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201154

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Showing 1-30 of 825 results for "201154" within Papers

Overexpression of the type 1 adenylyl cyclase in the forebrain leads to deficits of behavioral inhibition.

Xuanmao Chen et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(1), 339-351 (2015-01-09)

The type 1 adenylyl cyclase (AC1) is an activity-dependent, calcium-stimulated adenylyl cyclase expressed in the nervous system that is implicated in memory formation. We examined the locomotor activity, and impulsive and social behaviors of AC1+ mice, a transgenic mouse strain

Sepsis attenuates the anabolic response to skeletal muscle contraction.

Jennifer L Steiner et al.

Shock (Augusta, Ga.), 43(4), 344-351 (2014-11-26)

Electrically stimulated muscle contraction is a potential clinical therapy to treat sepsis-induced myopathy; however, whether sepsis alters contraction-induced anabolic signaling is unknown. Polymicrobial peritonitis was produced by cecal ligation and puncture (CLP) in male C57BL/6 mice and time-matched, pair-fed controls

MeCP2 deficiency is associated with reduced levels of tubulin acetylation and can be restored using HDAC6 inhibitors.

W A Gold et al.

Journal of molecular medicine (Berlin, Germany), 93(1), 63-72 (2014-09-12)

Rett syndrome (RTT) is a severe neurodevelopmental disorder, predominantly caused by loss of function mutations in the X-linked methyl-CpG-binding protein 2 (MECP2) gene. Despite the genetic cause being known in the majority of cases, the pathophysiology of the neurological phenotype

Metformin promotes irisin release from murine skeletal muscle independently of AMP-activated protein kinase activation.

D-J Li et al.

Acta physiologica (Oxford, England), 213(3), 711-721 (2014-11-11)

Irisin, a novel myocyte-secreted hormone mediating beneficial effects of exercise on metabolism, is supposed to be an ideal therapeutic target for metabolic disorders such as obesity and diabetes. Here, we investigated the potential effects of metformin and glibenclamide, two antidiabetic

TGF-β1, but not bone morphogenetic proteins, activates Smad1/5 pathway in primary human macrophages and induces expression of proatherogenic genes.

Dinara Nurgazieva et al.

Journal of immunology (Baltimore, Md. : 1950), 194(2), 709-718 (2014-12-17)

Macrophages are responsible for the control of inflammation and healing, and their malfunction results in cardiometabolic disorders. TGF-β is a pleiotropic growth factor with dual (protective and detrimental) roles in atherogenesis. We have previously shown that in human macrophages, TGF-β1

G-protein-coupled estrogen receptor 1 is anatomically positioned to modulate synaptic plasticity in the mouse hippocampus.

Elizabeth M Waters et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(6), 2384-2397 (2015-02-13)

Both estrous cycle and sex affect the numbers and types of neuronal and glial profiles containing the classical estrogen receptors α and β, and synaptic levels in the rodent dorsal hippocampus. Here, we examined whether the membrane estrogen receptor, G-protein-coupled

Xenopus laevis FGF receptor substrate 3 (XFrs3) is important for eye development and mediates Pax6 expression in lens placode through its Shp2-binding sites.

Yeon-Jin Kim et al.

Developmental biology, 397(1), 129-139 (2014-12-03)

Members of the fibroblast growth factor (FGF) family play important roles during various developmental processes including eye development. FRS (FGF receptor substrate) proteins bind to FGFR and serve as adapters for coordinated assembly of multi-protein complexes involved in Ras/MAPK and

Non-aggregating tau phosphorylation by cyclin-dependent kinase 5 contributes to motor neuron degeneration in spinal muscular atrophy.

Nimrod Miller et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(15), 6038-6050 (2015-04-17)

Mechanisms underlying motor neuron degeneration in spinal muscular atrophy (SMA), the leading inherited cause of infant mortality, remain largely unknown. Many studies have established the importance of hyperphosphorylation of the microtubule-associated protein tau in various neurodegenerative disorders, including Alzheimer's and

Ampelopsin induces apoptosis by regulating multiple c-Myc/S-phase kinase-associated protein 2/F-box and WD repeat-containing protein 7/histone deacetylase 2 pathways in human lung adenocarcinoma cells.

Xin-Mei Chen et al.

Molecular medicine reports, 11(1), 105-112 (2014-10-22)

Ampelopsin (AMP), a plant flavonoid, has been reported to inhibit cell growth and/or induce apoptosis in various types of tumor. The aim of the present study was to assess the apoptosis-inducing activity of AMP in A549 human lung adenocarcinoma epithelial

Acetylation mediates Cx43 reduction caused by electrical stimulation.

Viviana Meraviglia et al.

