometry fragmentation of 19 benzimidazoles was studied. Several atmospheric pressure ionization (API) sources (ESI, APCI and APPI) were evaluated showing that APCI was the best option, mainly for
Neil D Sargison et al.
International journal for parasitology. Drugs and drug resistance, 10, 92-100 (2019-08-20)
Anthelmintic resistant gastrointestinal helminths have become a major cause of poor health in sheep and goats. Sensitive and specific molecular markers are needed to monitor the genotypic frequency of resistance in field parasite populations. Gastrointestinal nematode resistance to benzimidazole is
Theany To et al.
Nature communications, 11(1), 2593-2593 (2020-05-24)
Metal-organic framework glasses feature unique thermal, structural, and chemical properties compared to traditional metallic, organic, and oxide glasses. So far, there is a lack of knowledge of their mechanical properties, especially toughness and strength, owing to the challenge in preparing
Mar Oroval et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 23(6), 1353-1360 (2016-11-20)
We describe herein the preparation of glucose-sensitive capped mesoporous silica nanoparticles for insulin delivery. The new material consists of an expanded-pore nanometric silica support grafted with 1-propyl-1-H-benzimidazole groups, loaded with fluorescein isothiocyanate-labeled insulin (FITC-Ins) and capped by the formation of
Jiumao Lin et al.
BMC cancer, 14, 729-729 (2014-10-01)
The development of hepatic cancer is tightly regulated by multiple intracellular signaling pathways. Therefore, most currently-used anti-tumor agents, which typically target single intracellular pathway, might not always be therapeutically effective. Additionally, long-term use of these agents probably generates drug resistance
Michele Macrelli et al.
Veterinary parasitology, 270, 1-6 (2019-06-20)
In 2016 suspected reduced ivermectin (IVM) efficacy in Oesophagostomum species in pigs was reported in England. Following this initial report, APHA raised awareness amongst private pig veterinary practitioners of the need to monitor the efficacy of the worm control on
Virginie Barrère et al.
Parasitology international, 62(5), 464-470 (2013-06-19)
Haemonchus contortus is a hemophilic nematode which infects sheep and causes anemia and death to lambs. Benzimidazole drugs are used to remove these parasites, but the phenomenon of resistance has arisen worldwide. A sensitive test to detect resistance before treatment
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