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Qingnian Goh et al.
Experimental cell research, 331(2), 292-308 (2014-10-05)
We previously demonstrated that the expression of intercellular adhesion molecule-1 (ICAM-1) by skeletal muscle cells after muscle overload contributes to ensuing regenerative and hypertrophic processes in skeletal muscle. The objective of the present study is to reveal mechanisms through which
Kamen P Simeonov et al.
PloS one, 9(6), e100134-e100134 (2014-06-26)
Direct reprogramming by overexpression of defined transcription factors is a promising new method of deriving useful but rare cell types from readily available ones. While the method presents numerous advantages over induced pluripotent stem (iPS) cell approaches, a focus on
Cornelia M Hooper et al.
PloS one, 9(11), e112909-e112909 (2014-11-21)
Medulloblastoma is the most common form of malignant paediatric brain tumour and is the leading cause of childhood cancer related mortality. The four molecular subgroups of medulloblastoma that have been identified - WNT, SHH, Group 3 and Group 4 -
Nahla S El-Shenawy et al.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 67(1), 65-76 (2014-12-03)
Sodium azide (SA) is used as an active ingredient to control a broad spectrum of soil borne pathogens including insects, weeds, nematodes, fungi, and bacteria. The purpose of this study was to evaluate the ameliorator property of vitamin E (Vit
X R Ji et al.
European review for medical and pharmacological sciences, 17(18), 2499-2503 (2013-10-04)
Scoliosis is the disease which has a long history over one century. However, the pathogenesis remains unclear at present. To demonstrate the effect of different selenium content in environment on the morbidity of adolescent idiopathic scoliosis (AIS). Retrospective cohort study
Digoxin and adenosine triphosphate enhance the functional properties of tissue-engineered cartilage.
Eleftherios A Makris et al.
Tissue engineering. Part A, 21(5-6), 884-894 (2014-12-05)
Toward developing engineered cartilage for the treatment of cartilage defects, achieving relevant functional properties before implantation remains a significant challenge. Various chemical and mechanical stimuli have been used to enhance the functional properties of engineered musculoskeletal tissues. Recently, Ca(2+)-modulating agents
Manjunath Ramanjaneya et al.
The Journal of endocrinology, 226(1), 1-11 (2015-04-15)
NUCB2/nesfatin and its proteolytically cleaved product nesfatin-1 are recently discovered anorexigenic hypothalamic neuroproteins involved in energy homeostasis. It is expressed both centrally and in peripheral tissues, and appears to have potent metabolic actions. NUCB2/nesfatin neurons are activated in response to
Seigo Hatada et al.
Stem cells translational medicine, 4(9), 998-1010 (2015-07-18)
Human pluripotent stem cells (hPSCs) are now being used for both disease modeling and cell therapy; however, efficient homologous recombination (HR) is often crucial to develop isogenic control or reporter lines. We showed that limited low-dose irradiation (LDI) using either
Xue-Ling Wei et al.
Clinica chimica acta; international journal of clinical chemistry, 438, 80-85 (2014-08-26)
Previous experimental studies have shown an antagonistic interaction between cadmium and selenium. We explored the interaction between cadmium and selenium on human breast cancer risk. A case-control study, enrolled 240 incident invasive breast cancer patients and 246 age-matched controls from
Brittany L Fay et al.
International journal of nanomedicine, 10, 6931-6941 (2015-11-27)
Nanoshell-mediated photothermal therapy (PTT) is currently being investigated as a standalone therapy for the treatment of cancer. The cellular effects of PTT include loss of membrane integrity, so we hypothesized that nanoshell-mediated PTT could potentiate the cytotoxicity of chemotherapy by
Alessandro R Zorzi et al.
International journal of molecular sciences, 16(11), 26813-26831 (2015-11-17)
Cell therapy is a promising approach to improve cartilage healing. Adipose tissue is an abundant and readily accessible cell source. Previous studies have demonstrated good cartilage repair results with adipose tissue mesenchymal stem cells in small animal experiments. This study
Jing-Jing Xu et al.
International journal of clinical and experimental medicine, 8(1), 916-921 (2015-03-19)
Systemic lupus erythematosus (SLE) involves multiple factors, which result in the breakdown of self-tolerance and development of autoimmunity with organ damage. Bone marrow mesenchymal stem cells (BMMSCs) from the patients with SLE showed an impaired proliferative capacity compared with that
S M Cheng et al.
British journal of pharmacology, 172(1), 214-234 (2014-09-16)
The aim of this study was to determine the potency and molecular mechanism of action of YM155, a first-in-class survivin inhibitor that is currently under phase I/II clinical investigations, in various drug-resistant breast cancers including the oestrogen receptor positive (ER(+)
Junko Nio-Kobayashi et al.
Molecular human reproduction, 21(8), 645-654 (2015-05-25)
Intense macrophage infiltration is observed during luteolysis in various animals including women; however, we still do not know how macrophage infiltration into the human corpus luteum (CL) during luteolysis is regulated. In this study, we examined the expression, localization and
Yuvabharath Kondaveeti et al.
Cancer letters, 364(1), 44-58 (2015-04-29)
Epithelial-mesenchymal transition (EMT) induces invasive properties in epithelial tumors and promotes metastasis. Although EMT-mediated cellular and molecular changes are well understood, very little is known about EMT-induced metabolic changes. HER2-positive BT-474 breast cancer cells were induced to undergo a stable
Young-Ah Cho et al.