Journal of molecular and cellular cardiology, 87, 54-64 (2015-08-13)

Communication between cardiomyocytes depends upon gap junctions (GJ). Previous studies have demonstrated that electrical stimulation induces GJ remodeling and modifies histone acetylase (HAT) and deacetylase (HDAC) activities, although these two results have not been linked. The aim of this work

A dihydroselenoquinazoline inhibits S6 ribosomal protein signalling, induces apoptosis and inhibits autophagy in MCF-7 cells.

Esther Moreno et al.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 63, 87-95 (2014-07-11)

The PI3K/Akt/mTOR/S6 ribosomal protein signalling pathway is a key potential target in breast cancer therapy, playing a central role in proliferation and cell survival. In this study, we found that the seleno-compound 2,4-dihydroselenoquinazoline (3a) generally inhibited this signalling axis in

Alisertib, an Aurora kinase A inhibitor, induces apoptosis and autophagy but inhibits epithelial to mesenchymal transition in human epithelial ovarian cancer cells.

Yong-Hui Ding et al.

Drug design, development and therapy, 9, 425-464 (2015-01-28)

Ovarian cancer is a leading killer of women, and no cure for advanced ovarian cancer is available. Alisertib (ALS), a selective Aurora kinase A (AURKA) inhibitor, has shown potent anticancer effects, and is under clinical investigation for the treatment of

Sodium fluoride inhibits MMP-2 and MMP-9.

M T Kato et al.

Journal of dental research, 93(1), 74-77 (2013-11-08)

The importance of fluoride (F) in preventing dental caries by favorably interfering in the demineralization-remineralization processes is well-established, but its ability to inhibit matrix metalloproteinases (MMPs), which could also help to prevent dentin caries, has not been investigated. This study

Microvascular lesions by estrogen-induced ID3: its implications in cerebral and cardiorenal vascular disease.

Jayanta K Das et al.

Journal of molecular neuroscience : MN, 55(3), 618-631 (2014-08-19)

Severe symptoms of cerebral and cardiorenal vascular diseases can be triggered when cerebral, coronary, or glomerular arterioles grow inappropriately as a result of abnormal cell proliferation. The risk factor(s) and molecular mechanisms responsible for microvascular lesion formation are largely unknown.

Role of SM22 in the differential regulation of phasic vs. tonic smooth muscle.

Satish Rattan et al.

American journal of physiology. Gastrointestinal and liver physiology, 308(7), G605-G612 (2015-01-27)

Preliminary proteomics studies between tonic vs. phasic smooth muscles identified three distinct protein spots identified to be those of transgelin (SM22). The latter was found to be distinctly downregulated in the internal anal sphincter (IAS) vs. rectal smooth muscle (RSM)

Metformin Impairs Glutamine Metabolism and Autophagy in Tumour Cells.

Serena Saladini et al.

Cells, 8(1) (2019-01-17)

Metformin has been shown to inhibit glutaminase (GLS) activity and ammonia accumulation thereby reducing the risk of hepatic encephalopathy in type 2 diabetic patients. Since tumour cells are addicted to glutamine and often show an overexpression of glutaminase, we hypothesize

Mechanisms of expression and translocation of major fission yeast glucose transporters regulated by CaMKK/phosphatases, nuclear shuttling, and TOR.

Shigeaki Saitoh et al.

Molecular biology of the cell, 26(2), 373-386 (2014-11-21)

Hexose transporters are required for cellular glucose uptake; thus they play a pivotal role in glucose homeostasis in multicellular organisms. Using fission yeast, we explored hexose transporter regulation in response to extracellular glucose concentrations. The high-affinity transporter Ght5 is regulated

Facile synthesis of multifunctional beta-NaGdF4:Yb3+/Er3+ nanoparticles in oleylamine.

Qian Cheng et al.

Journal of nanoscience and nanotechnology, 13(1), 529-532 (2013-05-08)

Multifunctional beta-NaGdF4:Yb3+/Er3+ nanoparticles (NPs) were successfully synthesized using oleylamine as both solvent and stabilizer via the thermolysis method. They have uniform morphology with a mean size of 12.7 nm and show efficient up-conversion emission when excited by a 980 nm

Reciprocal feedback inhibition of the androgen receptor and PI3K as a novel therapy for castrate-sensitive and -resistant prostate cancer.

Wenqing Qi et al.

Oncotarget, 6(39), 41976-41987 (2015-10-28)

Gain-of-function of the androgen receptor (AR) and activation of PI3K/AKT/mTOR pathway have been demonstrated to correlate with progression to castration-resistant prostate cancer (CRPC). However, inhibition of AR or PI3K/mTOR alone results in a reciprocal feedback activation. Therefore, we hypothesized that

Inhibition of Hepatocyte Apoptosis: An Important Mechanism of Corn Peptides Attenuating Liver Injury Induced by Ethanol.

Zhili Ma et al.

International journal of molecular sciences, 16(9), 22062-22080 (2015-09-18)

In this study, the effects of mixed corn peptides and synthetic pentapeptide (QLLPF) on hepatocyte apoptosis induced by ethanol were investigated in vivo. QLLPF, was previously characterized from corn protein hydrolysis, which had been shown to exert good facilitating alcohol

Respiratory syncytial virus nonstructural proteins 1 and 2 are crucial pathogenic factors that modulate interferon signaling and Treg cell distribution in mice.

Pu Yang et al.

Virology, 485, 223-232 (2015-08-25)

Respiratory syncytial virus (RSV) nonstructural (NS) proteins 1 and 2 have multiple functions in suppressing the innate immune response and modulating T helper cell subset differentiation. However, little is known about the roles of NS proteins as independent virulence factors.

Networks of protein kinases and phosphatases in the individual phases of contextual fear conditioning in the C57BL/6J mouse.

Goran Mucic et al.

Behavioural brain research, 280, 45-50 (2014-12-03)

Although protein kinases and phosphatases have been reported to be involved in fear memory, information about these signalling molecules in the individual phases of contextual fear conditioning (cFC) is limited. C57BL/6J mice were tested in cFC, sacrificed and hippocampi were

Generation of an anti-EpCAM antibody and epigenetic regulation of EpCAM in colorectal cancer.

Mei-Ying Liao et al.

International journal of oncology, 46(4), 1788-1800 (2015-02-06)

We have generated a novel monoclonal antibody (mAb), OCAb9-1, which specifically binds to various types of cancer cell lines, but not to normal cells. According to the results of immunoaffinity chromatography, LC-MS/MS analysis, co-immunoprecipitation, and RNA interference studies, the target

Microtubule-bundling activity of the centrosomal protein, Cep169, and its binding to microtubules.

Yusuke Mori et al.

Biochemical and biophysical research communications, 467(4), 754-759 (2015-10-21)

CDK5RAP2 is a centrosomal protein that regulates the recruitment of a γ-tubulin ring complex (γ-TuRC) onto centrosomes and microtubules (MTs) dynamics as a member of MT plus-end-tracking proteins (+TIPs). In our previous report, we found mammalian Cep169 as a CDK5RAP2

Resveratrol attenuates HMGB1 signaling and inflammation in house dust mite-induced atopic dermatitis in mice.

Vengadeshprabhu Karuppagounder et al.

International immunopharmacology, 23(2), 617-623 (2014-12-04)

Resveratrol is a polyphenol abundantly found in red grape skin and is effective against antiaging and anti-inflammation associated with immune responses. In this study, we have investigated the effect of resveratrol on skin lesion, high mobility group box (HMGB)1 and

Vitamin D analog EB1089 could repair the defective bone marrow-derived mesenchymal stromal cells in patients with systemic lupus erythematosus.

Jing-Jing Xu et al.

International journal of clinical and experimental medicine, 8(1), 916-921 (2015-03-19)

Systemic lupus erythematosus (SLE) involves multiple factors, which result in the breakdown of self-tolerance and development of autoimmunity with organ damage. Bone marrow mesenchymal stem cells (BMMSCs) from the patients with SLE showed an impaired proliferative capacity compared with that

The HIV-1 Gp120/CXCR4 axis promotes CCR7 ligand-dependent CD4 T cell migration: CCR7 homo- and CCR7/CXCR4 hetero-oligomer formation as a possible mechanism for up-regulation of functional CCR7.

Haruko Hayasaka et al.

PloS one, 10(2), e0117454-e0117454 (2015-02-18)

During human immunodeficiency virus (HIV) infection, enhanced migration of infected cells to lymph nodes leads to efficient propagation of HIV-1. The selective chemokine receptors, including CXCR4 and CCR7, may play a role in this process, yet the viral factors regulating

Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation.

Ara Koh et al.

Cell metabolism, 32(4), 643-653 (2020-08-14)

Metformin is the first-line therapy for type 2 diabetes, but there are large inter-individual variations in responses to this drug. Its mechanism of action is not fully understood, but activation of AMP-activated protein kinase (AMPK) and changes in the gut

YM155 down-regulates survivin and XIAP, modulates autophagy and induces autophagy-dependent DNA damage in breast cancer cells.

S M Cheng et al.

British journal of pharmacology, 172(1), 214-234 (2014-09-16)

The aim of this study was to determine the potency and molecular mechanism of action of YM155, a first-in-class survivin inhibitor that is currently under phase I/II clinical investigations, in various drug-resistant breast cancers including the oestrogen receptor positive (ER(+)

Carlson, S. et al.

Inorganic Chemistry, 37, 1486-1486 (1998)

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