Journal of pineal research, 58(1), 127-135 (2014-11-29)
Melatonin's effect on hepatic differentiation of stem cells remains unclear. The aim of this study was to investigate the action of melatonin on hepatic differentiation as well as its related signaling pathways of human dental pulp stem cells (hDPSCs) and
Urban Alehagen et al.
PloS one, 10(12), e0141641-e0141641 (2015-12-02)
Selenium and coenzyme Q10 are important antioxidants in the body. As the intake of selenium is low in Europe, and the endogenous production of coenzyme Q10 decreases as age increases, an intervention trial using selenium and coenzyme Q10 for four
Junhong Zhang et al.
PloS one, 10(7), e0132318-e0132318 (2015-07-08)
The developmental competence of oocytes during in vitro maturation (IVM) is compromised due to asynchronous nuclear and cytoplasmic maturation. To improve IVM efficiency, a pre-maturation culture or two-step maturation strategy has been established, involving meiosis arrest induced by pharmacological agents
Yu-Bin Ji et al.
Asian Pacific journal of cancer prevention : APJCP, 15(8), 3651-3657 (2014-05-30)
Hepatocellular carcinoma (HCC) has a relatively higher incidence in many countries of Asia. Globally, HCC has a high fatality rate and short survival. Epirubicin, a doxorubicin analogue, may be administered alone or in combination with other agents to treat primary
Amlan Kanti Ghosh et al.
Cytokine, 73(1), 44-52 (2015-02-24)
Nonconventional innate memory CD8(+) T cells characteristically expressing CD44, CD122, eomesodermin (Eomes) and promyelocytic leukemia zinc finger (PLZF) were derived in culture from CD4(+)CD8(+) double positive (DP) thymocytes of normal BALB/c and C57BL/6 mice. These culture-differentiated cells constitutively express toll-like
Lei Yang et al.
Asian Pacific journal of cancer prevention : APJCP, 14(4), 2181-2184 (2013-06-04)
Prostate cancer is the most common malignancy in men in the United States. Surgery or radiation are sometimes unsatisfactory treatments because of the complications such as incontinence or erectile dysfunction. Selenium was found to be effective to prevent prostate cancer
Immunomodulatory of selenium nano-particles decorated by sulfated Ganoderma lucidum polysaccharides.
Jianguo Wang et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 68, 183-189 (2014-03-15)
In this study, we employed a one-step method to prepare selenium nanoparticles (SeNPs) decorated by the water-soluble derivative of Ganoderma lucidum polysaccharides (SPS). The SeNPs-SPS complexes were stable, and the diameter of the SeNPs was homogeneous at around 25 nm.
N Qin et al.
Poultry science, 94(9), 2235-2246 (2015-07-19)
The SLIT/Roundabout (ROBO) pathway is involved in follicle development of mammalian ovary, and 2 secreted hormones activin A and inhibin A have potential roles in modulation of the SLIT/ROBO system, but the related actions remain poorly understood in bird. The
Mi-Jeong Kwon et al.
Cell biology and toxicology, 31(3), 149-159 (2015-04-22)
In the present study, we differentiated hepatocyte-like cells (HLCs) from human adipose tissue-derived mesenchymal stem cells (AT-MSCs). The hepatic differentiation was confirmed by increases in hepatic proteins or genes, the cytochrome P450 (CYP) activities, albumin secretion, and glycogen storage. To
M B Stockler-Pinto et al.
Biological trace element research, 163(1-2), 67-72 (2014-11-15)
Brazil nut is the richest known food source of selenium. The supplementation with Brazil nut during 3 months was effective in reducing oxidative stress and inflammation in hemodialysis (HD) patients. However, there are no available data on the antioxidant effect after
Rupak Shivakoti et al.
Nutrients, 6(11), 5061-5078 (2014-11-18)
A case-cohort study, within a multi-country trial of antiretroviral therapy (ART) efficacy (Prospective Evaluation of Antiretrovirals in Resource Limited Settings (PEARLS)), was conducted to determine if pre-ART serum selenium deficiency is independently associated with human immunodeficiency virus (HIV) disease progression
Fang Wang et al.
Systems biology in reproductive medicine, 60(3), 136-142 (2014-02-13)
We explored the molecular mechanisms of obesity and insulin resistance in patients with polycystic ovary syndrome (PCOS) using a human embryonic stem cell model (hESCs). Three PCOS-derived and one non-PCOS-derived hESC lines were induced into adipocytes, and then total RNA
C C Ude et al.
Osteoarthritis and cartilage, 23(8), 1294-1306 (2015-04-19)
Our previous studies on osteoarthritis (OA) revealed positive outcome after chondrogenically induced cells treatment. Presently, the functional improvements of these treated OA knee joints were quantified followed by evaluation of the mechanical properties of the engineered cartilages. Baseline electromyogram (EMGs)
Diana L Moughon et al.
Cancer research, 75(22), 4742-4752 (2015-10-17)
Malignant ascites is a common complication in the late stages of epithelial ovarian cancer (EOC) that greatly diminishes the quality of life of patients. Malignant ascites is a known consequence of vascular dysfunction, but current approved treatments are not effective
Michelle S Gupta et al.
Cell and tissue research, 358(2), 527-539 (2014-08-06)
Intervertebral disc (IVD) degeneration is associated with several pathophysiologic changes of the IVD, including dehydration of the nucleus pulposus (NP). Tissue engineering strategies may be used to restore both biological and mechanical function of the IVD following removal of NP
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